Novel enzymatic crosslinked hydrogels that mimic extracellular matrix for skin wound healing

2018 ◽  
Vol 53 (8) ◽  
pp. 5909-5928 ◽  
Author(s):  
Chenhui Zhu ◽  
Huan Lei ◽  
Daidi Fan ◽  
Zhiguang Duan ◽  
Xian Li ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Skin Wound ◽  
Skin Wound Healing

scholarly journals Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

2015 ◽  
Vol 4 (8) ◽  
pp. 479-489 ◽  
Author(s):  
Priscilla S. Briquez ◽  
Jeffrey A. Hubbell ◽  
Mikaël M. Martino
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Growth Factor ◽  
Delivery Systems ◽  
Skin Wound ◽  
Growth Factor Delivery ◽  
Skin Wound Healing

scholarly journals Toward understanding scarless skin wound healing and pathological scarring

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 787 ◽  
Author(s):  
Sanna-Maria Karppinen ◽  
Ritva Heljasvaara ◽  
Donald Gullberg ◽  
Kaisa Tasanen ◽  
Taina Pihlajaniemi
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Healing Process ◽  
Cell Types ◽  
Skin Wound ◽  
Skin Wounds ◽  
Medical Problems ◽  
Skin Wound Healing ◽  
Recent Developments ◽  
Acute Wound

The efficient healing of skin wounds is crucial for securing the vital barrier function of the skin, but pathological wound healing and scar formation are major medical problems causing both physiological and psychological challenges for patients. A number of tightly coordinated regenerative responses, including haemostasis, the migration of various cell types into the wound, inflammation, angiogenesis, and the formation of the extracellular matrix, are involved in the healing process. In this article, we summarise the central mechanisms and processes in excessive scarring and acute wound healing, which can lead to the formation of keloids or hypertrophic scars, the two types of fibrotic scars caused by burns or other traumas resulting in significant functional or aesthetic disadvantages. In addition, we discuss recent developments related to the functions of activated fibroblasts, the extracellular matrix and mechanical forces in the wound environment as well as the mechanisms of scarless wound healing. Understanding the different mechanisms of wound healing is pivotal for developing new therapies to prevent the fibrotic scarring of large skin wounds.

scholarly journals Connexin 43 deficiency accelerates skin wound healing and extracellular matrix remodeling in mice

2015 ◽  
Vol 79 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Bruno Cogliati ◽  
Mathieu Vinken ◽  
Tereza C. Silva ◽  
Cintia M.M. Araújo ◽  
Thiago P.A. Aloia ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Connexin 43 ◽  
Skin Wound ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Skin Wound Healing

scholarly journals The Role of Extracellular Matrix in Skin Wound Healing

2021 ◽  
Vol 10 (24) ◽  
pp. 5947
Author(s):  
Nikolai N. Potekaev ◽  
Olga B. Borzykh ◽  
German V. Medvedev ◽  
Denis V. Pushkin ◽  
Marina M. Petrova ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Modern Medicine ◽  
Skin Wound ◽  
Economic Losses ◽  
Skin Wound Healing ◽  
Impaired Wound Healing ◽  
Risk Levels ◽  
Fundamental Research ◽  
Chronic Skin

Impaired wound healing is one of the unsolved problems of modern medicine, affecting patients’ quality of life and causing serious economic losses. Impaired wound healing can manifest itself in the form of chronic skin wounds or hypertrophic scars. Research on the biology and physiology of skin wound healing disorders is actively continuing, but, unfortunately, a single understanding has not been developed. The attention of clinicians to the biological and physiological aspects of wound healing in the skin is necessary for the search for new and effective methods of prevention and treatment of its consequences. In addition, it is important to update knowledge about genetic and non-genetic factors predisposing to impaired wound healing in order to identify risk levels and develop personalized strategies for managing such patients. Wound healing is a very complex process involving several overlapping stages and involving many factors. This thematic review focuses on the extracellular matrix of the skin, in particular its role in wound healing. The authors analyzed the results of fundamental research in recent years, finding promising potential for their transition into real clinical practice.

scholarly journals Self-Associating Polymers Chitosan and Hyaluronan for Constructing Composite Membranes as Skin-Wound Dressings Carrying Therapeutics

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2535
Author(s):  
Katarína Valachová ◽  
Ladislav Šoltés
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Composite Membranes ◽  
Skin Wound ◽  
Wound Dressings ◽  
Structural Components ◽  
Skin Wound Healing ◽  
Associating Polymers

Chitosan, industrially acquired by the alkaline N-deacetylation of chitin, belongs to β-N-acetyl-glucosamine polymers. Another β-polymer is hyaluronan. Chitosan, a biodegradable, non-toxic, bacteriostatic, and fungistatic biopolymer, has numerous applications in medicine. Hyaluronan, one of the major structural components of the extracellular matrix in vertebrate tissues, is broadly exploited in medicine as well. This review summarizes that these two biopolymers have a mutual impact on skin wound healing as skin wound dressings and carriers of remedies.

scholarly journals Gene Expression Profiling of the Extracellular Matrix Signature in Macrophages of Different Activation Status: Relevance for Skin Wound Healing

2019 ◽  
Vol 20 (20) ◽  
pp. 5086 ◽  
Author(s):  
Julia Etich ◽  
Manuel Koch ◽  
Raimund Wagener ◽  
Frank Zaucke ◽  
Mario Fabri ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Transcriptome Profiling ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Specific Expression ◽  
Skin Repair

The extracellular matrix (ECM) provides structural support for tissue architecture and is a major effector of cell behavior during skin repair and inflammation. Macrophages are involved in all stages of skin repair but only limited knowledge exists about macrophage-specific expression and regulation of ECM components. In this study, we used transcriptome profiling and bioinformatic analysis to define the unique expression of ECM-associated genes in cultured macrophages. Characterization of the matrisome revealed that most genes were constitutively expressed and that several genes were uniquely regulated upon interferon gamma (IFNγ) and dexamethasone stimulation. Among those core matrisome and matrisome-associated components transforming growth factor beta (TGFβ)-induced, matrix metalloproteinase 9 (MMP9), elastin microfibril interfacer (EMILIN)-1, netrin-1 and gliomedin were also present within the wound bed at time points that are characterized by profound macrophage infiltration. Hence, macrophages are a source of ECM components in vitro as well as during skin wound healing, and identification of these matrisome components is a first step to understand the role and therapeutic value of ECM components in macrophages and during wound healing.

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