scholarly journals Synthesis and characterisation of cationic quaternary ammonium-modified polyvinyl alcohol hydrogel beads as a drug delivery embolisation system

2016 ◽  
Vol 27 (3) ◽  
Author(s):  
Clare L. Heaysman ◽  
Gary J. Phillips ◽  
Andrew W. Lloyd ◽  
Andrew L. Lewis
Keyword(s):  
Drug Delivery ◽  
Polyvinyl Alcohol ◽  
Quaternary Ammonium ◽  
Hydrogel Beads

scholarly journals The Impact of Magnesium–Aluminum-Layered Double Hydroxide-Based Polyvinyl Alcohol Coated on Magnetite on the Preparation of Core-Shell Nanoparticles as a Drug Delivery Agent

2019 ◽  
Vol 20 (15) ◽  
pp. 3764 ◽  
Author(s):  
Mona Ebadi ◽  
Kalaivani Buskaran ◽  
Bullo Saifullah ◽  
Sharida Fakurazi ◽  
Mohd Zobir Hussein
Keyword(s):  
Drug Delivery ◽  
Polyvinyl Alcohol ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
The Body ◽  
Normal Fibroblast ◽  
Cellular Environment ◽  
Double Hydroxide ◽  
The Impact

One of the current developments in drug research is the controlled release formulation of drugs, which can be released in a controlled manner at a specific target in the body. Due to the diverse physical and chemical properties of various drugs, a smart drug delivery system is highly sought after. The present study aimed to develop a novel drug delivery system using magnetite nanoparticles as the core and coated with polyvinyl alcohol (PVA), a drug 5-fluorouracil (5FU) and Mg–Al-layered double hydroxide (MLDH) for the formation of FPVA-FU-MLDH nanoparticles. The existence of the coated nanoparticles was supported by various physico-chemical analyses. In addition, the drug content, kinetics, and mechanism of drug release also were studied. 5-fluorouracil (5FU) was found to be released in a controlled manner from the nanoparticles at pH = 4.8 (representing the cancerous cellular environment) and pH = 7.4 (representing the blood environment), governed by pseudo-second-order kinetics. The cytotoxicity study revealed that the anticancer delivery system of FPVA-FU-MLDH nanoparticles showed much better anticancer activity than the free drug, 5FU, against liver cancer and HepG2 cells, and at the same time, it was found to be less toxic to the normal fibroblast 3T3 cells.

Polyvinyl Alcohol/Hydroxyethylcellulose Containing Ethosomes as a Scaffold for Transdermal Drug Delivery Applications

2020 ◽  
Vol 191 (4) ◽  
pp. 1624-1637
Author(s):  
Gomaa El Fawal ◽  
Huoyan Hong ◽  
Xinran Song ◽  
Jinglei Wu ◽  
Meiqi Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyvinyl Alcohol ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Applications

scholarly journals Quaternary Ammonium Chitosans: The Importance of the Positive Fixed Charge of the Drug Delivery Systems

2020 ◽  
Vol 21 (18) ◽  
pp. 6617 ◽  
Author(s):  
Angela Fabiano ◽  
Denise Beconcini ◽  
Chiara Migone ◽  
Anna Maria Piras ◽  
Ylenia Zambito
Keyword(s):  
Drug Delivery ◽  
Quaternary Ammonium ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Fixed Charge ◽  
Innovative Drug ◽  
Natural Polysaccharide ◽  
The Impact

As a natural polysaccharide, chitosan has good biocompatibility, biodegradability and biosecurity. The hydroxyl and amino groups present in its structure make it an extremely versatile and chemically modifiable material. In recent years, various synthetic strategies have been used to modify chitosan, mainly to solve the problem of its insolubility in neutral physiological fluids. Thus, derivatives with negative or positive fixed charge were synthesized and used to prepare innovative drug delivery systems. Positively charged conjugates showed improved properties compared to unmodified chitosan. In this review the main quaternary ammonium derivatives of chitosan will be considered, their preparation and their applications will be described to evaluate the impact of the positive fixed charge on the improvement of the properties of the drug delivery systems based on these polymers. Furthermore, the performances of the proposed systems resulting from in vitro and ex vivo experiments will be taken into consideration, with particular attention to cytotoxicity of systems, and their ability to promote drug absorption.

A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier

2010 ◽  
Vol 148-149 ◽  
pp. 1449-1452 ◽  
Author(s):  
Kui Lin Deng ◽  
Yu Bo Gou ◽  
Jian Zuo ◽  
Li Rong Dong ◽  
Qian Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Network ◽  
Phosphate Buffer Solution ◽  
Interpenetrating Polymer Network ◽  
Temperature Sensitive ◽  
Buffer Solution ◽  
Hydrogel Beads ◽  
Drug Delivery Carrier ◽  
Temperature Sensitive Hydrogel ◽  
Stimuli Sensitive

A series of pH/temperature sensitive hydrogel beads with semi-interpenetrating polymer network (semi-IPN), composed of sodium alginate and poly(N-acryloylglycinate) were prepared as drug delivery carrier. In pH=2.3 phosphate buffer solution (PBS), the release amount of indomethacin incorporated into the beads was about 9% within 610 min, while this value approached to 68% in pH=7.4 PBS. The release rate of indomethacin was higher at 37 than that at 20 . In addition, the release amount of indomethacin was increased with increasing poly(N-acryloylglycinate) content. These results suggest that the stimuli-sensitive beads have the potential to be used as an effective pH/temperature delivery system in bio-medical fields.

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