Interventions to Increase Multivitamin Use Among Women in the Interconception Period: An IMPLICIT Network Study

Introduction: A multivitamin (MV) is the most commonly taken supplement in older U.S. adults. Arterial stiffness is an important intermediate marker of cardiovascular disease (CVD). However, few studies have examined the association of MV use and arterial stiffness. Hypothesis: Regular multivitamin use is associated with lower levels of arterial stiffness. Methods: A subcohort of participants enrolled in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS), a large scale randomized clinical trial testing a MV and a cocoa extract supplement on CVD and cancer, completed baseline measurement of arterial stiffness assessed by pulse wave velocity (PWV), augmentation index (AI), and central blood pressure (CBP). Frequency and duration of MV use was assessed via self-report questionnaire at baseline. The cross-sectional association of MV use and arterial stiffness was evaluated by multivariate linear regression with adjustment for conventional CVD risk factors. We also performed subgroup analyses to evaluate effect modification between MV use and sex, age, body mass index (BMI), and hypertension. Results: A total of 470 (229 women and 241 men) COSMOS participants were included in this study, with mean age 69.1±5.2 years, of whom 150 (32%) reported current MV use at baseline. Multivariate linear regression analysis revealed that current MV use (yes versus no) was significantly associated with lower PWV (β:-0.59±1.02, p=0.004) but not associated with other measures of arterial stiffness, including AI or CBP. There were also no consistent associations between frequency and duration of MV use with any of the measures of arterial stiffness. Also, there was no effect modification by sex, age, BMI, or hypertension on the association between MV use and arterial stiffness. Conclusions: MV use was associated with lower PWV in older subjects. Further results from the COSMOS trial on randomized MV supplementation and changes in arterial stiffness over 2 years will further elucidate the effects of MV on arterial stiffness.

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Multivitamin use and risk of preeclampsia in a high-income population: A cohort study

Sexual & Reproductive Healthcare ◽

10.1016/j.srhc.2020.100500 ◽

2020 ◽

Vol 24 ◽

pp. 100500

Author(s):

Stinne Høgh ◽

Hanne Trap Wolf ◽

My von Euler-Chelpin ◽

Lene Huusom ◽

Anja Pinborg ◽

...

Keyword(s):

Cohort Study ◽

High Income ◽

Multivitamin Use ◽

Risk Of Preeclampsia

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Alcohol, smoking, folic acid and multivitamin use among women attending maternity care in London: A cross-sectional study

Sexual & Reproductive Healthcare ◽

10.1016/j.srhc.2019.100461 ◽

2019 ◽

Vol 22 ◽

pp. 100461 ◽

Cited By ~ 1

Author(s):

Aalaa Jawad ◽

Dilisha Patel ◽

Nataliya Brima ◽

Judith Stephenson

Keyword(s):

Folic Acid ◽

Maternity Care ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Multivitamin Use

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Multivitamin supplement use and risk of invasive breast cancer

Public Health Nutrition ◽

10.1017/s1368980009992187 ◽

2009 ◽

Vol 13 (10) ◽

pp. 1540-1545 ◽

Cited By ~ 5

Author(s):

Johanna M Meulepas ◽

Polly A Newcomb ◽

Andrea N Burnett-Hartman ◽

John M Hampton ◽

Amy Trentham-Dietz

Keyword(s):

Breast Cancer ◽

Cancer Risk ◽

Menopausal Status ◽

Population Based ◽

Supplement Use ◽

Multivitamin Supplement ◽

The Usa ◽

History Of ◽

Multivitamin Use ◽

Hormone Use

AbstractObjectiveMultivitamin supplements are used by nearly half of middle-aged women in the USA. Despite this high prevalence of multivitamin use, little is known about the effects of multivitamins on health outcomes, including cancer risk. Our main objective was to determine the association between multivitamin use and the risk of breast cancer in women.DesignWe conducted a population-based case–control study among 2968 incident breast cancer cases (aged 20–69 years), diagnosed between 2004 and 2007, and 2982 control women from Wisconsin, USA. All participants completed a structured telephone interview which ascertained supplement use prior to diagnosis, demographics and risk factor information. Odds ratios and 95 % confidence intervals were calculated using multivariable logistic regression.ResultsCompared with never users of multivitamins, the OR for breast cancer was 1·02 (95 % CI 0·87, 1·19) for current users and 0·99 (95 % CI 0·74, 1·33) for former users. Further, neither duration of use (for ≥10 years: OR = 1·13, 95 % CI 0·93, 1·38, P for trend = 0·25) nor frequency (>7 times/week: OR = 1·00, 95 % CI 0·77, 1·28, P for trend = 0·97) was related to risk in current users. Stratification by menopausal status, family history of breast cancer, age, alcohol, tumour staging and postmenopausal hormone use did not significantly modify the association between multivitamin use and breast cancer.ConclusionsThe current study found no association between multivitamin supplement use and breast cancer risk in women.

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