Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer

2009 ◽  
Vol 37 (1) ◽  
pp. 515-520 ◽  
Author(s):  
Ruiping Hou ◽  
Bangwei Cao ◽  
Zhongdong Chen ◽  
Yong Li ◽  
Tao Ning ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Gene Haplotype

Cytotoxic T‐lymphocyte‐associated protein 4 in gastric cancer: Prognosis and association with PD‐L1 expression

2021 ◽  
Author(s):  
Marina Alessandra Pereira ◽  
Tiago Biachi Castria ◽  
Marcus Fernando Kodama Pertille Ramos ◽  
André Roncon Dias ◽  
Leonardo Cardili ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Cancer Prognosis

Estimation of associations between 10 common gene polymorphisms and gastric cancer: evidence from a meta-analysis

2019 ◽  
Vol 73 (6) ◽  
pp. 318-321
Author(s):  
Zongjing Xie ◽  
Bingmei Wang ◽  
Yongjie Chai ◽  
Junyin Chen
Keyword(s):  
Gastric Cancer ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Meta Analysis ◽  
Interleukin 4 ◽  
East Asians ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Positive Results ◽  
Review Manager

AimsAssociations between polymorphisms in cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)/mannose-binding lectin (MBL)/interleukin-4 (IL-4)/interleukin-6 (IL-6)/phospholipase C ε−1 (PLCE1) and gastric cancer (GC) were already reported by many studies, yet the conclusions of these studies were somehow controversial. The aim of this meta-analysis was to better clarify associations between polymorphisms in CTLA-4/MBL/IL-4/IL-6/PLCE1 and GC by combing the results of all relevant studies.MethodsEligible studies were searched from PubMed, Embase, WOS and CNKI. We used Review Manager to combine the results of individual studies.ResultsForty-three studies were included in this meta-analysis. Combined results revealed that CTLA-4 rs5742909 (dominant comparison: OR: 1.58, 95 % CI: 1.01 to 2.48; allele comparison: OR: 1.69, 95 % CI: 1.12 to 2.56) and PLCE1 rs2274223 (dominant comparison: OR: 0.84, 95 % CI: 0.72 to 0.98; recessive comparison: OR: 1.23, 95 % CI: 1.08 to 1.40; over-dominant comparison: OR: 1.16, 95 % CI: 1.00 to 1.34; allele comparison: OR 0.88, 95 % CI 0.78 to 0.99) polymorphisms were significantly associated with GC in the general population. We also obtained similar significant associations with GC for rs5742909 and rs2274223 polymorphisms in East Asians. Nevertheless, no positive results were observed for the other eight investigated polymorphisms.ConclusionCollectively, this meta-analysis demonstrated that CTLA-4 rs5742909 and PLCE1 rs2274223 polymorphisms may confer susceptibility to GC, especially for East Asians.

Analysis of Promoter Methylation, Polymorphism and Expression Prole of Cytotoxic T-Lymphocyte-Associated Antigen-4 in Patients with Gastric Cancer

2014 ◽  
Vol 23 (3) ◽  
pp. 249-253 ◽  
Author(s):  
Dor Mohammad Kordi-Tamandani ◽  
Shahrbbanou Karimi Davani ◽  
Taybeh Baranzehi ◽  
Simin Hemati
Keyword(s):  
Gastric Cancer ◽  
T Cell Activation ◽  
T Lymphocyte ◽  
Promoter Methylation ◽  
Cytotoxic T Lymphocyte ◽  
Methylation Status ◽  
Cancer Tissue ◽  
Tissue Samples ◽  
Increased Risk ◽  
Ctla4 Gene

AbstractBackground & Aim: Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) is a crucial immune-checkpoint receptor regulating T-cell activation. The current study was carried out to evaluate the function of CTLA4 gene in patients with gastric cancer.Methods: The methylation of CTLA4 gene promoter was evaluated by methylation-specific polymerase chain reaction (MSP) technique using 85 paraffin-embedded gastric cancer tissue samples and normal tissue on the tumor margins as control tissue samples. Expression analysis was performed on paraffin-embedded tissue samples (25 each of cancerous and normal tissues) using Real-time PCR.Results: Statistically significant differences were observed between the tumor and margin-cell areas withrespect to promoter methylation status (OR = 4.829, 95% CI: 2.46-9.48, p < 0.001) and CTLA4 expression profile (mean ± SD = 7.56 ± 17.35, p = 0.04).Conclusion: To the best of our knowledge, the current study is the first one highlighting the association between promoter hypermethylation of CTLA4 gene, decreased CTLA4 expression, and increased risk of gastric cancer.

scholarly journals Association of cytotoxic T lymphocyte-associated protein 4 gene -1772T/C polymorphism with gastric cancer risk

Medicine ◽  
2020 ◽  
Vol 99 (50) ◽  
pp. e23542
Author(s):  
Chenyi Zhuo ◽  
Tingzhuang Yi ◽  
Cheng Wei ◽  
Xianjian Wu ◽  
Xiaoning Cen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Gastric Cancer Risk
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