Influence of Cardiopulmonary Bypass on the State of Cognitive Functions in Patients with Ischemic Heart Disease

2006 ◽  
Vol 36 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Yu. I. Buziashvili ◽  
S. G. Ambat'ello ◽  
Yu. A. Aleksakhina ◽  
M. V. Pashchenkov
Keyword(s):  
Heart Disease ◽  
Cardiopulmonary Bypass ◽  
Ischemic Heart Disease ◽  
Cognitive Functions ◽  
The State ◽  
Ischemic Heart

Glutamine Is Cardioprotective in Patients with Ischemic Heart Disease following Cardiopulmonary Bypass

2011 ◽  
Vol 14 (6) ◽  
pp. 384 ◽  
Author(s):  
Vladimir V. Lomivorotov ◽  
Sergey M. Efremov ◽  
Vladimir A. Shmirev ◽  
Dmitry N. Ponomarev ◽  
Vladimir N. Lomivorotov ◽  
...  
Keyword(s):  
Heart Disease ◽  
Placebo Group ◽  
Cardiopulmonary Bypass ◽  
Ischemic Heart Disease ◽  
Troponin I ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Left Ventricular Ejection ◽  
Study Group ◽  
Cardioprotective Effects

<p><b>Background:</b> The aim of the present study was to investigate the cardioprotective effects of the perioperative use of N(2)-L-alanyl-L-glutamine (GLN) in patients with ischemic heart disease (IHD) who undergo their operations under cardiopulmonary bypass (CPB).</p><p><b>Methods:</b> This double-blind, placebo-controlled, randomized study included 50 patients who underwent cardiac surgery with CPB. Exclusion criteria were a left ventricular ejection fraction <50%, diabetes mellitus, <3 months since the onset of myocardial infarction, and emergency surgery. Patients in the study group (n = 25) received 0.4 g/kg GLN (Dipeptiven, 20% solution) per day. Patients in the control group (n = 25) were administered a placebo (0.9% NaCl). The primary end point was the dynamics of troponin I at the following stages: (1) prior to anesthesia, (2) 30 minutes after CPB, (3) 6 hours after CPB, (4) 24 hours after surgery, and (5) 48 hours after surgery. Secondary end points included measurements of hemodynamics with a Swan-Ganz catheter.</p><p><b>Results:</b> On the first postoperative day after the surgery, the median troponin I level was significantly lower in the study group than in the placebo group: 1.280 ng/mL (interquartile range [IQR], 0.840-2.230 ng/mL) versus 2.410 ng/mL (IQR, 1.060-6.600 ng/mL) (<i>P</i> = .035). At 4 hours after cardiopulmonary bypass (CPB), the median cardiac index was higher in the patients in the study group: 2.58 L/min per m<sup>2</sup> (IQR, 2.34-2.91 L/min per m<sup>2</sup>) versus 2.03 L/min per m<sup>2</sup> (IQR, 1.76-2.32 L/min per m<sup>2</sup>) (<i>P</i> = .002). The median stroke index also was higher in the patients who received GLN: 32.8 mL/m<sup>2</sup> (IQR, 27.8-36.0 mL/m<sup>2</sup>) versus 26.1 mL/m<sup>2</sup> (IQR, 22.6-31.8 mL/m<sup>2</sup>) (<i>P</i> = .023). The median systemic vascular resistance index was significantly lower in the study group than in the placebo group: 1942 dyn�s/cm<sup>5</sup> per m<sup>2</sup> (IQR, 1828-2209 dyn�s/cm<sup>5</sup> per m<sup>2</sup>) versus 2456 dyn�s/cm<sup>5</sup> per m<sup>2</sup> (IQR, 2400-3265 dyn�s/cm<sup>5</sup> per m<sup>2</sup>) (<i>P</i> = .001).</p><p><b>Conclusion:</b> Perioperative administration of GLN during the first 24 hours has cardioprotective effects in IHD patients following CPB. This technique enhances the troponin concentration at 24 hours after surgery and is associated with improved myocardial function.</p>

Hypertonic disease and its involvement in the class of diseases of the circulatory system: epidemiological situation in Ukraine

2020 ◽  
Vol 26 (2-3) ◽  
pp. 68-74
Author(s):  
V.V. Ruden' ◽  
◽  
V.I. Diachyschyn ◽  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Cerebrovascular Disease ◽  
Negative Impact ◽  
Circulatory System ◽  
Well Being ◽  
The State ◽  
Ischemic Heart ◽  
Steady Increase ◽  
Circulatory System Diseases

Aim. A substantiation by the types of morbidity of biostatistic tendencies in the development of hypertonic disease and its involvement in the existing pathologies of the class of diseases of the circulatory system among the population of Ukraine. Material and Methods. An epidemiological, cross-sectional, continuous, prospective study was conducted with the use of statistical data of the Health Statistics Center of the Ministry of Health of Ukraine and the State Statistics Service of Ukraine (1993 and 2017), summarizing and processing them in spreadsheets of Microsoft Office Excel 2016 using retrospective, biostatistical and abstract research methods, as well as methods of copying, deductive awareness, structural-logical analysis and systematic principles. Results and Discussion. The results clearly indicated a steady increase in all forms of hypertonic disease among the population of Ukraine over the studied time period by Рincr=119.8%, when in 2017 this pathology affected ngen=10,388,376 persons, with the prevalence indicator Рgen= 29,844.1о/оооо, which testified that every fourth citizen had a case of hypertonic disease, whereas hypertonic disease accompanied ischemic heart disease in Рpr=40.4% of cases, - cerebrovascular disease in Рpr=23.1% of cases and - strokes in Рpr= 35.8% of cases. Conclusions. It is established that hypertonic disease is one of the most prevalent diseases of the cardiovascular system and has a direct negative impact on of socio-economic well-being and resource provision for society and, based on achievements in etiopathology, diagnostics and treatment, requires the highest governmental structures of the state to undertake prompt and adequate managerial preventive actions aimed at strengthening the health of patients with hypertonic disease and of changing the lifestyle of the population in consideration of established risk factors in the occurrence of this pathology. Keywords: circulatory system diseases, hypertonic disease, general and primary morbidity, tendencies, involvement, ischemic heart disease, cerebrovascular disease, stroke

scholarly journals COGNITIVE DYSFUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE

2014 ◽  
Vol 13 (6) ◽  
pp. 48-56 ◽  
Author(s):  
O. V. Yeremina ◽  
M. M. Petrova ◽  
S. V. Prokopenko ◽  
N. V. Isaeva ◽  
D. S. Kaskaeva
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Cognitive Dysfunction ◽  
Cognitive Functions ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Life Quality ◽  
Vascular Diseases ◽  
Neurological Complications ◽  
Ischemic Heart

Coronary artery bypass graft surgery (CABG) is one of the most effective methods of surgical treatment of ischemic heart disease (IHD). However, even improvement of life quality is evident in patients underwent CABG, some neuropsychological, cognitive alterations may appear. Therefore, the problem of neurological complications in cardiac surgery is still of current interest. Prevalence of cognitive dysfunction after CABG varies from 12 to 79%. One third of the patients have alterations of cognitive functions for 1 year and more after the operation. In this review, we will discuss the current understandings on etiology, pathogenesis and prevalence of cognitive dysfunction in patients with IHD after CABG. The following factors determine development of long-lasting cognitive deficiency: lower educational level, advanced age, significant alterations of cognitive functions in preoperative period. At present, age, comorbid pathology (arterial hypertension, diabetes mellitus, vascular diseases, lung diseases), heart fai­lure, alcohol and drug abuse, preoperative cognitive dysfunction are considered as major risk factors for CABG-induced neurological complications. Importance of timely diagnostics and early beginning of treatment of cognitive dysfunction will be discussed.

scholarly journals Mapping risk of ischemic heart disease using machine learning in a Brazilian state

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243558
Author(s):  
Marcela Bergamini ◽  
Pedro Henrique Iora ◽  
Thiago Augusto Hernandes Rocha ◽  
Yolande Pokam Tchuisseu ◽  
Amanda de Carvalho Dutra ◽  
...  
Keyword(s):  
Machine Learning ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
The State ◽  
Machine Learning Algorithms ◽  
Ischemic Heart ◽  
Geographical Information ◽  
Support Vector ◽  
P Value ◽  
Municipal Level

Cardiovascular diseases are the leading cause of deaths globally. Machine learning studies predicting mortality rates for ischemic heart disease (IHD) at the municipal level are very limited. The goal of this paper was to create and validate a Heart Health Care Index (HHCI) to predict risk of IHD based on location and risk factors. Secondary data, geographical information system (GIS) and machine learning were used to validate the HHCI and stratify the IHD municipality risk in the state of Paraná. A positive spatial autocorrelation was found (Moran’s I = 0.6472, p-value = 0.001), showing clusters of high IHD mortality. The Support Vector Machine, which had an RMSE of 0.789 and error proportion close to one (0.867), was the best for prediction among eight machine learning algorithms after validation. In the north and northwest regions of the state, HHCI was low and mortality clusters patterns were high. By creating an HHCI through ML, we can predict IHD mortality rate at municipal level, identifying predictive characteristics that impact health conditions of these localities’ guided health management decisions for improvements for IHD within the emergency care network in the state of Paraná.

2.P.322 The influence of butter and vegetable oil loadings on the state of thrombocyte membranes in patients with ischemic heart disease (IHD)

1997 ◽  
Vol 134 (1-2) ◽  
pp. 184
Author(s):  
I.V. Medvedeva ◽  
S.I. Matayev ◽  
E.F. Dorodneva ◽  
E.Z. Kogan ◽  
S.Yu. Shevchuk
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Vegetable Oil ◽  
The State ◽  
Ischemic Heart
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