Determinants of global quality of life before and after major cancer surgery: an exploratory study

Abstract Purpose To assess whether higher dispositional optimism could predict better health-related quality of life (HRQL) after esophageal cancer surgery. Methods This Swedish nationwide longitudinal study included 192 patients who underwent esophagectomy for cancer. The exposure was dispositional optimism measured by the Life Orientation Test-Revised (LOT-R) at 1 year post-surgery. Patients were categorized into four subgroups (very low, moderately low, moderately high, and very high dispositional optimism) based on the quartile of the LOT-R sum score. The outcome was HRQL assessed by the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30) and Quality of Life Questionnaire-Esophago-Gastric module 25 (QLQ-OG25) at 1, 1.5, and 2 years post-surgery. Linear mixed-effects models, adjusted for potential confounders, were used to examine the mean score difference (MSD) with 95% confidence interval of HRQL among the four patient subgroups. Results Patients with very high dispositional optimism reported clinically relevantly better global quality of life, emotional function, and social function (MSD range 10–16) and less severe symptoms in pain, dyspnea, diarrhea, eating difficulty, anxiety, dry mouth, trouble with taste, worry about weight loss, and self-doubt about body image (MSD range − 9 to − 22) than patients with lower dispositional optimism. Patients with moderately high dispositional optimism reported clinically and statistically significantly better global quality of life (MSD 10) and less severe diarrhea (MSD − 9) than patients with lower dispositional optimism. Adjusted MSDs were constant over the three time points in all aspects except for eating difficulty. Conclusions Measuring dispositional optimism could help identify patients at higher risk of poor HRQL recovery after esophageal cancer surgery.

Download Full-text

Measurement of Quality of Life VII. Statistical Covariation and Global Quality of Life Data: The Method of Weight-Modified Linear Regression

The Scientific World JOURNAL ◽

10.1100/tsw.2003.89 ◽

2003 ◽

Vol 3 ◽

pp. 1020-1029 ◽

Cited By ~ 3

Author(s):

Soren Ventegodt ◽

Joav Merrick

Keyword(s):

Quality Of Life ◽

Linear Regression ◽

Scientific Community ◽

Population Studies ◽

Life Data ◽

Global Quality ◽

Global Quality Of Life ◽

Psychometric Measures ◽

Exact Size

Existing standard statistical procedures do not seem to fulfill the needs of the researcher in global quality-of-life (QOL) research, because the most interesting question seems to be the exact size of statistical covariations. A method is necessary if we are to isolate the most important factors connected to quality of life among the thousands of possible factors in life. We have developed a new procedure we call �weight-modified linear regression�. Unfortunately as demonstrated in the discussion, the procedure is not totally without problems and weaknesses. In spite of the critique, we believe the procedure to be valid for the purpose of estimating the size of the covariation in population studies including psychometric measures of global quality of life. As we need to be certain that the procedure is valid, we hereby invite the scientific community to give us further critique of the method and suggestions for its improvement.

Download Full-text

Fertility Related Quality of Life in Primary Infertile Couples: A Comparative Study from Eastern India

International Journal of Indian Psychology ◽

10.25215/0501.062 ◽

2017 ◽

Vol 5 (1) ◽

Author(s):

Swarnali Bose ◽

Bharati Roy

Keyword(s):

Quality Of Life ◽

Infertile Couple ◽

Psychological Burden ◽

Primary Infertility ◽

Global Quality ◽

Global Quality Of Life ◽

The Family ◽

Related Quality ◽

Written Informed Consent

Fertility is considered as a marital responsibility in most the communities and a kind of social respectability for couples. The societal and parental pressures for propagation of the family name can also place a psychological burden on the infertile couple and may significantly affect quality of life. The present study aimed to investigate the gender differences in fertility related quality of life in primary infertility. 30 couples with primary infertility were recruited for the study after a written informed consent. Hindi version of FertiQoL was applied to all participants. Males had significantly better emotional, relational, social and global quality of life (QoL) as compared to females. Tolerability to infertility related problems was significantly better in females compared to males. This study found that primary infertility has extensive negative repercussions on the QOL of women as compared to males.

Download Full-text

Variety of activity: Relationship with health status, demographic variables and global quality of life

Psychology Health & Medicine ◽

10.1080/135485099106180 ◽

1999 ◽

Vol 4 (3) ◽

pp. 241-254 ◽

Cited By ~ 8

Author(s):

M. E. Hyland ◽

S. C. Sodergren ◽

S. J. Singh

Keyword(s):

Quality Of Life ◽

Health Status ◽

Demographic Variables ◽

Activity Relationship ◽

Global Quality ◽

Global Quality Of Life

Download Full-text

Trend of global quality of life in localized or metastatic prostate cancer patients after treatment

Urological Science ◽

10.1016/j.urols.2016.05.196 ◽

2016 ◽

Vol 27 (2) ◽

pp. S53-S54

Author(s):

Yao-Lin Kao ◽

Yuh-Shyan Tsai ◽

Zong-Ying Lin ◽

Chien-Hui Ou ◽

Wen-Horng Yang ◽

...

Keyword(s):

Quality Of Life ◽

Prostate Cancer ◽

Cancer Patients ◽

Metastatic Prostate Cancer ◽

Global Quality ◽

Global Quality Of Life

Download Full-text

Quality of life in persons living with HIV–AIDS in three healthcare institutions of Cali, Colombia

Colombia Medica ◽

10.25100/cm.v41i3.706 ◽

2010 ◽

pp. 206-214 ◽

Cited By ~ 5

Author(s):

Claudia Patricia Valencia ◽

Gladys Eugenia Canaval ◽

Diana Marín ◽

Carmen J. Portillo

Keyword(s):

Quality Of Life ◽

Health Insurance ◽

Antiretroviral Therapy ◽

Satisfaction With Life ◽

Pearson Correlation ◽

Global Quality ◽

Persons Living With Hiv ◽

Global Quality Of Life ◽

Hiv Aids

Antecedents: The Human Immunodeficiency Virus is currently considered a chronic disease; hence, quality of life is an important goal for those suffering the disease or living with someone afflicted by the virus. Objectives: We sought to measure the quality of life in individuals living with acquired immunodeficiency syndrome virus and establish its relationship with socio-demographic and clinical variables. Methods: This is a cross-sectional, descriptive study with a sample of 137 HIV-infected individuals attending three healthcare institutions in the city of Cali, Colombia. Quality of life was measured via the HIV/AIDS-Targeted Quality of Life (HAT-QoL) instrument. The descriptive analyses included mean and standard deviation calculations. To determine the candidate variables, we used the student t test and the Pearson correlation. The response variable in the multiple linear regression was the score for quality of life. Results: Some 27% of the sample were women and 3% were transgender; the mean age of the sample was 35 + 10.2 years; 88% had some type of health insurance; 27% had been diagnosed with AIDS, and 64% were taking antiretroviral medications at the time of the study. Quality of life was measured through a standard scale with scores from 0 to 100. Participants’ global quality of life mean was 59 + 17.8. The quality-of-life dimensions with the highest scores were sexual function, satisfaction with the healthcare provider, and satisfaction with life. The highest quality-of-life scores were obtained by participants who received antiretroviral therapy, had health insurance, lower symptoms of depression, low frequency and intensity of symptoms, and no prior reports of sexual abuse. Eight variables explained 53% of the variability of the global quality of life. Conclusions: Those receiving antiretroviral therapy and who report fewer symptoms best perceived their quality of life. Implications for practice: Healthcare providers, especially nursing professional face a challenge in caring to alleviate symptoms and contribute to improving the quality of life of their patients.

Download Full-text

FC26-03 - Comparison of quality of life and global function in chronic psychiatric patients before and after rehabilitation center in kashan (2009)

European Psychiatry ◽

10.1016/s0924-9338(11)73664-1 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 1961-1961

Author(s):

A. Ahmadvand ◽

Z. Sepehrmanesh ◽

R. Saei

Keyword(s):

Quality Of Life ◽

Psychiatric Patients ◽

Rehabilitation Center ◽

Global Function ◽

Global Quality Of Life ◽

Before And After ◽

Quasi Experimental ◽

The Mean ◽

Time Of Admission

IntroductionThe concept of quality of life has considerably important in evaluation of efficacy of therapeutic and rehabilitation programs in all medical fields, especially psychiatric disabilities therefore any intervention which cannot improve patient’s quality of life, their effectiveness is doubt. The aim of this study is evaluation of quality of life of chronic mental patients, before and after residence in rehabilitation center.MethodesThis study is quasi experimental that carried out on all of patients in rehabilitation center in Kashan(Iran). Demographic, Quality of Life and Global Function Scale questionnaires were used at the time of admission and next 6 months. Data were analyzed by paired T-Test and correlation tests.ResultsThe mean of function level was at the time of admission 31/47+/−7/5 and after of 6 months 36/52+/−7/15, that this difference was significant (p = 0/0001).The mean of physical quality of life was 49/28+/−16/01 at the time of admission and after 6 months was 56/64+/−16/99, so the mean of mental quality of life at the time of admission was 37/20+/− 11/10 and after follow up 46/19+/−4/05.the mean of global quality of life was 42/75+/− 10/34 at the time of admission and after 6 months 54/59+/− 12/84, which this difference was significant.(p = 0/0001)In this study relation between age and quality of life was significant. (p = 0/0001)ConclusionResults showed that various factors may have role in this change. Such as type of provided services, quality of treatment, emotional support of staff and family, homogenous group therapy, organized life.

Download Full-text

Quality of Life After Transhiatal Compared With Extended Transthoracic Resection for Adenocarcinoma of the Esophagus

Journal of Clinical Oncology ◽

10.1200/jco.2004.11.102 ◽

2004 ◽

Vol 22 (20) ◽

pp. 4202-4208 ◽

Cited By ~ 119

Author(s):

A.G.E.M. de Boer ◽

J.J.B. van Lanschot ◽

J.W. van Sandick ◽

J.B.F. Hulscher ◽

P.F.M. Stalmeier ◽

...

Keyword(s):

Quality Of Life ◽

Psychological Symptoms ◽

Well Being ◽

Physical Symptoms ◽

Activity Level ◽

Gradual Improvement ◽

Global Quality ◽

Global Quality Of Life ◽

Generic Quality

PurposeTo assess 3 years of quality of life in patients with esophageal cancer in a randomized trial comparing limited transhiatal resection with extended transthoracic resection.Patients and MethodsQuality-of-life questionnaires were sent at baseline and at 5 weeks; 3, 6, 9, and 12 months; and 1.5, 2, 2.5, and 3 years after surgery. Physical and psychological symptoms, activity level, and global quality of life were assessed with the disease-specific Rotterdam Symptom Checklist. Generic quality of life was measured with the Medical Outcomes Study Short Form-20.ResultsA total of 199 patients participated. Physical symptoms and activity level declined after the operation and gradually returned toward baseline within the first year (P < .01). Psychological well-being consistently improved after baseline (P < .01), whereas global quality of life showed a small initial decline followed by continuous gradual improvement (P < .01). Quality of life stabilized in the second and third year. Three months after the operation, patients in the transhiatal esophagectomy group (n = 96) reported fewer physical symptoms (P = .01) and better activity levels (P < .01) than patients in the transthoracic group (n = 103), but no differences were found at any other measurement point. For psychological symptoms and global quality of life, no differences were found at any follow-up measurement. A similar pattern was found for generic quality of life.ConclusionNo lasting differences in quality of life of patients who underwent either transhiatal or transthoracic resection were found. Compared with baseline, quality of life declined after the operation but was restored within a year in both groups.

Download Full-text

Regaining a satisfactory quality of life and predicting functional decline after major cancer surgery in older adults: The Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery (GOSAFE) study.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.12051 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. 12051-12051

Author(s):

Isacco Montroni ◽

Giampaolo Ugolini ◽

Nicole Saur ◽

Antonino Spinelli ◽

Siri Rostoft ◽

...

Keyword(s):

Quality Of Life ◽

Functional Recovery ◽

Functional Outcomes ◽

Older Patients ◽

Functional Decline ◽

Geriatric Oncology ◽

Cancer Surgery ◽

Before And After ◽

After Cancer

12051 Background: Older cancer patients value quality of life (QoL) and functional outcomes as much as survival but surgical studies lack specific data. The international, multicenter GOSAFE study (ClinicalTrials.gov NCT03299270) aims to evaluate patients’ QoL and functional recovery (FR) after cancer surgery and to assess predictors of FR Methods: GOSAFE prospectively collected functional and clinical data before and after major elective cancer surgery on senior adults (≥70 years). Surgical outcomes were recorded (30, 90, and 180 days post-operatively) with QoL (EQ-5D-3L) and FR (Activities of Daily Living (ADL), Timed Up and Go (TUG) and MiniCog), 26 centers enrolled patients from February 2017 to April 2019. Results: 942 patients underwent a major cancer resection. Median age was 78 (range 70-95); 52.2% males, ASA III-IV 49%. 934 (99%) lived at home, 51% lived alone, and 87% were able to go out. Patients dependent (ADL < 5) were 8%. Frailty was detected by means of G8 ≤14 in 68.8% and fTRST ≥2 in 37% of patients. Major comorbidities (CCI > 6) were reported in 36% and 21% had cognitive impairment according to MiniCog (2.2% self-reported). 25% had > 3 kg weight loss, 27% were hospitalized in the last 90 days, 54% had ≥3 medications (6% none). Postoperative overall morbidity was 39.1% (30 day) and 22.5% (90 day), but Clavien-Dindo III-IV complications were only 13.4% and 6.9% respectively. 30/90/180-day mortality was 3.6/6/8.9% (10/30/33% in patients with severe functional disability). At 3 months after surgery, QoL was stable/improved (mean EQ-5D index 0.78 was equivalent before vs. after surgery, while the EQ-5D VAS score > 60 raised from 74.3% at baseline to 80.2%, p < 0.01). 76.6% experienced postoperative FR/stability. Logistic regression analysis showed that ASA 3-4, CCI≥7 and CD III-IV complications are significantly associated with functional decline while a G8 > 14 has a positive association with functional recovery. Age is not associated with functional outcomes. Conclusions: The largest prospective study on older patients undergoing structured frailty assessment before and after major elective cancer surgery has shown that QoL remains stable/improves after cancer surgery. The majority of patients return to independence and G8 can predict functional recovery. Older patients with multiple comorbidities, high ASA score or postoperative severe complications are likely to functionally deteriorate after oncologic surgery Clinical trial information: NCT03299270 .

Download Full-text