ProCTA: program characteristic-based thread partition approach

AbstractCharney's target article convincingly demonstrates the need for the discipline of quantitative human behavior genetics to discard its false assumptions and to employ the techniques, assumptions, and research program characteristic of modern developmental psychobiology.

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Recruiting International Students to Your Campus

Journal of International Students ◽

10.32674/jis.v2i2.528 ◽

2012 ◽

Vol 2 (2) ◽

pp. 157-167 ◽

Cited By ~ 5

Author(s):

Cheryl McFadden ◽

Cathy Maahs-Fladung ◽

William Mallett

Keyword(s):

International Students ◽

Research University ◽

Response Rate ◽

The United States ◽

Decision Making Process ◽

Admission Process ◽

Time To Degree ◽

Public Research University ◽

Program Characteristic ◽

Degree Level

The purpose of this paper was to determine what institutional, program, and recruitment characteristics influenced international students to attend institutions in the United States. Two hundred sixteen international students at a Southern public research university responded to the survey (53% response rate) from 56 countries representing 8 regions. An empirical analysis using t-tests and analysis of variance was conducted to determine what characteristics international students found to be most important when selecting an institution. Regardless of degree level, all students ranked faculty/student ratio as an important program characteristic. Second, students ranked both the admission process and time to degree as important characteristics. Third, doctoral, master’s, and bachelor’s students respectively ranked funding as an important characteristic in their decision making process. There are three basic implications for recruitment officers. First, as size matters, international students need to feel connected to faculty and staff.

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Helping the Academically Handicapped Reader: Peer Tutoring Revisited

Australasian Journal of Special Education ◽

10.1017/s103001120002128x ◽

1985 ◽

Vol 9 (1) ◽

pp. 16-21

Author(s):

W. Malcolm Gill

Keyword(s):

Peer Tutoring ◽

Reading Ability ◽

Low Cost ◽

Control Group ◽

Computer Assisted ◽

Poor Reading ◽

Quality Program ◽

Program Characteristic ◽

Assisted Instruction

AbstractThe characteristics of computer-assisted instruction (CAI) which makes it so worthy of consideration for use by the teacher of pupils with special needs, whose time for individual attention with her pupils is limited, are briefly discussed, and comment is made about the limitations of this approach. Attention is drawn to the alternative approach of peer tutoring, where the desirable one-to-one characteristic is attainable, and where there is the possibility that the sensitivity to the quality of the computer program, which is one of the limitations of the approach of CAI, may be contrasted with the not-so-sensitive-to-quality-of-program characteristic of peer tutoring. This possibility is examined in the context of a sample of poor reading Year eight pupils who were given a period of peer tutoring by Year eleven and twelve pupils in the same school, where the demonstrably not high quality program consisted of relatively few meetings between tutor and tutee, of short duration, at which it was expected that there would be talk, reading and being read to. Use of a control group enabled the conclusions to be reached that this peer tutoring resulted in gains for the tutees in reading ability and in attitude towards and behaviour in school, this being suggestive of the power of this low staff input, low cost, low technology technique in the area of special education.

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Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival

PLoS Genetics ◽

10.1371/journal.pgen.1006384 ◽

2016 ◽

Vol 12 (10) ◽

pp. e1006384 ◽

Cited By ~ 39

Author(s):

Dennis Liang Fei ◽

Hayley Motowski ◽

Rakesh Chatrikhi ◽

Sameer Prasad ◽

Jovian Yu ◽

...

Keyword(s):

Cell Survival ◽

Wild Type ◽

Program Characteristic

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An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1514076113 ◽

2015 ◽

Vol 113 (2) ◽

pp. E117-E126 ◽

Cited By ~ 23

Author(s):

Aude De Gassart ◽

Bojan Bujisic ◽

Léa Zaffalon ◽

Laurent A. Decosterd ◽

Antonia Di Micco ◽

...

Keyword(s):

Stress Response ◽

Stress Responses ◽

Translation Initiation Factor ◽

Hiv Protease ◽

Initiation Factor ◽

Hiv Protease Inhibitors ◽

Integrated Stress Response ◽

Α Subunit ◽

Eif2α Phosphorylation ◽

Program Characteristic

Inhibitors of the HIV aspartyl protease [HIV protease inhibitors (HIV-PIs)] are the cornerstone of treatment for HIV. Beyond their well-defined antiretroviral activity, these drugs have additional effects that modulate cell viability and homeostasis. However, little is known about the virus-independent pathways engaged by these molecules. Here we show that the HIV-PI Nelfinavir decreases translation rates and promotes a transcriptional program characteristic of the integrated stress response (ISR). Mice treated with Nelfinavir display hallmarks of this stress response in the liver, including α subunit of translation initiation factor 2 (eIF2α) phosphorylation, activating transcription factor-4 (ATF4) induction, and increased expression of known downstream targets. Mechanistically, Nelfinavir-mediated ISR bypassed direct activation of the eIF2α stress kinases and instead relied on the inhibition of the constitutive eIF2α dephosphorylation and down-regulation of the phophatase cofactor CReP (Constitutive Repressor of eIF2α Phosphorylation; also known as PPP1R15B). These findings demonstrate that the modulation of eIF2α-specific phosphatase cofactor activity can be a rheostat of cellular homeostasis that initiates a functional ISR and suggest that the HIV-PIs could be repositioned as therapeutics in human diseases to modulate translation rates and stress responses.

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ET-receptor antagonism, myocardial gene expression, and ventricular remodeling during CHF in rats

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1998.275.3.h868 ◽

1998 ◽

Vol 275 (3) ◽

pp. H868-H877 ◽

Cited By ~ 10

Author(s):

Erik Øie ◽

Reidar Bjønerheim ◽

Haakon K. Grøgaard ◽

Heidi Kongshaug ◽

Otto A. Smiseth ◽

...

Keyword(s):

Gene Expression ◽

Ventricular Remodeling ◽

Myocardial Hypertrophy ◽

Oral Treatment ◽

Left Ventricular ◽

Receptor Antagonism ◽

Hypertrophic Response ◽

Lv Remodeling ◽

Program Characteristic ◽

Myocardial Gene Expression

Both myocardial and plasma endothelin-1 (ET-1) are elevated in congestive heart failure (CHF). However, the role played by endogenous ET-1 in the progression of CHF remains unknown. The aim of the present study was to investigate and correlate myocardial gene expression programs and left ventricular (LV) remodeling during chronic ET-receptor antagonism in CHF rats. After ligation of the left coronary artery, rats were randomized to oral treatment with a nonselective ET-receptor antagonist (bosentan, 100 mg ⋅ kg−1 ⋅ day−1, n = 11) or vehicle (saline, n = 13) for 15 days, starting 24 h after induction of myocardial infarction. Bosentan substantially attenuated LV dilatation during postinfarction failure as evaluated by echocardiography. Furthermore, bosentan decreased LV systolic and end-diastolic pressures and increased fractional shortening. Myocardial expression of preproET-1 mRNA and a fetal gene program characteristic of myocardial hypertrophy were increased in the CHF rats and were not affected by bosentan. Consistently, right ventricular-to-body weight ratios, diameters of cardiomyocytes, and echocardiographic analysis demonstrated a sustained hypertrophic response and a normalized relative wall thickness after intervention with bosentan. Thus the modest reduction of preload and afterload provided by bosentan substantially attenuates LV dilatation, causing improved pressure-volume relationships. However, the compensatory hypertrophic response was not altered by ET-receptor antagonism. Therefore, ET-1 does not appear to play a crucial role in the mechanisms of myocardial hypertrophy during the early phase of postinfarction failure.

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CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities

Nature Communications ◽

10.1038/s41467-019-13438-1 ◽

2019 ◽

Vol 10 (1) ◽

Cited By ~ 14

Author(s):

Tomasz Ahrends ◽

Julia Busselaar ◽

Tesa M. Severson ◽

Nikolina Bąbała ◽

Evert de Vries ◽

...

Keyword(s):

T Cell ◽

Cytotoxic T Lymphocyte ◽

Effector Memory ◽

Memory Cd8 T Cells ◽

Effector Genes ◽

Genome Wide ◽

Program Characteristic ◽

Memory Differentiation ◽

And Function ◽

T Cell Help

AbstractCD4+ T cell help is required for the generation of CD8+ cytotoxic T lymphocyte (CTL) memory. Here, we use genome-wide analyses to show how CD4+ T cell help delivered during priming promotes memory differentiation of CTLs. Help signals enhance IL-15-dependent maintenance of central memory T (TCM) cells. More importantly, help signals regulate the size and function of the effector memory T (TEM) cell pool. Helped TEM cells produce Granzyme B and IFNγ upon antigen-independent, innate-like recall by IL-12 and IL-18. In addition, helped memory CTLs express the effector program characteristic of helped primary CTLs upon recall with MHC class I-restricted antigens, likely due to epigenetic imprinting and sustained mRNA expression of effector genes. Our data thus indicate that during priming, CD4+ T cell help optimizes CTL memory by creating TEM cells with innate and help-independent antigen-specific recall capacities.

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Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia

Blood ◽

10.1182/blood-2013-01-477133 ◽

2013 ◽

Vol 122 (15) ◽

pp. 2694-2703 ◽

Cited By ~ 31

Author(s):

Liat Goldberg ◽

Marloes R. Tijssen ◽

Yehudit Birger ◽

Rebecca L. Hannah ◽

Sarah J. Kinston ◽

...

Keyword(s):

Transcription Factor ◽

Stem Cell ◽

Transgenic Mice ◽

Myeloid Leukemia ◽

Therapeutic Targets ◽

Leukemia Stem Cell ◽

Factor Binding ◽

Key Points ◽

Program Characteristic ◽

Genome Scale

Key Points ERG overexpression in transgenic mice induces a transcriptional leukemia stem cell program characteristic of human AML. PIM1 and RAS are relevant ERG therapeutic targets.

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Induced reprogramming of adult murine cardiomyocytes to pluripotency in vivo

10.1101/2021.12.22.473302 ◽

2021 ◽

Author(s):

Irene de Lázaro ◽

Christina M Tringides ◽

Tiara L Orejon-Sanchez ◽

David Mooney

Keyword(s):

Gene Expression ◽

Adult Mouse ◽

Cardiac Regeneration ◽

Control Of Gene Expression ◽

Mouse Tissues ◽

Cre Recombination ◽

Program Characteristic ◽

Cell Type Specific ◽

Expression Program

Partial cell reprogramming has been demonstrated in certain mouse tissues by in situ overexpression of Oct3/4, Klf4, Sox2 and cMyc (OKSM) transcription factors, and can trigger rejuvenation and/or augment regeneration of aged or injured tissues. In vivo reprogramming of adult mouse cardiomyocytes has been elusive, but success could overcome the lack of endogenous cardiomyocyte turnover that contributes to the poor resolution of heart disease. Here, we exploited cell type-specific Cre recombination and conditional, doxycycline-inducible, control of gene expression to generate cardiomyocyte-specific, inducible, reprogrammable mice. Eighteen days of doxycycline-induced OKSM expression in this model established a gene expression program characteristic of the pluripotent state and triggered the generation of teratomas of confirmed cardiomyocyte origin. These findings confirm that OKSM reprograms adult mouse cardiomyocytes to pluripotency and will enable studies of the contribution of reprogrammed cardiomyocytes to cardiac regeneration.

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MODELLING THE SOFTWARE TESTING PROCESS

National Security Studies ◽

10.37055/sbn/135244 ◽

2014 ◽

Vol 6 (2) ◽

pp. 359-375

Author(s):

Kazimierz WORWA

Keyword(s):

Software Testing ◽

Mean Value ◽

Characteristic Matrix ◽

Reliability Growth ◽

Testing Strategy ◽

Formal Modelling ◽

Program Testing ◽

Program Characteristic ◽

The Mean ◽

Program Reliability

An approach to formal modelling the program testing process is proposed in the paper. Considerations are based on some program reliability-growth model that is constructed for assumed scheme of the program testing process. In this model the program under the testing is characterized by means of so-called characteristic matrix and the program testing process is determined by means of so-called testing strategy. The formula for determining the mean value of the predicted number of errors encountered during the program testing is obtained. This formula can be used if the characteristic matrix and the testing strategy are known. Formulae for evaluating this value when the program characteristic matrix is not known are also proposed in the paper.

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