The role of antioxidants enzymes of E. coli ASU3, a tolerant strain to heavy metals toxicity, in combating oxidative stress of copper

2009 ◽  
Vol 26 (2) ◽  
pp. 241-247 ◽  
Author(s):  
Romany N. N. Abskharon ◽  
Sedky H. A. Hassan ◽  
Mohammad Humayun Kabir ◽  
Syed Abdul Qadir ◽  
Sanaa M. F. Gad El-Rab ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
E Coli ◽  
Tolerant Strain ◽  
Antioxidants Enzymes ◽  
Heavy Metals Toxicity

The role of oxidative stress in spring barley cross-adaptation to different heavy metals

2016 ◽  
Vol 63 (8) ◽  
pp. 1037-1048 ◽  
Author(s):  
Giedrė Kacienė ◽  
Romualdas Juknys ◽  
Irena Januškaitienė
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Spring Barley ◽  
Cross Adaptation

Role of Transporters during Heavy Metals Toxicity in Plants

2021 ◽  
pp. 49-62
Author(s):  
Misbah Naz ◽  
Mohammad Sohidul Islam ◽  
Muhammad Aamir Iqbal ◽  
Sytar Okana ◽  
Ratnasekera Disna ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Heavy Metals Toxicity

scholarly journals The Role of theExo-XisRegion in Oxidative Stress-Mediated Induction of Shiga Toxin-Converting Prophages

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Katarzyna Licznerska ◽  
Aleksandra Dydecka ◽  
Sylwia Bloch ◽  
Gracja Topka ◽  
Bożena Nejman-Faleńczyk ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Shiga Toxin ◽  
Regulatory Genes ◽  
Prophage Induction ◽  
Dramatic Decrease ◽  
E Coli ◽  
Genetic Elements ◽  
Efficient Expression

Previous studies indicated that these genetic elements could be involved in the regulation of lysogenization and prophage induction processes. The effects were dramatic in Shiga toxin-converting phageΦ24Bafter treatment with oxidative stress-inducing agent, hydrogen peroxide, while they were less pronounced in bacteriophageλand in both phages irradiated with UV. The hydrogen peroxide-caused prophage induction was found to be RecA-dependent. Importantly, in hydrogen peroxide-treatedE. colicells lysogenic for eitherλorΦ24B, deletion of theexo-xisregion resulted in a significant decrease in the levels of expression of the S.O.S. regulon genes. Moreover, under these conditions, a dramatic decrease in the levels of expression of phage genes crucial for lytic development (particularlyxis, exo, N, cro, O, Q, andR) could be observed inΦ24B-, but not inλ-bearing cells. We conclude that genes located in theexo-xisregion are necessary for efficient expression of both host S.O.S regulon in lysogenic bacteria and regulatory genes of Shiga toxin-converting bacteriophageΦ24B.

scholarly journals Molecular Mechanism and Role of Translational Values of Heat Shock Protein (HSP27) in Various Disease

2020 ◽  
pp. 110-118
Author(s):  
Sameer Chaudhary ◽  
Sapana Sameer Chaudhary ◽  
Sakshi Rawat ◽  
Savneet Kaur ◽  
Bogireddy Devi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Scientific Data ◽  
Protein Homeostasis ◽  
Post Translational Modifications ◽  
Member Gene ◽  
And Oxidative Stress ◽  
Potential Cancer ◽  
Antioxidant Molecule

HSP27, also known as HSPB1, was first discovered with a molecular weight 27kDa belonging to the four member gene family. Elevated levels of HSP27 are seen when different unfavorable conditions prevail such as increase in temperature and oxidative stress or exposure to heavy metals or organic solvents. They possess ATP-independent chaperone like activity which helps in maintaining protein homeostasis. It can also form large oligomers (300-600 kDa) containing different numbers of subunits. It is composed of total 205 amino acids. HSP27 undergoes post-translational modifications i.e. phosphorylation thereby converting large oligomers into dimers. It can act as an anti-apoptotic and antioxidant molecule during oxidative stress.  The elevated form of HSP27 is also seen in some cancer belongs to breast, ovary, prostate, brain, colorectal, hepatocellular carcinoma, lung, liver, and cervical regions. Keeping in view of molecular roles of HSP27 signaling in various pathways, we have proposed their translational values in different diseases. In addition, we have also reported the existing scientific data on the HSP27 as the potential cancer biomarker and their therapeutic targets for improved prognosis and treatment in different diseases.

scholarly journals Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Manal Abudawood ◽  
Hajera Tabassum ◽  
Atheer H. Alanazi ◽  
Fatmah Almusallam ◽  
Feda Aljaser ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Health Concern ◽  
Control Group ◽  
Polycystic Ovaries ◽  
Strong Negative Correlation ◽  
Pcos Group

AbstractPolycystic ovary syndrome (PCOS) is a global health concern for women of reproductive age, as 6.5% of women worldwide are affected by this syndrome. PCOS is marked by hyperandrogenism, anovulation, menstrual abnormalities, and polycystic ovaries. Metals such as arsenic, cadmium, lead and mercury are considered to be systemic toxicants/human carcinogens and seem to have devastating effects on humans, even at minimal exposures. One of the probable aetiological factors for PCOS has been identified as oxidative stress. In view of the probable associations among oxidative stress, metal toxicity and PCOS, the present study examined the role of heavy metals in the generation of oxidative stress among females. This prospective study included 106 women (56 women diagnosed with PCOS and 50 women who were not diagnosed with PCOS as control women). There were no significant differences in the sociodemographic characteristics between the two groups except for the irregularity of menses and the presence of acne. The serum As, Cd, Pb, and Hg levels increased and the serum glutathione (GSH) and superoxide dismutase (SOD) levels diminished significantly in the PCOS group compared to the control group at P < 0.001. The SOD levels were negatively correlated with the As and Pb levels at P < 0.05. Additionally, the PCOS group exhibited a strong negative correlation between the GSH and As levels (P < 0.01), GSH and Pb levels (P < 0.05) and GSH and Hg levels (P < 0.01). Furthermore, the As levels were positively correlated with increased levels of Cd, Pb and Hg among PCOS women. Significant positive correlations were observed between Pb and Cd and between Cd and Hg at P < 0.001. The outcome of the study provides clear insight into the role of metal-induced oxidative stress, which plays a vital role in the pathophysiology underlying PCOS and suggests the use of these markers as prognostic tools to reduce the consequences of high-risk exposure to these metals among females.

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