Associations of maternal bisphenol urine concentrations during pregnancy with neonatal metabolomic profiles

Abstract Background Fetal exposure to bisphenols is associated with altered fetal growth, adverse birth outcomes and childhood cardio-metabolic risk factors. Metabolomics may serve as a tool to identify the mechanisms underlying these associations. We examined the associations of maternal bisphenol urinary concentrations in pregnancy with neonatal metabolite profiles from cord blood. Methods In a population-based prospective cohort study among 225 mother–child pairs, maternal urinary bisphenol A, S and F concentrations in first, second and third trimester were measured. LC–MS/MS was used to determine neonatal concentrations of amino acids, non-esterified fatty acids (NEFA), phospholipids (PL), and carnitines in cord blood. Results No associations of maternal total bisphenol concentrations with neonatal metabolite profiles were present. Higher maternal average BPA concentrations were associated with higher neonatal mono-unsaturated alkyl-lysophosphatidylcholine concentrations, whereas higher maternal average BPS was associated with lower neonatal overall and saturated alkyl-lysophosphatidylcholine (p-values < 0.05).Trimester-specific analyses showed that higher maternal BPA, BPS and BPF were associated with alterations in neonatal NEFA, diacyl-phosphatidylcholines, acyl-alkyl-phosphatidylcholines, alkyl-lysophosphatidylcholine, sphingomyelines and acyl-carnitines, with the strongest effects for third trimester maternal bisphenol and neonatal diacyl-phosphatidylcholine, sphingomyeline and acyl-carnitine metabolites (p-values < 0.05). Associations were not explained by maternal socio-demographic and lifestyle characteristics or birth characteristics. Discussion Higher maternal bisphenol A, F and S concentrations in pregnancy are associated with alterations in neonatal metabolite profile, mainly in NEFA, PL and carnitines concentrations. These findings provide novel insight into potential mechanisms underlying associations of maternal bisphenol exposure during pregnancy with adverse offspring outcomes but need to be replicated among larger, diverse populations.

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Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

Environmental Health ◽

10.1186/s12940-021-00747-6 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Chalana M. Sol ◽

Charissa van Zwol - Janssens ◽

Elise M. Philips ◽

Alexandros G. Asimakopoulos ◽

Maria-Pilar Martinez-Moral ◽

...

Keyword(s):

Birth Outcomes ◽

Fetal Growth ◽

Head Circumference ◽

Lower Risk ◽

First Trimester ◽

Population Based ◽

Third Trimester ◽

Bisphenol S ◽

Fetal Head ◽

Urine Concentrations

Abstract Background Exposure to bisphenols may affect fetal growth and development. The trimester-specific effects of bisphenols on repeated measures of fetal growth remain unknown. Our objective was to assess the associations of maternal bisphenol urine concentrations with fetal growth measures and birth outcomes and identify potential critical exposure periods. Methods In a population-based prospective cohort study among 1379 pregnant women, we measured maternal bisphenol A, S and F urine concentrations in the first, second and third trimester. Fetal head circumference, length and weight were measured in the second and third trimester by ultrasound and at birth. Results An interquartile range increase in maternal pregnancy-averaged bisphenol S concentrations was associated with larger fetal head circumference (difference 0.18 (95% confidence interval (CI) 0.01 to 0.34) standard deviation scores (SDS), p-value< 0.05) across pregnancy. When focusing on specific critical exposure periods, any detection of first trimester bisphenol S was associated with larger second and third trimester fetal head circumference (difference 0.15 (95% CI 0.05 to 0.26) and 0.12 (95% CI 0.02 to 0.23) SDS, respectively) and fetal weight (difference 0.12 (95% CI 0.02 to 0.22) and 0.16 (95% CI 0.06 to 0.26) SDS, respectively). The other bisphenols were not consistently associated with fetal growth outcomes. Any detection of bisphenol S and bisphenol F in first trimester was also associated with a lower risk of being born small size for gestational age (Odds Ratio 0.56 (95% CI 0.38 to 0.74) and 0.55 (95% CI 0.36 to 0.85), respectively). Bisphenols were not associated with risk of preterm birth. Conclusions Higher maternal bisphenol S urine concentrations, especially in the first trimester, seem to be related with larger fetal head circumference, higher weight and a lower risk of being small size for gestational age at birth.

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Acquisition and Elimination of Bacterial Vaginosis During Pregnancy: A Danish Population-Based Study

Infectious Diseases in Obstetrics and Gynecology ◽

10.1155/idog/2006/94646 ◽

2006 ◽

Vol 2006 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Ida Vogel ◽

Poul Thorsen ◽

Bernard Jeune ◽

Bo Jacobsson ◽

Niels Ebbesen ◽

...

Keyword(s):

Bacterial Vaginosis ◽

Early Pregnancy ◽

Elimination Rate ◽

Population Based ◽

Gradual Change ◽

Third Trimester ◽

Clinical Criteria ◽

Vaginal Ph ◽

Increased Risk ◽

In Pregnancy

Objectives: the aim was to examine factors associated with acquisition and elimination of bacterial vaginosis in pregnancy.Methods: a group of 229 pregnant women were randomly selected from a population-based prospective cohort study of 2927. They were examined at enrollment (mean gestational weeks16w+0d) and again in mid-third trimester (mean gestational age32w+3d).Measures: BV (Amsel's clinical criteria), microbiological cultures of the genital tract and questionnaire data.Results: BV prevalence decreased from 17% in early second trimester to 14% in mid-third trimester due to a tenfold higher elimination rate (39%) than incidence rate (4%). Heavy smokers(>10/d)in early pregnancy were at increased risk(5.3 [1.1−25])for the acquisition of BV during pregnancy, as were women receiving public benefits(4.8 [1.0−22]), having a vaginal pH above4.5 (6.3 [1.4−29])or vaginal anaerobe bacteria(18 [2.7−122])at enrollment. A previous use of combined oral contraceptives was preventive for the acquisition of BV(0.2 [0.03−0.96]). Elimination of BV in pregnancy tended to be associated with a heavy growth ofLactobacillus (3.2 [0.8−13])at enrollment.Conclusions: acquisition of BV during pregnancy is rare and is associated with smoking, while the presence of anaerobe bacteria and a vaginal pH> 4.5are interpreted as steps on a gradual change towards BV. In the same way heavy growth ofLactobacillusspp in early pregnancy may be an indicator of women on the way to eliminate BV.

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Adiponectin and Leptin in Maternal Serum, Cord Blood, and Breast Milk

Clinical Chemistry ◽

10.1373/clinchem.2006.071019 ◽

2006 ◽

Vol 52 (11) ◽

pp. 2095-2102 ◽

Cited By ~ 82

Author(s):

Maria Weyermann ◽

Christopher Beermann ◽

Hermann Brenner ◽

Dietrich Rothenbacher

Keyword(s):

Birth Weight ◽

Breast Milk ◽

Cord Blood ◽

Large Population ◽

Population Based ◽

Maternal Serum ◽

Current Analysis ◽

Population Based Study ◽

P Values ◽

The University

Abstract Background: The presence of the adipokines adiponectin and leptin in cord blood and placental and fetal tissues suggests a possible role in fetal development. Methods: We measured concentrations of adiponectin and leptin in maternal serum, cord blood, and breast milk and examined their correlations within a large, population-based study. Between November 2000 and November 2001, we recruited all mothers and their newborns after delivery at the University of Ulm (Ulm, Germany). The current analysis included 766 mothers with available breast milk samples collected 6 weeks postpartum. Adipokine concentrations were measured with commercially available ELISAs (R&D Systems). Results: Median adiponectin concentrations in maternal serum (n = 713), cord blood (n = 709), and breast milk (n = 766) were 8.6 mg/L, 30.6 mg/L, and 10.9 μg/L, respectively. Median leptin concentrations were 12.8 μg/L in maternal serum, 7.8 μg/L in cord blood, and 174.5 ng/L in breast milk. Whereas increases in leptin concentrations with increasing birth weight, birth weight according to gestational age, and ponderal index were statistically significant in cord blood (all P values <0.0001), cord blood adiponectin was clearly related only to birth weight (P = 0.0004). Concentrations of both adipokines were moderately correlated in breast milk and maternal serum (both Spearman ρ values were 0.43; P <0.0001). Conclusions: Concentrations of adiponectin and leptin vary strongly in maternal serum, cord blood, and breast milk, with only moderate correlations between both adipokines in maternal serum and breast milk. The health implications of these patterns warrant further investigation.

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Cord blood insulin-like peptide 3 is reduced in idiopathic cryptorchidism and inversely related to free bisphenol A: a marker and/or an actor of foetal exposure to endocrine disruptors?

Endocrine Abstracts ◽

10.1530/endoabs.37.gp.08.07 ◽

2015 ◽

Author(s):

Patrick Fenichel ◽

Najiba Lahlou ◽

Nicolas Chevalier ◽

Patrick Coquillard ◽

Patricia Panaia-Ferrari ◽

...

Keyword(s):

Bisphenol A ◽

Cord Blood ◽

Endocrine Disruptors ◽

Blood Insulin

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Faculty Opinions recommendation of Randomized intervention trial to decrease bisphenol A urine concentrations in women: pilot study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726858830.793525098 ◽

2016 ◽

Author(s):

Paul Terry ◽

Jiangang Chen

Keyword(s):

Pilot Study ◽

Bisphenol A ◽

Intervention Trial ◽

Randomized Intervention ◽

Urine Concentrations

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How often do we incidentally find a fetal abnormality at the routine third-trimester growth scan? A population-based study

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2020.05.052 ◽

2020 ◽

Vol 223 (6) ◽

pp. 919.e1-919.e13 ◽

Cited By ~ 1

Author(s):

Lior Drukker ◽

Angelo Cavallaro ◽

Ibtisam Salim ◽

Christos Ioannou ◽

Lawrence Impey ◽

...

Keyword(s):

Population Based ◽

Third Trimester ◽

Fetal Abnormality ◽

Population Based Study

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Prenatal electrocardiogram testing and postpartum depression: A population-based cohort study

Obstetric Medicine ◽

10.1177/1753495x211012502 ◽

2021 ◽

pp. 1753495X2110125

Author(s):

Jonathan S Zipursky ◽

Deva Thiruchelvam ◽

Donald A Redelmeier

Keyword(s):

Cohort Study ◽

Postpartum Depression ◽

Pregnant Women ◽

Odds Ratio ◽

Population Based ◽

Relative Increase ◽

Organic Disease ◽

Increased Risk ◽

Clinical Clue ◽

In Pregnancy

Background Cardiovascular symptoms in pregnancy may be a clue to psychological distress. We examined whether electrocardiogram testing in pregnant women is associated with an increased risk of subsequent postpartum depression. Methods We conducted a population-based cohort study of pregnant women who delivered in Ontario, Canada comparing women who received a prenatal ECG to women who did not. Results In total, 3,238,218 women gave birth during the 25-year study period of whom 157,352 (5%) received an electrocardiogram during prenatal care. Receiving an electrocardiogram test was associated with a one-third relative increase in the odds of postpartum depression (odds ratio 1.34; 95% confidence interval 1.29–1.39, p < 0.001). Conclusion The association between prenatal electrocardiogram testing and postpartum depression suggests a possible link of organic disease with mental illness, and emphasizes that cardiovascular symptoms may be a clinical clue to the presence of an underlying mood disorder.

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Chitin Degradation Machinery and Secondary Metabolite Profiles in the Marine Bacterium Pseudoalteromonas rubra S4059

Marine Drugs ◽

10.3390/md19020108 ◽

2021 ◽

Vol 19 (2) ◽

pp. 108

Author(s):

Xiyan Wang ◽

Thomas Isbrandt ◽

Mikael Lenz Strube ◽

Sara Skøtt Paulsen ◽

Maike Wennekers Nielsen ◽

...

Keyword(s):

Secondary Metabolite ◽

Genetic Manipulation ◽

Genome Mining ◽

Hydrolytic Enzymes ◽

Metabolite Profile ◽

Chitinolytic Enzyme ◽

Chitin Degradation ◽

Metabolite Profiles ◽

Bioactive Potential ◽

Pseudoalteromonas Rubra

Genome mining of pigmented Pseudoalteromonas has revealed a large potential for the production of bioactive compounds and hydrolytic enzymes. The purpose of the present study was to explore this bioactivity potential in a potent antibiotic and enzyme producer, Pseudoalteromonas rubra strain S4059. Proteomic analyses (data are available via ProteomeXchange with identifier PXD023249) indicated that a highly efficient chitin degradation machinery was present in the red-pigmented P. rubra S4059 when grown on chitin. Four GH18 chitinases and two GH20 hexosaminidases were significantly upregulated under these conditions. GH19 chitinases, which are not common in bacteria, are consistently found in pigmented Pseudoalteromonas, and in S4059, GH19 was only detected when the bacterium was grown on chitin. To explore the possible role of GH19 in pigmented Pseudoalteromonas, we developed a protocol for genetic manipulation of S4059 and deleted the GH19 chitinase, and compared phenotypes of the mutant and wild type. However, none of the chitin degrading ability, secondary metabolite profile, or biofilm-forming capacity was affected by GH19 deletion. In conclusion, we developed a genetic manipulation protocol that can be used to unravel the bioactive potential of pigmented pseudoalteromonads. An efficient chitinolytic enzyme cocktail was identified in S4059, suggesting that this strain could be a candidate with industrial potential.

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