Modulatory role of dietary Thymus vulgaris essential oil and Bacillus subtilis against thiamethoxam-induced hepatorenal damage, oxidative stress, and immunotoxicity in African catfish (Clarias garipenus)

2020 ◽  
Vol 27 (18) ◽  
pp. 23108-23128 ◽  
Author(s):  
Omnia I. El Euony ◽  
Samar S. Elblehi ◽  
Hany M. Abdel-Latif ◽  
Mohamed M. Abdel-Daim ◽  
Yasser S. El-Sayed
Keyword(s):  
Oxidative Stress ◽  
Bacillus Subtilis ◽  
Essential Oil ◽  
Thymus Vulgaris ◽  
African Catfish

scholarly journals Thymus vulgaris Essential Oil Protects Zebrafish against Cognitive Dysfunction by Regulating Cholinergic and Antioxidants Systems

Antioxidants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1083 ◽  
Author(s):  
Luminita Capatina ◽  
Elena Todirascu-Ciornea ◽  
Edoardo Marco Napoli ◽  
Giuseppe Ruberto ◽  
Lucian Hritcu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Essential Oil ◽  
Ache Activity ◽  
Cholinergic Neurons ◽  
Thymus Vulgaris ◽  
Object Recognition Test ◽  
Memory Impairments ◽  
Beneficial Effects ◽  
Gas Chromatograph Mass Spectrometry ◽  
The Brain

Thymus vulgaris L. is an aromatic herb used for medicinal purposes such as antimicrobial, spasmolytic, antioxidant, anti-inflammatory, antinociceptive, antitumor, and may have beneficial effects in the treatment of Alzheimer’s disease. The present study aimed to investigate whether Thymus vulgaris L. essential oil enhances cognitive function via the action on cholinergic neurons using scopolamine (Sco)-induced zebrafish (Danio rerio) model of memory impairments. Thymus vulgaris L. essential oil (TEO, 25, 150, and 300 µL/L) was administered by immersion to zebrafish once daily for 13 days, whereas memory impairment was induced by Sco (100 μM), a muscarinic receptor antagonist, delivered 30 min before behavioral tests. Spatial memory was assessed using the Y-maze test and novel object recognition test (NOR). Anxiety and depression were measured in the novel tank diving test (NTT). Gas Chromatograph-Mass Spectrometry (GC-MS) analysis was used to study the phytochemical composition of TEO. Acetylcholinesterase (AChE) activity and oxidative stress response in the brain of zebrafish were determined. TEO ameliorated Sco-induced increasing of AChE activity, amnesia, anxiety, and reduced the brain antioxidant capacity. These results suggest that TEO may have preventive and/or therapeutic potentials in the management of memory deficits and brain oxidative stress in zebrafish with amnesia.

Protective potential of the essential oil of Thymus vulgaris L. against Dicofol-induced poisoning in rats as established through clinical chemistry, histopathology and 1H-NMR-based metabonomics

2019 ◽  
Vol 8 (2) ◽  
pp. 49-56
Author(s):  
Fouzia Benourad ◽  
Zehra-Cagla Kahvecioglu ◽  
Mokhtar Youcef-Benkada ◽  
Jean-Marie Colet
Keyword(s):  
Essential Oil ◽  
1H Nmr ◽  
Clinical Chemistry ◽  
Protective Role ◽  
Thymus Vulgaris ◽  
Metabolic Disturbances ◽  
Liver And Kidney ◽  
Derivatives Of ◽  
Phytosanitary Products

Pesticides, organochlorines, analogues and derivatives of DDT, those are all terms often associated with health risks, intoxications, nephropathies and other hepatotoxicities. These are phytosanitary products that interfere with the internal metabolism of sensitive organs, such as the kidney or the liver, which orchestrate the metabolism and elimina on of xenobiotics. In this study, a group of Wistar rats was intraperitoneally exposed to Dicofol, a pesticide analogue of DDT. A second group received preven ve injec ons of a diluted thyme essen al oil solu on for four days before exposure to Dicofol. The evaluation of the toxic effects possibly induced by Dicofol in the two experimental groups was carried out using a mul disciplinary approach in- cluding clinical chemistry, histopathology and 1H-NMR-based metabonomics. Histopathological examina on showed pulmonary in amma on and kidney damage in the group exposed to Dicofol. The metabonomic study revealed metabolic disturbances in the liver and kidney. The protective role of the essential oil of thyme was clearly demonstrated from the metabonomic profiles and was confirmed by histological examina on of organs.

scholarly journals Toxic, Oviposition Deterrent and Oxidative Stress Effects of Thymus vulgaris Essential Oil against Acanthoscelides obtectus

Insects ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 563
Author(s):  
Jelica Lazarević ◽  
Stojan Jevremović ◽  
Igor Kostić ◽  
Miroslav Kostić ◽  
Ana Vuleta ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Essential Oil ◽  
Adult Emergence ◽  
Adult Survival ◽  
Thymus Vulgaris ◽  
Contact Toxicity ◽  
Dependent Manner ◽  
Acanthoscelides Obtectus ◽  
Thyme Oil ◽  
Protein Thiols

The bean weevil Acanthoscelides obtectus Say (Coleoptera: Chrysomelidae: Bruchinae) can cause significant losses in production of its primary host common bean Phaseolus vulgaris L. To avoid bean protection with environmentally risky chemical insecticides and provide sustainable and safe production of food, new pest management methods based on natural compounds are investigated. In the present study, we evaluated protective potential of the essential oil (EO) from the common thyme Thymus vulgaris L. applied on bean seeds. We assessed residual contact toxicity of thyme EO and its effects on A. obtectus longevity, oviposition and adult emergence. Furthermore, to elucidate the role of oxidative stress in thyme EO toxicity, we estimated the levels of oxidatively damaged proteins and lipids, as well as the level of thiols which have important role for antioxidant capacity. We found that thyme oil significantly reduced adult survival and longevity, induced oxidative damage to lipids and proteins and depleted protein and non-protein thiols in a concentration-dependent manner. Females appeared to be more tolerant to thyme oil treatment than males. Sublethal EO concentrations affected oxidative stress indices, deterred oviposition and strongly inhibited adult emergence. The results suggest that thyme oil has the potential to be used as an ecofriendly insecticide for A. obtectus control.

scholarly journals Discovery of the role of a SLOG superfamily biological conflict systems associated protein IodA (YpsA) in oxidative stress protection and cell division inhibition in Gram-positive bacteria

2018 ◽  
Author(s):  
Robert S. Brzozowski ◽  
Gianni Graham ◽  
A. Maxwell Burroughs ◽  
Mirella Huber ◽  
Merryck Walker ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Staphylococcus Aureus ◽  
Bacillus Subtilis ◽  
Cell Division ◽  
Ligand Binding ◽  
Binding Proteins ◽  
Control Cell ◽  
Global Network ◽  
Cell Division Inhibition

ABSTRACTBacteria adapt to different environments by regulating cell division and several conditions that modulate cell division have been documented. Understanding how bacteria transduce environmental signals to control cell division is critical to comprehend the global network of cell division regulation. In this article we describe a role forBacillus subtilisYpsA, an uncharacterized protein of the SLOG superfamily of nucleotide and ligand-binding proteins, in cell division. We observed that YpsA provides protection against oxidative stress as cells lackingypsAshow increased susceptibility to hydrogen peroxide treatment. We found that increased expression ofypsAleads to cell division inhibition due to defective assembly of FtsZ, the tubulin-like essential protein that marks the sites of cell division. We showed that cell division inhibition by YpsA is linked to glucose availability. We generated YpsA mutants that are no longer able to inhibit cell division. Finally, we show that the role of YpsA is possibly conserved in Firmicutes, as overproduction of YpsA inStaphylococcus aureusalso impairs cell division. Therefore, we proposeypsAto be renamed asiodAforinhibitorofdivision.IMPORTANCEAlthough key players of cell division in bacteria have been largely characterized, the factors that regulate these division proteins are still being discovered and evidence for the presence of yet-to-be discovered factors has been accumulating. How bacteria sense the availability of nutrients and how that information is used to regulate cell division positively or negatively is less well-understood even though some examples exist in the literature. We discovered that a protein of hitherto unknown function belonging to the SLOG superfamily of nucleotide/ligand-binding proteins, YpsA, influences cell division inBacillus subtilisby integrating metabolic status such as the availability of glucose. We showed that YpsA is important for oxidative stress response inB. subtilis. Furthermore, we provide evidence that cell division inhibition function of YpsA is also conserved in another FirmicuteStaphylococcus aureus. This first report on the role of YpsA (IodA) brings us a step closer in understanding the complete tool set that bacteria have at their disposal to regulate cell division precisely to adapt to varying environmental conditions.

792: Role of Oxidative Stress in Tumorigenic Potential of Bladder Cancer Cells

2005 ◽  
Vol 173 (4S) ◽  
pp. 214-215 ◽  
Author(s):  
Daniel Cho ◽  
Xiao Fang Ha ◽  
J. Andre Melendez ◽  
Louis J. Giorgi ◽  
Badar M. Mian
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Cancer Cells ◽  
Tumorigenic Potential ◽  
Bladder Cancer Cells
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