Fc(COOH)2@ zeolitic imidazolate frameworks-8/three-dimensional macroporous carbon for ascorbic acid sensing

Ionics ◽  
2017 ◽  
Vol 23 (9) ◽  
pp. 2377-2385 ◽  
Author(s):  
Guangxing Pan ◽  
Yonghai Song ◽  
Longfei Miao ◽  
Li Wang
Keyword(s):  
Ascorbic Acid ◽  
Three Dimensional ◽  
Zeolitic Imidazolate Frameworks ◽  
Macroporous Carbon

scholarly journals Effects of Natural Antioxidants on Phospholipid and Ceramide Profiles of 3D-Cultured Skin Fibroblasts Exposed to UVA or UVB Radiation

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 578
Author(s):  
Agnieszka Gęgotek ◽  
Wojciech Łuczaj ◽  
Elżbieta Skrzydlewska
Keyword(s):  
Ascorbic Acid ◽  
High Performance ◽  
Three Dimensional ◽  
Natural Antioxidants ◽  
Phospholipid Metabolism ◽  
Culture Conditions ◽  
Membrane Properties ◽  
Dimensional System ◽  
Uvb Radiation ◽  
Liquid Chromatograph

Ultraviolet (UV) radiation is one of the primary factors responsible for disturbances in human skin cells phospholipid metabolism. Natural compounds that are commonly used to protect skin, due to their lipophilic or hydrophilic nature, show only a narrow range of cytoprotective activity, which prompts research on their combined application. Therefore, the aim of this study was to examine the effect of ascorbic acid and rutin on the phospholipid and ceramide profiles in UV-irradiated fibroblasts cultured in a three-dimensional system that approximates the culture conditions to the dermis. An ultra-high-performance liquid chromatograph coupled with a quadrupole time-of-flight mass spectrometer was used for phospholipid and ceramide profiling. As a result of UVA and UVB cells irradiation, upregulation of phosphatidylcholines, ceramides, and downregulation of sphingomyelins were observed, while treatment with ascorbic acid and rutin of UVA/UVB-irradiated fibroblast promoted these changes to provide cells a stronger response to stress. Moreover, an upregulation of phosphatidylserines in cells exposed to UVB and treated with both antioxidants suggests the stimulation of UV-damaged cells apoptosis. Our findings provide new insight into action of rutin and ascorbic acid on regulation of phospholipid metabolism, which improves dermis fibroblast membrane properties.

Synthesis of nanosized 58S bioactive glass particles by a three-dimensional ordered macroporous carbon template

2017 ◽  
Vol 75 ◽  
pp. 590-595 ◽  
Author(s):  
Lijun Ji ◽  
Wei Qiao ◽  
Kai Huang ◽  
Yuheng Zhang ◽  
Huayu Wu ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Three Dimensional ◽  
Carbon Template ◽  
Ordered Macroporous ◽  
Macroporous Carbon

scholarly journals Synergistic Cytoprotective Effects of Rutin and Ascorbic Acid on the Proteomic Profile of 3D-Cultured Keratinocytes Exposed to UVA or UVB Radiation

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2672 ◽  
Author(s):  
Agnieszka Gęgotek ◽  
Iwona Jarocka-Karpowicz ◽  
Elżbieta Skrzydlewska
Keyword(s):  
Ascorbic Acid ◽  
Synergistic Effect ◽  
Protein Biosynthesis ◽  
Three Dimensional ◽  
Antioxidant Response ◽  
Proteomic Profile ◽  
Uvb Radiation ◽  
Skin Cells ◽  
Protective System ◽  
Skin Damages

The combination of ascorbic acid and rutin, often used in oral preparations, due to antioxidant and anti-inflammatory properties, can be used to protect skin cells against the effects of UV radiation from sunlight. Therefore, the aim of this study was to investigate the synergistic effect of rutin and ascorbic acid on the proteomic profile of UVA and UVB irradiated keratinocytes cultured in a three-dimensional (3D) system. Results showed that the combination of rutin and ascorbic acid protects skin cells against UV-induced changes. In particular, alterations were observed in the expression of proteins involved in the antioxidant response, DNA repairing, inflammation, apoptosis, and protein biosynthesis. The combination of rutin and ascorbic acid also showed a stronger cytoprotective effect than when using either compound alone. Significant differences were visible between rutin and ascorbic acid single treatments in the case of protein carboxymethylation/carboxyethylation. Ascorbic acid prevented UV or rutin-induced protein modifications. Therefore, the synergistic effect of rutin and ascorbic acid creates a potentially effective protective system against skin damages caused by UVA and UVB radiation.

scholarly journals Three-Dimensional Au/Holey-Graphene as Efficient Electrochemical Interface for Simultaneous Determination of Ascorbic Acid, Dopamine and Uric Acid

Micromachines ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 84 ◽  
Author(s):  
Aihua Jing ◽  
Gaofeng Liang ◽  
Yixin Yuan ◽  
Wenpo Feng
Keyword(s):  
Electron Microscopy ◽  
Ascorbic Acid ◽  
Uric Acid ◽  
Graphene Oxide ◽  
Composite Structures ◽  
Three Dimensional ◽  
High Sensitivity ◽  
Cyclic Voltammograms ◽  
Brain Physiology

The quantification of ascorbic acid (AA), dopamine (DA), and uric acid (UA) has been an important area of research, as these molecules’ determination directly corresponds to the diagnosis and control of diseases of nerve and brain physiology. In our research, graphene oxide (GO) with nano pores deposited with gold nanoparticles were self-assembled to form three-dimensional (3D) Au/holey-graphene oxide (Au/HGO) composite structures. The as-prepared 3DAu/HGO composite structures were characterized for their structures by X-ray diffraction, Raman spectrum, scanning electron microscopy, and transmission electron microscopy coupled with cyclic voltammograms. Finally, the proposed 3DAu/HGO displayed high sensitivity, excellent electron transport properties, and selectivity for the simultaneous electrochemical determination of AA, DA and UA with linear response ranges of 1.0–500 μM, 0.01–50 μM and 0.05–50 μM respectively. This finding paves the way for graphene applications as a biosensor for detecting three analytes in human serum.

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