Therapeutic Effects of Boric Acid in a Septic Arthritis Model Induced by Escherichia coli in Rats

Author(s):  
Kadri Yıldız ◽  
Mustafa Makav ◽  
Yasemin Adalı ◽  
Menekşe Bulut
Author(s):  
Xiwen Zhang ◽  
Shinji Sugita ◽  
Airan Liu ◽  
Yoshifumi Naito ◽  
Wonjung Hwang ◽  
...  

Introduction: We previously reported that extracellular vesicles (EVs) released during Escherichia coli bacterial pneumonia were inflammatory, and administration of high molecular weight hyaluronic acid (HMW HA) suppressed several indices of acute lung injury (ALI) from Escherichia coli pneumonia by binding to these inflammatory EVs. The current study was undertaken to study the therapeutic effects of HMW HA in ex vivo perfused human lungs injured with Pseudomonas aeruginosa (PA)103 bacterial pneumonia. Methods: For lungs with baseline alveolar fluid clearance (AFC)<10%/h, HMW HA 1 or 2 mg was injected intravenously after 1 h (N = 4-9), and EVs released during PA pneumonia were collected from the perfusate over 6 h. For lungs with baseline AFC>10%/h, HMW HA 2 mg was injected intravenously after 1 h (N = 6). In vitro experiments were conducted to evaluate the effects of HA on inflammation and bacterial phagocytosis. Results: For lungs with AFC<10%/h, administration of HMW HA intravenously significantly restored AFC and numerically decreased protein permeability and alveolar inflammation from PA103 pneumonia but had no effect on bacterial counts at 6 h. However, HMW HA improved bacterial phagocytosis by human monocytes and neutrophils and suppressed the inflammatory properties of EVs released during pneumonia on monocytes. For lungs with AFC>10%/h, administration of HMW HA intravenously improved AFC from PA103 pneumonia but had no significant effects on protein permeability, inflammation or bacterial counts. Discussion: In the presence of impaired alveolar epithelial transport capacity, administration of HMW HA improved the resolution of pulmonary edema from Pseudomonas PA103 bacterial pneumonia.


2019 ◽  
Vol 392 (12) ◽  
pp. 1577-1589 ◽  
Author(s):  
Murside Ayse Demirel ◽  
Sevtap Han ◽  
Aytekin Tokmak ◽  
Nilufer Ercan Gokay ◽  
Mecit Orhan Uludag ◽  
...  

2012 ◽  
Vol 161 (3) ◽  
pp. 772-780 ◽  
Author(s):  
Bernard C.M. te Boekhorst ◽  
Linda B. Jensen ◽  
Stefano Colombo ◽  
Amir K. Varkouhi ◽  
Raymond M. Schiffelers ◽  
...  

2020 ◽  
Vol 11 (5) ◽  
pp. 4428-4445 ◽  
Author(s):  
Na Li ◽  
Bing Pang ◽  
Junjun Li ◽  
Guanwen Liu ◽  
Xiaoguang Xu ◽  
...  

Reducing the viability of pathogens may also play an important role for the therapeutic effects of Lactobacillus rhamnosus SHA113 against multiple-drug-resistant E. coli, as well as influencing on the intestinal integrity and functions of animals.


2011 ◽  
Vol 20 (1) ◽  
pp. 8-13 ◽  
Author(s):  
Mithat Oner ◽  
Ibrahim Kafadar ◽  
Ahmet Guney ◽  
Mehmet Halici ◽  
Kemal Deniz ◽  
...  

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