Modulation of Cardiopulmonary Toxicity and Oxidative Stress by Phenolic-Rich Fraction of Croton zambiscus Leaves in Rat Exposed to Chronic Mixture of Environmental Toxicants

2020 ◽  
Author(s):  
J. K. Akintunde ◽  
G. O. Oyedibu ◽  
N. J. Olanipekun ◽  
O. A. Olaleye
Keyword(s):  
Oxidative Stress ◽  
Environmental Toxicants ◽  
And Oxidative Stress

scholarly journals Perfluorooctanesulfonic Acid and Perfluorohexanesulfonic Acid Alter the Blood Lipidome and the Hepatic Proteome in a Murine Model of Diet-Induced Obesity

2020 ◽  
Vol 178 (2) ◽  
pp. 311-324
Author(s):  
Marisa Pfohl ◽  
Lishann Ingram ◽  
Emily Marques ◽  
Adam Auclair ◽  
Benjamin Barlock ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Expression Profiles ◽  
Environmental Toxicants ◽  
High Fat ◽  
High Carbohydrate ◽  
Lipid Species ◽  
Perfluorooctanesulfonic Acid ◽  
The Impact ◽  
And Oxidative Stress

Abstract Perfluoroalkyl substances (PFAS) represent a family of environmental toxicants that have infiltrated the living world. This study explores diet-PFAS interactions and the impact of perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic (PFHxS) on the hepatic proteome and blood lipidomic profiles. Male C57BL/6J mice were fed with either a low-fat diet (10.5% kcal from fat) or a high fat (58% kcal from fat) high carbohydrate (42 g/l) diet with or without PFOS or PFHxS in feed (0.0003% wt/wt) for 29 weeks. Lipidomic, proteomic, and gene expression profiles were determined to explore lipid outcomes and hepatic mechanistic pathways. With administration of a high-fat high-carbohydrate diet, PFOS and PFHxS increased hepatic expression of targets involved in lipid metabolism and oxidative stress. In the blood, PFOS and PFHxS altered serum phosphatidylcholines, phosphatidylethanolamines, plasmogens, sphingomyelins, and triglycerides. Furthermore, oxidized lipid species were enriched in the blood lipidome of PFOS and PFHxS treated mice. These data support the hypothesis that PFOS and PFHxS increase the risk of metabolic and inflammatory disease induced by diet, possibly by inducing dysregulated lipid metabolism and oxidative stress.

Bioaccumulation, Oxidative Stress, Immune Responses in Channa Argus Exposure to Waterborne Hexavalent Chromium

2021 ◽  
Author(s):  
Jia-hua du ◽  
Zhe Yu ◽  
Jun-liang Zhao ◽  
Zhi-hui Bai ◽  
Ze-hao Guo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Immune Responses ◽  
Hexavalent Chromium ◽  
Biochemical Parameters ◽  
Immunoglobulin M ◽  
Environmental Toxicants ◽  
The World ◽  
Channa Argus ◽  
And Oxidative Stress

Abstract Hexavalent chromium (Cr (VI)) is a very common and harmful heavy metal pollutant in the world. However, the responses of Cr (VI) to aquatic environmental toxicants have not been well described. In this study, we evaluated the waterborne Cr (VI) [ 0 mg/L (C1), 0.5 mg/L (C2), 1 mg/L (C3), 2 mg/L (C4)] exposed chronically to Channa argus. After 14 and 28 days, we measured biochemical parameters, Cr (VI) accumulation, antioxidant activity and immune response in the serum, liver and gill, respectively. Our results shown that Cr (VI) accumulation will occur in certain tissues as the time of exposure in water prolongs, and the biochemical parameters in the serum will increase. Antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) gradually decreased with the increasing time of Cr (VI) concentration, while the malondialdehyde concentration increases. In addition, in the immune response, cortisol, aminotransferase (ALT), aspartate aminotransferases (AST), alkaline phosphatase (AKP), immunoglobulin M increase, but lysozyme decrease. These results indicated that exposure to waterborne Cr (VI) can exert adverse effects in C. argus by inducing Cr (VI) accumulation, immune responses and oxidative stress.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

Effects of Off-Pump Versus On-Pump Coronary Artery Bypass Grafting: Apoptosis, Inflammation, and Oxidative Stress

2014 ◽  
Vol 17 (5) ◽  
pp. 271 ◽  
Author(s):  
Murat Bicer ◽  
Tunay Senturk ◽  
Murat Yanar ◽  
Ahmet Tutuncu ◽  
Arzu Yilmaztepe Oral ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ischemia Reperfusion ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Artery Bypass Grafting ◽  
Cabg Surgery ◽  
Off Pump ◽  
Pump Cabg ◽  
Hs Crp ◽  
And Oxidative Stress

<strong>Background</strong>: It has been suggested that off-pump coronary<br />artery bypass grafting (CABG) surgery reduces myocardial<br />ischemia-reperfusion injury, postoperative systemic<br />inflammatory response, and oxidative stress. The aim of this<br />study was to measure serum malondialdehyde (MDA), highsensitivity<br />C-reactive protein (hs-CRP), M30, and M65 levels<br />and to investigate the relationship between M30 levels and<br />oxidative stress and inflammation in patients undergoing onand<br />off-pump CABG surgery.<br /><strong>Methods</strong>: Fifty patients were randomly assigned to onpump<br />or off-pump CABG surgery (25 patients off-pump and<br />25 on-pump CABG surgery), and blood samples were collected<br />prior to surgery, and 30 minutes, 60 minutes, 6 hours,<br />and 24 hours after CABG surgery.<br /><strong>Results</strong>: Compared to the on-pump group, serum MDA<br />levels at 30 minutes, 60 minutes, 6 hours, and 24 hours after<br />the CABG surgery were significantly lower in the off-pump<br />group (P = .001, P = .001, P = .001, and P = .001, respectively).<br />Serum M30 levels were found to be elevated in both groups,<br />returning to baseline at 24 hours. When compared to baseline,<br />the hs-CRP level reached its peak at 24 hours at 13.28 ±<br />5.32 mg/dL in the on-pump group, and 15.44 ± 4.02 mg/dL<br />in the off-pump group.<br /><strong>Conclusion</strong>: CABG surgery is associated with an increase<br />in inflammatory markers and serum M30 levels, indicating<br />epithelial/endothelial apoptosis in the early period.

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