The Immunomodulatory Potential of Mesenchymal Stem Cells in a Retinal Inflammatory Environment

2019 ◽  
Vol 15 (6) ◽  
pp. 880-891 ◽  
Author(s):  
Barbora Hermankova ◽  
Jan Kossl ◽  
Pavla Bohacova ◽  
Eliska Javorkova ◽  
Michaela Hajkova ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immunomodulatory Potential

The Immunomodulatory Potential of Murine Adipose-Derived Mesenchymal Stem Cells is enhanced Following Culture on Chitosan Film

2021 ◽  
pp. 101709
Author(s):  
Sheida Farrokhi ◽  
Fattah sotoodehnejadnematalahi ◽  
Anwar Fathollahi ◽  
Mostafa Haji Molla Hoseini ◽  
Seyed Mahmoud Hashemi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Chitosan Film ◽  
Immunomodulatory Potential

scholarly journals Old Friends with Unexploited Perspectives: Current Advances in Mesenchymal Stem Cell-Based Therapies in Asthma

2021 ◽  
Author(s):  
Marlena Tynecka ◽  
Marcin Moniuszko ◽  
Andrzej Eljaszewicz
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Immune System ◽  
Mesenchymal Stem Cell ◽  
Clinical Studies ◽  
Experimental Models ◽  
Airway Epithelial ◽  
Immunomodulatory Potential ◽  
Old Friends

AbstractMesenchymal stem cells (MSCs) have a great regenerative and immunomodulatory potential that was successfully tested in numerous pre-clinical and clinical studies of various degenerative, hematological and inflammatory disorders. Over the last few decades, substantial immunoregulatory effects of MSC treatment were widely observed in different experimental models of asthma. Therefore, it is tempting to speculate that stem cell-based treatment could become an attractive means to better suppress asthmatic airway inflammation, especially in subjects resistant to currently available anti-inflammatory therapies. In this review, we discuss mechanisms accounting for potent immunosuppressive properties of MSCs and the rationale for their use in asthma. We describe in detail an intriguing interplay between MSCs and other crucial players in the immune system as well as lung microenvironment. Finally, we reveal the potential of MSCs in maintaining airway epithelial integrity and alleviating lung remodeling. Graphical abstract

scholarly journals Effects of Normal Synovial Fluid and Interferon Gamma on Chondrogenic Capability and Immunomodulatory Potential Respectively on Equine Mesenchymal Stem Cells

2021 ◽  
Vol 22 (12) ◽  
pp. 6391
Author(s):  
Mohammed Zayed ◽  
Steve Adair ◽  
Madhu Dhar
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Synovial Fluid ◽  
Interferon Gamma ◽  
Bone Marrow Mscs ◽  
Chondrogenic Medium ◽  
Calcein Am ◽  
Ifn Γ ◽  
Immunomodulatory Potential ◽  
Tgf Β1

Synovial fluid contains cytokines, growth factors and resident mesenchymal stem cells (MSCs). The present study aimed to (1) determine the effects of autologous and allogeneic synovial fluid on viability, proliferation and chondrogenesis of equine bone marrow MSCs (BMMSCs) and (2) compare the immunomodulatory properties of equine synovial fluid MSCs (SFMSCs) and BMMSCs after stimulation with interferon gamma (INF-γ). To meet the first aim of the study, the proliferation and viability of MSCs were evaluated by MTS and calcein AM staining assays. To induce chondrogenesis, MSCs were cultured in a medium containing TGF-β1 or different concentrations of synovial fluid. To meet the second aim, SFMSCs and BMMSCs were stimulated with IFN-γ. The concentration of indoleamine-2,3-dioxygenase (IDO) and nitric oxide (NO) were examined. Our results show that MSCs cultured in autologous or allogeneic synovial fluid could maintain proliferation and viability activities. Synovial fluid affected chondrocyte differentiation significantly, as indicated by increased glycosaminoglycan contents, compared to the chondrogenic medium containing 5 ng/mL TGF-β1. After culturing with IFN-γ, the conditioned media of both BMMSCs and SFMSCs showed increased concentrations of IDO, but not NO. Stimulating MSCs with synovial fluid or IFN-γ could enhance chondrogenesis and anti-inflammatory activity, respectively, suggesting that the joint environment is suitable for chondrogenesis.

scholarly journals Immunomodulatory Potential of Human Adipose Mesenchymal Stem Cells Derived Exosomes on in vitro Stimulated T Cells

2014 ◽  
Vol 5 ◽  
Author(s):  
Rebeca Blazquez ◽  
Francisco Miguel Sanchez-Margallo ◽  
Olga de la Rosa ◽  
Wilfried Dalemans ◽  
Verónica Álvarez ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Mesenchymal Stem Cells ◽  
Immunomodulatory Potential

scholarly journals Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Xiangling Li ◽  
Yanjun Guan ◽  
Chaochao Li ◽  
Tieyuan Zhang ◽  
Fanqi Meng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Peripheral Nerve ◽  
Immune Cells ◽  
Peripheral Nerve Injuries ◽  
Local Inflammatory Response ◽  
Inflammatory Microenvironment ◽  
Free Treatment ◽  
Immunomodulatory Potential

AbstractVarious immune cells and cytokines are present in the aftermath of peripheral nerve injuries (PNI), and coordination of the local inflammatory response is of great significance for the recovery of PNI. Mesenchymal stem cells (MSCs) exhibit immunosuppressive and anti-inflammatory abilities which can accelerate tissue regeneration and attenuate inflammation, but the role of MSCs in the regulation of the local inflammatory microenvironment after PNI has not been widely studied. Here, we summarize the known interactions between MSCs, immune cells, and inflammatory cytokines following PNI with a focus on the immunosuppressive role of MSCs. We also discuss the immunomodulatory potential of MSC-derived extracellular vesicles as a new cell-free treatment for PNI.

scholarly journals Analysis of Same Selected Immunomodulatory Properties of Chorionic Mesenchymal Stem Cells

2020 ◽  
Vol 10 (24) ◽  
pp. 9040
Author(s):  
Darina Bačenková ◽  
Marianna Trebuňová ◽  
Lukáš Zachar ◽  
Radovan Hudák ◽  
Gabriela Ižaríková ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bioactive Molecules ◽  
Cell Contact ◽  
Response Modulation ◽  
Activated Lymphocytes ◽  
Lymphocyte Adhesion ◽  
Immunomodulatory Properties ◽  
Immunomodulatory Action ◽  
Immunomodulatory Potential

Mesenchymal stem cells (MSCs) represent a population of adherent cells that can be isolated from multiple adult tissues. MSCs have immunomodulatory capacity and the ability to differentiate into many cell lines. Research study examines the immunomodulatory properties of MSCs isolated from chorion (CMSCs). Following the stimulation process, it was found that MSCs are capable of immunomodulatory action via the release of bioactive molecules as well as through direct contact with the immune cells. Immunomodulatory potential of the CMSCs was analyzed by modifying proliferative capacity of mitogen-activated lymphocytes. CMSCs and lymphocytes were tested in cell-to-cell contact. Lymphocytes were stained with carboxyfluorescein diacetate succinimidyl ester. Inhibition of the proliferation of activated lymphocytes was observed. Following the co-cultivation, the expression of markers involved in the immune response modulation was assessed. Afterwards, an increase in CMSCs expression of IL-10 was detected. Following the co-cultivation with activated lymphocyte, adhesion molecules CD54 and CD44 in the CMSCs increased. An increase of CD54 expression was observed. The properties of CMSCs, adherence and differentiation ability, were confirmed. The phenotype of CMSCs CD105+, CD90+, CD73+, CD44+, CD29+, CD45−, CD34−, CD54+ was characterized. It was demonstrated that chorion-derived MSCs have important immunomodulatory effects.

Sign in / Sign up

Export Citation Format

Share Document