Cell biology of glioblastoma multiforme: from basic science to diagnosis and treatment

2018 ◽  
Vol 35 (3) ◽  
Author(s):  
George S. Stoyanov ◽  
Deyan Dzhenkov ◽  
Peter Ghenev ◽  
Bogomil Iliev ◽  
Yavor Enchev ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Basic Science ◽  
Cell Biology ◽  
Diagnosis And Treatment

scholarly journals Basic Science and The NIH

1994 ◽  
Vol 5 (3) ◽  
pp. 267-272 ◽  
Author(s):  
Harold Varmus
Keyword(s):  
Public Policy ◽  
New Orleans ◽  
Annual Meeting ◽  
Basic Science ◽  
Cell Biology ◽  
National Institutes Of Health ◽  
Keynote Speech ◽  
American Society

The following is an edited version of the Keynote Speech delivered at the Annual Meeting of the American Society for Cell Biology by Harold Varmus, Director of the National Institutes of Health. The address, entitled Basic Science and the NIH, was given at the opening of the meeting in New Orleans on December 11, 1993. It was Varmus' first public policy talk as NIH Director.

scholarly journals Prediction and Analysis of Key Genes in Glioblastoma Based on Bioinformatics

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Hao Long ◽  
Chaofeng Liang ◽  
Xi’an Zhang ◽  
Luxiong Fang ◽  
Gang Wang ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Prediction Model ◽  
Basic Science ◽  
Prediction Accuracy ◽  
Genetic Basis ◽  
Bioinformatics Analysis ◽  
Clinical Treatment ◽  
Structural Level ◽  
Biotechnological Application ◽  
Key Genes

Understanding the mechanisms of glioblastoma at the molecular and structural level is not only interesting for basic science but also valuable for biotechnological application, such as the clinical treatment. In the present study, bioinformatics analysis was performed to reveal and identify the key genes of glioblastoma multiforme (GBM). The results obtained in the present study signified the importance of some genes, such as COL3A1, FN1, and MMP9, for glioblastoma. Based on the selected genes, a prediction model was built, which achieved 94.4% prediction accuracy. These findings might provide more insights into the genetic basis of glioblastoma.

Glioblastoma Multiforme, Diagnosis and Treatment; Recent Literature Review

2017 ◽  
Vol 24 (27) ◽  
Author(s):  
Ron Batash ◽  
Noam Asna ◽  
Pamela Schaffer ◽  
Nicole Francis ◽  
Moshe Schaffer
Keyword(s):  
Glioblastoma Multiforme ◽  
Literature Review ◽  
Recent Literature ◽  
Diagnosis And Treatment

scholarly journals Glioblastoma Multiforme Oncogenomics and Signaling Pathways

2009 ◽  
Vol 3 ◽  
pp. CMO.S1008 ◽  
Author(s):  
Okezie O. Kanu ◽  
Betsy Hughes ◽  
Chunhui Di ◽  
Ningjing Lin ◽  
Jinrong Fu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Glioblastoma Multiforme ◽  
Signaling Pathways ◽  
Cell Biology ◽  
De Novo ◽  
Genetic Alterations ◽  
Migration And Invasion ◽  
Low Grade ◽  
Stem Cell Biology ◽  
Glioma Stem Cell

In the adult population, glioblastoma multiforme is one of the most common primary brain tumors encountered. Unfortunately, this highly malignant tumor represents over 50% of all types of primary central nervous system gliomas. The vast majority of GBMs develops quite rapidly without clinical, radiological, or morphologic evidence of a less malignant precursor lesion (primary or de novo GBMs), as compared to secondary GBMs that develop slowly by progression from diffuse low-grade astrocytomas. These GBM subtypes must be kept in mind because they may constitute distinct disease entities. Even though they look histologically quite similar, they likely involve different genetic alterations and signaling pathways. Decades of surgical therapy, radiotherapy, and chemotherapy have failed to drastically change survival. Clearly, we do not fully understand this tumor; however, the exciting genetic revolution in glioma research over the past decade is providing a promising outlook for exploring this tumor at the genetic level. Science has begun to elucidate the numerous genetic alterations and critical signaling pathways, and it has opened new exciting areas of research such as glioma stem cell biology and neoangiogenesis. This work has already begun to improve our understanding of GBM cell proliferation, migration, and invasion. Indeed, exciting novel targeted therapies are making their way to clinical trials based on this increased knowledge. This review provides the current understanding of GBM oncogenomics, signaling pathways, and glioma stem cell biology and discusses the potential new therapeutic targets on the horizon.

Hyaline moulds

2017 ◽  
Author(s):  
Elizabeth M. Johnson
Keyword(s):  
Risk Factors ◽  
Mucous Membrane ◽  
Cell Biology ◽  
Diagnosis And Treatment ◽  
Small Subset ◽  
Human Pathogens ◽  
Filamentous Form ◽  
Invasive Infections ◽  
Incidence Risk ◽  
Taxonomic Grouping

Hyaline moulds are fungi that grow predominantly in a filamentous form with colourless hyphae. This is not a taxonomic grouping and encompasses many thousands of different fungal genera. However, there is a small subset of environmental saprobes or plant pathogenic moulds, currently comprising at least 75 species from 30 different genera, that are opportunistic human pathogens and have been implicated in invasive infections referred to as hyalohyphomycosis. In addition they may cause less invasive cutaneous, subcutaneous, mucous membrane, and corneal infections. This group of organisms includes Fusarium, Sarocladium, Paecilomyces, Purpureocillium, Scedosporium, Rasamsonia, and Scopulariopsis spp., and it is these that form the focus of this chapter. Aspects of taxonomy, cell biology, pathogenesis, epidemiology, incidence, risk factors, presentation, diagnosis, and treatment are discussed with particular reference to those features that are specific to hyaline moulds.

The Cell Biology of SARS-CoV-2

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Anthony Futerman
Keyword(s):  
Life Cycle ◽  
Critical Point ◽  
Host Cell ◽  
Basic Science ◽  
Cell Biology ◽  
Science Research ◽  
Host Cells ◽  
Biological Features ◽  
Basic Science Research

The critical point in the life cycle of a virus is gaining entry into a host cell so that the virus can replicate. Anthony Futerman describes the distinct biological features of SARS-CoV-2, including its method of entering host cells. He finally urges more support for basic science research so that future biologists will be better prepared to stem diseases before they reach pandemic proportions.

Considerations and recent advances in neuroscience

2009 ◽  
Vol 37 (1) ◽  
pp. 299-302
Author(s):  
Adrienne M. Gorman ◽  
Karen M. Doyle
Keyword(s):  
Translational Research ◽  
Glial Cell ◽  
Basic Science ◽  
Cell Biology ◽  
Recent Advances ◽  
Developing Area

Neuroscience is a rapidly developing area of science which has benefitted from the blurring of interdisciplinary boundaries. This was apparent in the range of papers presented at this year's Neuroscience Ireland Conference, held in Galway during August 2008. The event was attended by academics, postdoctoral and postgraduate researchers, scientists from industry and clinicians. The themes of this year's conference, neurodegeneration, neuroregeneration, pain, glial cell biology and psychopharmacology, were chosen for their reflection of areas of strength in neuroscience within Ireland. In addition to basic science, translational research also featured strongly.

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