scholarly journals Chemokines and Cancer Progression: A Qualitative Review on the Role of Stromal Cell-derived Factor 1-alpha and CXCR4 in Endometrial Cancer

2010 ◽  
Vol 3 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Ashley S. Felix ◽  
Robert Edwards ◽  
Robert Bowser ◽  
Faina Linkov
Keyword(s):  
Endometrial Cancer ◽  
Cancer Progression ◽  
Stromal Cell ◽  
Qualitative Review ◽  
Stromal Cell Derived Factor

scholarly journals Mitochondrial Transfer and Regulators of Mesenchymal Stromal Cell Function and Therapeutic Efficacy

2020 ◽  
Vol 8 ◽  
Author(s):  
Amina Mohammadalipour ◽  
Sandeep P. Dumbali ◽  
Pamela L. Wenzel
Keyword(s):  
Regenerative Medicine ◽  
Cancer Progression ◽  
Mesenchymal Stromal Cell ◽  
Tissue Repair ◽  
Stromal Cell ◽  
Nutrient Utilization ◽  
Metabolic Reprogramming ◽  
Mitochondrial Activity ◽  
Mitochondrial Transfer

Mesenchymal stromal cell (MSC) metabolism plays a crucial role in the surrounding microenvironment in both normal physiology and pathological conditions. While MSCs predominantly utilize glycolysis in their native hypoxic niche within the bone marrow, new evidence reveals the importance of upregulation in mitochondrial activity in MSC function and differentiation. Mitochondria and mitochondrial regulators such as sirtuins play key roles in MSC homeostasis and differentiation into mature lineages of the bone and hematopoietic niche, including osteoblasts and adipocytes. The metabolic state of MSCs represents a fine balance between the intrinsic needs of the cellular state and constraints imposed by extrinsic conditions. In the context of injury and inflammation, MSCs respond to reactive oxygen species (ROS) and damage-associated molecular patterns (DAMPs), such as damaged mitochondria and mitochondrial products, by donation of their mitochondria to injured cells. Through intercellular mitochondria trafficking, modulation of ROS, and modification of nutrient utilization, endogenous MSCs and MSC therapies are believed to exert protective effects by regulation of cellular metabolism in injured tissues. Similarly, these same mechanisms can be hijacked in malignancy whereby transfer of mitochondria and/or mitochondrial DNA (mtDNA) to cancer cells increases mitochondrial content and enhances oxidative phosphorylation (OXPHOS) to favor proliferation and invasion. The role of MSCs in tumor initiation, growth, and resistance to treatment is debated, but their ability to modify cancer cell metabolism and the metabolic environment suggests that MSCs are centrally poised to alter malignancy. In this review, we describe emerging evidence for adaptations in MSC bioenergetics that orchestrate developmental fate decisions and contribute to cancer progression. We discuss evidence and potential strategies for therapeutic targeting of MSC mitochondria in regenerative medicine and tissue repair. Lastly, we highlight recent progress in understanding the contribution of MSCs to metabolic reprogramming of malignancies and how these alterations can promote immunosuppression and chemoresistance. Better understanding the role of metabolic reprogramming by MSCs in tissue repair and cancer progression promises to broaden treatment options in regenerative medicine and clinical oncology.

Tumor progression in osteosarcoma (OS): Role of the chemokine receptor CXCR4 and of its ligand stromal-cell derived factor 1 (SDF-1)

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9021-9021 ◽  
Author(s):  
E. Perissinotto ◽  
V. Fonsato ◽  
G. Cavalloni ◽  
F. Leone ◽  
S. Mitola ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Chemokine Receptor ◽  
Stromal Cell ◽  
Chemokine Receptor Cxcr4 ◽  
Stromal Cell Derived Factor

scholarly journals Role of stromal-cell derived factor-1 in the development of autoimmune diseases in non-obese diabetic mice

Immunology ◽  
2002 ◽  
Vol 107 (2) ◽  
pp. 222-232 ◽  
Author(s):  
Khairul Matin ◽  
M. Abdus Salam ◽  
Joynab Akhter ◽  
Nobuhiro Hanada ◽  
Hidenobu Senpuku
Keyword(s):  
Autoimmune Diseases ◽  
Stromal Cell ◽  
Diabetic Mice ◽  
Stromal Cell Derived Factor

scholarly journals The role of a stromal cell-derived factor-1 chemokine gene variant in the clinical course of HIV-1 infection

AIDS ◽  
1998 ◽  
Vol 12 (9) ◽  
pp. F85-F90 ◽  
Author(s):  
Ronald P. van Rij ◽  
Silvia Broersen ◽  
Jaap Goudsmit ◽  
Roel A. Coutinho ◽  
Hanneke Schuitemaker
Keyword(s):  
Stromal Cell ◽  
Clinical Course ◽  
Gene Variant ◽  
Chemokine Gene ◽  
Stromal Cell Derived Factor ◽  
Hiv 1

scholarly journals Role of Stromal Cell-Derived Factor-1 in Patients With Non-ST Elevation Acute Coronary Syndrome

2014 ◽  
Vol 55 (3) ◽  
pp. 219-227 ◽  
Author(s):  
Guoxin Tong ◽  
Ningfu Wang ◽  
Yujie Zhou ◽  
Jianhang Leng ◽  
Wei Gao ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Stromal Cell ◽  
Coronary Syndrome ◽  
St Elevation ◽  
Elevation Acute Coronary Syndrome ◽  
Stromal Cell Derived Factor

scholarly journals LncRNA DCST1-AS1 Promotes Endometrial Cancer Progression by Modulating the MiR-665/HOXB5 and MiR-873-5p/CADM1 Pathways

2021 ◽  
Vol 11 ◽  
Author(s):  
Jie Wang ◽  
Changjiang Lei ◽  
Pingping Shi ◽  
Huaixiang Teng ◽  
Lixiang Lu ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Progression ◽  
Noncoding Rna ◽  
Migration And Invasion ◽  
Potential Therapeutic Target ◽  
Tumorigenesis And Progression ◽  
Cell Adhesion Molecule 1

Dysregulation of long noncoding RNA (lncRNA) is implicated in the initiation and progression of various tumors, including endometrial cancer (EC). However, the mechanism of lncRNAs in EC tumorigenesis and progression remains largely unexplored. In this work, we identified a novel lncRNA DC-STAMP domain-containing 1-antisense 1 (DCST1-AS1), which is highly upregulated and correlated with poor survival in EC patients. Overexpression of DCST1-AS1 significantly enhanced EC cell proliferation, colony formation, migration, and invasion in vitro and promoted tumor growth of EC in vivo. Mechanistically, DCST1-AS1 mediated EC progression by inducing the expression of homeobox B5 (HOXB5) and cell adhesion molecule 1 (CADM1), via acting as a competing endogenous RNA for microRNA-665 (miR-665) and microRNA-873-5p (miR-873-5p), respectively. In addition, we found that the expression of miR-665 and miR-873-5p was significantly downregulated, while HOXB5 and CADM1 expression levels were increased in EC tissues. Taken together, our findings support the important role of DCST1-AS1 in EC progression, and DCST1-AS1 may be used as a prognostic biomarker as well as a potential therapeutic target for EC.

EP569 Potential role of PAI-1 in endometrial cancer progression and its regulation by epigenetic mechanisms

2019 ◽  
Author(s):  
J Marí-Alexandre ◽  
C Agababyan ◽  
P Pascual-Utiel ◽  
M Cubertorer-Navarro ◽  
J García-Oms ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Progression ◽  
Potential Role ◽  
Epigenetic Mechanisms ◽  
Pai 1
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