scholarly journals Elucidation of the Molecular Mechanisms of Action of the Natural Antimicrobial Peptide Subtilosin Against the Bacterial Vaginosis-associated Pathogen Gardnerella vaginalis

2010 ◽  
Vol 3 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Katia Sutyak Noll ◽  
Patrick J. Sinko ◽  
Michael L. Chikindas
Keyword(s):  
Antimicrobial Peptide ◽  
Bacterial Vaginosis ◽  
Molecular Mechanisms ◽  
Mechanisms Of Action ◽  
Gardnerella Vaginalis ◽  
Natural Antimicrobial

scholarly journals The Natural Antimicrobial Peptide Subtilosin Acts Synergistically with Glycerol Monolaurate, Lauric Arginate, and ε-Poly-l-Lysine against Bacterial Vaginosis-Associated Pathogens but Not Human Lactobacilli

2012 ◽  
Vol 56 (4) ◽  
pp. 1756-1761 ◽  
Author(s):  
Katia Sutyak Noll ◽  
Mark N. Prichard ◽  
Arkady Khaykin ◽  
Patrick J. Sinko ◽  
Michael L. Chikindas
Keyword(s):  
Antimicrobial Peptide ◽  
Bacterial Vaginosis ◽  
Bacillus Amyloliquefaciens ◽  
Antimicrobial Agents ◽  
Gardnerella Vaginalis ◽  
Human Pathogen ◽  
Natural Antimicrobial ◽  
Content Type ◽  
Lauric Arginate ◽  
Glycerol Monolaurate

ABSTRACTSubtilosin is a cyclical antimicrobial peptide produced byBacillus amyloliquefaciensthat has antimicrobial activity against the bacterial vaginosis-associated human pathogenGardnerella vaginalis. The ability of subtilosin to inhibitG. vaginalisalone and in combination with the natural antimicrobial agents glycerol monolaurate (Lauricidin), lauric arginate, and ε-poly-l-lysine was tested using a checkerboard approach. Subtilosin was found to act synergistically with all of the chosen antimicrobials. These promising results indicate that lower concentrations of subtilosin in combination with other compounds could effectively be used to inhibit growth of the pathogen, thereby decreasing the risk of developed antimicrobial resistance. This is the first report on the effects of subtilosin combined with other natural antimicrobials againstG. vaginalis.

scholarly journals The correlation between lncRNAs and Helicobacter pylori in gastric cancer

2019 ◽  
Vol 77 (9) ◽  
Author(s):  
Narges Dastmalchi ◽  
Seyed Mahdi Banan Khojasteh ◽  
Mirsaed Miri Nargesi ◽  
Reza Safaralizadeh
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Molecular Mechanisms ◽  
Gastrointestinal Diseases ◽  
Mechanisms Of Action ◽  
Molecular Pathways ◽  
Gastric Diseases ◽  
Non Coding Rnas ◽  
H Pylori ◽  
The Relationship

ABSTRACT Helicobacter pylori infection performs a key role in gastric tumorigenesis. Long non-coding RNAs (lncRNAs) have demonstrated a great potential to be regarded as effective malignancy biomarkers for various gastrointestinal diseases including gastric cancer (GC). The present review highlights the relationship between lncRNAs and H. pylori in GC. Several studies have examined not only the involvement of lncRNAs in H. pylori-associated GC progression but also their molecular mechanisms of action. Among the pertinent studies, some have addressed the effects of H. pylori infection on modulatory networks of lncRNAs, while others have evaluated the effects of changes in the expression level of lncRNAs in H. pylori-associated gastric diseases, especially GC. The relationship between lncRNAs and H. pylori was found to be modulated by various molecular pathways.

scholarly journals Gene Transcription as a Therapeutic Target in Leukemia

2021 ◽  
Vol 22 (14) ◽  
pp. 7340
Author(s):  
Alvina I. Khamidullina ◽  
Ekaterina A. Varlamova ◽  
Nour Alhuda Hammoud ◽  
Margarita A. Yastrebova ◽  
Alexandra V. Bruter
Keyword(s):  
Gene Transcription ◽  
Molecular Mechanisms ◽  
Hematological Malignancies ◽  
Mechanisms Of Action ◽  
Special Program ◽  
Cell Plasticity ◽  
Hematopoietic Stem ◽  
Promising Strategy ◽  
Tumor Cell Plasticity ◽  
Transcriptional Landscape

Blood malignancies often arise from undifferentiated hematopoietic stem cells or partially differentiated stem-like cells. A tight balance of multipotency and differentiation, cell division, and quiescence underlying normal hematopoiesis requires a special program governed by the transcriptional machinery. Acquisition of drug resistance by tumor cells also involves reprogramming of their transcriptional landscape. Limiting tumor cell plasticity by disabling reprogramming of the gene transcription is a promising strategy for improvement of treatment outcomes. Herein, we review the molecular mechanisms of action of transcription-targeted drugs in hematological malignancies (largely in leukemia) with particular respect to the results of clinical trials.

FK778: New Cellular and Molecular Mechanisms of Action

2006 ◽  
Vol 38 (3) ◽  
pp. 757-761 ◽  
Author(s):  
S. Schrepfer ◽  
T. Deuse ◽  
F. Koch-Nolte ◽  
C. Detter ◽  
H. Reichenspurner
Keyword(s):  
Molecular Mechanisms ◽  
Mechanisms Of Action

scholarly journals Genome Sequences of 15 Gardnerella vaginalis Strains Isolated from the Vaginas of Women with and without Bacterial Vaginosis: TABLE 1 

2016 ◽  
Vol 4 (5) ◽  
Author(s):  
Lloyd S. Robinson ◽  
Justin Perry ◽  
Sai Lek ◽  
Aye Wollam ◽  
Erica Sodergren ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Health Outcomes ◽  
Bacterial Vaginosis ◽  
Draft Genome ◽  
Gardnerella Vaginalis ◽  
Genome Sequences ◽  
Predominant Species ◽  
Adverse Health ◽  
Adverse Health Outcomes

Gardnerella vaginalis is a predominant species in bacterial vaginosis, a dysbiosis of the vagina that is associated with adverse health outcomes, including preterm birth. Here, we present the draft genome sequences of 15 Gardnerella vaginalis strains (now available through BEI Resources) isolated from women with and without bacterial vaginosis.

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