Impact of a high-cholesterol diet on expression levels of Niemann–Pick C1-like 1 and intestinal transporters in rats and mice

2015 ◽  
Vol 41 (4) ◽  
pp. 457-463 ◽  
Author(s):  
Atsushi Kawase ◽  
Yasuha Araki ◽  
Yukiko Ueda ◽  
Sayaka Nakazaki ◽  
Masahiro Iwaki
Keyword(s):  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Expression Levels ◽  
Intestinal Transporters ◽  
Niemann Pick ◽  
Rats And Mice

scholarly journals Rutin Attenuates Hepatotoxicity in High-Cholesterol-Diet-Fed Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Shakir D. AlSharari ◽  
Salim S. Al-Rejaie ◽  
Hatem M. Abuohashish ◽  
Mohamed M. Ahmed ◽  
Mohamed M. Hafez
Keyword(s):  
Signaling Pathway ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Kinase Inhibitor ◽  
High Cholesterol Diet ◽  
Protective Agent ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Expression Levels ◽  
Male Wistar Rats

Background and Objective.High-cholesterol diet (HCD) intends to increase the oxidative stress in liver tissues inducing hepatotoxicity. Rutin is a natural flavonoid (vitamin p) which is known to have antioxidative properties. The aim of the present study was to investigate the potential effects of Rutin on hypercholesterolemia-induced hepatotoxicity in rats.Materials and Methods.Male Wistar rats were divided into four groups: G-I control, G-II Rutin, G-III HCD, and G-IV Rutin + HCD. The liver functions and lipid profile were used to evaluate the HCD-induced hepatotoxicity. Quantitative real time-PCR was carried out to evaluate the expression levels of genes in TGF-β/Smad signaling pathway.Results.Rutin in combination with HCD showed a significant protective effect against hepatotoxicity. HCD caused significant increase in the mRNA expression of transforming growth factor beta (TGF-β), Mothers Against Decapentaplegic Homolog 2 (Smad-2), Mothers Against Decapentaplegic Homolog 4 (Smad-4), Bcl-2-binding component 3 (Bbc3),caspase-3,P53and Interleukin-6 (IL-6) and decrease in the expression levels of Cyclin depended kinase inhibitor (P21) and Interleukin-3(IL-3) in hepatic cells.Conclusion. TGF-β/Smadsignaling pathway is involved in HCD-induced hepatotoxicity and Rutin inhibits the hepatotoxicity via suppressing this pathway. Therefore, Rutin might be considered as a protective agent for hepatotoxicity.

Hypolipidemic and antioxidant effect of Ajuga iva in rats fed a high-cholesterol diet

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
MA Lacaille-Dubois ◽  
A Chenni ◽  
DA Yahia ◽  
FO Boukortt ◽  
J Prost ◽  
...  
Keyword(s):  
Antioxidant Effect ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

Serum lipoproteins of diabetic rats fed a high cholesterol diet

Diabetes ◽  
1980 ◽  
Vol 29 (10) ◽  
pp. 774-777 ◽  
Author(s):  
C. M. Arbeeny ◽  
D. Edelstein ◽  
S. R. Freedman ◽  
H. A. Eder
Keyword(s):  
Diabetic Rats ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
Serum Lipoproteins ◽  
High Cholesterol

Effect of Polygonum multiflorum Thunberg Extract on Lipid Metabolism in Rats Fed High-Cholesterol Diet

2012 ◽  
Vol 41 (7) ◽  
pp. 957-962 ◽  
Author(s):  
Jun-Hweok Choi ◽  
Hye-Sung Lee ◽  
Young-Eon Kim ◽  
Byoung-Mok Kim ◽  
In-Ho Kim ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Polygonum Multiflorum
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