Protective Mechanisms of Quercetin on Cisplatin Induced Oxidative Damage in Hepatic Tissue of Wistar Rats

2017 ◽  
Vol 88 (4) ◽  
pp. 1399-1407 ◽  
Author(s):  
Pawan K. Verma ◽  
Rajinder Raina ◽  
Shahid Prawez ◽  
Mudasir Sultana ◽  
Maninder Singh ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Wistar Rats ◽  
Hepatic Tissue ◽  
Protective Mechanisms

scholarly journals Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage

2017 ◽  
Vol 2017 ◽  
pp. 1-22 ◽  
Author(s):  
Bettina P. Mihalas ◽  
Kate A. Redgrove ◽  
Eileen A. McLaughlin ◽  
Brett Nixon
Keyword(s):  
Oxidative Damage ◽  
Molecular Mechanisms ◽  
Spindle Assembly Checkpoint ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Oocyte Quality ◽  
Protein Repair ◽  
Protective Mechanisms ◽  
Pronounced Increase ◽  
Age Related

In their midthirties, women experience a decline in fertility, coupled to a pronounced increase in the risk of aneuploidy, miscarriage, and birth defects. Although the aetiology of such pathologies are complex, a causative relationship between the age-related decline in oocyte quality and oxidative stress (OS) is now well established. What remains less certain are the molecular mechanisms governing the increased vulnerability of the aged oocyte to oxidative damage. In this review, we explore the reduced capacity of the ageing oocyte to mitigate macromolecular damage arising from oxidative insults and highlight the dramatic consequences for oocyte quality and female fertility. Indeed, while oocytes are typically endowed with a comprehensive suite of molecular mechanisms to moderate oxidative damage and thus ensure the fidelity of the germline, there is increasing recognition that the efficacy of such protective mechanisms undergoes an age-related decline. For instance, impaired reactive oxygen species metabolism, decreased DNA repair, reduced sensitivity of the spindle assembly checkpoint, and decreased capacity for protein repair and degradation collectively render the aged oocyte acutely vulnerable to OS and limits their capacity to recover from exposure to such insults. We also highlight the inadequacies of our current armoury of assisted reproductive technologies to combat age-related female infertility, emphasising the need for further research into mechanisms underpinning the functional deterioration of the ageing oocyte.

scholarly journals Modafinil Effects on Behavior and Oxidative Damage Parameters in Brain of Wistar Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Felipe Ornell ◽  
Samira S. Valvassori ◽  
Amanda V. Steckert ◽  
Pedro F. Deroza ◽  
Wilson R. Resende ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Open Field ◽  
Wistar Rats ◽  
Thiobarbituric Acid ◽  
Protein Carbonyl ◽  
Behavioral Changes ◽  
Protein Damage ◽  
Behavioral Parameters ◽  
Carbonyl Formation ◽  
The Brain

The effects of modafinil (MD) on behavioral and oxidative damage to protein and lipid in the brain of rats were evaluated. Wistar rats were given a single administration by gavage of water or MD (75, 150, or 300 mg/kg). Behavioral parameters were evaluated in open-field apparatus 1, 2, and 3 h after drug administration. Thiobarbituric acid reactive substances (TBARS) and protein carbonyl formation were measured in the brain. MD increased locomotor activity at the highest dose 1 and 3 h after administration. MD administration at the dose of 300 mg/kg increased visits to the center of open-field 1 h after administration; however, 3 h after administration, all administered doses of MD increased visits to the open-field center. MD 300 mg/kg increased lipid damage in the amygdala, hippocampus, and striatum. Besides, MD increased protein damage in the prefrontal cortex, amygdala, and hippocampus; however, this effect varies depending on the dose administered. In contrast, the administration of MD 75 and 300 mg/kg decreased the protein damage in the striatum. This study demonstrated that the MD administration induces behavioral changes, which was depending on the dose used. In addition, the effects of MD on oxidative damage parameters seemed to be in specific brain region and doses.

Zingerone prevents lead‐induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats

2020 ◽  
Author(s):  
Insha Amin ◽  
Ishraq Hussain ◽  
Muneeb U. Rehman ◽  
Bilal Ahmad Mir ◽  
Showkat Ahmad Ganaie ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Wistar Rats ◽  
Liver And Kidney

Oleic acid protects against cadmium induced cardiac and hepatic tissue injury in male Wistar rats: A mechanistic study

Life Sciences ◽  
2020 ◽  
Vol 244 ◽  
pp. 117324 ◽  
Author(s):  
Bharati Bhattacharjee ◽  
Palash Kumar Pal ◽  
Aindrila Chattopadhyay ◽  
Debasish Bandyopadhyay
Keyword(s):  
Oleic Acid ◽  
Wistar Rats ◽  
Tissue Injury ◽  
Mechanistic Study ◽  
Hepatic Tissue ◽  
Male Wistar Rats

scholarly journals Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats

2012 ◽  
Vol 2 (11) ◽  
pp. 910-915 ◽  
Author(s):  
Viswanadha Vijaya Padma ◽  
Gurusamy Lalitha ◽  
Nicholson Puthanveedu Shirony ◽  
Rathinasamy Baskaran
Keyword(s):  
Wistar Rats ◽  
Hepatic Tissue ◽  
Tissue Lipids

LC–MS/MS methods for the detection of isoprostanes (iPF2α-III and 8,12-iso-iPF2α-VI) as biomarkers of CCl4-induced oxidative damage to hepatic tissue

2008 ◽  
Vol 861 (1) ◽  
pp. 48-55 ◽  
Author(s):  
Tina Sicilia ◽  
Angela Mally ◽  
Ute Schauer ◽  
Axel Pähler ◽  
Wolfgang Völkel
Keyword(s):  
Oxidative Damage ◽  
Hepatic Tissue
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