Web-based patient surveillance cost effective in lung cancer

2019 ◽  
Vol 823 (1) ◽  
pp. 35-35
Keyword(s):  
Lung Cancer ◽  
Cost Effective ◽  
Web Based

scholarly journals Cost-Effectiveness of Smoking Cessation Interventions in the Lung Cancer Screening Setting: A Simulation Study

2021 ◽  
Author(s):  
Christopher J Cadham ◽  
Pianpian Cao ◽  
Jinani Jayasekera ◽  
Kathryn L Taylor ◽  
David T Levy ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Smoking Cessation ◽  
Cost Effectiveness ◽  
Cancer Screening ◽  
Task Force ◽  
Lung Cancer Screening ◽  
Cancer Registries ◽  
Web Based ◽  
Screening Programs ◽  
Life Years

Abstract Background Guidelines recommend offering cessation interventions to smokers eligible for lung cancer screening, but there is little data comparing specific cessation approaches in this setting. We compared the benefits and costs of different smoking cessation interventions to help screening programs select specific cessation approaches. Methods We conducted a societal-perspective cost-effectiveness analysis using a Cancer Intervention and Surveillance Modeling Network model simulating individuals born in 1960 over their lifetimes. Model inputs were derived from Medicare, national cancer registries, published studies, and micro-costing of cessation interventions. We modeled annual lung cancer screening following 2014 US Preventive Services Task Force guidelines plus cessation interventions offered to current smokers at first screen, including pharmacotherapy only or pharmacotherapy with electronic and/or web-based, telephone, individual, or group counseling. Outcomes included lung cancer cases and deaths, life-years saved, quality-adjusted life-years (QALYs) saved, costs, and incremental cost-effectiveness ratios. Results Compared with screening alone, all cessation interventions decreased cases of and deaths from lung cancer. Compared incrementally, efficient cessation strategies included pharmacotherapy with either web-based cessation ($555 per QALY), telephone counseling ($7562 per QALY), or individual counseling ($35 531 per QALY). Cessation interventions continued to have costs per QALY well below accepted willingness to pay thresholds even with the lowest intervention effects and was more cost-effective in cohorts with higher smoking prevalence. Conclusion All smoking cessation interventions delivered with lung cancer screening are likely to provide benefits at reasonable costs. Because the differences between approaches were small, the choice of intervention should be guided by practical concerns such as staff training and availability.

A Web-Based Process/Material Advisory System

2000 ◽  
Author(s):  
Yusheng Chen ◽  
Satyandra K. Gupta ◽  
Shaw Feng
Keyword(s):  
Conceptual Design ◽  
Cost Effective ◽  
Design Stage ◽  
Material Combination ◽  
Web Based ◽  
Advisory System ◽  
Conceptual Design Stage ◽  
Design Requirements ◽  
Parameter Ranges ◽  
Process Material

Abstract This paper describes a web-based process/material advisory system that can be used during conceptual design. Given a set of design requirements for a part during conceptual design stage, our system produces process sequences that can meet the design requirements. Quite often during conceptual design stage, design requirements are not precisely defined. Therefore, we allow users to describe design requirements in terms of parameter ranges. Parameter ranges are used to capture uncertainties in design requirements. Our system accounts for uncertainties in design requirements in generating and evaluating process/material combinations. Our system uses a two step algorithm. During the first step, we generate a material/process option tree. This tree represents various process/material options that can be used to meet the given set of design requirements. During the second step, we evaluate various alternative process/material options using a depth first branch and bound algorithm to identify and recommend the least expensive process/material combination to the designer. Our system can be accessed on the World Wide Web using a standard browser. Our system allows designs to consider a wide variety of process/material options during the conceptual design stage and allows them to find the most cost-effective combination. By selecting the process/material combination during the early design stages, designers can ensure that the detailed design is compatible with all of the process constraints for the selected process.

scholarly journals Investigating the practical viability of walk-sharing in improving pedestrian safety

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Debjit Bhowmick ◽  
Stephan Winter ◽  
Mark Stevenson ◽  
Peter Vortisch
Keyword(s):  
Public Perception ◽  
Performance Metrics ◽  
Social Preferences ◽  
Cost Effective ◽  
Pedestrian Safety ◽  
Web Based ◽  
Proactive Approach ◽  
Community Acceptance ◽  
Urban Scenario ◽  
Spatio Temporal

AbstractWalk-sharing is a cost-effective and proactive approach that promises to improve pedestrian safety and has been shown to be technically (theoretically) viable. Yet, the practical viability of walk-sharing is largely dependent on community acceptance, which has not, until now, been explored. Gaining useful insights on the community’s spatio-temporal and social preferences in regard to walk-sharing will ensure the establishment of practical viability of walk-sharing in a real-world urban scenario. We aim to derive practical viability using defined performance metrics (waiting time, detour distance, walk-alone distance and matching rate) and by investigating the effectiveness of walk-sharing in terms of its major objective of improving pedestrian safety and safety perception. We make use of the results from a web-based survey on the public perception on our proposed walk-sharing scheme. Findings are fed into an existing agent-based walk-sharing model to investigate the performance of walk-sharing and deduce its practical viability in urban scenarios.

scholarly journals MULTI-FACTOR AUTHENTICATION AT JAGGED PEAK

10.28945/3557 ◽  
2016 ◽  
Vol 1 ◽  
pp. 001-016
Author(s):  
Grandon Gill ◽  
Joni Jones
Keyword(s):  
Healthcare Providers ◽  
Cost Effective ◽  
Third Party ◽  
Security Measures ◽  
Web Based ◽  
User Training ◽  
Gift Cards ◽  
Security Challenge ◽  
Security Questions ◽  
Risk Managers

Jeffrey Stiles pondered these seemingly straightforward questions. As IT Director of Jagged Peak, Inc., a developer of e-commerce solutions located in the Tampa Bay region of Florida, it would be his responsibility to oversee the implementation of security measures that went beyond the existing user name and password currently required for each user. Recent events suggested that a move towards increased security might be inevitable. In just the past year, highly publicized security failures at the U.S. Department of Defense, major healthcare providers and large companies, such as Sony and JP Morgan Chase, had made executives acutely aware of the adverse consequences of IT system vulnerabilities. In fact, a study of business risk managers conducted in 2014 found that 69% of all businesses had experienced some level of hacking in the previous year. The nature of Jagged Peak’s business made the security of its systems a particular concern. The company, which had grown rapidly over the years, reporting over $61 million in revenue in 2014, provided its customers with software that supported web-based ordering, fulfillment and logistics activities, built around a philosophy of “buy anywhere, fulfill anywhere, return anywhere”. To support these activities, the company’s Edge platform needed to handle a variety of payment types, including gift cards (a recent target of hackers), as well as sensitive personal identifying information (PII). Compounding the security challenge: each customer ran its own instance of the Edge platform, and managed its own users. When only a single customer was being considered, the addition of further layers of security to authenticate uses was an eminently solvable problem. A variety of alternative approaches existed, including the use of various biometrics, key fobs that provided codes the user could enter, personalized security questions, and many others. The problem was that where multiple customers were involved, it was much more difficult to form a consensus. One customer might object to biometrics because it users lacked the necessary hardware. Another might object to security keys as being too costly, easily stolen or lost. Personalized questions might be considered too failure-prone by some customers. Furthermore, it was not clear that adding additional layers of authentication would necessarily be the most cost-effective way to reduce vulnerability. Other approaches, such as user training might provide greater value. Even if Stiles decided to proceed with additional authentication, questions remained. Mandatory or a free/added-cost option? Developed in house or by a third party? Used for internal systems only, customer platforms only, or both? Implementation could not begin until these broad questions were answered.

scholarly journals Web-based intervention for depressive symptoms in adults with types 1 and 2 diabetes mellitus: a health economic evaluation

2018 ◽  
Vol 212 (4) ◽  
pp. 199-206 ◽  
Author(s):  
Stephanie Nobis ◽  
David Daniel Ebert ◽  
Dirk Lehr ◽  
Filip Smit ◽  
Claudia Buntrock ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Treatment Response ◽  
Active Control ◽  
Cost Effective ◽  
Control Group ◽  
Active Control Group ◽  
Comorbid Depression ◽  
Web Based ◽  
Life Years ◽  
The Cost

BackgroundWeb-based interventions are effective in reducing depression. However, the evidence for the cost-effectiveness of these interventions is scarce.AimsThe aim is to assess the cost-effectiveness of a web-based intervention (GET.ON M.E.D.) for individuals with diabetes and comorbid depression compared with an active control group receiving web-based psychoeducation.MethodWe conducted a cost-effectiveness analysis with treatment response as the outcome and a cost-utility analysis with quality-adjusted life-years (QALYs) alongside a randomised controlled trial with 260 participants.ResultsAt a willingness-to-pay ceiling of €5000 for a treatment response, the intervention has a 97% probability of being regarded as cost-effective compared with the active control group. If society is willing to pay €14 000 for an additional QALY, the intervention has a 51% probability of being cost-effective.ConclusionsThis web-based intervention for individuals with diabetes and comorbid depression demonstrated a high probability of being cost-effective compared with an active control group.Declaration of interestS.N., D.D.E., D.L., M.B. and B.F. are stakeholders of the Institute for Online Health Trainings, which aims to transfer scientific knowledge related to this research into routine healthcare.

Modern Paradigm Towards Potential Target Identification for Antiviral (SARS-nCoV-2) and Anticancer Lipopeptides: A Pharmacophore-Based Approach

2022 ◽  
Author(s):  
Manisha Yadav ◽  
J. Satya Eswari
Keyword(s):  
Drug Discovery ◽  
Target Identification ◽  
Target Prediction ◽  
Cost Effective ◽  
Time Saving ◽  
Web Based ◽  
Target Proteins ◽  
Lead Compounds ◽  
Potential Target ◽  
Biopharmaceutical Properties

Background: Lipopeptides are potential microbial metabolites that are abandoned with broad spectrum biopharmaceutical properties ranging from antimicrobial, antiviral and anticancer, etc. Clinical studies are not much explored beyond the experimental methods to understand drug mechanisms on target proteins at the molecular level for large molecules. Due to the less available studies on potential target proteins of lipopeptide based drugs, their potential inhibitory role for more obvious treatment on disease have not been explored in the direction of lead optimization. However, Computational approaches need to be utilized to explore drug discovery aspects on lipopeptide based drugs, which are time saving and cost-effective techniques. Methods: Here a ligand-based drug discovery approach is coupled with reverse pharmacophore-mapping for the prediction of potential targets for antiviral (SARS-nCoV-2) and anticancer lipopeptides. Web-based servers PharmMapper and Swiss Target Prediction are used for the identification of target proteins for lipopeptides surfactin and iturin produced by Bacillus subtilis. Results: The studies have given the insight to treat the diseases with next-generation large molecule therapeutics. Results also indicate the affinity for Angiotensin-Converting Enzymes (ACE) and proteases as the potential viral targets for these categories of peptide therapeutics. A target protein for the Human Papilloma Virus (HPV) has also been mapped. Conclusion: The work will further help in exploring computer-aided drug designing of novel compounds with greater efficiency where the structure of the target proteins and lead compounds are known.  

Brigatinib is a cost-effective treatment in first-line anaplastic lymphoma kinase mutation-positive (ALK + ) advanced non-small cell lung cancer (NSCLC) with brain metastases

2022 ◽  
pp. 107815522110734
Author(s):  
Jacopo Giuliani
Keyword(s):  
Lung Cancer ◽  
Cost Effectiveness ◽  
Brain Metastases ◽  
Cost Effective ◽  
Small Cell ◽  
Control Group ◽  
Small Cell Lung ◽  
First Line ◽  
Anaplastic Lymphoma ◽  
Kinase Mutation

Introduction The aim of this paper was to assess the cost-effectiveness of alectinib and brigatinib in first-line for anaplastic lymphoma kinase mutation-positive (ALK+) advanced non-small cell lung cancer (NSCLC). Pivotal phase III RCTs were considered. Four hundred and eighty-two patients were included. Both trials, which compared alectinib and brigatinib versus (vs.) crizotinib (control group), respectively, showed a gain in pharmacological costs, compared to the control group, of 194.80 € for alectinib and 648.48 € for brigatinib for an entire treatment of a single patient. Brigatinib was the less expensive, with a cost of 269.78 € for each month of PFS for both intention-to-treat (ITT) population that patients with baseline brain metastases (BBM). In conclusion, combining pharmacological costs of drugs with the measure of efficacy represented by PFS, both alectinib and brigatinib are cost-effective treatments in first-line for ALK+ NSCLC. In the BBM population brigatinib seems to be the most cost-effectiveness.

Development and Patient Usability Analysis of a Veteran Centric Web-based Decision Aid for Lung Cancer Screening (Preprint)

2021 ◽  
Author(s):  
Marilyn Schapira ◽  
Sumedha Chhatre ◽  
Jason Prigge ◽  
Jessica Meline ◽  
Dana Kaminstein ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Trial ◽  
Cancer Screening ◽  
Medical Center ◽  
Clinical Care ◽  
Lung Cancer Screening ◽  
Potential Range ◽  
Medical Terminology ◽  
Web Based ◽  
System Usability Scale

BACKGROUND Web based tools developed to facilitate a Shared Decision Making (SDM) process may facilitate implementation of lung cancer screening (LCS), an evidence based intervention to improve cancer outcomes. Veterans have specific risk factors and shared experiences that impact the benefit and potential harms of LCS, so may value a Veteran centric LCS SDM too OBJECTIVE To develop and conduct usability testing of a LCS Decision Tool (LCSDecTool) designed for Veterans receiving care at a Veteran Affairs Medical Center (VAMC). METHODS A user-centered design approach was undertaken to develop the LCSDecTool. Usability of a prototype was assessed among 18 Veterans from two VA sites. Usability of a high fidelity version was assessed among 43 Veterans as part of a clinical trial. Outcomes included the System Usability Scale (SUS), the End User Computer Satisfaction (EUCS), and the Patient Engagement (PE) scale. Qualitative data from observations and short interviews with users were analyzed and themes pertaining to usability identified. RESULTS The mean (SD) in the pilot clinical trial (n=43) for the SUS (potential range 0 [low] to 100 [high] was 65.76 [15.23]); EUCS (potential range 1 [low] to 5 [high] was 3.91 [0.95]); and PE (potential range 1[low) to 5 [high] was 4.62 [0.67]). Time to completion of the LCSDecTool in minutes (median, intra-quartile range) was (13, 10-16). Emerging themes included: 1) a baseline gap in awareness of LCS with knowledge gained from using the LCSDecTool, 2) an interest in details about the LCS process, 3) the LCSDecTool was easy to use overall but specific navigation challenges identified, and 4) difficulty in understanding medical terminology. CONCLUSIONS The LCSDecTool demonstrates a good level of usability among Veterans when testing in the context of clinical care. Study findings will inform further modifications of the tool, including shortening the length and simplifying language. CLINICALTRIAL ClinicalTrials.gov Identifier: NCT02899754

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