Factors Influencing AMPK Activation During Cycling Exercise: A Pooled Analysis and Meta-Regression

2021 ◽  
Author(s):  
Jeffrey A. Rothschild ◽  
Hashim Islam ◽  
David J. Bishop ◽  
Andrew E. Kilding ◽  
Tom Stewart ◽  
...  
Keyword(s):  
Pooled Analysis ◽  
Ampk Activation ◽  
Cycling Exercise ◽  
Factors Influencing ◽  
Meta Regression

Insulin therapy and outcome from coronavirus disease 2019 (COVID-19): A Systematic Review, Meta-Analysis, and Meta-Regression

2021 ◽  
Vol 21 ◽  
Author(s):  
Timotius Ivan Hariyanto ◽  
Nata Pratama Hardjo Lugito ◽  
Theo Audi Yanto ◽  
Jeremia Immanuel Siregar ◽  
Andree Kurniawan
Keyword(s):  
Systematic Review ◽  
Insulin Therapy ◽  
Meta Analysis ◽  
Random Effect ◽  
Pooled Analysis ◽  
The Poor ◽  
Meta Regression ◽  
Insulin Use ◽  
The Relationship ◽  
Review Manager

Background: Currently, the relationship between insulin therapy and COVID-19 outcome is not yet established. Our study aims to evaluate the possible association between insulin and the poor composite development of COVID-19. Methods: We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until December 12th, 2020. All articles published on COVID-19 and insulin were retrieved. Statistical analysis was done using Review Manager 5.4 and Comprehensive Meta-Analysis version 3 software. Results: Our pooled analysis showed that insulin use was associated with poor composite development of COVID-19 [OR 2.06 (95% CI 1.70 – 2.48), p < 0.00001, I2 = 83%, random-effect modelling], and its subgroup which comprised of risk of COVID-19 [OR 1.70 (95% CI 1.40 – 2.08), p < 0.00001, I2 = 34%, random-effect modelling], severe COVID-19 [OR 2.30 (95% CI 1.60 – 3.30), p < 0.00001, I2 = 88%, random-effect modelling], and mortality [OR 2.14 (95% CI 1.47 – 3.10), p < 0.0001, I2 = 85%, random-effect modelling]. Meta-regression showed that the association was influenced by age (p = 0.008), but not by diabetes (p = 0.423), and cardiovascular disease (p = 0.086). Conclusion: Physicians should be more aware and take extra precautions with diabetes patients who use insulin therapy.

P1022Upstream therapy using preoperative renin-angiotensin system inhibitors in prevention of postoperative atrial fibrillation and adverse events: a collaborative pooled-analysis over 27,000 patients

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S Chen ◽  
B Schmidt ◽  
P Sommer ◽  
S Liu ◽  
M W Krucoff ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Surgery ◽  
Adverse Events ◽  
Renin Angiotensin System ◽  
Pooled Analysis ◽  
Postoperative Atrial Fibrillation ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Subgroup Analyses ◽  
Meta Regression

Abstract Background Renin-angiotensin-system inhibitors (RASIs) have been suggested as an upstream therapy for selected AF patients; however, the evidence in surgical setting is limited. Objective We aimed to evaluate the role of preoperative RASIs in prevention of postoperative atrial fibrillation (POAF) and adverse events for patients undergoing cardiac surgery. Methods In this collaborative pooled-analysis, both randomized and nonrandomized controlled trials comparing preoperative RASIs with no preoperative RASIs treatment on the incidence of POAF were identified. Sensitivity and subgroup analyses of RCTs were performed to test the stability of the overall-effect, and meta-regression to explore the potential risk of bias. The primary outcome was POAF, and the secondary outcomes includes rate of stroke, mortality and duration of hospitalization. Results Eleven trials involving 27885 patients (male 74%, median age 65yrs) were included. As compared to the control group, preoperative RASIs did not significantly reduce the risk of POAF (OR: 1.04, 95% CI: 0.91–1.19), stroke (OR: 0.86, 95% CI: 0.62–1.19), death (OR: 1.07, 95% CI: 0.85–1.35), composite adverse cardiac events (OR: 1.04, 95% CI: 0.91–1.18), and hospital stay (WMD: −0.04, 95% CI: −1.05 to 0.98). Pooled-analysis of randomized trials showed consistent results. The primary overall-effect was maintained in sensitivity and subgroup analyses. Meta-regression showed that male-gender was a significant risk-factor of POAF and use of Beta-blockers was associated with a significantly reduced risk in developing POAF. Conclusion and relevance This study demonstrates that preoperative RASIs do not offer additional benefit in reducing the risk of postoperative AF, stroke, death and hospitalization in the setting of cardiac surgery. The results provide no support for use of RASIs for the prevention of POAF and adverse events in patients undergoing cardiac surgery.

scholarly journals Factors influencing subjective quality of life in patients with schizophrenia and other mental disorders: A pooled analysis

2010 ◽  
Vol 121 (1-3) ◽  
pp. 251-258 ◽  
Author(s):  
Stefan Priebe ◽  
Ulrich Reininghaus ◽  
Rosemarie McCabe ◽  
Tom Burns ◽  
Mona Eklund ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Disorders ◽  
Pooled Analysis ◽  
Subjective Quality ◽  
Subjective Quality Of Life ◽  
Factors Influencing

scholarly journals Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression

2021 ◽  
Vol 14 ◽  
pp. 117955142199067
Author(s):  
Indriwanto Sakidjan Atmosudigdo ◽  
Michael Anthonius Lim ◽  
Basuni Radi ◽  
Joshua Henrina ◽  
Emir Yonas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Literature Search ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Male Gender ◽  
Composite Outcome ◽  
Funnel Plot ◽  
Poor Outcome ◽  
Registration Number ◽  
Meta Regression

Objective: This systematic review and meta-analysis aimed to evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association. Methods: A systematic literature search using PubMed, Embase, and EuropePMC was performed on 8 October 2020. This study’s main outcome is a poor composite outcome, comprising of mortality and severe COVID-19. Results: There were 9 studies with 3663 patients. The prevalence of dyslipidemia in this pooled analysis was 18% (4%-32%). Dyslipidemia was associated with increased composite poor outcome (RR 1.39 [1.02, 1.88], P = .010; I2: 56.7%, P = .018). Subgroup analysis showed that dyslipidemia was associated with severe COVID-19 (RR 1.39 [1.03, 1.87], P = .008; I2: 57.4%, P = .029). Meta-regression showed that the association between dyslipidemia and poor outcome varies by age (coefficient: −0.04, P = .033), male gender (coefficient: −0.03, P = .042), and hypertension (coefficient: −0.02, P = .033), but not diabetes (coefficient: −0.24, P = .135) and cardiovascular diseases (coefficient: −0.01, P = .506). Inverted funnel-plot was relatively symmetrical. Egger’s test indicates that the pooled analysis was not statistically significant for small-study effects ( P = .206). Conclusion: Dyslipidemia potentially increases mortality and severity of COVID-19. The association was stronger in patients with older age, male, and hypertension. PROSPERO Registration Number: CRD42020213491

scholarly journals Factors influencing nursing students' intention to accept COVID-19 vaccination: A pooled analysis of seven European countries

2021 ◽  
pp. 105010
Author(s):  
Evridiki Patelarou ◽  
Petros Galanis ◽  
Enkeleint A. Mechili ◽  
Agathi Argyriadi ◽  
Alexandros Argyriadis ◽  
...  
Keyword(s):  
Nursing Students ◽  
Pooled Analysis ◽  
European Countries ◽  
Factors Influencing

scholarly journals Sex Differences in Salmonellosis Incidence Rates—An Eight-Country National Data-Pooled Analysis

2021 ◽  
Vol 10 (24) ◽  
pp. 5767
Author(s):  
Victoria Peer ◽  
Naama Schwartz ◽  
Manfred S. Green
Keyword(s):  
Sex Differences ◽  
Age Groups ◽  
Pooled Analysis ◽  
Incidence Rates ◽  
National Data ◽  
Time Period ◽  
Meta Regression ◽  
Rate Ratios ◽  
Male To Female ◽  
Country Specific

Background: There are few studies on sex differences in the incidence rates (IR) for salmonellosis over several countries by age and time period. The purpose of this study was to explore the extent and consistency of the sex and age-specific differences. Methods: We analyzed national data from eight countries between 1994 and 2016. We computed country-specific male to female incidence rate ratios (IRRs) for each age group and pooled the data using meta-analytic methods. Variations of the IRRs by age, country and time period were evaluated using meta-regression. Results: The pooled male to female incidence RRs for ages 0–1, 1–4, 5–9 and 10–14, were 1.04 (1.02–1.06), 1.02 (1.01–1.03), 1.07 (1.05–1.08) and 1.28 (1.23–1.33), respectively. For the ages 15–44 and 45–64, the incidence rates were significantly higher in females. Meta-regression analyses indicate that age groups contributed most of the variation in the male to female IRRs. Conclusions: We suggest that genetic and hormonal factors and interactions between hormones and gut microbiota could contribute to the sex differences observed in young children. These findings should provide clues about the mechanisms of the infection, and should be useful in targeting treatments and development of vaccines. Highlights: (1) This manuscript provides consistent estimates of the excess salmonellosis incidence rates in male children up to age 15, which suggests an impact of sex hormones or genetic differences. (2) Our findings should promote the further investigations on sex-related determinants of infectious diseases.

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