scholarly journals Side-Effects Causing Hidden Conflicts in Software-Defined Networks

2020 ◽  
Vol 1 (5) ◽  
Author(s):  
Vitalian Danciu ◽  
Cuong Ngoc Tran
Keyword(s):  
Side Effects ◽  
Communication Interface ◽  
Control Applications ◽  
Concurrent Control ◽  
State Evaluation ◽  
New Type ◽  
Observed Behaviour ◽  
Prediction Approach ◽  
Prediction Functions ◽  
Conflict Prediction

Abstract The Software-Defined Networking (SDN) architecture facilitates the flexible deployment of network functions by detaching them from network devices to a logically centralized point, the so-called SDN controller, and maintaining a common communication interface between them. While promoting innovation for each side, this architecture also induces a higher chance of conflicts between concurrent control applications compared to existing traditional networks. We have discovered a new type of anomalies that we call hidden conflicts. They appear to occur only due to side-effects of control application’s behaviour and to be independent of and distinct from the class of conflicts between rules present in the network devices. We analyse the SDN interaction primitives susceptible to such disruptions and present experiments supporting our analysis, the result of which indicates the necessity of the knowledge on the control mechanics in detecting hidden conflicts. We present a hidden conflict prediction approach that employs speculative provocation to determine the deployed applications’ behaviour. The observed behaviour can be leveraged to predict undesired network state. Evaluation of our prediction prototype suggests that prediction functions should be integrated into control applications.

scholarly journals Current and New Approaches to Predict the Deflections of One-Way Flexural Members with a Focus on Composite Steel Deck Slabs Voided by Circular Tubes

Materials ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 421
Author(s):  
Chang-Hwan Lee ◽  
Iman Mansouri ◽  
Jaehoon Bae ◽  
Jaeho Ryu
Keyword(s):  
Structural Function ◽  
Flexural Members ◽  
Long Span ◽  
Deck Slabs ◽  
New Type ◽  
New Perspective ◽  
Flexural Tests ◽  
Prediction Approach ◽  
Steel Deck

A new type of composite voided slab, the TUBEDECK (TD), which utilizes the structural function of profiled steel decks, has recently been proposed. Previous studies have confirmed that the flexural strength of TD slabs can be calculated based on the full composite contribution of the steel deck, but for long-span flexural members, the deflection serviceability requirement is often dominant. Herein, we derived a novel deflection prediction approach using the results of flexural tests on slab specimens, focusing on TD slabs. First, deflection prediction based on modifications of the current code was proposed. Results revealed that TD slabs exhibited smaller long-term deflections and at least 10% longer maximum span lengths than solid slabs, indicating their greater efficiency. Second, a novel rational method was derived for predicting deflections without computing the effective moment of inertia. The ultimate deflections predicted by the proposed method correlated closely with the deflection under maximum bending moments. To calculate immediate deflections, variation functions for the concrete strain at the extreme compression fiber and neutral axis depth were assumed with predictions in good agreement with experiments. The proposed procedure has important implications in highlighting a new perspective on the deflection prediction of reinforced concrete and composite flexural members.

Synergistic photo-release of drugs by non-linear excitation

2014 ◽  
Vol 1688 ◽  
Author(s):  
Valerio Voliani ◽  
Giovanni Signore ◽  
Orazio Vittorio ◽  
Paolo Faraci ◽  
Stefano Luin ◽  
...  
Keyword(s):  
Side Effects ◽  
Chemotherapeutic Agent ◽  
Therapeutic Action ◽  
Gold Nanospheres ◽  
Modular Systems ◽  
On Demand ◽  
Human Osteosarcoma ◽  
Apoptotic Effect ◽  
New Type ◽  
The One

ABSTRACTNanomaterials engineered in novel multi-modular systems in which every component works in a synergistic way with others could potentially lead to a completely new type of tools for nanomedicine. The development of nanostructures able to release drugs directly within the target after a stimulus can drastically improve the therapeutics efficiency by reducing side effects. Gold nanoparticles offer one of the most suitable platforms for the development of modular nano-devices. On the one hand, their surface properties enable effective coating by peptides containing at least one cysteine, thus yielding stable and non-cytotoxic systems. On the other, their intriguing photophysics, characterized by the surface plasmon resonance, can be exploited for novel excitation schemes. Doxorubicin is a widely used, but toxic, cancer chemotherapeutic agent. In order to localize its therapeutic action while minimizing its side effects, doxorubicin was covalently conjugated to 30 nm peptide-encapsulated gold nanospheres by click-chemistry and then it was photo-released in a controlled fashion through the cleavage of the 1,2,3-triazolic ring by a multiphoton process using 561 nm irradiation at µW power. Selective apoptosis of human osteosarcoma (U2OS) cells was observed only in the irradiated 100x100 micron area in less than six minutes after the stimulus. Notably, the apoptotic effect of doxorubicin was completely inhibited for at least eight hours until its release “on demand” was externally light-triggered.

scholarly journals Antibody Drug Conjugate Bioinformatics: Drug Delivery through the Letterbox

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Dimitrios Vlachakis ◽  
Sophia Kossida
Keyword(s):  
Side Effects ◽  
Adaptive Immune Response ◽  
Antibody Fragment ◽  
Therapeutic Window ◽  
Single Chain ◽  
Antibody Drug Conjugate ◽  
Drug Conjugates ◽  
Underlying Principle ◽  
New Type ◽  
Antibody Drug

Antibodies appear to be the first line of defence in the adaptive immune response of vertebrates and thereby are involved in a multitude of biochemical mechanisms, such as regulation of infection, autoimmunity, and cancer. It goes without saying that a full understanding of antibody function is required for the development of novel antibody-interacting drugs. These drugs are the Antibody Drug Conjugates (ADCs), which are a new type of targeted therapy, used for example for cancer. They consist of an antibody (or antibody fragment such as a single-chain variable fragment [scFv]) linked to a payload drug (often cytotoxic). Because of the targeting, the side effects should be lower and give a wider therapeutic window. Overall, the underlying principle of ADCs is to discern the delivery of a drug that is cytotoxic to a target that is cancerous, hoping to increase the antitumoural potency of the original drug by reducing adverse effects and side effects, such as toxicity of the cancer target. This is a pioneering field that employs state-of-the-art computational and molecular biology methods in the fight against cancer using ADCs.

Research of Geosynthetics in Seepage Prevention of Rock-Fill Dam

2015 ◽  
Vol 713-715 ◽  
pp. 2819-2822
Author(s):  
Ying Gao
Keyword(s):  
Project Investment ◽  
Control Applications ◽  
Construction Period ◽  
Rock Fill ◽  
Seepage Control ◽  
New Type

With the increasing of its products, Geosynthetics materials is a very promising new type of dam materials, which is the more and more widely used. It not only has seepage control and drainage, filtration, isolation, protection and other functions, especially in the rock-fill dam seepage control applications, but also played a save the effect of project investment, shorten the construction period, which is worth popularizing in rock-fill dam engineering widespread use.

scholarly journals Dynamic replanning: Some comments on the practical application of the analytical forecast

1984 ◽  
Vol 15 (3) ◽  
pp. 169-172
Author(s):  
J. G. Kotzé ◽  
N. P. Du Preez
Keyword(s):  
Control System ◽  
Side Effects ◽  
System Application ◽  
Practical Implementation ◽  
Great Success ◽  
Practical Application ◽  
Control Applications ◽  
Planning And Control ◽  
Proposed Modification ◽  
And Control

The importance of formal processes of planning and control in any organization has been recognized for the last two decades. Planning and replanning require some form of forecasting. Unfortunately, most forecasts utilized in practice consist of a complex mix of managerial expectations, organizational momentum, the predicted impact of managerial actions, as well as proposed managerial actions and good intentions. The evaluation of and control over such a forecast is difficult, if not impossible. This has led to efforts to analyse such a forecast into its major components. The practical implementation of these different forecast elements has yielded great success in planning applications. In control applications some undesirable side-effects have become apparent in recent years. A proposed modification to the control system application should eliminate such effects.

scholarly journals Biocomputational Prediction Approach Targeting FimH by Natural SGLT2 Inhibitors: A Possible Way to Overcome the Uropathogenic Effect of SGLT2 Inhibitor Drugs

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 582
Author(s):  
Mutaib M. Mashraqi ◽  
Navaneet Chaturvedi ◽  
Qamre Alam ◽  
Saleh Alshamrani ◽  
Mosa M. Bahnass ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Side Effects ◽  
Critical Role ◽  
Sglt2 Inhibitor ◽  
Sglt2 Inhibitors ◽  
Dynamics Simulation ◽  
Diabetic Patients ◽  
Bacterial Strains ◽  
Prediction Approach ◽  
Better Than

The Food and Drug Administration (FDA) approved a new class of anti-diabetic medication (a sodium–glucose co-transporter 2 (SGLT2) inhibitor) in 2013. However, SGLT2 inhibitor drugs are under evaluation due to their associative side effects, such as urinary tract and genital infection, urinary discomfort, diabetic ketosis, and kidney problems. Even clinicians have difficulty in recommending it to diabetic patients due to the increased probability of urinary tract infection. In our study, we selected natural SGLT2 inhibitors, namely acerogenin B, formononetin, (−)-kurarinone, (+)-pteryxin, and quinidine, to explore their potential against an emerging uropathogenic bacterial therapeutic target, i.e., FimH. FimH plays a critical role in the colonization of uropathogenic bacteria on the urinary tract surface. Thus, FimH antagonists show promising effects against uropathogenic bacterial strains via their targeting of FimH’s adherence mechanism with less chance of resistance. The molecular docking results showed that, among natural SGLT2 inhibitors, formononetin, (+)-pteryxin, and quinidine have a strong interaction with FimH proteins, with binding energy (∆G) and inhibition constant (ki) values of −5.65 kcal/mol and 71.95 µM, −5.50 kcal/mol and 92.97 µM, and −5.70 kcal/mol and 66.40 µM, respectively. These interactions were better than those of the positive control heptyl α-d-mannopyranoside and far better than those of the SGLT2 inhibitor drug canagliflozin. Furthermore, a 50 ns molecular dynamics simulation was conducted to optimize the interaction, and the resulting complexes were found to be stable. Physicochemical property assessments predicted little toxicity and good drug-likeness properties for these three compounds. Therefore, formononetin, (+)-pteryxin, and quinidine can be proposed as promising SGLT2 inhibitors drugs, with add-on FimH inhibition potential that might reduce the probability of uropathogenic side effects.

The Design of New-Type Digital Readout Device by Inductosyn

2014 ◽  
Vol 909 ◽  
pp. 439-443
Author(s):  
Xin Juan Shang ◽  
Quan Jing Wang
Keyword(s):  
Error Compensation ◽  
System Structure ◽  
Readout System ◽  
Digital Readout ◽  
Communication Interface ◽  
Readout Device ◽  
Lcd Display ◽  
New Type ◽  
Phase Demodulation

The paper introduces the operation principle and system structure of intelligence digital readout system by inductosyn. The system adopts integrated subdivision circuit on the basis of AD2S90 and QA740210 and is controlled by MCU. It adopts phase demodulation mode, with functions of multipoint preset, power-fail protect, absolute origin setting, software error compensation, LCD display and so on, except simple PLC function and standard RS485 communication interface.

Self-Assembled Au4Cu4/Au25 NCs@Liposome tumor nanotheranostics with PT/fluorescence imaging-guided synergetic PTT/PDT †

2021 ◽  
Author(s):  
Xinyu Liu ◽  
Ying Yang ◽  
Xueyan Wang ◽  
Xuan Liu ◽  
Hanlong Cheng ◽  
...  
Keyword(s):  
Side Effects ◽  
Fluorescence Imaging ◽  
Hot Spot ◽  
Diagnosis And Treatment ◽  
New Type ◽  
Self Assembled

Exploring and developing a new type of nanoplatform with diagnosis and treatment to effectively cure tumors and reduce side effects has become a hot spot for researchers and is of...

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