Self-Assembled Au4Cu4/Au25 NCs@Liposome tumor nanotheranostics with PT/fluorescence imaging-guided synergetic PTT/PDT †

We report a new type of metamaterial comprising a highly ordered 3D network of 3–7 nm lead sulfide quantum dots self-assembled in an organic matrix formed by amphiphilic ligands (oleic acid molecules).

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Controllable Synthesis of Variable-sized Magnetic Nanocrystals Self-assembled into Porous Nanostructures for Enhanced Cancer Chemo-ferroptosis Therapy and MR Imaging

Nanoscale Advances ◽

10.1039/d1na00767j ◽

2022 ◽

Author(s):

Jiangxiang Xu ◽

Hanyuan Zhang ◽

Yifei Zhang ◽

Xu Zhang ◽

Teng Wang ◽

...

Keyword(s):

Mr Imaging ◽

Cancer Diagnosis ◽

Diagnosis And Treatment ◽

Controllable Synthesis ◽

Magnetic Nanocrystals ◽

Porous Nanostructures ◽

Self Assembled

Magnetic-based nanomaterials are promising for cancer diagnosis and treatment. Herein, we develop a self-assembled approach for preparation of a porous magnetic nanosystem, DOX/Mn(0.25)-Fe3O4-III NPs, which can simultaneously achieve chemotherapy, ferroptosis...

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Skin care physicians insight on epidemiological patterns, diagnosis and treatment modalities for female pattern hair loss

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20204997 ◽

2020 ◽

Vol 7 (1) ◽

pp. 11

Author(s):

Krishna Rajesh Kilaru ◽

Suhasini Attada ◽

Pooja Munnangi ◽

Manogna Chowdary Kilaru

Keyword(s):

Side Effects ◽

Hair Loss ◽

Treatment Guidelines ◽

Age Of Onset ◽

Platelet Rich Plasma ◽

Diagnosis And Treatment ◽

Treatment Modalities ◽

Common Side Effect ◽

Medication Cost ◽

Female Pattern Hair Loss

Background: Female pattern hair loss (FPHL) is a common cause of hair loss in women characterized by a diffuse reduction in hair density over the crown and frontal scalp with retention of the frontal hairline. The underlying pathophysiology is multifactorial. There are no universally agreed treatment guidelines available. The objective of the study was to understand the diagnosis and treatment pattern of female pattern hair loss and the role of minoxidil topical formulation and its combination in the management of FPHL.Methods: Predesigned questionnaire on FPHL was prepared based on review of literature and was filled by 80 consultant dermatologists. Recorded data was statistically analyzed.Results: Common age of onset of FPHL was between 20 to 30 years. Majority (96.25%) have reported FPHL in association with psychological morbidity. The most preferred treatment in mild and severe FPHL was minoxidil 5% and platelet rich plasma (PRP) plus minoxidil respectively. Most dermatologists (47.5%) treated with minoxidil for over 6 months. Majority (27.5%) reported flaking as the most common side effect with minoxidil followed by dryness, scalp irritation and itching. Majority (27.5%) observed that long treatment duration was contributing to non-compliance followed by medication cost and side effects. Majority of the dermatologists (90%) felt the need for treatment guidelines in the current Indian scenario.Conclusions: Minoxidil was the most common preferred treatment for mild and severe FPHL. PRP is the most common choice of combination therapy with minoxidil. Minimizing side effects, patient education and universal treatment guidelines can help manage FPHL better.

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Nano strategies in diagnosis and treatment of inflammatory Hyperlagesia

Current Nanomaterials ◽

10.2174/2468187311666210118114000 ◽

2021 ◽

Vol 06 ◽

Author(s):

Atul R Chopade ◽

Suraj N. Mali ◽

Pramod A Patil

Keyword(s):

Pain Management ◽

Side Effects ◽

Drug Carrier ◽

Unmet Need ◽

Diagnosis And Treatment ◽

Systematic Analysis ◽

Probable Answer ◽

Anti Inflammatory ◽

Nano Science ◽

Effective Diagnosis

Background: There is an unmet need for effective diagnosis and treatment of chronic inflammatory pain and subsequent hypersensitivity (hyperalgesia). The nanotechnology and nano drug delivery could be a probable answer to solve this problem; this novel technique will surely take diagnosis of pain and anti-inflammatory therapy to newer heights offering faster pain relief to the patient. Objective: This study aims to collect more information about aspects of nanotechnology based applications towards pain management. Methods: A systemic search has been carried out using PubMed, Google Scholar, CNKI, etc. for relevant articles. Results and Conclusions: The article reviews possible application of nano science for betterment of anti-inflammatory therapy, which may help pain researchers. Our systematic analysis of previous studies showed that, with the ease of nanotechnology, we can effectively lower down the side effects and tolerance associated with current pain management systems. Advance nanomaterial based therapies will undoubtedly reduce the time span associated along with fewer side effects. By merging nanotechnology aspects along with drug carrier systems, we can effectively design such systems with inherent properties to treat pain.

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Ticagrelor-Related Severe Dyspnoea: Mechanisms, Characteristic Features, Differential Diagnosis and Treatment

Clinical Medicine Insights Case Reports ◽

10.1177/1179547620956634 ◽

2020 ◽

Vol 13 ◽

pp. 117954762095663 ◽

Cited By ~ 1

Author(s):

Alicja Krakowiak ◽

Jakub Kuleta ◽

Iwona Plech ◽

Maciej Zarębiński ◽

Małgorzata Wojciechowska ◽

...

Keyword(s):

Differential Diagnosis ◽

Side Effects ◽

Stent Implantation ◽

Diagnosis And Treatment ◽

Antiplatelet Drug ◽

Number Of Patients ◽

Characteristic Features ◽

Severe Dyspnoea ◽

The Way

With a growing number of patients on ticagrelor therapy after stent implantation, we observe many cases of side effects of the drug, mostly dyspnoea and bradycardia. In our article we present 2 patients, in which the symptoms were particularly severe. Then we describe possible mechanisms of these complications, explain how to carry out differential diagnosis, discuss when to switch ticagrelor to other antiplatelet drug and finally we present the way to deal with the symptoms.

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Packaging of DNA origami in viral capsids

Nanoscale ◽

10.1039/c8nr10113b ◽

2019 ◽

Vol 11 (21) ◽

pp. 10160-10166 ◽

Cited By ~ 9

Author(s):

Idit Kopatz ◽

Ran Zalk ◽

Yael Levi-Kalisman ◽

Efrat Zlotkin-Rivkin ◽

Gabriel A. Frank ◽

...

Keyword(s):

Dna Origami ◽

Medical Applications ◽

Viral Capsids ◽

New Type ◽

Self Assembled

DNA origami in self-assembled SV40 capsid, a new type of encapsulation substrate for medical applications.

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MIANSERIN: A NEW TYPE OF ANTIDEPRESSANT WITH FEWER SIDE-EFFECTS

InPharma ◽

10.1007/bf03288997 ◽

1976 ◽

Vol 60 (1) ◽

pp. 12-12

Keyword(s):

Side Effects ◽

New Type

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Lepromatous Leprosy: Nasal Manifestations and Treatment with Minocycline

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949210100310 ◽

1992 ◽

Vol 101 (3) ◽

pp. 261-264 ◽

Cited By ~ 9

Author(s):

Anil K. Lalwani ◽

Thomas A. Tami ◽

Robert H. Gelber

Keyword(s):

Side Effects ◽

Clinical Presentation ◽

Lepromatous Leprosy ◽

Diagnosis And Treatment ◽

Traditional Therapy ◽

Tetracycline Antibiotic ◽

Nasal Symptoms ◽

Minocycline Hydrochloride ◽

New Treatment

Nasal involvement in lepromatous leprosy is universal and occurs early in the course of the disease. Nasal symptoms include obstruction, crusting, bleeding, and hyposmia. Traditional therapy with dapsone, rifampin, and clofazimine is limited by its cost and toxicity. Minocycline hydrochloride, a tetracycline antibiotic with limited side effects, is promising as a new treatment for leprosy. A case is presented that highlights the clinical presentation, diagnosis, and treatment of lepromatous leprosy.

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Side-Effects of Monoclonal Antibody Infusions for the Diagnosis and Treatment of Cancer

The International Journal of Biological Markers ◽

10.1177/172460088800300301 ◽

1988 ◽

Vol 3 (3) ◽

pp. 147-153 ◽

Cited By ~ 2

Author(s):

E.F.H. van der Linden ◽

M.J.P.G. van Kroonenburgh ◽

E.K.J. Pauwels

Keyword(s):

Monoclonal Antibody ◽

Monoclonal Antibodies ◽

Side Effects ◽

Diagnosis And Treatment ◽

Target Cells ◽

Clinical Use ◽

Skin Reactions ◽

Discontinuation Of Treatment ◽

Diagnostic Applications ◽

Toxic Reactions

This literature review presents an inventory of the nature and incidence of side-effects that arise from the clinical application of monoclonal antibodies (MoAb) for the diagnosis and treatment of cancer. Most side-effects occurred during therapy. Toxic reactions, such as fever, sweating and chills, were more common than immunological skin reactions; they were observed predominantly in association with the elimination of circulating target cells. Dosage and rate of administration of the MoAb appeared to have little influence on the reactions, which disappeared quickly and did not necessitate discontinuation of treatment. Serum sickness, anaphylactic reactions and bronchospasms were not common; the patients reacted quickly to the indicated therapy. Prevention of the side-effects described here, especially during diagnostic applications, was such that they need not form a barrier to the clinical use of MoAb.

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