A novel tricationic fullerene C60 as broad-spectrum antimicrobial photosensitizer: mechanisms of action and potentiation with potassium iodide

2021 ◽  
Vol 20 (3) ◽  
pp. 327-341
Author(s):  
Maximiliano L. Agazzi ◽  
Javier E. Durantini ◽  
Ezequiel D. Quiroga ◽  
M. Gabriela Alvarez ◽  
Edgardo N. Durantini
Keyword(s):  
Potassium Iodide ◽  
Broad Spectrum ◽  
Mechanisms Of Action ◽  
Fullerene C60

scholarly journals Broad-Spectrum Antiviral Strategies and Nucleoside Analogues

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 667
Author(s):  
Robert J. Geraghty ◽  
Matthew T. Aliota ◽  
Laurent F. Bonnac
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Broad Spectrum ◽  
Vaccine Development ◽  
Fast Response ◽  
Mechanisms Of Action ◽  
Public Health Emergency ◽  
Nucleoside Analogues ◽  
The Family ◽  
Antiviral Nucleoside

The emergence or re-emergence of viruses with epidemic and/or pandemic potential, such as Ebola, Zika, Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory Syndrome Coronavirus 1 and 2 (SARS and SARS-CoV-2) viruses, or new strains of influenza represents significant human health threats due to the absence of available treatments. Vaccines represent a key answer to control these viruses. However, in the case of a public health emergency, vaccine development, safety, and partial efficacy concerns may hinder their prompt deployment. Thus, developing broad-spectrum antiviral molecules for a fast response is essential to face an outbreak crisis as well as for bioweapon countermeasures. So far, broad-spectrum antivirals include two main categories: the family of drugs targeting the host-cell machinery essential for virus infection and replication, and the family of drugs directly targeting viruses. Among the molecules directly targeting viruses, nucleoside analogues form an essential class of broad-spectrum antiviral drugs. In this review, we will discuss the interest for broad-spectrum antiviral strategies and their limitations, with an emphasis on virus-targeted, broad-spectrum, antiviral nucleoside analogues and their mechanisms of action.

New Plant Growth Stimulants Based on Water-Soluble Nanoparticles of N-Substituted Monoamino-Acid Derivatives of Fullerene C60 and the Study of their Mechanisms of Action

BIOPHYSICS ◽  
2020 ◽  
Vol 65 (4) ◽  
pp. 635-641
Author(s):  
V. A. Volkov ◽  
O. V. Yamskova ◽  
M. V. Voronkov ◽  
D. V. Kurilov ◽  
V. S. Romanova ◽  
...  
Keyword(s):  
Plant Growth ◽  
Mechanisms Of Action ◽  
Fullerene C60 ◽  
Water Soluble ◽  
Plant Growth Stimulants ◽  
Derivatives Of

scholarly journals Potassium Iodide Potentiates Broad-Spectrum Antimicrobial Photodynamic Inactivation Using Photofrin

2017 ◽  
Vol 3 (4) ◽  
pp. 320-328 ◽  
Author(s):  
Liyi Huang ◽  
Grzegorz Szewczyk ◽  
Tadeusz Sarna ◽  
Michael R. Hamblin
Keyword(s):  
Potassium Iodide ◽  
Broad Spectrum ◽  
Photodynamic Inactivation

scholarly journals Prospective pharmacological effects of psoralen photoxidation products and their cycloadducts with aminothiols: chemoinformatic analysis

2020 ◽  
Author(s):  
VV Skarga ◽  
AD Zadorozhny ◽  
BV Shilov ◽  
EV Nevezhin ◽  
VV Negrebetsky ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Mechanisms Of Action ◽  
Therapeutic Use ◽  
Therapeutic Effects ◽  
Pharmacological Effects ◽  
Puva Therapy ◽  
New Directions

Psoralens are medicinal photosensitizing furocoumarins which are used in photochemotherapy and photoimmunotherapy of dermatoses. Psoralen photooxidation products may be involved in therapeutic effects, but the possible mechanisms of their action remain unclear. The study was aimed to assess the prospective pharmacological effects and mechanisms of activity for six previously identified ortho–hydroxyformyl-containing psoralen photooxidation products and their cycloadducts with aminothiols, as well as for structurally similar compounds (furocoumaric acid and tucaresol). Chemoinformatic analysis of the prospective pharmacological effects and mechanisms of action of these compounds was performed using the PASS and PharmaExpert software. The predicted pharmacological effects partially confirmed by previous studies highlight the possible involvement of psoralen photooxidation products in the effects of PUVA therapy or photopheresis during the course of dermatoses and proliferative disorders treatment. A broad spectrum of pharmacological effects found for furocoumaric acid and cycloadducts of coumarinic and benzofuranic photoproducts of psoralen with cysteine and homocysteine appoints new directions of research relating to therapeutic use of psoralens.

scholarly journals Enhancement of Biocontrol Efficacy of Pichia kudriavzevii Induced by Ca Ascorbate against Botrytis cinerea in Cherry Tomato Fruit and the Possible Mechanisms of Action

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Keyu Sun ◽  
Ziwuzhen Wang ◽  
Xuanqing Zhang ◽  
Ze Wei ◽  
Xue Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Broad Spectrum ◽  
Tomato Fruit ◽  
Mechanisms Of Action ◽  
Cherry Tomato ◽  
Pichia Kudriavzevii ◽  
Biocontrol Efficacy ◽  
Broad Spectrum Resistance ◽  
Fruit Decay ◽  
Antagonistic Yeast

Antagonistic yeast is a promising way to control postharvest fruit decay because of its safety and broad-spectrum resistance. However, the biocontrol efficacy of yeast is limited by environmental stress, such as oxidative stress.

scholarly journals Potential role of hypovitaminosis D and vitamin D supplementation during COVID-19 pandemic

QJM ◽  
2020 ◽  
Author(s):  
M Verdoia ◽  
G De Luca
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Broad Spectrum ◽  
Potential Role ◽  
Hypovitaminosis D ◽  
Mechanisms Of Action ◽  
Vitamin D Supplementation ◽  
Current Status ◽  
Special Focus

Summary Vitamin D deficiency is a pandemic disorder affecting over 1 billion of subjects worldwide and displaying a broad spectrum of implications on cardiovascular and inflammatory disorders. Since the initial reports of the association between hypovitaminosis D and COVID-19, Vitamin D has been pointed as a potentially interesting treatment for SARS-CoV-2 infection. We provide an overview on the current status of vitamin D deficiency, the mechanisms of action of vitamin D and the current literature on the topic, with a special focus on the potential implications for COVID-19 pandemic.

scholarly journals Plant Defensins from a Structural Perspective

2020 ◽  
Vol 21 (15) ◽  
pp. 5307 ◽  
Author(s):  
Valentina Kovaleva ◽  
Irina Bukhteeva ◽  
Oleg Y. Kit ◽  
Irina V. Nesmelova
Keyword(s):  
Anticancer Activity ◽  
Broad Spectrum ◽  
Mammalian Cells ◽  
Mechanisms Of Action ◽  
Structure Dynamics ◽  
Plant Defensins ◽  
Structural Perspective

Plant defensins form a family of proteins with a broad spectrum of protective activities against fungi, bacteria, and insects. Furthermore, some plant defensins have revealed anticancer activity. In general, plant defensins are non-toxic to plant and mammalian cells, and interest in using them for biotechnological and medicinal purposes is growing. Recent studies provided significant insights into the mechanisms of action of plant defensins. In this review, we focus on structural and dynamics aspects and discuss structure-dynamics-function relations of plant defensins.

scholarly journals Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics

2014 ◽  
Vol 31 (7) ◽  
pp. 905-923 ◽  
Author(s):  
Bo Li ◽  
Walter J. Wever ◽  
Christopher T. Walsh ◽  
Albert A. Bowers
Keyword(s):  
Natural Products ◽  
Broad Spectrum ◽  
Mechanisms Of Action ◽  
Anticancer Activities

Dithiolopyrrolone natural products have unique structures and exhibit a broad-spectrum of antimicrobial and anticancer activities. Isolated in the late 1940s, these molecules have attracted an increasing interest towards their biosynthesis, synthesis and mechanisms of action.

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