Clinical experience with hemolytic disease of newborn infants

1958 ◽  
Vol 75 (5) ◽  
pp. 1160
Author(s):  
Robert C. Knapp
Keyword(s):  
Clinical Experience ◽  
Newborn Infants ◽  
Hemolytic Disease

CONCENTRATION OF BILIRUBIN IN CEREBROSPINAL FLUID IN HEMOLYTIC DISEASE OF THE NEWBORN

PEDIATRICS ◽  
1955 ◽  
Vol 16 (2) ◽  
pp. 184-195
Author(s):  
Robert Stempfel ◽  
Rolf Zetterström
Keyword(s):  
Total Protein ◽  
Neonatal Period ◽  
Single Case ◽  
Newborn Infants ◽  
Spinal Fluid ◽  
Hemolytic Disease ◽  
Indirect Bilirubin ◽  
Individual Variations ◽  
Brain Barrier Permeability ◽  
Absorption Studies

1. Twenty-four full-term, newborn infants, of whom 23 were Rh-isoimmunized, were followed with serial determinations of the serum and spinal fluid bilirubin and spinal fluid total protein during the neonatal period. Of the 51 spinal fluid samples examined, measurable quantities of bilirubin were present in all cases. 2. In the presence of marked indirect hyperbilirubinemia, the spinal fluid bilirubin was predominantly indirect-reacting, though no linear relationship exists between the serum and spinal fluid bilirubin. It is suggested that this is a manifestation of individual variations in blood-brain barrier permeability within the neonatal period. A significant correlation between the spinal fluid indirect bilirubin and the spinal fluid total protein is further evidence to support this view. 3. Spectrophotometric absorption studies of 13 serum and spinal fluid samples from 8 infants with hemolytic disease of the newborn are discussed. These studies tend to confirm the observation that there is no direct correlation between the hyperbilirubinemia and the spinal fluid bilirubin concentration, though the configuration of the absorption pattern of the serum closely follows that obtained from the corresponding spinal fluid. 4. The findings in the Rh-isoimmunized group of infants were not unlike those observed in a single case of "physiologic jaundice" presented. 5. The question of indirect bilirubin neurotoxicity is briefly reviewed.

scholarly journals Phosphate Partition in the Erythrocytes of Normal Newborn Infants and Infants with Erythroblastosis Fetalis. IV. Ion Exchange Chromatography

Blood ◽  
1963 ◽  
Vol 22 (5) ◽  
pp. 589-599 ◽  
Author(s):  
T. J. GREENWALT ◽  
S. A. MORELL ◽  
V. E. AYERS
Keyword(s):  
Ion Exchange ◽  
Pernicious Anemia ◽  
Perchloric Acid ◽  
Blood Cells ◽  
Newborn Infants ◽  
Severe Form ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Hemolytic Disease ◽  
High Level

Abstract Ion exchange chromatography was used to study perchloric acid extracts of the erythrocytes from the cord blood of normal infants and infants with erythroblastosis fetalis due to anti-D and, for comparison, the red blood cells of adults. Adenosine triphosphate, 2,3-diphosphoglycerate and the total phosphates were found to be highest in the infants with the most severe form of erythroblastosis fetalis. Evidence is given to show that these findings are not related to the relative immaturity of the erythrocytes in hemolytic discase of the newborn. No changes could be demonstrated in the partition of the intraerythrocytic phosphates in a patient with pernicious anemia before B12 therapy and at the height of the reticulocyte response. It is suggested that the high level of 2,3-diphosphoglycerate found in the erythrocytes in hemolytic disease due to anti-D may be due to alterations in the Embden-Meyerhof glycolytic pathway. The nature of the upheaval is not clear at present.

20 Years of Follow-up Alloimmunization and Hemolytic Disease in Newborn: Has Anything Changed in the Field Over the Years?

2020 ◽  
Vol 232 (06) ◽  
pp. 314-320
Author(s):  
Marjana Jerkovic Raguz ◽  
Zeljka Prce ◽  
Vedran Bjelanovic ◽  
Ivana Bjelanovic ◽  
Sanja Dzida ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Preventive Measures ◽  
Newborn Infants ◽  
Significant Progress ◽  
Hemolytic Disease ◽  
The West ◽  
The Past ◽  
Precautionary Measures ◽  
In Pregnancy

Abstract Objective of the study is to research the epidemiological aspects of maternal alloimmunization against erythrocyte antigens of fetuses (AB0, Rhesus, Lewis, Kell, Duffy and others) and to identify the most common types of hemolytic disease of the newborn (HDN) in the West Herzegovina region. Study Design The 20-year retrospective epidemiological study includes all pregnant women who had been immunologically tested and newborn treated for HDN. Results The indirect antiglobulin (IAT) detected antibodies against antigens in 545 (1.8%) pregnant women of the 29 663 who were tested at the Department of Transfusion Medicine. During the 20-year-long study 310 (1.0%) newborn with HDN were treated. Our results indicate that 42% (230/545) of the pregnant women had AB0 immunization. The most common form of HDN is AB0 HDN 64% (199/310), whereas RhD HDN was treated in 19% (59/310) of the newborn infants. ETR was performed on 29 (19%) infants, 21 (72.4%) with AB0 HDN, and 7 (26%) with RhD HDN. Conclusion This 20-year-long study concludes that, even though there has been significant progress in the prevention of immunization and proactive treatment of HDN, precautionary measures are still required as is the need for gynecologists and obstetricians to be active. The reasons for this are the non-existence of preventive measures for non-RhD immunization, the irregular immunological screening of RhD positive women in pregnancy in the region encompassed by the study in the past few years. The above raises new questions and recommends further research and monitoring of immunization and HDN treatment worldwide.

Prevention of Rh Hemolytic Disease — Ten Years' Clinical Experience with Rh Immune Globulin

1975 ◽  
Vol 292 (19) ◽  
pp. 1014-1016 ◽  
Author(s):  
Vincent J. Freda ◽  
John G. Gorman ◽  
William Pollack ◽  
Edward Bowe
Keyword(s):  
Immune Globulin ◽  
Clinical Experience ◽  
Hemolytic Disease

GLUTAMIC-OXALACETIC TRANSAMINASE OF SERUM IN INFANCY AND CHILDHOOD

PEDIATRICS ◽  
1959 ◽  
Vol 24 (3) ◽  
pp. 362-366
Author(s):  
Robert E. Stanton ◽  
Howard A. Joos
Keyword(s):  
Renal Disease ◽  
Rheumatic Fever ◽  
Normal Values ◽  
Newborn Infants ◽  
Major Surgery ◽  
Hemolytic Disease ◽  
Normal Children ◽  
Glutamic Oxalacetic Transaminase ◽  
Hepatic Diseases ◽  
Infancy And Childhood

Activity of glutamic-oxalacetic transaminase in serum (S-GOT) has been evaluated in normal infants and children and in a wide variety of diseases, including convalescent rheumatic fever, renal disease, hemolytic disease, infections and various hepatic disorders. In 46 normal children, the observed range was 7-41 units. The range of normal values in newborn infants was somewhat wider, 29-79 units. Convalescent rheumatic fever and infections not involving the liver were associated with normal S-GOT. S-GOT was normal with the hemolytic diseases in the absence of fulminant hemolysis. It was frequently exceptionally low in association with renal disease, and slightly elevated for a few days after major surgery. S-GOT is elevated in diseases of the liver, but the results are too variable for specific differentiation of hepatic diseases in early life. The test is best employed in conjunction with careful clinical evaluation and with other measures of liver function.

Necrotizing enterocolitis following intensive phototherapy in full-term newborns – is there a possible association?

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Arieh Riskin ◽  
Amir Kugelman ◽  
David Bader
Keyword(s):  
Necrotizing Enterocolitis ◽  
Newborn Infants ◽  
Full Term ◽  
Clinical Implications ◽  
Hemolytic Disease ◽  
Term Infants ◽  
Term Newborn ◽  
Vascular Bed ◽  
Term Newborns ◽  
Clinical Awareness

AbstractNecrotizing enterocolitis is rare in full-term infants, and is currently not considered a known complication of phototherapy.Three cases of necrotizing enterocolitis in full-term babies possibly associated to intensive phototherapy for treatment of early neonatal hyperbilirubinemia due to isoimmune hemolytic disease of the newborn.Although rare, the association between occurrences of necrotizing enterocolitis in full-term newborn infants and intensive phototherapy merits caution and clinical awareness to such possible complication. Presumptive explanation is that intensive phototherapy causes marked vasodilataion in the skin that may result in decreased perfusion of the intestine leading to ischemia and necrotizing enterocolitis. This calls for further studies to investigate the effects of phototherapy on the vascular bed in the gut and other vital organs that could have clinical implications.

scholarly journals ERYTHROPHAGOCYTOSIS IN HEMOLYTIC DISEASE OF THE NEWBORN

Blood ◽  
1950 ◽  
Vol 5 (7) ◽  
pp. 678-683 ◽  
Author(s):  
MARY B. COOPER
Keyword(s):  
Newborn Infants ◽  
Hemolytic Disease ◽  
Control Series ◽  
Blood Smears

Abstract Blood smears of 27 cases of hemolytic disease of the newborn were studied intensively for erythrophagocytes. In 25 cases, the smears were positive for this phenomenon. In a control series of 30 normal newborn infants, these cells were not found. Prolonged search and optimum magnification of the smears were important factors in determining the presence or absence of erythrophagocytes in the cases under study.

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