The dose-dependent effect of warfarin on vitamin K1 metabolism and clotting factor synthesis in the rabbit

1980 ◽  
Vol 29 (11) ◽  
pp. 1601-1602 ◽  
Author(s):  
B.K. Park ◽  
J.B. Leck ◽  
A.M. Breckenridge
Keyword(s):  
Clotting Factor ◽  
Vitamin K1 ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

scholarly journals Silver‐doped sol‐gel borate glasses: Dose‐dependent effect on Pseudomonas aeruginosa biofilms and keratinocyte function

2021 ◽  
Author(s):  
Shiva Naseri ◽  
Gabriele Griffanti ◽  
William C. Lepry ◽  
Vimal B. Maisuria ◽  
Nathalie Tufenkji ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Sol Gel ◽  
Borate Glasses ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

Dose-Dependent Effect of Statins on the Incidence of Acute Kidney Injury After Cardiac Surgery

2011 ◽  
Vol 91 (2) ◽  
pp. 520-525 ◽  
Author(s):  
Salima Mithani ◽  
Michael Kuskowski ◽  
Yelena Slinin ◽  
Areef Ishani ◽  
Edward McFalls ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Kidney Injury ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

Ligand-Regulated Expression of TNF Receptors 1 and 2 Determines Receptor-Mediated Functional Responses

2021 ◽  
pp. 1-12
Author(s):  
Alina Alshevskaya ◽  
Olga Koneva ◽  
Irina Belomestnova ◽  
Julia Lopatnikova ◽  
Irina Evsegneeva ◽  
...  
Keyword(s):  
Biological Effects ◽  
High Expression ◽  
Functional Responses ◽  
Double Positive ◽  
Dependent Effect ◽  
Similar Expression Profile ◽  
Proliferation Response ◽  
Dose Dependent ◽  
Dose Dependent Effect ◽  
Mcf 7

<b><i>Introduction:</i></b> Modulating specific biological effects through the changes in cytokine receptors’ expression level remains poorly understood. This study aimed to investigate the influence of the dose-dependent effect of TNF on the balance between proapoptotic and proliferation response depending on the parameters of TNFR1/2 expression density. <b><i>Methods:</i></b> Tumor cell lines (HEp-2, K-562, MCF-7, ZR-75/1, MOLT-4, IM-9, and Raji) were characterized for TNFR1/2 co-expression using flow cytometry and were studied to reveal the dose-dependent effect of rhTNF on cell cycle and apoptosis parameters. The associations among the studied parameters were estimated by correlation and regression analysis. <b><i>Results:</i></b> It was found for ZR-75/1 cells (the cell line characterized by high expression of both types) that a dose-dependent increase in expression of both types of TNF-α receptors on cells reduces the proliferative activity of cells. For MOLT-4 cells (which are characterized by lower expression), an increase in proliferative response of cells was positively associated with the percentage of both TNFR1<sup>+</sup> and TNFR2<sup>+</sup> cells. However, opposite effects on the cells were shown for the K-562 and MCF-7 lines having a similar expression profile. A similarity (a large percentage of double-positive cells) was revealed for the lines having similar effects (K-562 and ZR-75/1). <b><i>Conclusions:</i></b> High expression of TNF receptor type 1 is not always associated with predominant activation of proapoptotic pathways. However, in the case of simultaneous high expression of both types of receptors, the proportion of double-positive cells is crucial for the activation of either the proapoptotic or proliferation pathways.

scholarly journals Dose-dependent effect of low-intensity pulsed ultrasound on callus formation during rapid distraction osteogenesis

2006 ◽  
Vol 24 (11) ◽  
pp. 2072-2079 ◽  
Author(s):  
Chun Wai Chan ◽  
Ling Qin ◽  
Kwong Man Lee ◽  
Wing Hoi Cheung ◽  
Jack Chun Yiu Cheng ◽  
...  
Keyword(s):  
Distraction Osteogenesis ◽  
Callus Formation ◽  
Pulsed Ultrasound ◽  
Dependent Effect ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Dose Dependent ◽  
Dose Dependent Effect

Dose-Dependent Effect of Octreotide on Insulin Secretion after OGTT in Obesity

1997 ◽  
Vol 49 (1) ◽  
pp. 17-21 ◽  
Author(s):  
A. Bertoli ◽  
R. Magnaterra ◽  
P. Borboni ◽  
M.A. Marini ◽  
A. Barini ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

scholarly journals Evaluation of cyclooxygenase-2 inhibition in an orthotopic murine model of lung cancer for dose-dependent effect

2005 ◽  
Vol 129 (6) ◽  
pp. 1242-1249 ◽  
Author(s):  
Eric M. Sievers ◽  
Robert D. Bart ◽  
Leah M. Backhus ◽  
Yuanguang Lin ◽  
Margaret Starnes ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Murine Model ◽  
Cyclooxygenase 2 ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

scholarly journals Effect of the anticancer drug methotrexate on the ascites form of a teratocarcinoma and survival of mice

2018 ◽  
Vol 16 (3) ◽  
pp. 32-35
Author(s):  
Pavel A. Dyban
Keyword(s):  
Stem Cells ◽  
Body Weight ◽  
Morphological Analysis ◽  
Abdominal Cavity ◽  
Dependent Effect ◽  
Experimental Animals ◽  
Body Weights ◽  
Ascites Form ◽  
Dose Dependent ◽  
Dose Dependent Effect

The dose-dependent effect of a methotrexate is established as on an ascite form of a teratocarcinoma CBA9H6, and mice-recipients, however various doses of the entered methotrexate (6; 4 and 2 mkg/g body weights of an animal), at repeated introduction at an interval of 48 and 24 hours, don't destroy all population of embrioid bodies. So, at 3-fold and even 10-fold daily injections in a dose of 2 mkg/g of body weight in an abdominal cavity of mice 1,6 ± 0,2% and 0,038 ± 0,01% embrioid bodies (ascite form of a teratocarcinoma ) remain, respectively, at survival of mice 93,0 ± 8,5% and 14,0 ± 3,0%. The morphological analysis of a mode of a differentiation of embrioid bodies retransplantated from experimental animals to intact has shown earlier that the methotrexate hasn't had effect on histoblastic potentialities of stem cells of a teratocarcinoma CBA9H6.

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