Karyotypic variability and evolutionary characteristics of a polymorphous low grade adenocarcinoma in the parotid gland

1991 ◽  
Vol 55 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Joachim Mark ◽  
Barbro Wedell ◽  
Rigmor Dahlenfors ◽  
Göran Stenman
Keyword(s):  
Parotid Gland ◽  
Low Grade ◽  
Karyotypic Variability

Terminal duct adenocarcinomas of the parotid gland

1995 ◽  
Vol 109 (5) ◽  
pp. 466-468 ◽  
Author(s):  
Bonnie L. Kemp ◽  
John G. Batsakis ◽  
Adel K. El-Naggar ◽  
Sophia N. Kotliar ◽  
Mario A. Luna
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Minor Salivary Gland ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Biological Behaviour ◽  
Parotid Neoplasms ◽  
Clinicopathological Study

AbstractThe major salivary glands are considered to rarely be the sites of primary terminal duct adenocarcinomas, a neoplasm with a considerable predilection for origin from intraoral minor salivary glands. We present a clinicopathological study of 22 terminal duct adenocarcinomas of the parotid gland, the largest single series to date. A comparison between the parotid neoplasms and over 200 minor salivary gland terminal duct adenocarcinomas indicates there is little difference in biological behaviour and confirms the low-grade quality of the carcinomas, regardless of site of origin.

scholarly journals Dedifferentiated Acinic Cell Carcinoma of the Parotid Gland With Myoepithelial Features

2002 ◽  
Vol 126 (9) ◽  
pp. 1104-1105 ◽  
Author(s):  
Simonetta Piana ◽  
Alberto Cavazza ◽  
Corrado Pedroni ◽  
Rosa Scotti ◽  
Luigi Serra ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Clinical Course ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Epithelial Proliferation ◽  
Acinic Cell

Abstract Dedifferentiated acinic cell carcinoma of the salivary gland is an uncommon variant of acinic cell carcinoma, characterized by the coexistence of both an usual low-grade acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course. We describe a case of acinic cell carcinoma of the parotid gland in a 67-year-old woman, which recurred 4 times after surgery and radiotherapy. The recurrences consisted of residual foci of acinic cell carcinoma intermingled with a high-grade epithelial proliferation; the latter was focally constituted by cells with morphologic and immunohistochemical features of myoepithelium.

Simultaneous Phenotypically Distinct but Clonally Identical Mucosa-Associated Lymphoid Tissue and Follicular Lymphoma in a Patient With Sjögren’s Syndrome

Blood ◽  
1999 ◽  
Vol 94 (7) ◽  
pp. 2247-2251 ◽  
Author(s):  
Antonella Aiello ◽  
Ming-Qing Du ◽  
Tim C. Diss ◽  
Huai-Zheng Peng ◽  
Francesco Pezzella ◽  
...  
Keyword(s):  
Lymph Node ◽  
Parotid Gland ◽  
Follicular Lymphoma ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Molecular Genetic ◽  
Pcr Amplification ◽  
Pcr Analysis ◽  
Chain Gene ◽  
Low Grade

A 44-year-old woman with a 12-year history of Sjögren’s syndrome (SS) developed a low-grade mucosa-associated lymphoid tissue (MALT) lymphoma in the parotid gland. Two years later, she presented with generalized lymphadenopathy and hepatosplenomegaly and a follicular lymphoma was diagnosed. To investigate the relationship of the two histologically distinct lymphomas, we re-examined their histology and immunophenotype and studied the lymphomatous tissue from the parotid, cervical lymph node, and spleen using molecular genetic methods. Histologic and immunophenotypic studies confirmed the previous diagnoses and also identified a previously unnoticed focus of follicular lymphoma in the second parotid gland biopsy. Polymerase chain reaction (PCR) amplification of the rearranged Ig heavy-chain gene showed the same sized dominant product in the MALT lymphoma and the follicular lymphoma. Similarly, PCR analysis of the t(14:18) translocation yielded an identical sized band from both MALT and follicular lymphoma. Cloning and sequencing of the Ig PCR products showed an identical CDR3 sequence from each lesion, indicating a common clonal lineage. The follicular lymphoma of the parotid gland lymph node and the follicular lymphoma of the spleen showed an identical mutation signature to that of the salivary gland MALT lymphoma. We propose that follicular lymphoma in the parotid gland lymph node may have resulted from colonization of lymphoid follicles by MALT lymphoma cells, following which the tumor cells were induced to express a follicular lymphoma phenotype, due to Bcl-2 overexpression caused by t(14;18), leading to a change in clinical behavior resulting in rapid widespread dissemination of disease. These observations suggest that the distinct phenotypes of low-grade B-cell lymphomas may be the consequence of interplay between genetic and local microenvironmental factors.

scholarly journals Postoperative Radiation Therapy for Parotid Mucoepidermoid Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Meghan P. Olsen ◽  
Allen O. Mitchell ◽  
Edward F. Miles
Keyword(s):  
Radiation Therapy ◽  
Parotid Gland ◽  
Mucoepidermoid Carcinoma ◽  
Controlled Trials ◽  
Adjuvant Radiation ◽  
Low Grade ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy ◽  
Randomized Controlled

Salivary gland cancers are rare and represent approximately 5% of all head and neck cancers and only 0.3% of all malignancies. The majority (75%) of salivary gland tumors occur in the parotid gland, and while benign lesions are more common, mucoepidermoid carcinoma (MEC) makes up 40–50% of malignant parotid gland tumors. No randomized controlled trials exist regarding the role of adjuvant radiation for patients who undergo surgical resection of low-grade MECs. Herein, we report two cases of successful postoperative radiation therapy in low-grade, pT2N0 MEC of the parotid gland. The role of adjuvant radiation therapy for patients with MEC of the parotid gland is based on data from institution reviews and lacks data from randomized controlled trials. Per our review of the literature, the pathological findings of positive surgical margins and/or perineural invasion in two patients with low-grade MEC of the parotid gland warranted adjuvant radiation for improved local control after partial parotidectomy. Both patients tolerated postoperative radiation therapy with only mild side effects and, at last follow-up, five years after completion of therapy, had no clinical or radiographic evidence of either local recurrence or distant metastasis.

Elective neck dissection versus observation in primary parotid carcinoma

2005 ◽  
Vol 132 (3) ◽  
pp. 387-391 ◽  
Author(s):  
P. Zbären ◽  
J. Schüpbach ◽  
M. Nuyens ◽  
E. Stauffer
Keyword(s):  
Parotid Gland ◽  
Neck Dissection ◽  
Frozen Section ◽  
Disease Free Survival ◽  
Neck Surgery ◽  
Primary Carcinoma ◽  
Elective Neck Dissection ◽  
Low Grade ◽  
Tumor Type ◽  
Observation Group

OBJECTIVE: To evaluate the efficacy of elective neck dissection in the clinically negative neck of patients with primary carcinoma of the parotid gland. STUDY DESIGN AND SETTING: A retrospective analysis was undertaken at a university Department of Otorhinolaryngology-Head and Neck Surgery on 83 previously untreated patients with primary carcinoma of the parotid gland and a clinically negative neck. The reliability of fine needle aspiration cytology, frozen section, and the clinico-pathologic findings of patients with occult neck metastases were analyzed. The regional recurrence rate and the outcome were compared among 2 groups; one with elective neck dissection (N = 41) and one without elective neck dissection (N = 42). RESULTS: The diagnosis of malignancy was known preoperatively in 59 (71%) cases, the exact histologic tumor type in 36 (43%) and the grade in 37 (44%) of 83 cases. Occult metastases were detected in 8 (20%) of 41 cNO patients, in 5 cases associated with a high-grade and in 3 cases with a low-grade carcinoma. Recurrence of disease developed in 5 (12%) patients in the elective neck dissection group and in 11 (26%) patients in the observation group. All of the 7 neck recurrences occurred in the observation group. The 5-year actuarial and disease-free survival rate was 80% and 86% for patients with elective neck dissection and 83% and 69% for patients without neck dissection. CONCLUSION AND SIGNIFICANCE: A routine elective neck dissection is suggested in all patients with primary carcinoma of the parotid gland. The efficacy of elective neck dissection, nevertheless, has never been evaluated prospectively.

Pathology Consultation Low-Grade and High-Grade Adenocarcinomas of the Salivary Duct System

1989 ◽  
Vol 98 (2) ◽  
pp. 162-163 ◽  
Author(s):  
John G. Batsakis ◽  
Mario A. Luna
Keyword(s):  
Oral Cavity ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Low Grade ◽  
High Grade ◽  
Duct System ◽  
Salivary Duct ◽  
Adenoid Cystic ◽  
Major Salivary Glands

Adenocarcinomas of salivary glands are encountered less frequently than adenoid cystic or mucoepidermoid carcinomas. They fall into two well-defined clinicopathologic groups: 1) those arising from intercalated ducts and 2) those from the excretory and interlobular ducts. The former, designated terminal duct adenocarcinomas, are low-grade malignancies found preponderantly in the oral cavity, especially the palate. The latter, designated salivary duct carcinomas, are high-grade neoplasms and arise almost exclusively in major salivary glands, especially the parotid gland.

Massive crystal-storing histiocytosis associated with low-grade malignant B-cell lymphoma of MALT-Type of the parotid gland

1997 ◽  
Vol 17 (2) ◽  
pp. 148-152 ◽  
Author(s):  
Montserrat Llobet ◽  
Pilar Castro ◽  
Cristina Barceló ◽  
Jose Maria Trull ◽  
Elias Campo ◽  
...  
Keyword(s):  
Parotid Gland ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Low Grade

Polymorphous low-grade adenocarcinoma of the parotid gland

1998 ◽  
Vol 19 (5) ◽  
pp. 322-324 ◽  
Author(s):  
Andrew P. Barak ◽  
Mary Ann Grobbel ◽  
David R. Rabaja
Keyword(s):  
Parotid Gland ◽  
Low Grade

scholarly journals Polymorphous low grade adenocarcinoma of the parotid gland: A case report with cytohistological correlation and its immunohistochemical study

2012 ◽  
Vol 2 (4) ◽  
pp. 331-334
Author(s):  
S Shrestha ◽  
CB Pun ◽  
R Basyal ◽  
T Pathak ◽  
S Bastola ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Malignant Tumor ◽  
Immunohistochemical Study ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Major Salivary Glands

Polymorphous low-grade adenocarcinoma is a rare salivary gland malignant tumor of low aggressiveness, commonly occurring in minor salivary glands. Its origin in major salivary glands is considered exceedingly rare. We report a case of polymorphous low grade adenocarcinoma arising from left parotid in a 21-yearold female patient.Journal of Pathology of Nepal (2012) Vol. 2, 331-334DOI: http://dx.doi.org/10.3126/jpn.v2i4.6890

scholarly journals Histological surprise, mammary analogue secretory carcinoma of parotid gland

2021 ◽  
Vol 8 (12) ◽  
pp. 3731
Author(s):  
Iram T. Pasha ◽  
Akhila K. ◽  
Ravikumar V. ◽  
Sandeep Kumar
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Parotid Gland ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Carcinoma Of The Breast ◽  
Mammary Analogue Secretory Carcinoma ◽  
Male Preponderance ◽  
Slow Growing

A recent described entity, mammary analogue secretary carcinoma (MASC) in 2010 by Skalova et al whose morphological and immunohistochemical features are similar in secretory carcinoma of the breast and salivary gland. This is a low-grade carcinoma which presents as a firm, slow-growing, circumscribed lesion with male preponderance. We present a case report of MASC.

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