The relationship between the clinical course, pathologic findings and HLA antigens in graves' disease

Abstract. Among 78 consecutive patients with Graves' disease, an increased frequency of HLA-B8 and HLA-DR3 antigens was found. The relative risk for Graves' disease among individuals with these HLA antigens was calculated as 4.4 and 3.9, respectively. Thus, genes promoting the development of Graves' disease are clearly associated to the B8 and DR3 haplotypes. In groups of patients with different clinical expressions of the disease, such as thyroid hormone levels, autoantibodies and relapse rates, the frequency of B8 and DR3 antigens was found to be similar. Consequently, factors influencing the clinical expression and the course of the disease do not have a stronger association to these antigens.

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The relationship between free T4 and thyrotropin receptor antibodies is log-linear and negatively influenced by age and smoking in patients with Graves' disease

Endocrine Abstracts ◽

10.1530/endoabs.50.p392 ◽

2017 ◽

Author(s):

Earn H Gan ◽

Vasileios Tsatlidis ◽

David Kennedy ◽

Salman Razvi

Keyword(s):

Graves Disease ◽

Thyrotropin Receptor ◽

Free T4 ◽

Thyrotropin Receptor Antibodies ◽

Log Linear ◽

The Relationship ◽

Receptor Antibodies

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The relationship between thyroid receptor antibody and anti mullerian hormone in Graves' disease

Endocrine Abstracts ◽

10.1530/endoabs.63.p352 ◽

2019 ◽

Author(s):

Keziban Demir ◽

Hakan Kursat ◽

Sevde Yazici ◽

Hamide Pişkinpaşa ◽

Evin Bozkir ◽

...

Keyword(s):

Graves Disease ◽

Receptor Antibody ◽

Thyroid Receptor ◽

The Relationship

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Novel treatment opportunities in Graves’ orbitopathy

Orvosi Hetilap ◽

10.1556/oh.2014.29963 ◽

2014 ◽

Vol 155 (33) ◽

pp. 1295-1300

Author(s):

Annamária Erdei ◽

Annamária Gazdag ◽

Miklós Bodor ◽

Eszter Berta ◽

Mónika Katkó ◽

...

Keyword(s):

Clinical Experience ◽

Clinical Course ◽

Treatment Protocol ◽

Treatment Modalities ◽

Graves Disease ◽

Novel Treatment ◽

Graves Orbitopathy ◽

Cd20 Antibody ◽

Anti Cd20 ◽

Novel Therapeutic

Graves’ orbitopathy is the most common extrathyroidal manifestation of Graves’ disease. Up to now, curative treatment modalities for the most severe sight-threatening cases have not been developed. Here the authors summarize the treatment protocol of Graves’ orbitopathy and review novel therapeutic options. They review the literature on this topic and present their own clinical experience. The authors point out that anti-CD20 antibody could positively influence the clinical course of Graves’ orbitopathy. Selenium is efficient in mild cases. Further prospective investigations are warranted. Orv. Hetil., 2014, 155(33), 1295–1300.

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COVID-19 in children: Pathogenesis and current status

Allergy and Asthma Proceedings ◽

10.2500/aap.2020.42.200104 ◽

2020 ◽

Author(s):

Lawrence Frenkel ◽

Fernando Gomez ◽

Joseph A Bellanti

Keyword(s):

Respiratory Disease ◽

Respiratory Symptoms ◽

Distress Syndrome ◽

Clinical Course ◽

Current Status ◽

Current Evidence ◽

Initial Description ◽

Relationship Of ◽

Inflammatory Syndrome ◽

The Relationship

Background: Since its initial description in December 2019 in Wuhan, China, coronavirus disease 2019 (COVID-19) has rapidly progressed into a worldwide pandemic, which has affected millions of lives. Unlike the disease in adults, the vast majority of children with COVID-19 have mild symptoms and are largely spared from severe respiratory disease. However, thereare children who have significant respiratory disease, and some may develop a hyperinflammatory response similar to thatseen in adults with COVID-19 and in children with Kawasaki disease (KD), which has been termed multisystem inflammatory syndrome in children (MIS-C).Objective: The purpose of this report was to examine the current evidence that supports the etiopathogenesis of COVID-19 in children and the relationship of COVID-19 with KD and MIS-C as a basis for a better understanding of the clinical course, diagnosis, and management of these clinically perplexing conditions.Results: The pathogenesis of COVID-19 is carried out in two distinct but overlapping phases of COVID-19: the first triggered by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) itself and the second by the host immune response. Children with KD have fewer of the previously described COVID-19–associated KD features with less prominent acute respiratory distress syndrome and shock than children with MIS-C.Conclusion: COVID-19 in adults usually includes severe respiratory symptoms and pathology, with a high mortality. Ithas become apparent that children are infected as easily as adults but are more often asymptomatic and have milder diseasebecause of their immature immune systems. Although children are largely spared from severe respiratory disease, they canpresent with a SARS-CoV-2–associated MIS-C similar to KD.

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The Relationship between Clinical Tests, Ultrasound Findings and Selected Field-Based Wheelchair Skills Tests in a Cohort of Quadriplegic Wheelchair Rugby Athletes: A Pilot Study

Applied Sciences ◽

10.3390/app11094162 ◽

2021 ◽

Vol 11 (9) ◽

pp. 4162

Author(s):

Lucrezia Tognolo ◽

Alfredo Musumeci ◽

Andrea Pignataro ◽

Nicola Petrone ◽

Michael Benazzato ◽

...

Keyword(s):

Rotator Cuff ◽

Shoulder Joint ◽

Rating Scale ◽

Clinical Tests ◽

Wheelchair Rugby ◽

Manual Wheelchair ◽

Shoulder Pathology ◽

Cord Injury ◽

Pathologic Findings ◽

The Relationship

Manual wheelchair use may determine shoulder joint overload and rotator cuff injury. Chronic shoulder pathologies can also influence the propulsion ability of wheelchair athletes with spinal cord injury (SCI) during sport activities. However, the relationship between shoulder pathology and wheelchair performances has never been explored. Therefore, the study aimed to investigate the correlation between shoulder pathologic findings with clinical tests and ultrasonography evaluation and the results of wheelchair performance tests. Nineteen quadriplegic wheelchair rugby players were evaluated to investigate the association between clinical and ultrasound shoulder pathologic findings and their correlation with the performance of field-based selected wheelchair skills tests (WSTs). The outcome measures were the International Wheelchair Rugby Classification Score, dominant and non-dominant Physical Examination Shoulder Score, and dominant and non-dominant Ultrasound Shoulder Pathology Rating Scale (USPRS). The WST was measured at the beginning and at one-year follow-up. A statistically significant correlation was found between the time since SCI and dominant USPRS (p < 0.005). The non-dominant USPRS was strongly related to WST at the beginning (p < 0.005) and the end of the study (p < 0.05). Data suggest that the severity of the non-dominant shoulder pathology detected on the ultrasound is related to lower performance on the WST. Chronic manual wheelchair use could be responsible for dominant SCI shoulder joint and rotator cuff muscle damage, while non-dominant USPRS could be related to performance on the WST.

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Postoperative Rise of Circulating Mitochondrial DNA Is Associated with Inflammatory Response in Patients following Pancreaticoduodenectomy

European Surgical Research ◽

10.1159/000514661 ◽

2021 ◽

pp. 1-7

Author(s):

Niv Pencovich ◽

Nadav Nevo ◽

Roi Weiser ◽

Ekaterina Bonder ◽

Yoel Bogoch ◽

...

Keyword(s):

Mitochondrial Dna ◽

Inflammatory Response ◽

Delayed Gastric Emptying ◽

Clinical Course ◽

Severe Trauma ◽

Postoperative Fever ◽

Postoperative Course ◽

Cell Counts ◽

White Blood Cell Counts ◽

The Relationship

Introduction: Accumulation of plasma mitochondrial DNA (mtDNA) following severe trauma has been shown to correlate with the development of systemic inflammatory response syndrome (SIRS) and may predict mortality. Our objective was to investigate the relationship between levels of circulatory mtDNA following pancreaticoduodenectomy (PD) and the postoperative course. Methods: Levels of plasma mtDNA were assessed by real-time PCR of the mitochondrial genes ND1 and COX3 in 23 consecutive patients who underwent PD 1 day prior to surgery, within 8 h after surgery, and on postoperative day (POD)1 and POD5. The abundance of mtDNA was assessed relative to preoperative levels and in relation to parameters reflecting the postoperative clinical course. Results: When pooled for all patients, the circulating mtDNA levels were significantly increased after surgery. However, while a significant (at least >2-fold and up to >20-fold) rise was noted in 11 patients, no change in mtDNA levels was noted in the other 12 following surgery. Postoperative rise in circulating mtDNA was associated with an increased rate of postoperative fever until day 5, decreased hemoglobin and albumin levels, and increased white blood cell counts. These patients also suffered from increased rates of delayed gastric emptying. No significant differences were demonstrated in other postoperative parameters. Conclusion: Circulating mtDNA surge is associated with an inflammatory response following PD and may potentially be used as an early marker for postoperative course. Studies of larger patient cohorts are warranted.

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Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis

Multiple Sclerosis Journal ◽

10.1191/1352458504ms1015oa ◽

2004 ◽

Vol 10 (3) ◽

pp. 266-271 ◽

Cited By ~ 33

Author(s):

B Zakrzewska-Pniewska ◽

M Styczynska ◽

A Podlecka ◽

R Samocka ◽

B Peplonska ◽

...

Keyword(s):

Multiple Sclerosis ◽

Apolipoprotein E ◽

Brain Atrophy ◽

Genetic Factors ◽

Clinical Course ◽

Progression Rate ◽

Disease Course ◽

Familial Cases ◽

Sporadic Cases ◽

The Relationship

The importance of apolipoprotein E (ApoE) and myeloperoxidase (MPO) genotypes in the clinical characteristics of multiple sclerosis (MS) has been recently emphasized. In a large group of Polish patients we have tested the hypothesis that polymorphism in ApoE and MPO genes may influence the course of the disease. G enotypes were determined in 117 MS patients (74 females and 43 males; 99 sporadic and 18 familial cases) with mean EDSS of 3.6, mean age of 44.1 years, mean duration of the disease 12.8 years and mean onset of MS at 31.2 years, and in 100 healthy controls. The relationship between ApoE and MPO genes’ polymorphism and the MS activity as well as the defect of remyelination (diffuse demyelination) and brain atrophy on MRI were analysed. The ApoE o4 allele was not related to the disease course or the ApoE o2 to the intensity of demyelination on MRI. The genotype MPO G/G was found in all familial MS and in 57% (56/99) of sporadic cases. This genotype was also related to more pronounced brain atrophy on MRI. The MPO G/G subpopulation was characterized by a significantly higher proportion of patients with secondary progressive MS (PB- 0.05) and by a higher value of EDSS. A ccording to our results the MPO G allele is frequently found (in 96% of cases) among Polish patients with MS. More severe nervous tissue damage in the MPO G/G form can be explained by the mechanism of accelerated oxidative stress. It seems that MPO G/G genotype may be one of the genetic factors influencing the progression rate of disability in MS patients.

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HLA ANTIGENS AND THYROID AUTOANTIBODIES IN PATIENTS WITH GRAVES' DISEASE AND THEIR FIRST DEGREE RELATIVES

Clinical Endocrinology ◽

10.1111/j.1365-2265.1980.tb02130.x ◽

1980 ◽

Vol 12 (2) ◽

pp. 155-163 ◽

Cited By ~ 26

Author(s):

B. A. MATHER ◽

D. F. ROBERTS ◽

M. F. SCANLON ◽

E. D. MUKHTAR ◽

T. F. DAVIES ◽

...

Keyword(s):

Hla Antigens ◽

Graves Disease ◽

Thyroid Autoantibodies ◽

First Degree Relatives

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Clinical Significance of the Serotonin Release Assay and Platelet Count Monitoring After Cardiac Surgery

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/1076029617734308 ◽

2017 ◽

Vol 24 (6) ◽

pp. 944-949 ◽

Cited By ~ 1

Author(s):

Shinya Motohashi ◽

Takefumi Matsuo ◽

Hidenori Inoue ◽

Makoto Kaneko ◽

Shunya Shindo

Keyword(s):

Cardiac Surgery ◽

Platelet Count ◽

Clinical Course ◽

Serotonin Release ◽

Enzyme Linked Immunosorbent Assay ◽

Heparin Induced Thrombocytopenia ◽

Release Assay ◽

Immunological Assays ◽

Platelet Count Monitoring ◽

The Relationship

Heparin-induced thrombocytopenia (HIT) is one of the serious complications in patients who undergo cardiac surgery. However, there remains a major problem in diagnosing HIT because the current immunological assays for detection of HIT antibody have limitations. Furthermore, the clinical course of thrombocytopenia in this surgery makes it increasingly difficult to diagnose HIT. We investigated the relationship between platelet count and HIT antibody in 59 patients who underwent cardiac surgery using cardiopulmonary bypass (CPB). The number of postoperative HIT antibody-positive patients evaluated using enzyme-linked immunosorbent assay kit (polyanion IgG/IgA/IgM complex antibodies/antiplatelet factor 4 enhanced) was 37 (62.7%). In contrast, platelet activation by HIT antibody was evaluated using the serotonin release assay (SRA). More than 20% and 50% release of serotonin was obtained from 12 patients (20.3%) and 8 patients (13.6%), respectively. The levels of d-dimer were significantly different on postoperative day 14 between SRA-positive and SRA-negative groups; however, postoperative thrombus complication was not detected using sonography in the patients with positive serotonin release at all. After being decreased by the operation, their platelet count recovered within 2 weeks in both groups equally. In our study, although the patients were positive in the platelet activating HIT antibody assay, they remained free from thrombosis and their platelet count recovered after early postoperative platelet decrease. Therefore, in addition to the SRA, monitoring of platelet count might be still considered an indispensable factor to facilitate the prediction of HIT thrombosis prior to manifestation in the patients undergoing cardiac surgery using CPB.

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