The dynamics of tetanus epidemiology and control in rural Uttar Pradesh studied through computer simulation

1984 ◽  
Vol 18 (4) ◽  
pp. 303-313
Author(s):  
Monica Sharma ◽  
P.D. Sharma
1999 ◽  
Vol 342 (3) ◽  
pp. 597-604 ◽  
Author(s):  
Peter J. MULQUINEY ◽  
Philip W. KUCHEL

This is the third of three papers [see also Mulquiney, Bubb and Kuchel (1999) Biochem. J. 342, 565-578; Mulquiney and Kuchel (1999) Biochem. J. 342, 579-594] for which the general goal was to explain the regulation and control of 2,3-bisphosphoglycerate (2,3-BPG) metabolism in human erythrocytes. 2,3-BPG is a major modulator of haemoglobin oxygen affinity and hence is vital in blood oxygen transport. A detailed mathematical model of erythrocyte metabolism was presented in the first two papers. The model was refined through an iterative loop of experiment and simulation and it was used to predict outcomes that are consistent with the metabolic behaviour of the erythrocyte under a wide variety of experimental and physiological conditions. For the present paper, the model was examined using computer simulation and Metabolic Control Analysis. The analysis yielded several new insights into the regulation and control of 2,3-BPG metabolism. Specifically it was found that: (1) the feedback inhibition of hexokinase and phosphofructokinase by 2,3-BPG are equally as important as the product inhibition of 2,3-BPG synthase in controlling the normal in vivo steady-state concentration of 2,3-BPG; (2) H+ and oxygen are effective regulators of 2,3-BPG concentration and that increases in 2,3-BPG concentrations are achieved with only small changes in glycolytic rate; (3) these two effectors exert most of their influence through hexokinase and phosphofructokinase; (4) flux through the 2,3-BPG shunt changes in absolute terms in response to different energy demands placed on the cell. This response of the 2,3-BPG shunt contributes an [ATP]-stabilizing effect. A ‘cost’ of this is that 2,3-BPG concentrations are very sensitive to the energy demand of the cell and; (5) the flux through the 2,3-BPG shunt does not change in response to different non-glycolytic demands for NADH.


1982 ◽  
Vol 104 (1) ◽  
pp. 41-48
Author(s):  
C. R. Burrows

An assessment is made of a surveillance-radar control system designed to provide a sector-search capability and continuous control of antenna speed without unwanted torque-reaction on the supporting mast. These objectives are attained by utilizing regenerative braking, and control is exercised through Perbury CVTs. A detailed analysis of the system is given. The models derived for the Perbury CVTs supplement the qualitative data contained in earlier papers. Some results from a computer simulation are presented. Although the paper is concerned with a particular problem, the analysis of the CVTs, and the concept of using energy transfer to control large inertial loads, are of more general interest.


Author(s):  
Andrew P. Schmalz ◽  
Sunil K. Agrawal

This paper addresses the issues of control and workspace determination of planar active tensegrity or tensegrity-like structures. The motion of such structures is generally produced by actuated cables, which cannot tolerate compressive forces. Hence, a controller which not only satisfies the system dynamic equations, but also maintains positive tension in cables is necessary. A null-space controller based on feedback linearization theory is developed for this purpose. This controller utilizes redundant active cables to overactuate the system. The concept of a ‘dynamic workspace’ for these structures is then introduced. This workspace consists of all configurations that are achievable from a given initial configuration while maintaining positive tensions throughout the entire system motion and is a powerful tool in analyzing the performance of a variety of tensegrity structures. This idea extends the concept of the static workspace, which consists of statically maintainable configurations, by incorporating system motion and dynamics to guarantee positive tensions during transition between the states. A critical benefit of this procedure is that it may be used to find the dynamic workspace of a system regardless of whether actuator redundancy is utilized, and thus can be used to objectively illustrate the degree to which overactuation improves mobility of a tensegrity structure. The effectiveness of the developed concepts is demonstrated through computer simulation and actual physical experimentation.


2018 ◽  
Vol 3 (01) ◽  
pp. 84-86
Author(s):  
P. K. Madke ◽  
Devendra Pal ◽  
Satya Prakash ◽  
Anant Kumar

A field study was conducted in Ghaziabad District to observe the effect of mineral mixture feeding on milk yield in Buffalo. Animals were selected randomly from 5 villages of Ghaziabad, Uttar Pradesh viz. Muradnagar, Noorpur, Kanoja, Kusalia, and Badka. 20 Buffaloes were selected in their 2nd and 3rd stage of lactation and divided into two groups of 10 animals each. First group (T) was fed with 60 gm mineral mixture daily till 90 days of lactation. Other groups (C) of 10 animals were not fed additional mineral mixture, which is farmers practice in that particular area. The farmers were not fed scientific method of feeding. They could not added proper quantity of mineral mixture in balance ration. To keeping in mind a trial was conducted in Ghaziabad District since 2016-17 to 2017-18. Milk yield of these animals was recorded by their owners and these values were averaged for fortnightly interval. Milk production parameters like average daily milk yield, peak yield and total milk yield were compared between treatment and control groups. It was observed that average daily milk yield, peak yield and total milk yield were found significantly (P less than 0.05) higher by 11.04, 12.37 and 11.61% in mineral mixture fed group than control group. On the basis of this, it is recommended that continuous feeding of mineral mixture bettered performance of milk yield in buffaloes.


2012 ◽  
Vol 485 ◽  
pp. 165-168
Author(s):  
Qiang Li ◽  
Cheng Zhi Yang ◽  
Wen Bo Zhang ◽  
Yang Yu

Leaching rate is one of the key parameters in the nickel stir leaching process of sulfuric acid and it is hard to online measure directly due to a lot of uncertain facts. In this paper, the prediction model of nickel leaching rate is established by least squares identification method. A controller combining predictive control(PFC) and PID control is designed to control nickel leaching rate in stir leaching process of sulfuric acid and better results of leaching rate control is proved by computer simulation.


1983 ◽  
Vol 17 (1) ◽  
pp. 35-57 ◽  
Author(s):  
Stephen Henningham

In north India in the nineteenth and early twentieth centuries several great landed estates played a crucial part in the consolidation of imperial rule and in the support of the social and economic order. These estates have attracted considerable scholarly attention, but previous research has concentrated primarily on their relations with the colonial administraton and on their general intermediary role in north Indian society. The only study directly concerned with their internal affairs is Dr. P. J. Musgrave's ‘Landlords and Lords of the Land: Estate Management and Social Control in Uttar Pradesh 1860–1920’ (Modern Asian Studies, 6, 3 (1972), pp. 257–75), in which official sources are used as the basis for an account of the internal operations of the great estates in the United Provinces of Agra and Oudh. Hitherto the major obstacle to the examination of the administration of the great estates has been the absence of comprehensive estate records. Fortunately the extensive and well-organized archives of the Raj Darbhanga of Bihar recently have been opened to scholars. In this paper the Raj archives have been drawn upon to provide evidence for an account of the structure and operation of the administration of the Raj Darbhanga during the late nineteenth and early twentieth centuries. The paper argues that despite substantial difficulties the Raj Darbhanga effectively pursued its interests by means of a bureaucratic system of management and that therefore Dr Musgrave's conclusions concerning the limited power of the great landed estates need substantial qualification and correction.


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