Equilibria of the brain-state-in-a-box (BSB) neural model

1988 ◽  
Vol 1 (4) ◽  
pp. 323-324 ◽  
Author(s):  
Harvey J. Greenberg
Keyword(s):  
2000 ◽  
Vol 12 (2) ◽  
pp. 451-472 ◽  
Author(s):  
Fation Sevrani ◽  
Kennichi Abe

In this article we present techniques for designing associative memories to be implemented by a class of synchronous discrete-time neural networks based on a generalization of the brain-state-in-a-box neural model. First, we address the local qualitative properties and global qualitative aspects of the class of neural networks considered. Our approach to the stability analysis of the equilibrium points of the network gives insight into the extent of the domain of attraction for the patterns to be stored as asymptotically stable equilibrium points and is useful in the analysis of the retrieval performance of the network and also for design purposes. By making use of the analysis results as constraints, the design for associative memory is performed by solving a constraint optimization problem whereby each of the stored patterns is guaranteed a substantial domain of attraction. The performance of the designed network is illustrated by means of three specific examples.


Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1118
Author(s):  
Jan Homolak ◽  
Ana Babic Perhoc ◽  
Ana Knezovic ◽  
Jelena Osmanovic Barilar ◽  
Melita Salkovic-Petrisic

The gastrointestinal system may be involved in the etiopathogenesis of the insulin-resistant brain state (IRBS) and Alzheimer’s disease (AD). Gastrointestinal hormone glucagon-like peptide-1 (GLP-1) is being explored as a potential therapy as activation of brain GLP-1 receptors (GLP-1R) exerts neuroprotection and controls peripheral metabolism. Intracerebroventricular administration of streptozotocin (STZ-icv) is used to model IRBS and GLP-1 dyshomeostasis seems to be involved in the development of neuropathological changes. The aim was to explore (i) gastrointestinal homeostasis in the STZ-icv model (ii) assess whether the brain GLP-1 is involved in the regulation of gastrointestinal redox homeostasis and (iii) analyze whether brain-gut GLP-1 axis is functional in the STZ-icv animals. Acute intracerebroventricular treatment with exendin-3(9-39)amide was used for pharmacological inhibition of brain GLP-1R in the control and STZ-icv rats, and oxidative stress was assessed in plasma, duodenum and ileum. Acute inhibition of brain GLP-1R increased plasma oxidative stress. TBARS were increased, and low molecular weight thiols (LMWT), protein sulfhydryls (SH), and superoxide dismutase (SOD) were decreased in the duodenum, but not in the ileum of the controls. In the STZ-icv, TBARS and CAT were increased, LMWT and SH were decreased at baseline, and no further increment of oxidative stress was observed upon central GLP-1R inhibition. The presented results indicate that (i) oxidative stress is increased in the duodenum of the STZ-icv rat model of AD, (ii) brain GLP-1R signaling is involved in systemic redox regulation, (iii) brain-gut GLP-1 axis regulates duodenal, but not ileal redox homeostasis, and iv) brain-gut GLP-1 axis is dysfunctional in the STZ-icv model.


2019 ◽  
Author(s):  
Jarno Tuominen ◽  
Sakari Kallio ◽  
Valtteri Kaasinen ◽  
Henry Railo

Can the brain be shifted into a different state using a simple social cue, as tests on highly hypnotisable subjects would suggest? Demonstrating an altered brain state is difficult. Brain activation varies greatly during wakefulness and can be voluntarily influenced. We measured the complexity of electrophysiological response to transcranial magnetic stimulation (TMS) in one “hypnotic virtuoso”. Such a measure produces a response outside the subject’s voluntary control and has been proven adequate for discriminating conscious from unconscious brain states. We show that a single-word hypnotic induction robustly shifted global neural connectivity into a state where activity remained sustained but failed to ignite strong, coherent activity in frontoparietal cortices. Changes in perturbational complexity indicate a similar move toward a more segregated state. We interpret these findings to suggest a shift in the underlying state of the brain, likely moderating subsequent hypnotic responding. [preprint updated 20/02/2020]


2009 ◽  
Vol 59 (4) ◽  
pp. 320-356 ◽  
Author(s):  
N. Andrew Browning ◽  
Stephen Grossberg ◽  
Ennio Mingolla

Author(s):  
M. Atif Yaqub ◽  
Keum-Shik Hong ◽  
Amad Zafar ◽  
Chang-Seok Kim

Transcranial direct current stimulation (tDCS) has been shown to create neuroplasticity in healthy and diseased populations. The control of stimulation duration by providing real-time brain state feedback using neuroimaging is a topic of great interest. This study presents the feasibility of a closed-loop modulation for the targeted functional network in the prefrontal cortex. We hypothesize that we cannot improve the brain state further after reaching a specific state during a stimulation therapy session. A high-definition tDCS of 1[Formula: see text]mA arranged in a ring configuration was applied at the targeted right prefrontal cortex of 15 healthy male subjects for 10[Formula: see text]min. Functional near-infrared spectroscopy was used to monitor hemoglobin chromophores during the stimulation period continuously. The correlation matrices obtained from filtered oxyhemoglobin were binarized to form subnetworks of short- and long-range connections. The connectivity in all subnetworks was analyzed individually using a new quantification measure of connectivity percentage based on the correlation matrix. The short-range network in the stimulated hemisphere showed increased connectivity in the initial stimulation phase. However, the increase in connection density reduced significantly after 6[Formula: see text]min of stimulation. The short-range network of the left hemisphere and the long-range network gradually increased throughout the stimulation period. The connectivity percentage measure showed a similar response with network theory parameters. The connectivity percentage and network theory metrics represent the brain state during the stimulation therapy. The results from the network theory metrics, including degree centrality, efficiency, and connection density, support our hypothesis and provide a guideline for feedback on the brain state. The proposed neuro-feedback scheme is feasible to control the stimulation duration to avoid overdosage.


Author(s):  
Joseph Levine

There are two basic philosophical problems about colour. The first concerns the nature of colour itself. That is, what sort of property is it? When I say of the shirt that I am wearing that it is red, what sort of fact about the shirt am I describing? The second problem concerns the nature of colour experience. When I look at the red shirt I have a visual experience with a certain qualitative character – a ‘reddish’ one. Thus colour seems in some sense to be a property of my sensory experience, as well as a property of my shirt. What sort of mental property is it? Obviously, the two problems are intimately related. In particular, there is a great deal of controversy over the following question: if we call the first sort of property ‘objective colour’ and the second ‘subjective colour’, which of the two, objective or subjective colour, is basic? Or do they both have an independent ontological status? Most philosophers adhere to the doctrine of physicalism, the view that all objects and events are ultimately constituted by the fundamental physical particles, properties and relations described in physical theory. The phenomena of both objective and subjective colour present problems for physicalism. With respect to objective colour, it is difficult to find any natural physical candidate with which to identify it. Our visual system responds in a similar manner to surfaces that vary along a wide range of physical parameters, even with respect to the reflection of light waves. Yet what could be more obvious than the fact that objects are coloured? In the case of subjective colour, the principal topic of this entry, there is an even deeper puzzle. It is natural to think of the reddishness of a visual experience – its qualitative character – as an intrinsic and categorical property of the experience. Intrinsic properties are distinguished from relational properties in that an object’s possession of the former does not depend on its relation to, or even the existence of, other objects, whereas its possession of the latter does. Categorical properties are distinguished from dispositional ones. A dispositional property is one that an object has by virtue of its tendency to behave in certain ways, or cause certain effects, in particular circumstances. So being brittle is dispositional in that it involves being liable to break under slight pressure, whereas being six feet tall, say, is categorical. If subjective colour is intrinsic and categorical, then it would seem to be a neural property of a brain state. But what sort of neural property could explain the reddishness of an experience? Furthermore, reduction of subjective colour to a neural property would rule out even the possibility that forms of life with different physiological structures, or intelligent robots, could have experiences of the same qualitative type as our experiences of red. While some philosophers endorse this consequence, many find it quite implausible. Neural properties seem best suited to explain how certain functions are carried out, and therefore it might seem better to identify subjective colour with the property of playing a certain functional role within the entire cognitive system realized by the brain. This allows the possibility that structures physically different from human brains could support colour experiences of the same type as our own. However, various puzzles undermine the plausibility of this claim. For instance, it seems possible that two people could agree in all their judgements of relative similarity and yet one sees green where the other sees red. If this ‘inverted spectrum’ case is a genuine logical possibility, as many philosophers advocate, then it appears that subjective colour must not be a matter of functional role, but rather an intrinsic property of experience. Another possibility is that qualitative character is just a matter of features the visual system, in the case of colour, is representing objects in the visual field to have. Reddish experiences are just visual representations of red. But this view too has problems with spectrum-inversion scenarios, and also entails some counterintuitive consequences concerning our knowledge of our own qualitative states. Faced with the dilemmas posed by subjective colour for physicalist doctrine, some philosophers opt for eliminativism, the doctrine that subjective colour is not a genuine, or real, phenomenon after all. On this view the source of the puzzle is a conceptual confusion; a tendency to extend our judgements concerning objective colour, what appear to be intrinsic and categorical properties of the surfaces of physical objects, onto the properties of our mental states. Once we see that nothing qualitative is happening ‘inside’, we will understand why we cannot locate any state or property of the brain with which to identify subjective colour. The controversy over the nature of subjective colour is part of a wider debate about the subjective aspect of conscious experience more generally. How does the qualitative character of experience – what it is like to see, hear and smell – fit into a physicalist scientific framework? At present all of the options just presented have their adherents, and no general consensus exists.


SLEEP ◽  
2020 ◽  
Author(s):  
Fengzhen Hou ◽  
Lulu Zhang ◽  
Baokun Qin ◽  
Giulia Gaggioni ◽  
Xinyu Liu ◽  
...  

Abstract Quantifying the complexity of the EEG signal during prolonged wakefulness and during sleep is gaining interest as an additional mean to characterize the mechanisms associated with sleep and wakefulness regulation. Here, we characterized how EEG complexity, as indexed by Multiscale Permutation Entropy (MSPE), changed progressively in the evening prior to light off and during the transition from wakefulness to sleep. We further explored whether MSPE was able to discriminate between wakefulness and sleep around sleep onset and whether MSPE changes were correlated with spectral measures of the EEG related to sleep need during concomitant wakefulness (theta power—Ptheta: 4–8 Hz). To address these questions, we took advantage of large datasets of several hundred of ambulatory EEG recordings of individual of both sexes aged 25–101 years. Results show that MSPE significantly decreases before light off (i.e. before sleep time) and in the transition from wakefulness to sleep onset. Furthermore, MSPE allows for an excellent discrimination between pre-sleep wakefulness and early sleep. Finally, we show that MSPE is correlated with concomitant Ptheta. Yet, the direction of the latter correlation changed from before light-off to the transition to sleep. Given the association between EEG complexity and consciousness, MSPE may track efficiently putative changes in consciousness preceding sleep onset. An MSPE stands as a comprehensive measure that is not limited to a given frequency band and reflects a progressive change brain state associated with sleep and wakefulness regulation. It may be an effective mean to detect when the brain is in a state close to sleep onset.


2015 ◽  
Vol 123 (4) ◽  
pp. 937-960 ◽  
Author(s):  
Patrick L. Purdon ◽  
Aaron Sampson ◽  
Kara J. Pavone ◽  
Emery N. Brown

Abstract The widely used electroencephalogram-based indices for depth-of-anesthesia monitoring assume that the same index value defines the same level of unconsciousness for all anesthetics. In contrast, we show that different anesthetics act at different molecular targets and neural circuits to produce distinct brain states that are readily visible in the electroencephalogram. We present a two-part review to educate anesthesiologists on use of the unprocessed electroencephalogram and its spectrogram to track the brain states of patients receiving anesthesia care. Here in part I, we review the biophysics of the electroencephalogram and the neurophysiology of the electroencephalogram signatures of three intravenous anesthetics: propofol, dexmedetomidine, and ketamine, and four inhaled anesthetics: sevoflurane, isoflurane, desflurane, and nitrous oxide. Later in part II, we discuss patient management using these electroencephalogram signatures. Use of these electroencephalogram signatures suggests a neurophysiologically based paradigm for brain state monitoring of patients receiving anesthesia care.


Neuroscience ◽  
1994 ◽  
Vol 59 (2) ◽  
pp. 229-243 ◽  
Author(s):  
K.J. Friston ◽  
G. Tononi ◽  
G.N. Reeke ◽  
O. Sporns ◽  
G.M. Edelman

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