Effectiveness of saffron on memory function, learning ability, and epilepsy

Saffron ◽  
2020 ◽  
pp. 423-430
Author(s):  
Hamid-Reza Sadeghnia ◽  
Arezoo Rajabian ◽  
Seyed-Mahmoud Hosseini
2018 ◽  
Vol 3 (11) ◽  
Author(s):  
Felecia Jefferson ◽  
Redeshia Burks ◽  
Ivy Malone ◽  
Adelia Mckinley

Sleep is the normal rest of an organism. There are two types of sleep. REM and NREM. REM is considered the deep sleep and NREM is considered the lighter sleep. Sleep is also, organized by the brain. You also can sleep what you eat, meaning that, whatever you eat can affect the way you sleep. Memory is the ability to attain, store, and retain and recall information and past experiences in the human brain. Sleep affects learning and memory in a cause and effect situation, if one does not attain enough sleep, their memory or learning ability will not be sufficient. One can maintain healthy or improve their learning and memory function by eating healthy, exercising, keeping stress level low and improving sleep quality. College students can improve sleep quality by revising instead of cramming, being active on campus and stimulating their brains by learning new information.


1969 ◽  
Vol 3 (2) ◽  
pp. 129-140 ◽  
Author(s):  
John Seamer ◽  
S. Peto

A quantitative investigation into the balancing and locomotor function, learning and memory of mice infected with an arthropod-borne virus is described. Mice can remain on a rod rotating in a horizontal plane about its long axis, and this natural ability can be assessed by counting the number of times they fall off. The mice improve their ability with experience and can retain the improved ability for short periods. Natural ability in mice about 25 days old was greater than in those 3 weeks older. This ability was diminished by the encephalomyelitis which resulted from infection with Langat virus. Within the limits of the experiments the rate of learning depended upon the number of trials rather than the interval between them. Memory lasting 10 days or longer was demonstrated in some mice but evidence on the effect of ageing on learning and memory was conflicting. Despite the presence of Langat virus infection the learning ability and memory of mice which showed no clinical signs of disease appeared to be unimpaired.


2018 ◽  
Vol 4 (01) ◽  
Author(s):  
Felecia Jefferson ◽  
Redeshia Burks ◽  
Ivy Malone ◽  
Adelia Mckinley

Sleep is the normal rest of an organism. There are two types of sleep. REM and NREM. REM is considered the deep sleep and NREM is considered the lighter sleep. Sleep is also, organized by the brain. You also can sleep what you eat, meaning that, whatever you eat can affect the way you sleep. Memory is the ability to attain, store, and retain and recall information and past experiences in the human brain. Sleep affects learning and memory in a cause and effect situation, if one does not attain enough sleep, their memory or learning ability will not be sufficient. One can maintain healthy or improve their learning and memory function by eating healthy, exercising, keeping stress level low and improving sleep quality. College students can improve sleep quality by revising instead of cramming, being active on campus and stimulating their brains by learning new information.


1959 ◽  
Vol 105 (439) ◽  
pp. 440-443 ◽  
Author(s):  
James Inglis

In his examination of elderly patients the psychiatrist is commonly concerned to obtain some indication of the individual's “memory function“. When the psychologist is asked to help in such assessment there are at least two factors which may handicap his ability to do so. Firstly, the conception of “memory”. as popularly used, even in the clinic, is rather narrow in its connotation, having come to refer almost exclusively to the reproduction of learned material. It would seem more satisfactory, from the psychologist's point of view, to substitute instead the notion of “learning ability” since this expression has a wider meaning. It admits of the discussion of separate aspects and takes into account, for example, the two broad phases of “acquisition” and “retention“. Secondly, those tests which the psychologist may have by him which purport to assess “memory” usually suffer from a number of disadvantages. For example, as Williams (12) has recently pointed out, they are seldom so constructed as to ensure that every subject has a standard opportunity to acquire what the test requires him to reproduce; in any case few of the tests available have ever been given to elderly people, so that “normal” performance in such age groups is unknown. A more important, and less often emphasized, disadvantage, however, is that performance on such tests is commonly closely related to performance on intelligence tests, so that although the ostensible content of the material used seems to be related to “memory”, in the popular sense, what the psychologist in fact gets from them is another measure of general intellectual ability. A study by Hall (1) has shown that, for a young population at least (mean age 29.11, sd 2.77), the results of the Wechsler Memory Scale (10) correlate with results on the Wechsler Bellevue Intelligence Scale (9) almost to the degree (r=0.77) to which the intelligence measure correlates with itself (r=0.94).


2021 ◽  
Author(s):  
Shaymaa Rezk ◽  
Samah Lashen ◽  
Mohamed EL-Adl ◽  
Gehad E. Elshopakey ◽  
Mona M. Elghareeb ◽  
...  

Abstract Rosemary oil (ROO) is known to have multiple pharmacological effects: it is an antioxidant, an anti-inflammatory, and cytoprotective. In the present study, we examined the effects of ROO on Human olfactory bulb neuronal stem cells (hOBNSCs) after their transplantation into rats, with the ibotenic (IBO) acid-induced cognitive deficit model. After 7 weeks, cognitive functions were assessed using the Morris water maze (MWM). After two months blood and the hippocampus were collected for biochemical, gene expression, and histomorphometric analyses. Learning ability and memory function were significantly enhanced after hOBNSCs transplantation and were nearly returned to normal in the treated group. The IBO acid injection was associated with a significant decline of total leukocyte count (TLC) and a significant increase in total and toxic neutrophils. As well, the level of IL-1β, TNF-α CRP in serum and levels of MDA and NO in hippocampus tissue were significantly elevated, while antioxidant markers (CAT, GSH, and SOD) were reduced in treated tissue compared to controls. The administration of ROO before or with cell transplantation attenuated all these parameters. In particular, the level of NO nearly returned to normal when rosemary was administrated before cell transplantation. Gene expression analysis revealed the potential protective effect of ROO and hOBNSCs via down-expression of R-βAmyl and R- CAS 3 and R-GFAP genes.


2020 ◽  
Author(s):  
Yahan Zhang ◽  
Qiushi Gao ◽  
Ziyi Wu ◽  
Hang Xue ◽  
Chang Li ◽  
...  

Abstract Sevoflurane postconditioning (SPC) had been reported to attenuate developing brain injury after hypoxia-ischemia encephalopathy (HIE)via inhibiting neural necrosis and autophagy process. Moreover, recent report elucidated sevoflurane may involve in neural cells migration after injury. Here we hypothesize neuronal migration and long-term cognition were ruined after HIE and SPC alleviated these injuries .Classical Rice–Vannucci model of Hypoxia-ischemia was conducted on P7 pups , which was followed by SPC at the 1 minimum alveolar concentration (MAC 2.4%) for 30 min. Piceatannol which can cleave Reelin into proteolytic fragments was used to detect whether Reelin/Dab1 is involved in neuroprotection exerted by SPC. Our findings suggest that hypoxia-ischemia disrupted cytoarchitecture of dentate gyrus (DG) by inhibiting the migration of dentate neurons of hippocampus, which may eventually lead to long-term cognition deficits. However, SPC could relieve the restricted hippocampal neurons from the subgranular zone of hippocampi combined with the repair of hippocampal-dependent memory function damaged by HIE through attenuating the overactivation of the Reelin/Dab1pathway. Taken together, these results demonstrate that SPC plays a pivotal role in ameliorating neuronal migration disorder and maintain normal cytoarchitecture and spatial learning ability of DG by regulating the Reelin/Dab1 downstream signaling pathway. This indicates the potential therapeutic use of SPC in treating HIE perinatally.


Epilepsia ◽  
1987 ◽  
Vol 28 (5) ◽  
pp. 547-554 ◽  
Author(s):  
Bruce P. Hermann ◽  
Allen R. Wyler ◽  
E. T. Richey ◽  
Jeanne M. Rea

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Ilhan Lim ◽  
Hye-Young Joung ◽  
A Ram Yu ◽  
Insop Shim ◽  
Jin Su Kim

A considerable number of patients with breast cancer complain of cognitive impairment after chemotherapy. In this study, we showed that donepezil enhanced memory function and increased brain glucose metabolism in a rat model of cognitive impairment after chemotherapy using behavioral analysis and positron emission tomography (PET). We found that chemotherapy affected spatial learning ability, reference memory, and working memory and that donepezil improved these cognitive impairments. According to PET analysis, chemotherapy reduced glucose metabolism in the medial prefrontal cortex and hippocampus, and donepezil increased glucose metabolism in the bilateral frontal lobe, parietal lobe, and hippocampus. Reduced glucose metabolism was more prominent after treatment with doxorubicin than cyclophosphamide. Our results demonstrated the neural mechanisms for cognitive impairment after chemotherapy and show that cognition was improved after donepezil intervention using both behavioral and imaging methods. Our results suggested that donepezil can be employed clinically for the treatment of cognitive deficits after chemotherapy.


2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Wei-ming Ren ◽  
Ze-bin Weng ◽  
Xin Li ◽  
Li-bin Zhan

Background. Diabetes-associated cognitive decline (DACD) is one of the nervous system dysfunctions induced by diabetes mellitus with cognitive impairment as the major symptom. In a previous preliminary proteomic study, we found that endoplasmic reticulum processing and PI3K-Akt signaling pathway might be impaired in DACD pathogenesis. In addition, growth factor receptor-bound protein 2 might be a crucial protein as a molecular target of the neuroprotective effects of ZiBuPiYin recipe (ZBPYR). Methods. In this study, 6-8 weeks aged db/db mice were treated with excipients or ZBPYR for 6 weeks. Body weight and RBG were recorded weekly. Oral glucose tolerance and insulin tolerance tests were used to assess insulin sensitivity. Morris water maze (MWM) tests were used to assess memory function. The expression of Grb2, Gab2, Akt, and GSK3β in mouse hippocampus and cerebral cortex were analyzed by Western blotting. Results. ZBPYR not only significantly reduced RGB and improved glucose tolerance and insulin resistance, but also improved spatial cognition in DACD mice. The expression of Grb2 and Gab2 in hippocampus and cerebral cortex of db/db mice was upregulated after treated with ZBPYR, and then affected the PI3K/Akt signaling pathway, and inhibited GSK3β overactivity. Conclusions. This study showed that ZBPYR could enhance the memory and learning ability of db/db mice. Such neuroprotective effect might be related to the activation of Grb2-PI3K/Akt signaling which might provide a novel therapeutic target for the clinical treatment of DACD.


2020 ◽  
Author(s):  
Masaharu Ueno ◽  
Yukio Ichitani ◽  
Kazuo Yamada

The present study showed that rats in the resilient group exhibited rapid extinction of conditioned fear and better performances in the spontaneous object–place and object recognition memory tasks. These findings suggest that individual resilience may depend on learning ability and memory function in rats.


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