scholarly journals Contribution to characterization of skin field cancerization activity: morphometric, chromatin texture, proliferation, and apoptosis aspects

2019 ◽  
Vol 94 (6) ◽  
pp. 698-703
Author(s):  
Anna Carolina Miola ◽  
Mariana Anteghini Castilho ◽  
Juliano Vilaverde Schmitt ◽  
Mariangela Esther Alencar Marques ◽  
Helio Amante Miot
Keyword(s):  
Field Cancerization ◽  
Proliferation And Apoptosis ◽  
Chromatin Texture

PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling

2021 ◽  
Vol 61 (1) ◽  
pp. 723-743
Author(s):  
Timothy R. Baffi ◽  
Ksenya Cohen-Katsenelson ◽  
Alexandra C. Newton
Keyword(s):  
Cell Signaling ◽  
Current Knowledge ◽  
Signaling Networks ◽  
Pleckstrin Homology Domain ◽  
Proliferation And Apoptosis ◽  
Tumor Suppressive Function ◽  
Prosurvival Kinase ◽  
Signaling Field ◽  
Leucine Rich Repeat Protein

Whereas protein kinases have been successfully targeted for a variety of diseases, protein phosphatases remain an underutilized therapeutic target, in part because of incomplete characterization of their effects on signaling networks. The pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP) is a relatively new player in the cell signaling field, and new roles in controlling the balance among cell survival, proliferation, and apoptosis are being increasingly identified. Originally characterized for its tumor-suppressive function in deactivating the prosurvival kinase Akt, PHLPP may have an opposing role in promoting survival, as recent evidence suggests. Additionally, identification of the transcription factor STAT1 as a substrate unveils a role for PHLPP as a critical mediator of transcriptional programs in cancer and the inflammatory response. This review summarizes the current knowledge of PHLPP as both a tumor suppressor and an oncogene and highlights emerging functions in regulating gene expression and the immune system. Understanding the context-dependent functions of PHLPP is essential for appropriate therapeutic intervention.

Computer-assisted chromatin texture characterization of Feulgen-stained nuclei in a series of 331 transitional bladder cell carcinomas

1994 ◽  
Vol 173 (3) ◽  
pp. 235-242 ◽  
Author(s):  
Roland Van Velthoven ◽  
Michel Petein ◽  
Alexandre Zlotta ◽  
Willem J. Oosterlinck ◽  
Adrian van der Meijden ◽  
...  
Keyword(s):  
Computer Assisted ◽  
Bladder Cell ◽  
Chromatin Texture ◽  
Texture Characterization

scholarly journals Comparative study of histopathology and immunohistochemistry of indefinite round cell cutaneous tumors and characterization of canine lymphoma

2015 ◽  
Vol 67 (1) ◽  
pp. 32-36 ◽  
Author(s):  
L.H.A. Machado ◽  
M.I.P. Palumbo ◽  
F.S. Zahn ◽  
R.L. Amorim ◽  
M.R. Farias ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Comparative Study ◽  
Round Cell ◽  
Immunohistochemical Examination ◽  
Canine Lymphoma ◽  
T Cell Lymphomas ◽  
Proliferation And Apoptosis ◽  
Immunohistochemical Diagnosis

With the purpose of shedding light on some doubts in veterinary oncology, the present article intends to compare the results of histopathological and immunohistochemical examinations of unspecific round cell neoplasia, to realize immunophenotyping of canine lymphoma cases, to establish the T or B origin of neoplastic cells, and to determine the degree of proliferation and apoptosis of lymphomas by immunohistochemistry. Of 11 animals presenting immunohistochemical diagnosis of lymphoma, five had been diagnosed as Lymphoma by HE staining of histopathological slides and six had been classified as unspecific round cell neoplasia. All cases submitted to immunohistochemical examination were T-cell lymphomas. There was a positive correlation between cell proliferation and apoptosis. The comparison among histopathological and immunohistochemical results obtained in the cases examined in the present study suggested that immunohistochemistry is essential for the differentiation of round cell neoplasia.

The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2β) in β-cells

2004 ◽  
Vol 82 (10) ◽  
pp. 824-832 ◽  
Author(s):  
John Turk ◽  
Sasanka Ramanadham
Keyword(s):  
Cell Proliferation ◽  
Β Cells ◽  
Proliferation And Apoptosis ◽  
Bromoenol Lactone ◽  
Suicide Substrate ◽  
Glucose Stimulated Insulin Secretion ◽  
Calcium Independent Phospholipase A2 ◽  
Insulinoma Cells ◽  
And Function

Many cells express a Group VIA phospholipase A2, designated iPLA2β, that does not require calcium for activation, is stimulated by ATP, and is sensitive to inhibition by a bromoenol lactone suicide substrate (BEL). Studies in various cell systems have led to the suggestion that iPLA2β has a role in phospholipid remodeling, signal transduction, cell proliferation, and apoptosis. We have found that pancreatic islets, β-cells, and glucose-responsive insulinoma cells express an iPLA2β that participates in glucose-stimulated insulin secretion but is not involved in membrane phos pho lipid remodeling. Additionally, recent studies reveal that iPLA2β is involved in pathways that contribute to β-cell proliferation and apoptosis, and that various phospholipid-derived mediators are involved in these processes. Detailed characterization of the enzyme suggests that the β-cells express multiple isoforms of iPLA2β, and we hypothesize that these participate in different cellular functions.Key words: signalling, apoptosis, isoforms, mass spectrometry.

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