Determination of drugs and drug metabolites by ion mobility-mass spectrometry: A review

2021 ◽  
Vol 1154 ◽  
pp. 338270
Author(s):  
Dylan H. Ross ◽  
Libin Xu
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Ion Mobility Mass Spectrometry ◽  
Drug Metabolites

scholarly journals Ion Mobility–Mass Spectrometry for Bioanalysis

Separations ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 33
Author(s):  
Xavier Garcia ◽  
Maria del Mar Sabaté ◽  
Jorge Aubets ◽  
Josep Maria Jansat ◽  
Sonia Sentellas
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Biological Samples ◽  
Ion Mobility Mass Spectrometry ◽  
Exogenous Compounds ◽  
Analytical Separation

This paper aims to cover the main strategies based on ion mobility spectrometry (IMS) for the analysis of biological samples. The determination of endogenous and exogenous compounds in such samples is important for the understanding of the health status of individuals. For this reason, the development of new approaches that can be complementary to the ones already established (mainly based on liquid chromatography coupled to mass spectrometry) is welcomed. In this regard, ion mobility spectrometry has appeared in the analytical scenario as a powerful technique for the separation and characterization of compounds based on their mobility. IMS has been used in several areas taking advantage of its orthogonality with other analytical separation techniques, such as liquid chromatography, gas chromatography, capillary electrophoresis, or supercritical fluid chromatography. Bioanalysis is not one of the areas where IMS has been more extensively applied. However, over the last years, the interest in using this approach for the analysis of biological samples has clearly increased. This paper introduces the reader to the principles controlling the separation in IMS and reviews recent applications using this technique in the field of bioanalysis.

scholarly journals Ion‐Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules

2019 ◽  
Vol 58 (33) ◽  
pp. 11324-11328 ◽  
Author(s):  
Anneli Kruve ◽  
Kenji Caprice ◽  
Roy Lavendomme ◽  
Jan M. Wollschläger ◽  
Stefan Schoder ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Rapid Determination ◽  
Ion Mobility Mass Spectrometry

scholarly journals Direct observation of C60− nano-ion gas phase ozonation via ion mobility-mass spectrometry

2019 ◽  
Vol 21 (20) ◽  
pp. 10470-10476 ◽  
Author(s):  
Chenxi Li ◽  
Christopher J. Hogan Jr
Keyword(s):  
Mass Spectrometry ◽  
Gas Phase ◽  
Ion Mobility ◽  
Atmospheric Pressure ◽  
Reaction Rates ◽  
Ion Mobility Mass Spectrometry ◽  
Mobility Analysis ◽  
Differential Mobility ◽  
Differential Mobility Analysis

Atmospheric pressure differential mobility analysis-mass spectrometry facilitates determination of nano-ion-neutral reaction rates approaching the collision controlled limit.

Determination of testosterone and epitestosterone glucuronides in urine by ultra performance liquid chromatography-ion mobility-mass spectrometry

The Analyst ◽  
2011 ◽  
Vol 136 (19) ◽  
pp. 3911 ◽  
Author(s):  
Gushinder Kaur-Atwal ◽  
James C. Reynolds ◽  
Christopher Mussell ◽  
Elodie Champarnaud ◽  
Tom W. Knapman ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Ion Mobility ◽  
Ultra Performance Liquid Chromatography ◽  
Ion Mobility Mass Spectrometry

scholarly journals Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides

2021 ◽  
Author(s):  
RL Miller ◽  
SE Guimond ◽  
Ralf Schwoerer ◽  
Olga Zubkova ◽  
Peter Tyler ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Heparan Sulfate ◽  
Ion Mobility ◽  
Collision Cross Section ◽  
Ion Mobility Mass Spectrometry ◽  
Biological Processes ◽  
Sequence Determination ◽  
Fragment Ions ◽  
Library Screen

© 2020, The Author(s). Despite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological processes, definitive information on the bioactive sequences of these polymers is lacking, with only a handful of natural structures sequenced to date. Here, we develop a “Shotgun” Ion Mobility Mass Spectrometry Sequencing (SIMMS2) method in which intact HS saccharides are dissociated in an ion mobility mass spectrometer and collision cross section values of fragments measured. Matching of data for intact and fragment ions against known values for 36 fully defined HS saccharide structures (from di- to decasaccharides) permits unambiguous sequence determination of validated standards and unknown natural saccharides, notably including variants with 3O-sulfate groups. SIMMS2 analysis of two fibroblast growth factor-inhibiting hexasaccharides identified from a HS oligosaccharide library screen demonstrates that the approach allows elucidation of structure-activity relationships. SIMMS2 thus overcomes the bottleneck for decoding the informational content of functional HS motifs which is crucial for their future biomedical exploitation.

scholarly journals Applications of Ion Mobility-Mass Spectrometry in Carbohydrate Chemistry and Glycobiology

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2557 ◽  
Author(s):  
Yuqing Mu ◽  
Benjamin Schulz ◽  
Vito Ferro
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Drift Time ◽  
Structural Complexity ◽  
Ion Mobility Mass Spectrometry ◽  
Vast Number ◽  
Disease States ◽  
Coupled Technique ◽  
Analytical Tools

Carbohydrate analyses are often challenging due to the structural complexity of these molecules, as well as the lack of suitable analytical tools for distinguishing the vast number of possible isomers. The coupled technique, ion mobility-mass spectrometry (IM-MS), has been in use for two decades for the analysis of complex biomolecules, and in recent years it has emerged as a powerful technique for the analysis of carbohydrates. For carbohydrates, most studies have focused on the separation and characterization of isomers in biological samples. IM-MS is capable of separating isomeric ions by drift time, and further characterizing them by mass analysis. Applications of IM-MS in carbohydrate analysis are extremely useful and important for understanding many biological mechanisms and for the determination of disease states, although efforts are still needed for higher sensitivity and resolution.

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