Femtosecond laser induced fixation of calcium alkali phosphate ceramics on titanium alloy bone implant material

As a further step towards a new generation of bone implant materials, we developed a procedure for biological functionalization of titanium alloy surfaces with inorganic calcium polyphosphate (Ca-polyP).

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Characterization and evaluation of a femtosecond laser-induced osseointegration and an anti-inflammatory structure generated on a titanium alloy

Regenerative Biomaterials ◽

10.1093/rb/rbab006 ◽

2021 ◽

Vol 8 (2) ◽

Author(s):

Yang Liu ◽

Zhongying Rui ◽

Wei Cheng ◽

Licheng Song ◽

Yunqiang Xu ◽

...

Keyword(s):

Titanium Alloy ◽

Femtosecond Laser ◽

Surface Properties ◽

Cellular Response ◽

Titanium Surface ◽

Macrophage Polarization ◽

Ti Alloy ◽

Bone Implant ◽

Cell Material Interactions ◽

Factor Secretion

Abstract Cell–material interactions during early osseointegration of the bone–implant interface are critical and involve crosstalk between osteoblasts and osteoclasts. The surface properties of titanium implants also play a critical role in cell–material interactions. In this study, femtosecond laser treatment and sandblasting were used to alter the surface morphology, roughness and wettability of a titanium alloy. Osteoblasts and osteoclasts were then cultured on the resulting titanium alloy disks. Four disk groups were tested: a polished titanium alloy (pTi) control; a hydrophilic micro-dislocation titanium alloy (sandblasted Ti (STi)); a hydrophobic nano-mastoid Ti alloy (femtosecond laser-treated Ti (FTi)); and a hydrophilic hierarchical hybrid micro-/nanostructured Ti alloy [femtosecond laser-treated and sandblasted Ti (FSTi)]. The titanium surface treated by the femtosecond laser and sandblasting showed higher biomineralization activity and lower cytotoxicity in simulated body fluid and lactate dehydrogenase assays. Compared to the control surface, the multifunctional titanium surface induced a better cellular response in terms of proliferation, differentiation, mineralization and collagen secretion. Further investigation of macrophage polarization revealed that increased anti-inflammatory factor secretion and decreased proinflammatory factor secretion occurred in the early response of macrophages. Based on the above results, the synergistic effect of the surface properties produced an excellent cellular response at the bone–implant interface, which was mainly reflected by the promotion of early ossteointegration and macrophage polarization.

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Differential fine-tuning of cochlear implant material-cell interactions by femtosecond laser microstructuring

Journal of Biomedical Materials Research Part B Applied Biomaterials ◽

10.1002/jbm.b.31084 ◽

2008 ◽

Vol 87B (1) ◽

pp. 146-153 ◽

Cited By ~ 27

Author(s):

Uta Reich ◽

Peter P. Mueller ◽

Elena Fadeeva ◽

Boris N. Chichkov ◽

Timo Stoever ◽

...

Keyword(s):

Femtosecond Laser ◽

Cochlear Implant ◽

Cell Interactions ◽

Fine Tuning ◽

Implant Material

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The Coating of Bovine-Source Hydroxyapatite on Titanium Alloy (Ti-6Al-4V ELI) Using Electrophoretic Deposition for Biomedical Application

Materials Science Forum ◽

10.4028/www.scientific.net/msf.1000.97 ◽

2020 ◽

Vol 1000 ◽

pp. 97-106

Author(s):

Dian Juliadmi ◽

Nuzul Ficky Nuswantoro ◽

Hidayatul Fajri ◽

Irma Yulia Indriyani ◽

Jon Affi ◽

...

Keyword(s):

Particle Size ◽

Titanium Alloy ◽

Electrophoretic Deposition ◽

Bone Growth ◽

Biomedical Application ◽

Size Variation ◽

Bone Implant ◽

Bioactive Substance ◽

Good Coating ◽

Bone Apatite

Research about the utilization of titanium alloy (Ti-6Al-4V ELI) as implant material in the treatment of orthopedic cases had been increasing. Health problems appear due to the drawbacks of using titanium. The lack of titanium using is bio-inertness characteristic, which decreasing its bioactivity and results in low bone growth and effect for implant failure. The titanium can be modified with coating on the surface using a bioactive substance that is natural-source hydroxyapatite. Bovine-source hydroxyapatite (bovineHA) contains apatite component that is similar to human bone apatite. The coating process was carried out using particle size variation (25 μm, 63 μm, and 125 μm) of bovineHA. The electrophoretic deposition (EPD) method was applied to coat hydroxyapatite with 10 volt for 5 minutes onto the titanium surface. The result showed that different size particles have an effect on coating properties. The coating composed by particle-sized 25 μm has better surface coverage (95.89%), indicating more particle mass (particle weight 6.97x103 μg) attached to surface material, thus resulting thick coating. The good coating characteristic using bovine-source hydroxyapatite with small particle size was expected can be used in biomedical applications due to fulfill the prerequisite of the bone implant.

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Nanocomposites as Bone Implant Material

Springer Handbook of Nanomaterials ◽

10.1007/978-3-642-20595-8_26 ◽

2013 ◽

pp. 941-976 ◽

Cited By ~ 2

Author(s):

Vinod Kumar ◽

Bipul Tripathi ◽

Anchal Srivastava ◽

Preeti S. Saxena

Keyword(s):

Bone Implant ◽

Implant Material

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Real-Time Imaging of Bacteria/Osteoblast Dynamic Coculture on Bone Implant Material in an in Vitro Postoperative Contamination Model

ACS Biomaterials Science & Engineering ◽

10.1021/acsbiomaterials.9b00050 ◽

2019 ◽

Vol 5 (7) ◽

pp. 3260-3269 ◽

Cited By ~ 1

Author(s):

Victor Prévost ◽

Karine Anselme ◽

Olivier Gallet ◽

Mathilde Hindié ◽

Tatiana Petithory ◽

...

Keyword(s):

Real Time ◽

Bone Implant ◽

Real Time Imaging ◽

Implant Material

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Periprosthetic bone response to axial loading following TKR

Multidiscipline Modeling in Materials and Structures ◽

10.1108/mmms-06-2018-0109 ◽

2019 ◽

Vol 16 (2) ◽

pp. 359-372

Author(s):

Ravishanker Baliga ◽

Sharat K. Rao ◽

Raghuvir Pai ◽

Satish B. Shenoy ◽

Atmananda K. Hegde ◽

...

Keyword(s):

Stress Shielding ◽

Axial Loading ◽

Computational Time ◽

System Response ◽

Polyethylene Insert ◽

Bone Implant ◽

Content Type ◽

Implant Material ◽

Bone Response ◽

Implant System

Purpose The purpose of this paper is to investigate by means of finite element analysis (FEA), the effect of polyethylene insert thickness and implant material, under axial loading following TKA. Design/methodology/approach The 3D geometric model of bone was processed using the CT scan data by MIMICS (3matic Inc.), package. Implant components were 3D scanned and subsequently 3D modeled using ANSYS Spaceclaim and meshed in Hypermesh (Altair Hyperworks). The assembled, meshed bone-implant model was then input to ABAQUS for FE simulations, considering axial loading. Findings Polyethylene insert thickness was found to have very little or no significance (p>0.05) on the mechanical performance, namely, stress, strain and stress shielding of bone-implant system. Implant material was found to have a very significant effect (p<0.05) on the performance parameters and greatly reduced the high stress zones up to 60 percent on the tibial flange region and periprosthetic region of tibia. Originality/value Very few FEA studies have been done considering a full bone with heterogeneous material properties, to save computational time. Moreover, four different polyethylene insert thickness with a metal-backed and all-poly tibial tray was considered as the variables affecting the bone-implant system response, under static axial loading. The authors believe that considering a full bone shall lead to more precise outcomes, in terms of the response of bone-implant system, namely, stress, strains and stress shielding in the periprosthetic region, to loading.

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Influence of femtosecond laser on the osteogenetic efficiency of polyetheretherketone and its composite

High Performance Polymers ◽

10.1177/0954008316667460 ◽

2016 ◽

Vol 29 (9) ◽

pp. 997-1005 ◽

Cited By ~ 6

Author(s):

Jing Guo ◽

Lijun Liu ◽

Hong Liu ◽

Kang Gan ◽

Xiuju Liu ◽

...

Keyword(s):

Surface Roughness ◽

Biological Activity ◽

Femtosecond Laser ◽

Femtosecond Lasers ◽

Cone Beam ◽

Test Results ◽

Bone Implant ◽

Peek Composite ◽

Trabecular Bones ◽

Push Out

Objective: This study aimed to evaluate the effect of a femtosecond laser on the osteogenetic efficiency of polyetheretherketone (PEEK) and its composite for clinical applications. Methods: One hundred pieces of PEEK and its composite (6 × 4 × 2 mm3) were randomly divided into four groups and treated as follows: group A1, PEEK; group A2, PEEK + femtosecond laser; group B1, PEEK composite; and group B2, PEEK composite + femtosecond. The surface morphology of the pieces of each group was observed through scanning electron microscopy. The surface roughness and wettability, which were considered as the main parameters affecting cell adhesion characteristics of implants, were measured. The animals whose mandibles were implanted with the four groups of materials were killed at the end of 6 and 12 weeks. Various characterization tests, such as Cone Beam Computed Tomography (CBCT), push-out test, microscope test, and bone implant contact , were conducted to investigate the healing effect between materials and bones. Results: In group B1, the nanoparticles in PEEK were uniformly distributed. In groups A2 and B2, many periodic nanostructures were observed. The surface roughness and wettability of group B2 were significantly increased compared to those of the other groups ( p < 0.05). At each time point, the number of trabecular bones, contact strength, and BIC of group B2 were higher than those of the three other groups ( p < 0.05). Compared with those of group A1, the test results of group B1 were significantly improved. Conclusion: Femtosecond lasers can effectively enhance the biological activity of PEEK and its composite; PEEK composite exhibits better biological activity than PEEK.

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