scholarly journals Timing is everything: Diel metabolic and physiological changes in the diatom Cyclotella cryptica grown in simulated outdoor conditions

2019 ◽  
Vol 42 ◽  
pp. 101598 ◽  
Author(s):  
Olga Gaidarenko ◽  
Corinne Sathoff ◽  
Kenneth Staub ◽  
Michael H. Huesemann ◽  
Maria Vernet ◽  
...  
Keyword(s):  
Physiological Changes ◽  
Cyclotella Cryptica

Inducing Unconscious Stress

2020 ◽  
Vol 34 (3) ◽  
pp. 192-201
Author(s):  
Melanie M. van der Ploeg ◽  
Jos F. Brosschot ◽  
Markus Quirin ◽  
Richard D. Lane ◽  
Bart Verkuil
Keyword(s):  
Repeated Measures ◽  
Activity Patterns ◽  
Physiological Changes ◽  
Implicit Measures ◽  
Prime Word ◽  
Student Sample ◽  
Priming Task ◽  
Subject Design ◽  
The Relationship ◽  
Stress And Health

Abstract. Stress-related stimuli may be presented outside of awareness and may ultimately influence health by causing repetitive increases in physiological parameters, such as blood pressure (BP). In this study, we aimed to corroborate previous studies that demonstrated BP effects of subliminally presented stress-related stimuli. This would add evidence to the hypothesis that unconscious manifestations of stress can affect somatic health. Additionally, we suggest that these findings may be extended by measuring affective changes relating to these physiological changes, using measures for self-reported and implicit positive and negative affectivity. Using a repeated measures between-subject design, we presented either the prime word “angry” ( n = 26) or “relax” ( n = 28) subliminally (17 ms) for 100 trials to a student sample and measured systolic and diastolic BP, heart rate (HR), and affect. The “angry” prime, compared to the “relax” prime, did not affect any of the outcome variables. During the priming task, a higher level of implicit negative affect (INA) was associated with a lower systolic BP and diastolic BP. No association was found with HR. Self-reported affect and implicit positive affect were not related to the cardiovascular (CV) activity. In sum, anger and relax primes elicited similar CV activity patterns, but implicit measures of affect may provide a new method to examine the relationship between (unconscious) stress and health.

Altitude acclimatization: plasma AVP response and physiological changes

2013 ◽  
pp. 1-1
Author(s):  
Meenakshi Sachidhanandam ◽  
Salthan Ashok Kumar ◽  
Som Nath Singh ◽  
UdaySankar Ray
Keyword(s):  
Physiological Changes ◽  
Altitude Acclimatization

Key facts on moderate to severe acute pain combined treatment with tramadol and dexketoprofen at fixed doses

2020 ◽  
Vol 13 (3) ◽  
pp. 304-310
Author(s):  
Jarosław Woroń
Keyword(s):  
Quality Of Life ◽  
Treatment Adherence ◽  
Acute Pain ◽  
Pain Treatment ◽  
Combined Treatment ◽  
Physiological Changes ◽  
Physiological Mechanisms ◽  
Pain Mechanisms ◽  
Proven Efficacy

The development of pain is associated with numerous physiological mechanisms. Improper acute pain treatment significantly reduces the quality of life and leads to a number of physiological changes that adversely affect the general condition of the patient. In many cases, inadequate analgesic therapy results in the transition from acute to chronic pain. For this reason, it is extremely important to use drugs that synergistically affect various pain mechanisms. Combined preparations, including the combination of tramadol and dexketoprofen, are very effective. This combination has many advantages, including proven efficacy and tolerability, ensures better treatment adherence and is easy to administer.

Analisis Penatalaksanaan Fluor Albus Pada Remaja Putri Kelas X Di MA Al-Fatimah Bojonegoro Tahun 2016

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Fela Putri Hariastuti ◽  
Andin Ajeng Rahmawati
Keyword(s):  
Qualitative Research ◽  
Adolescent Girls ◽  
Young Women ◽  
Sexual Development ◽  
Primary Data ◽  
Physiological Changes ◽  
Hormonal Activity ◽  
Research Subjects ◽  
Teenage Girls ◽  
The Central Nervous System

ABSTRAK            Masa remaja mengalami perkembangan fisiologis, psikososial, kognitif, moral dan perkembangan seksual. Perubahan fisiologis pada masa remaja merupakan hasil aktivitas hormonal dibawah pengaruh sistem saraf pusat. Menarche pada umumnya menjadi masalah bagi remaja, hal ini terjadi karena remaja masih belum tahu tentang apa itu menstruasi dan bagaimana menanganinya, sehingga kebersihan daerah genetalia tidak terjaga dan dapat menimbulkan terjadinya keputihan (Soetjiningsih, 2007).            Penelitian ini bertujuan untuk mengetahui penatalaksanaan flour albus pada remaja putri kelas X di SMA AL-Fatimah Bojonegoro tahun 2016. Jenis penelitian ini adalah kualitatif yaitu penelitian expose facto (mengungkap fakta) dengan pendekatan pengukuran secara langsung dengan menggunakan data primer. Subjek penelitian semua remaja putri kelas X yang mengalami keputihan di MA AL- Fatimah Kecamatan Bojonegoro Kabupaten Bojonegoro tahun 2016 yang berjumlah 30 responden.            Hasil penelitian yang didapatkan sebanyak 25 responden remaja putri sudah bisa melaksanakan penatalaksanaan pada flour albus. Kata Kunci : flour albus,  remaja putri ABSTRACT            Adolescence develops physiological, psychosocial, cognitive, moral and sexual development. Physiological changes in adolescence are the result of hormonal activity under the influence of the central nervous system. Menarche is generally a problem for teenagers, this is because teenagers still do not know what menstruation is and how to handle it, so that the cleanliness of the genetalia area is not maintained and can lead to whitish (Soetjiningsih, 2007).This study aims to determine the management of flour albus in adolescent girls of class X in SMA AL-Fatimah Bojonegoro in 2016. The type of this research is qualitative research that is expose facto (revealing fact) with approach of measurement directly by using primary data. Research subjects of all teenage girls of class X who experienced whiteness in MA Al-Fatimah Bojonegoro District Bojonegoro District in 2016, amounting to 30 respondents.The results obtained as many as 25 female teenage respondents have been able to implement management on flour albus. Keywords: flour albus, young women

Quantification of the kinetic differences between communities isolated from completely mixed activated sludge systems operated with or without a selector using a novel respirometric method

1994 ◽  
Vol 30 (11) ◽  
pp. 255-261 ◽  
Author(s):  
Barth F. Smets ◽  
Timothy G. Ellis ◽  
Stephanie Brau ◽  
Richard W. Sanders ◽  
C. P. Leslie Grady
Keyword(s):  
Oxygen Consumption ◽  
Activated Sludge ◽  
Physiological Changes ◽  
Biodegradation Kinetics ◽  
Substrate Removal ◽  
Biomass Yields ◽  
Selection For ◽  
Single Oxygen ◽  
Activated Sludge Systems

This study quantified the kinetic differences in microbial communities isolated from completely mixed activated sludge (CMAS) systems that were operated either with or without an aerobic selector preceding the main reactor. A new respirometric method was employed that allowed the determination of biodegradation kinetics from single oxygen consumption curves, thereby minimizing physiological changes to the examined communities during the assay. Results indicated that increased values for Ks and μmax for acetate, phenol, and 4-chlorophenol degradation were measured in the CMAS system operated with a selector. The biomass yields on acetate, phenol, and 4-chlorophenol were very similar in both systems. These findings indicate that the operation of CMAS systems with aerobic selectors may result in the selection for degrading populations with higher Ks and μmax values for both biogenic and xenobiotic organic compounds, and that substrate storage in the selector only partially contributes to increased substrate removal rates.

Pharmacokinetics, Placental and Breast Milk Transfer of Antiretroviral Drugs in Pregnant and Lactating Women Living with HIV

2019 ◽  
Vol 25 (5) ◽  
pp. 556-576 ◽  
Author(s):  
E.M. Hodel ◽  
C. Marzolini ◽  
C. Waitt ◽  
N. Rakhmanina
Keyword(s):  
Breast Milk ◽  
Protease Inhibitors ◽  
Drug Class ◽  
Drug Transporters ◽  
Maternal Plasma ◽  
Antiretroviral Drugs ◽  
Physiological Changes ◽  
Women Living With Hiv ◽  
Living With Hiv ◽  
In Pregnancy

Background:Remarkable progress has been achieved in the identification of HIV infection in pregnant women and in the prevention of vertical HIV transmission through maternal antiretroviral treatment (ART) and neonatal antiretroviral drug (ARV) prophylaxis in the last two decades. Millions of women globally are receiving combination ART throughout pregnancy and breastfeeding, periods associated with significant biological and physiological changes affecting the pharmacokinetics (PK) and pharmacodynamics (PD) of ARVs. The objective of this review was to summarize currently available knowledge on the PK of ARVs during pregnancy and transport of maternal ARVs through the placenta and into the breast milk. We also summarized main safety considerations for in utero and breast milk ARVs exposures in infants.Methods:We conducted a review of the pharmacological profiles of ARVs in pregnancy and during breastfeeding obtained from published clinical studies. Selected maternal PK studies used a relatively rich sampling approach at each ante- and postnatal sampling time point. For placental and breast milk transport of ARVs, we selected the studies that provided ratios of maternal to the cord (M:C) plasma and breast milk to maternal plasma (M:P) concentrations, respectively.Results:We provide an overview of the physiological changes during pregnancy and their effect on the PK parameters of ARVs by drug class in pregnancy, which were gathered from 45 published studies. The PK changes during pregnancy affect the dosing of several protease inhibitors during pregnancy and limit the use of several ARVs, including three single tablet regimens with integrase inhibitors or protease inhibitors co-formulated with cobicistat due to suboptimal exposures. We further analysed the currently available data on the mechanism of the transport of ARVs from maternal plasma across the placenta and into the breast milk and summarized the effect of pregnancy on placental and of breastfeeding on mammal gland drug transporters, as well as physicochemical properties, C:M and M:P ratios of individual ARVs by drug class. Finally, we discussed the major safety issues of fetal and infant exposure to maternal ARVs.Conclusions:Available pharmacological data provide evidence that physiological changes during pregnancy affect maternal, and consequently, fetal ARV exposure. Limited available data suggest that the expression of drug transporters may vary throughout pregnancy and breastfeeding thereby possibly impacting the amount of ARV crossing the placenta and secreted into the breast milk. The drug transporter’s role in the fetal/child exposure to maternal ARVs needs to be better understood. Our analysis underscores the need for more pharmacological studies with innovative study design, sparse PK sampling, improved study data reporting and PK modelling in pregnant and breastfeeding women living with HIV to optimize their treatment choices and maternal and child health outcomes.

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