Endometrial gene expression of acute phase extracellular matrix components following estrogen disruption of pregnancy in pigs

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Rodney D. Geisert
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Mary E. Zeigler ◽  
Max S. Wicha

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Hanumanth K. Reddy ◽  
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The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis.


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