scholarly journals In situ pPy-modification of chitosan porous membrane from mussel shell as a cardiac patch to repair myocardial infarction

2019 ◽  
Vol 15 ◽  
pp. 87-99 ◽  
Author(s):  
Xiaoping Song ◽  
Jie Mei ◽  
Genlan Ye ◽  
Leyu Wang ◽  
Annada Ananth ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Porous Membrane ◽  
Mussel Shell ◽  
Cardiac Patch

scholarly journals Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dashuai Zhu ◽  
Zhenhua Li ◽  
Ke Huang ◽  
Thomas G. Caranasos ◽  
Joseph S. Rossi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Minimally Invasive ◽  
Porcine Model ◽  
Cardiac Repair ◽  
Pericardial Cavity ◽  
Cardiac Functions ◽  
Induced Pluripotent ◽  
Cardiac Patch

AbstractCardiac patches are an effective way to deliver therapeutics to the heart. However, such procedures are normally invasive and difficult to perform. Here, we develop and test a method to utilize the pericardial cavity as a natural “mold” for in situ cardiac patch formation after intrapericardial injection of therapeutics in biocompatible hydrogels. In rodent models of myocardial infarction, we demonstrate that intrapericardial injection is an effective and safe method to deliver hydrogels containing induced pluripotent stem cells-derived cardiac progenitor cells or mesenchymal stem cells-derived exosomes. After injection, the hydrogels form a cardiac patch-like structure in the pericardial cavity, mitigating immune response and increasing the cardiac retention of the therapeutics. With robust cardiovascular repair and stimulation of epicardium-derived cells, the delivered therapeutics mitigate cardiac remodeling and improve cardiac functions post myocardial infarction. Furthermore, we demonstrate the feasibility of minimally-invasive intrapericardial injection in a clinically-relevant porcine model. Collectively, our study establishes intrapericardial injection as a safe and effective method to deliver therapeutic-bearing hydrogels to the heart for cardiac repair.

Flexible and highly interconnected, multi-scale patterned chitosan porous membrane produced in situ from mussel shell to accelerate wound healing

2017 ◽  
Vol 5 (6) ◽  
pp. 1101-1111 ◽  
Author(s):  
Xiaoping Song ◽  
Jie Mei ◽  
Xingying Zhang ◽  
Leyu Wang ◽  
Gurankit Singh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Porous Membrane ◽  
Full Thickness ◽  
Mussel Shell ◽  
Flexible Membrane ◽  
Accelerate Wound Healing ◽  
Multi Scale ◽  
Full Thickness Wound ◽  
Healing Processes

Mussel shell-derived dressing for full-thickness wound healing. The mussel shell-derived, in situ formed flexible membrane dressing promotes wound healing processes.

scholarly journals Flow Control in Porous Media: From Numerical Analysis to Quantitative μPAD for Ionic Strength Measurements

Sensors ◽  
2021 ◽  
Vol 21 (10) ◽  
pp. 3328
Author(s):  
Pouya Mehrdel ◽  
Hamid Khosravi ◽  
Shadi Karimi ◽  
Joan Antoni López Martínez ◽  
Jasmina Casals-Terré
Keyword(s):  
Porous Media ◽  
Limit Of Detection ◽  
Fluid Dynamic ◽  
Porous Membrane ◽  
External Pressure ◽  
Paper Substrate ◽  
Sensor Performance ◽  
Food Applications ◽  
Substrate Nature

Microfluidic paper-based analytical devices (µPADs) are a promising technology to enable accurate and quantitative in situ assays. Paper’s inherent hydrophilicity drives the fluids without the need for external pressure sources. However, controlling the flow in the porous medium has remained a challenge. This study addresses this problem from the nature of the paper substrate and its design. A computational fluid dynamic model has been developed, which couples the characteristics of the porous media (fiber length, fiber diameter and porosity) to the fluidic performance of the diffusion-based µPAD sensor. The numerical results showed that for a given porous membrane, the diffusion, and therefore the sensor performance is affected not only by the substrate nature but also by the inlets’ orientation. Given a porous substrate, the optimum performance is achieved by the lowest inlets’ angle. A diffusion-based self-referencing colorimetric sensor was built and validated according to the design. The device is able to quantify the hydronium concentration in wines by comparison to 0.1–1.0 M tartaric acid solutions with a 41.3 mM limit of detection. This research showed that by proper adjustments even the simplest µPADs can be used in quantitative assays for agri-food applications.

scholarly journals Recent fabrications and applications of cardiac patch in myocardial infarction treatment

View ◽  
2021 ◽  
pp. 20200153
Author(s):  
Mei Li ◽  
Hao Wu ◽  
Yuehui Yuan ◽  
Benhui Hu ◽  
Ning Gu
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Patch

In Situ Detection of Myocardial Infarction in Pig by Measurements of Aspartate Aminotransferase (ASAT) Activity in the Interstitial Fluid

1997 ◽  
Vol 31 (6) ◽  
pp. 343-349 ◽  
Author(s):  
Charles Kennergren ◽  
Britta Nyström ◽  
Ulla Nyström ◽  
Eva Berglin ◽  
Goran Larssön ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Aspartate Aminotransferase ◽  
Interstitial Fluid ◽  
In Situ Detection

OP-249 MANAGEMENT OF MYOCARDIAL INFARCTION RELATED TO IN-SITU THROMBOSIS

2012 ◽  
Vol 155 ◽  
pp. S64-S65
Author(s):  
A. Çoner ◽  
A. Yildirir ◽  
K. Okyay ◽  
H. Muderrisoglu
Keyword(s):  
Myocardial Infarction

Abstract 212: Fractalkine Neutralization Improves Cardiac Function After Myocardial Infarction

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Xiaosong Gu ◽  
Jiang Xu ◽  
Xiao-Ping Yang ◽  
Edward Peterson ◽  
Pamela Harding
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Function ◽  
Macrophage Infiltration ◽  
Receptor Subtype ◽  
Cross Sectional ◽  
Gelatinase Activity ◽  
Ep4 Receptor ◽  
In Situ Zymography ◽  
Circulating Levels

Background: Circulating levels of the chemokine fractalkine (FKN) are increased in patients with chronic heart failure (HF) and our studies show that aged mice lacking the prostaglandin E2 EP4 receptor subtype (EP4 KO) have increased cardiac FKN coupled with a phenotype of dilated cardiomyopathy. However, whether FKN is a causal factor for HF is not well established. Hypothesis: FKN contributes to the pathogenesis of HF post myocardial infarction (MI) and EP4 KO mice have a better response to anti-FKN treatment due to elevated FKN levels. Methods: Male EP4 KO mice and wild type (WT) littermates underwent surgery to induce MI. Mice were treated with an anti-FKN antibody (40μg/kg/day, ip) or IgG immediately after MI and echocardiography was performed 2 wks post MI. Hearts were excised for infarct size determination, myocyte cross-sectional area (MCSA) and interstitial collagen fraction (ICF) determined by morphometric analysis and macrophage infiltration using immunohistochemistry. Results: Anti-FKN treatment improved cardiac function and prevented remodeling (Table). In situ zymography revealed that gelatinase activity was markedly reduced by anti-FKN treatment in both strains. Moreover, anti-FKN treatment tended to improve survival in EP4 KO mice (p = 0.06, n=20). Conclusions: (1) FKN contributes to the pathogenesis of HF and anti-FKN treatment improves cardiac function and reduces cardiac remodeling. This may be related to reduced macrophage infiltration and decreased gelatinase activity.(2) Contrary to our hypothesis, EP4 KO mice do not have an enhanced response to anti-FKN treatment.

Flexible supercapacitors based on a polyaniline nanowire-infilled 10 nm-diameter carbon nanotube porous membrane by in situ electrochemical polymerization

2016 ◽  
Vol 4 (32) ◽  
pp. 12602-12608 ◽  
Author(s):  
Ranran Wang ◽  
Qiang Wu ◽  
Xiaohua Zhang ◽  
Zhaohui Yang ◽  
Lijun Gao ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nanotube ◽  
Conducting Polymers ◽  
Electrochemical Polymerization ◽  
Porous Membrane ◽  
Flexible Supercapacitors ◽  
Charge Discharge

Nano-confined channels of carbon nanotubes greatly suppress volumetric changes of conducting polymers during cyclic charge–discharge processes, preventing loss of capacitance and degradation of the electrodes.

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