scholarly journals c-MYC-mediated TRIB3/P62+ aggresomes accumulation triggers paraptosis upon the combination of everolimus and ginsenoside Rh2

2021 ◽  
Author(s):  
Min-Xia Su ◽  
Yu-Lian Xu ◽  
Xiao-Ming Jiang ◽  
Mu-Yang Huang ◽  
Le-Le Zhang ◽  
...  
Keyword(s):  
Ginsenoside Rh2

scholarly journals 20(S)-ginsenoside Rh2 inhibits the proliferation and induces the apoptosis of KG-1a cells through the Wnt/β-catenin signaling pathway

2016 ◽  
Vol 36 (1) ◽  
pp. 137-146 ◽  
Author(s):  
YI CHEN ◽  
ZE-HONG LIU ◽  
JING XIA ◽  
XIAO-PENG LI ◽  
KE-QIONG LI ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Ginsenoside Rh2

Advances in Biocatalytic Synthesis, Pharmacological Activities, Pharmaceutical Preparation and Metabolism of Ginsenoside Rh2

2021 ◽  
Vol 21 ◽  
Author(s):  
Li Liu ◽  
Huiyun Wang ◽  
Xiaoyun Chai ◽  
Qingguo Meng ◽  
Sheng Jiang ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Pharmaceutical Preparation ◽  
Ginsenoside Rh2 ◽  
Red Ginseng ◽  
Antitumor Effects ◽  
Pharmacological Activities ◽  
Anti Inflammatory

: Ginsenoside Rh2 (3β-O-Glc-protopanaxadiol), a trace but characteristic pharmacological component of red ginseng, exhibited versatile pharmacological activities, such as antitumor effects, improved cardiac function and fibrosis, anti-inflammatory effects, antibiosis and excellent medicinal potential. In recent years, increased research has been performed on the biocatalytic synthesis of ginsenoside Rh2. In this paper, advances in the biocatalytic synthesis, pharmacological activities, pharmaceutical preparation and metabolism of ginsenoside Rh2 are reviewed.

Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types (Review)

2021 ◽  
Vol 45 (4) ◽  
Author(s):  
Haibo Zhang ◽  
Song Park ◽  
Hai Huang ◽  
Eungyung Kim ◽  
Junkoo Yi ◽  
...  
Keyword(s):  
Ginsenoside Rh2 ◽  
Anticancer Effects ◽  
Cancer Types

Enhancement of oral bioavailability and immune response of Ginsenoside Rh2 by co-administration with piperine

2018 ◽  
Vol 16 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Zhao-Hui JIN ◽  
Wen QIU ◽  
Hui LIU ◽  
Xue-Hua JIANG ◽  
Ling WANG
Keyword(s):  
Immune Response ◽  
Oral Bioavailability ◽  
Ginsenoside Rh2

scholarly journals Antiproliferative Activity of Combined Biochanin A and Ginsenoside Rh2 on MDA-MB-231 and MCF-7 Human Breast Cancer Cells

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2908 ◽  
Author(s):  
Guixing Ren ◽  
Zhenxing Shi ◽  
Cong Teng ◽  
Yang Yao
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Human Breast Cancer ◽  
Synergistic Effects ◽  
Inhibitory Effect ◽  
Biochanin A ◽  
Migration And Invasion ◽  
Ginsenoside Rh2 ◽  
Human Breast ◽  
Mcf 7

Breast cancer is the most frequently diagnosed cancer in women worldwide. The antiproliferative activities of biochanin A (BA) and ginsenoside Rh2 were determined by evaluating their inhibitory effect on MDA-MB-231 human breast cancer cell proliferation. The combination of BA with Rh2 was also assessed. In MDA cells, combination treatment led to a decrease in the EC50 values of BA and Rh2 to 25.20 μM and 22.75 μM, respectively. In MCF-7 cells, the EC50 values of combined BA and Rh2 decreased to 27.68 μM and 25.41 μM, respectively. BA combined with Rh2 also improved the inhibition of MDA-MB-231 and MCF-7 cell migration and invasion compared to the individual compounds. Western blot analysis demonstrated upregulation in p-p53, p-p38, and p-ASK1 proteins while levels of TRAF2 were downregulated. These results suggest that BA combined with Rh2 exhibits synergistic effects against MDA-MB-231 and MCF-7 cell proliferation.

Ginsenoside Rh2 reverses cyclophosphamide‐induced immune deficiency by regulating fatty acid metabolism

2019 ◽  
Vol 106 (5) ◽  
pp. 1089-1100 ◽  
Author(s):  
Ying Qian ◽  
Rongrong Huang ◽  
Senlin Li ◽  
Rui Xie ◽  
Bei Qian ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Ginsenoside Rh2
Sign in / Sign up

Export Citation Format

Share Document