DNT1 Downregulation and Increased Ethanol Sensitivity in Transgenic Drosophila Models of Alzheimer's Disease

2021 ◽  
Vol 94 ◽  
pp. 104355
Author(s):  
Hoda Nikookar ◽  
Mohammad Haddadi ◽  
Mehrnaz Haghi ◽  
Raheleh Masoudi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ethanol Sensitivity ◽  
Transgenic Drosophila ◽  
Drosophila Models

Inhalational Anesthetic Sevoflurane Rescues Retina Function in Alzheimer’s Disease Transgenic Drosophila

2013 ◽  
Vol 10 (9) ◽  
pp. 1005-1014 ◽  
Author(s):  
Chia-Wen Chen ◽  
Wei-Yong Lin ◽  
Kuen-Bao Chen ◽  
Yih-Shyuan Wu ◽  
Yu-Cheng Kuo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Inhalational Anesthetic ◽  
Transgenic Drosophila

scholarly journals Enhanced sleep reverses memory deficits and underlying pathology in drosophila models of Alzheimer's disease

2017 ◽  
Vol 2 ◽  
pp. 15-26 ◽  
Author(s):  
Stephane Dissel ◽  
Markus Klose ◽  
Jeff Donlea ◽  
Lijuan Cao ◽  
Denis English ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Deficits ◽  
Underlying Pathology ◽  
Drosophila Models

scholarly journals Apolipoprotein E-Mimetics Inhibit Neurodegeneration and Restore Cognitive Functions in a Transgenic Drosophila Model of Alzheimer's Disease

PLoS ONE ◽  
2009 ◽  
Vol 4 (12) ◽  
pp. e8191 ◽  
Author(s):  
Svetlana Sarantseva ◽  
Svetlana Timoshenko ◽  
Olga Bolshakova ◽  
Eugenia Karaseva ◽  
Dmitry Rodin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Cognitive Functions ◽  
Model Of Alzheimer’S Disease ◽  
Drosophila Model ◽  
Transgenic Drosophila

Protective Effect of Kaempferol on the Transgenic Drosophila Model of Alzheimer’s Disease

2018 ◽  
Vol 17 (6) ◽  
pp. 421-429 ◽  
Author(s):  
Tanveer Beg ◽  
Smita Jyoti ◽  
Falaq Naz ◽  
Rahul ◽  
Fahad Ali ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Neuronal Damage ◽  
Natural Antioxidants ◽  
Acetylcholinesterase Activity ◽  
Model Of Alzheimer’S Disease ◽  
Climbing Ability ◽  
Transgenic Drosophila

Background: Alzheimer’s disease (AD) is characterized by the accumulation and deposition of β-amyloid peptides leading to a progressive neuronal damage and cell loss. Besides several hypotheses for explaining the neurodegenerative mechanisms, oxidative stress has been considered to be one of them. Till date, there is no cure for AD, but the pathogenesis of the disease could be delayed by the use of natural antioxidants. In this context, we decided to study the effect of kaempferol against the transgenic Drosophila expressing human amyloid beta-42. Method: The AD flies were allowed to feed on the diet having 10, 20, 30 and 40µM of kaempferol for 30 days. After 30 days of exposure, the amyloid beta flies were studied for their climbing ability and Aversive Phototaxis Suppression assay. Amyloid beta flies head homogenate was prepared for estimating the oxidative stress markers, Caspase and acetylcholinesterase activity. Results: The results of the present study reveal that the exposure of AD flies to kaempferol delayed the loss of climbing ability, memory, reduced the oxidative stress and acetylcholinesterase activity. Conclusion: Kaempferol could be used as a possible therapeutic agent against the progression of the Alzheimer’s disease.

Insights from Drosophila models of Alzheimer's disease

2010 ◽  
Vol 38 (4) ◽  
pp. 988-992 ◽  
Author(s):  
Catherine M. Cowan ◽  
David Shepherd ◽  
Amritpal Mudher
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorder ◽  
Protein Tau ◽  
Neurodegenerative Process ◽  
Abnormal Hyperphosphorylation ◽  
Ad Alzheimer’S Disease ◽  
The Relationship ◽  
Shed Light ◽  
Drosophila Models

AD (Alzheimer's disease) is a neurodegenerative disorder characterized by the abnormal hyperphosphorylation and aggregation of the microtubule-associated protein tau and the misfolding and deposition of Aβ peptide. The mechanisms by which tau and Aβ become abnormal is not clearly understood, neither is it known what role either protein plays in the neurodegenerative process underlying AD. We have modelled aspects of AD in Drosophila melanogaster to shed light on these processes and to further our understanding of the relationship between tau and amyloid in this disease.

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