scholarly journals Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities

2020 ◽  
Vol 60 ◽  
pp. 101050 ◽  
Author(s):  
Fedor Galkin ◽  
Polina Mamoshina ◽  
Alex Aliper ◽  
João Pedro de Magalhães ◽  
Vadim N. Gladyshev ◽  
...  
2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Vivian Rowoli Igenewari ◽  
Zakwan Skaf ◽  
Ian K. Jennions

Safety enhancement is a major goal of the aviation industry owing to the predicted increase in air travel. There is also the need to prevent fatalities, increase reliability and reduce monetary costs suffered as a result of delays and accidents that still occur. Accidents today are complex as a result of many causal factors acting alone but more often as a combination with other contributing factors. In tackling this trend, proactive measures have been put in place to find hazardous combinations that occur during flights in order to mitigate them before accidents occur. Flight Anomaly Detection (AD) methods are aimed at highlighting abnormal occurrences of a flight, that are different from the norm. As an improvement on the current state-of-the-art method, previous works have proposed different AD techniques for detection of previously unknown flight risks such as component faults, aircraft operational inefficiencies and some abnormal crew behaviour. However, current AD methods individually have limitations that prevent them from detecting certain significant anomalies in flight data. This paper surveys current flight AD approaches, their strengths and limitations as well as brings to light the benefits of a hybrid AD method to extend previous work and find safety-critical events, particularly those related to abnormal crew activity: a class of events known to amount for a substantial number of accidents/incidents today. It also highlights another emerging AD application opportunity, its challenges and how AD is beneficial in addressing them.


Author(s):  
Lillian J. Ratliff ◽  
Roy Dong ◽  
Shreyas Sekar ◽  
Tanner Fiez

The increasingly tight coupling between humans and system operations in domains ranging from intelligent infrastructure to e-commerce has led to a challenging new class of problems founded on a well-established area of research: incentive design. There is a clear need for a new tool kit for designing mechanisms that help coordinate self-interested parties while avoiding unexpected outcomes in the face of information asymmetries, exogenous uncertainties from dynamic environments, and resource constraints. This article provides a perspective on the current state of the art in incentive design from three core communities—economics, control theory, and machine learning—and highlights interesting avenues for future research at the interface of these domains.


2018 ◽  
Vol 54 (68) ◽  
pp. 9385-9393
Author(s):  
Rosa Arrigo ◽  
Andrew J. Logsdail ◽  
Laura Torrente-Murciano

The 2018 Faraday Discussion on “Designing Nanoparticle Systems for Catalysis” brought together leading scientists to discuss the current state-of-the-art in the fields of computational chemistry, characterization techniques, and nanomaterial synthesis, and to debate the challenges and opportunities going forward for rational catalyst design.


2021 ◽  
Vol 12 ◽  
Author(s):  
Monica Margoni ◽  
Francesca Rinaldi ◽  
Paola Perini ◽  
Paolo Gallo

Treatment of pediatric-onset multiple sclerosis (POMS) has been tailored after observational studies and data obtained from clinical trials in adult-onset multiple sclerosis (AOMS) patients. There are an increasing number of new therapeutic agents for AOMS, and many will be formally studied for use also in POMS. However, there are important efficacy and safety concerns regarding the use of these therapies in children and young adults. This review will discuss the current state of the art of POMS therapy and will focus on the newer therapies (oral and infusion disease-modifying drugs) and on those still currently under investigation.


Electronics ◽  
2021 ◽  
Vol 10 (18) ◽  
pp. 2305
Author(s):  
Iwona Grobelna ◽  
Andrei Karatkevich

Petri nets are a useful mathematical formalism for specification of manufacturing systems, supported by various analysis and verification methods. The progress made in automating control systems and the widespread use of Industry 4.0 pose a number of challenges to their application, starting from the education at university level and ending with modelling of real case studies. The paper aims to present and analyse the most relevant challenges and opportunities related to the use of Petri nets as a modelling technique of manufacturing systems. The review of the literature is primarily based on the years 2019–2020 to reflect the current state of the art. The newest approaches to deadlock prevention and recovering, but also other important analysis problems and difficulties in modelling real industrial processes are discussed. Trends for the future are also identified.


2021 ◽  
Vol 13 (4) ◽  
pp. 1829
Author(s):  
Carlos M. Vallez ◽  
Mario Castro ◽  
David Contreras

Bike-sharing systems (BSS) have raised in popularity in the last years due to their potential share in sustainable cities. Although the first attempts to implement a bike-sharing public service date back to 1965 (Amsterdam), their widespread use arrived with the millennium becoming a vibrant research area whose activity has increased steadily in the last decade. Several authors have attempted to summarize the current state of the art, but the literature on BSS is still scattered in different fields. Thus, there is a lack of literature that summarizes and categorizes the available research on BSS. In this paper, we perform a thorough review of the challenges behind rebalancing in bike-sharing systems. The objectives of this paper are to collect papers on the repositioning problem in dock-based bike-sharing services, classify them and point to novel research venues. We render a keyword analysis in the literature and a timeline that shows the evolution of those keywords throughout the last decade. We also include an exhaustive table that will assist researchers from different disciplines to address the open challenges in the field and to transition towards more sustainable cities.


2014 ◽  
Vol 165 (2) ◽  
pp. 97-135 ◽  
Author(s):  
Kevyn Collins-Thompson

Assessing text readability is a time-honored problem that has even more relevance in today’s information-rich world. This article provides background on how readability of texts is assessed automatically, reviews the current state-of-the-art algorithms in automatic modeling and predicting the reading difficulty of texts, and proposes new challenges and opportunities for future exploration not well-covered by current computational research.


Author(s):  
Mohammad Irfan Bala ◽  
Mohammad Ahsan Chishti

Purpose Fog computing is a new field of research and has emerged as a complement to the cloud which can mitigate the problems inherent to the cloud computing model such as unreliable latency, bandwidth constraints, security and mobility. This paper aims to provide detailed survey in the field of fog computing covering the current state-of-the-art in fog computing. Design/methodology/approach Cloud was developed for IT and not for Internet of Things (IoT); as a result, cloud is unable to meet the computing, storage, control and networking demands of the IoT applications. Fog is a companion for the cloud and aims to extend the cloud capabilities to the edge of the network. Findings Lack of survey papers in the area of fog computing was an important motivational factor for writing this paper. This paper highlights the capabilities of the fog computing and where it fits in between IoT and cloud. This paper has also presented architecture of the fog computing model and its characteristics. Finally, the challenges in the field of fog computing have been discussed in detail which need to be overcome to realize its full potential. Originality/value This paper presents the current state-of-the-art in fog computing. Lack of such papers increases the importance of this paper. It also includes challenges and opportunities in the fog computing and various possible solutions to overcome those challenges.


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