Prominent hypertrophy of perivascular adipocytes due to short-term high fat diet

The aim of this study was to determine the comparative effects of EA (EA) on the CV12, ST36 and ST40 to weight gain prevention over the short-term regulation of energy balance. The study was conducted with a completely randomized design. Rats were divided into five groups: negative control group (no treatment, n=5), positive control (sham EA/back, n=5), EA CV 12 (n=6), EA ST 36 (n=6) and EA ST 40 (n=7). Rats were exposed to high-fat diet for two weeks and EA was simultaneously performed once daily, five days a week for two weeks with 2 Hz, for 10 minutes with continuous wave. Body weight, BMI, front limb circumference and rear were measured during study. Levels of blood glucose, cholesterol, triglycerides, LDL and HDL were measured at the end of the study; which reflects the short-term regulation of energy homeostasis. For weight loss, EA CV12, ST36 and ST40 group have lost weight significantly compared to the negative and positive control group. The ST40 group has a significant decrease than ST36 and CV12. The most significant decrease in BMI found in the ST40 group. EA did not affect blood glucose levels, but modulated blood lipid profile. In ST 40 group there was a significant decrease in cholesterol, LDL and triglycerides. EA at point ST 40 is potential in preventing increased body weight and BMI in rats exposed to high-fat diet compared to the CV 12 and ST 36. ST 40 is a point with a potential of lowering LDL and triglycerides serum so that it can play a role in the short term regulation of energy homeostasis but also in the prevention of dyslipidemia.

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Short Term High Fat Diet Challenge Promotes Alternative Macrophage Polarization in Adipose Tissue via Natural Killer T Cells and Interleukin-4

Journal of Biological Chemistry ◽

10.1074/jbc.m112.371807 ◽

2012 ◽

Vol 287 (29) ◽

pp. 24378-24386 ◽

Cited By ~ 94

Author(s):

Yewei Ji ◽

Shengyi Sun ◽

Sheng Xia ◽

Liu Yang ◽

Xiaoqing Li ◽

...

Keyword(s):

T Cells ◽

Adipose Tissue ◽

Natural Killer ◽

High Fat Diet ◽

Macrophage Polarization ◽

Natural Killer T Cells ◽

Interleukin 4 ◽

High Fat ◽

Short Term ◽

Killer T Cells

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Short-term high-fat diet induces muscle fiber type-selective anabolic resistance to resistance exercise

Journal of Applied Physiology ◽

10.1152/japplphysiol.00889.2020 ◽

2021 ◽

Author(s):

Satoru Ato ◽

Takahiro Mori ◽

Yuki Fujita ◽

Taiga Mishima ◽

Riki Ogasawara

Keyword(s):

Insulin Resistance ◽

Resistance Exercise ◽

High Fat Diet ◽

Muscle Protein ◽

Fiber Type ◽

Type I ◽

High Fat ◽

Short Term ◽

Anabolic Resistance ◽

Mtorc1 Activation

Chronic obesity and insulin resistance are considered to inhibit contraction-induced muscle hypertrophy, through impairment of mTORC1 and muscle protein synthesis (MPS). A high-fat diet is known to rapidly induce obesity and insulin resistance within a month. However, the influence of a short-term high-fat diet on the response of mTORC1 activation and MPS to acute resistance exercise (RE) is unclear. Thus, the purpose of this study was to investigate the effect of a short-term high-fat diet on the response of mTORC1 activation and MPS to acute RE. Male Sprague-Dawley rats were randomly assigned to groups and fed a normal diet (ND), high-fat diet (HFD 4wk), or pair feed (PF 4wk) for 4 weeks. After dietary habituation, acute RE was performed on the gastrocnemius muscle via percutaneous electrical stimulation. The results showed that 4 weeks of a high fat-diet induced intramuscular lipid accumulation and insulin resistance, without affecting basal mTORC1 activity or MPS. The response of RE-induced mTORC1 activation and MPS was not altered by a high-fat diet. On the other hand, analysis of each fiber type demonstrated that response of MPS to an acute RE was disappeared specifically in type I and IIa fiber. These results indicate that a short-term high-fat diet causes anabolic resistance to acute RE, depending on the fiber type.

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