Impairment of spatial working memory and oxidative stress induced by repeated crack cocaine inhalation in rats

IntroductionCurcumin (CUR), a polyphenolic compound, extracted from Curcuma longa, is known for its neuroprotective, antioxidant and anti-inflammatory effects.ObjectivesTo evaluate the effect of CUR on ambulatory activity, spatial working memory and on oxidative stress in rats induced by Diazepam (DZP) administration.AimsTo analyze whether CUR may improve the cognitive performance and offer systemic protection from oxidative stress.MethodsThe effect of CUR on DZP-induced memory impairment and oxidative stress was studied on Wistar rats. Group I received a vehicle, group II – vehicle and CUR, group III – vehicle and DZP, group IV – vehicle, CUR and DZP. CUR (150 mg/kg bw) and vehicle were orally administered for five weeks long. DZP (2 mg/kg bw) was administered i.p. 20 minutes before the behavioral tests. Behavioral tests, i.e. Open Field and Y Maze Test, were performed. Malondialdehyde and reduced glutathione/oxidized glutathione ratio were determined in the serum and brain tissue homogenate. Hippocampal sections were histologically assessed. The data were statistically analyzed by one-way ANOVA, followed by Dunns post-test.ResultsDZP decreased (P < 0.01) the number of spontaneous alternations, as compared to control group, thus suggesting an impairment of spatial working memory. Behavioral tests revealed no enhancing effect of CUR on spontaneous alternation behaviors in Y Maze. CUR reversed (P < 0.01) the inhibitory effect of diazepam (P < 0.05) on the ambulatory activity in OFT and decreased the lipid peroxidation in the serum (P < 0.05).ConclusionsThe results show that CUR may offer systemic protection from oxidative stress, thus improving the cognitive performance.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Effect of Curcumin on Spatial Working Memory and Oxidative Stress Biomarkers in Alloxan-induced Diabetic Swiss Albino Mice

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2017/34411 ◽

2017 ◽

Vol 23 (2) ◽

pp. 1-8

Author(s):

Garkuwa Adamu ◽

Tanko Yusuf ◽

Adamu Yakubu ◽

Alhassan Abdulwahab

Keyword(s):

Oxidative Stress ◽

Working Memory ◽

Spatial Working Memory ◽

Oxidative Stress Biomarkers ◽

Swiss Albino Mice ◽

Stress Biomarkers ◽

Albino Mice ◽

And Oxidative Stress

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Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain

Antioxidants ◽

10.3390/antiox10111710 ◽

2021 ◽

Vol 10 (11) ◽

pp. 1710

Author(s):

Dhondup Namgyal ◽

Sher Ali ◽

Muhammad Delwar Hussain ◽

Mohsin Kazi ◽

Ajaz Ahmad ◽

...

Keyword(s):

Oxidative Stress ◽

Working Memory ◽

Prefrontal Cortex ◽

Neurodegenerative Diseases ◽

Spatial Working Memory ◽

Cellular Mechanisms ◽

Behavioral Impairment ◽

Age Related ◽

The Brain ◽

And Oxidative Stress

Age-related neurodegenerative diseases and vascular dementia are major challenges to the modern health care system. Most neurodegenerative diseases are associated with impaired spatial working memory and anxiety-like behavior. Thus, it is important to understand the underlying cellular mechanisms of neurodegenerative diseases in different regions of the brain to develop an effective therapeutic approach. In our previous research paper, we have reported the ameliorative effect of curcumin in Cd-induced hippocampal neurodegeneration. However, recently many researchers had reported the important role of the prefrontal cortex in higher cognitive functions. Therefore, to look into the cellular mechanism of curcumin protection against Cd-induced prefrontal cortex neurotoxicity, we investigated spatial working memory, anxiety-like behavior and analyzed prefrontal cortex inflammatory markers (IL-6, IL-10, and TNFα), antioxidant enzymes (SOD, GSH, and CAT), and pro-oxidant MDA level. Further, we conducted histological studies of the prefrontal cortex in Swiss albino mice exposed to cadmium (2.5 mg/kg). We observed that curcumin treatment improved the spatial working memory and anxiety-like behavior of mice through reduction of prefrontal cortex neuroinflammation and oxidative stress as well as increasing the number of viable prefrontal cortex neuronal cells. Our result suggests that environmental heavy metal cadmium can induce behavioral impairment in mice through prefrontal cortex cellular inflammation and oxidative stress. We found that curcumin has a potential therapeutic property to mitigate these behavioral and biochemical impairments induced by cadmium.

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Glucagon-like peptide-2 rescues memory impairments and neuropathological changes in a mouse model of dementia induced by the intracerebroventricular administration of streptozotocin

Scientific Reports ◽

10.1038/s41598-019-50167-3 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 3

Author(s):

Sachie Sasaki-Hamada ◽

Masaatsu Ikeda ◽

Jun-Ichiro Oka

Keyword(s):

Oxidative Stress ◽

Working Memory ◽

Memory Impairment ◽

Spatial Working Memory ◽

Thiobarbituric Acid ◽

Intracerebroventricular Administration ◽

Sporadic Alzheimer’S Disease ◽

Memory Impairments ◽

Glucagon Like Peptide ◽

Induced Changes

Abstract Glucagon-like peptide 2 (GLP-2) is derived from the proglucagon gene expressed in the intestines, pancreas and brain. Our previous study showed that GLP-2 improved lipopolysaccharide-induced memory impairments. The current study was designed to further investigated the potential of GLP-2 in memory impairment induced by intracerebroventricular administration of streptozotocin (ICV-STZ) in mice, which have been used as an animal model of sporadic Alzheimer’s disease (AD). STZ was administered on alternate days (Day-1 and Day-3) in order to induce dementia in male ddY mice. ICV-STZ-treated mice were administered GLP-2 (0.6 μg/mouse, ICV) for 5 days from 14 days after the first ICV administration of STZ. In these mice, we examined spatial working memory, the biochemical parameters of oxidative stress, or neurogenesis. The GLP-2 treatment restored spatial working memory in ICV-STZ-treated mice. ICV-STZ-treated mice showed markedly increased thiobarbituric acid reactive species (TBARS) and decreased glutathione (GSH) levels, and GLP-2 significantly restored these ICV-STZ-induced changes. GLP-2 also significantly restored neurogenesis in the subgranular zone of the dentate gyrus in ICV-STZ-treated mice. We herein demonstrated that GLP-2 significantly restored ICV-STZ-induced memory impairments as well as biochemical and histopathological alterations, and accordingly, propose that the memory restorative ability of GLP-2 is due to its potential to reduce oxidative stress.

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Citicoline Improves Human Vigilance and Visual Working Memory: The Role of Neuronal Activation and Oxidative Stress

Basic and Clinical Neuroscience Journal ◽

10.32598/bcn.11.4.1097.1 ◽

2020 ◽

Author(s):

Hayder M. Al-kuraishy ◽

Ali I. Al-Gareeb

Keyword(s):

Oxidative Stress ◽

Working Memory ◽

Visual Working Memory ◽

Neuronal Activation ◽

And Oxidative Stress

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Ampelopsin Improves Cognitive Impairment in Alzheimer’s Disease and Effects of Inflammatory Cytokines and Oxidative Stress in the Hippocampus

Current Alzheimer Research ◽

10.2174/1567205016666191203153447 ◽

2020 ◽

Vol 17 (1) ◽

pp. 44-51 ◽

Cited By ~ 1

Author(s):

Yan Wang ◽

Wei Lv ◽

Yueyang Li ◽

Dandan Liu ◽

Xiuting He ◽

...

Keyword(s):

Oxidative Stress ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Spatial Working Memory ◽

Learning Performance ◽

Signal Pathways ◽

Tnf Α ◽

Cognitive Deficiency ◽

Improved Learning ◽

And Oxidative Stress

Background: Neuroinflammation and oxidative stress have significant effects on cognitive deficiency in the pathophysiological development of Alzheimer’s disease (AD). In the present study, we studied the influences of Ampelopsin (AMP) on proinflammatory cytokines (PICs, IL-1β, IL-6 and TNF-α), and products of oxidative stress 8-isoprostaglandin F2α (8-iso PGF2α, a product of oxidative stress); and 8-hydroxy-2’-deoxyguanosine (8-OHdG, a key biomarker of protein oxidation) in the hippocampus using a rat model of AD. Methods: ELISA was used to examine PICs and oxidative stress production; and western blotting to examine NADPH oxidase (NOXs). The Spatial working memory tests and Morris water maze were utilized to assess cognitive functions. Results: We observed amplification of IL-1β, IL-6 and TNF-α as well as 8-iso PGF2α and 8-OHdG in the hippocampus of AD rats. AMP attenuated upregulation of PICs and oxidative stress production. AMP also inhibited NOX4 in the AD rat hippocampus. Notably, AMP mostly improved learning performance in AD rat and this was linked to signal pathways of PIC and oxidative stress. Conclusion: AMP plays a significant role in improving the memory deficiency in AD rats via inhibition of signal pathways of neuroinflammation and oxidative stress, suggesting that AMP is likely to prospect in preventing and relieving development of the cognitive dysfunctions in AD as a complementary alternative intervention.

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