Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system

A three-dimensional human neuromuscular tissue model that mimics the physically separated structures of motor neurons and skeletal muscle fibers is presented.

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Stretchable micro-scale concentrator photovoltaic module with 15.4% efficiency for three-dimensional curved surfaces

Communications Materials ◽

10.1038/s43246-020-00106-x ◽

2021 ◽

Vol 2 (1) ◽

Author(s):

Daisuke Sato ◽

Taizo Masuda ◽

Kenji Araki ◽

Masafumi Yamaguchi ◽

Kenichi Okumura ◽

...

Keyword(s):

Concentration Ratio ◽

Power Conversion ◽

Three Dimensional ◽

Thin Film Solar Cells ◽

Photovoltaic Module ◽

Silicon Compound ◽

Curved Surfaces ◽

Power Sources ◽

Micro Scale ◽

Module Design

AbstractStretchable photovoltaics are emerging power sources for collapsible electronics, biomedical devices, and buildings and vehicles with curved surfaces. Development of stretchable photovoltaics are crucial to achieve rapid growth of the future photovoltaic market. However, owing to their rigidity, existing thin-film solar cells based predominantly on silicon, compound semiconductors, and perovskites are difficult to apply to 3D curved surfaces, which are potential real-world candidates. Herein, we present a stretchable micro-scale concentrator photovoltaic module with a geometrical concentration ratio of 3.5×. When perfectly fitted on a 3D curved surface with a sharp curvature, the prototype module achieves an outdoor power conversion efficiency of 15.4% and the daily generated electricity yield improves to a maximum of 190% relative to a non-concentration stretchable photovoltaic module. Thus, this module design enables high areal coverage on 3D curved surfaces, while generating a higher electricity yield in a limited installation area.

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Application of combined three-dimensional bone and soft tissue model

International Journal of Oral and Maxillofacial Surgery ◽

10.1016/s0901-5027(98)80043-x ◽

1998 ◽

Vol 27 (6) ◽

pp. 482-484 ◽

Cited By ~ 1

Author(s):

Gert Santler ◽

Hans Kaercher ◽

Alexander Gaggl ◽

Guenter Schultes

Keyword(s):

Soft Tissue ◽

Three Dimensional ◽

Tissue Model

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Evaluation of photodynamic therapy efficiency using an in vitro three-dimensional microfluidic breast cancer tissue model

Lab on a Chip ◽

10.1039/c4lc01065e ◽

2015 ◽

Vol 15 (3) ◽

pp. 735-744 ◽

Cited By ~ 52

Author(s):

Yamin Yang ◽

Xiaochuan Yang ◽

Jin Zou ◽

Chao Jia ◽

Yue Hu ◽

...

Keyword(s):

Breast Cancer ◽

Gold Nanoparticles ◽

Photodynamic Therapy ◽

Three Dimensional ◽

Therapeutic Agents ◽

Breast Cancer Tissue ◽

Cancer Tissue ◽

Tissue Model

A microfluidic-based in vitro three-dimensional (3D) breast cancer tissue model was established for determining the efficiency of photodynamic therapy (PDT) with therapeutic agents (photosensitizer and gold nanoparticles) under various irradiation conditions.

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Three-dimensional tissue model in direct contact with an on-chip vascular bed enabled by removable membranes

Lab on a Chip ◽

10.1039/d1lc00751c ◽

2022 ◽

Author(s):

Yoshikazu Kameda ◽

Surachada Chuaychob ◽

Miwa Tanaka ◽

Yang Liu ◽

Ryu Okada ◽

...

Keyword(s):

Tissue Culture ◽

Direct Contact ◽

Three Dimensional ◽

Culture Period ◽

Tissue Model ◽

Vascular Bed ◽

On Chip

Three-dimensional (3D) tissue culture is a powerful tool for understanding physiological events. However, 3D tissues still have limitations in their size, culture period, and maturity, which are caused by the...

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Investigation of a Three-Dimensional Micro-Scale Sensing System Based on a Tapered Self-Assembly Four-Cores Fiber Bragg Grating Probe

Sensors ◽

10.3390/s18092824 ◽

2018 ◽

Vol 18 (9) ◽

pp. 2824 ◽

Cited By ~ 1

Author(s):

Kunpeng Feng ◽

Jiwen Cui ◽

Xun Sun ◽

Hong Dang ◽

Tangjun Shi ◽

...

Keyword(s):

Fiber Bragg Grating ◽

Self Assembly ◽

Three Dimensional ◽

Critical Length ◽

Bragg Grating ◽

Manufacturing Method ◽

Micro Scale ◽

Sensing Model ◽

Shift Point ◽

Better Than

Three-dimensional micro-scale sensors are in high demand in the fields of metrology, precision manufacturing and industry inspection. To extend the minimum measurable dimension and enhance the accuracy, a tapered four-cores fiber Bragg grating (FBG) probe is proposed. The sensing model is built to investigate the micro-scale sensing characteristics of this method and the design of the tapered stylus is found to influence the accuracy. Therefore, a π/2 phase-shift point is introduced into the FBGs comprised in the probe to suppress spectrum distortion and improve accuracy. Then, the manufacturing method based on capillary self-assembly is proposed to form the probe and the critical length to form a square array for four cylindrical fibers is verified to be effective for the tapered fibers. Experimental results indicate that the design of the tapered stylus can extend the minimum measurable dimension by twofold and has nearly no influence on its sensitivity. The three-dimensional measurement repeatability is better than 31.1 nm and the stability is better than 200 nm within once measuring process. Furthermore, the measurement precision of the three-dimensional micro-scale measurement results is less than 150 nm. It would be widely used in measuring micro-scale features for industry inspection or metrology.

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On the Two-Scale Modelling of Elastohydrodynamic Lubrication in Tilted-Pad Bearings

Lubricants ◽

10.3390/lubricants6030078 ◽

2018 ◽

Vol 6 (3) ◽

pp. 78 ◽

Cited By ~ 3

Author(s):

Gregory de Boer ◽

Andreas Almqvist

Keyword(s):

Surface Topography ◽

Load Capacity ◽

Three Dimensional ◽

Elastohydrodynamic Lubrication ◽

Multiscale Methods ◽

Operating Conditions ◽

Real Surface ◽

Micro Scale ◽

Macro Scale ◽

Heterogeneous Multiscale

A two-scale method for modelling the Elastohydrodynamic Lubrication (EHL) of tilted-pad bearings is derived and a range of solutions are presented. The method is developed from previous publications and is based on the Heterogeneous Multiscale Methods (HMM). It facilitates, by means of homogenization, incorporating the effects of surface topography in the analysis of tilted-pad bearings. New to this article is the investigation of three-dimensional bearings, including the effects of both ideal and real surface topographies, micro-cavitation, and the metamodeling procedure used in coupling the problem scales. Solutions for smooth bearing surfaces, and under pure hydrodynamic operating conditions, obtained with the present two-scale EHL model, demonstrate equivalence to those obtained from well-established homogenization methods. Solutions obtained for elastohydrodynamic operating conditions, show a dependency of the solution to the pad thickness and load capacity of the bearing. More precisely, the response for the real surface topography was found to be stiffer in comparison to the ideal. Micro-scale results demonstrate periodicity of the flow and surface topography and this is consistent with the requirements of the HMM. The means of selecting micro-scale simulations based on intermediate macro-scale solutions, in the metamodeling approach, was developed for larger dimensionality and subsequent calibration. An analysis of the present metamodeling approach indicates improved performance in comparison to previous studies.

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Effects of Shiga Toxin Type 2 on a Bioengineered Three-Dimensional Model of Human Renal Tissue

Infection and Immunity ◽

10.1128/iai.02143-14 ◽

2014 ◽

Vol 83 (1) ◽

pp. 28-38 ◽

Cited By ~ 10

Author(s):

Teresa M. DesRochers ◽

Erica Palma Kimmerling ◽

Dakshina M. Jandhyala ◽

Wassim El-Jouni ◽

Jing Zhou ◽

...

Keyword(s):

Cell Culture ◽

Renal Failure ◽

Shiga Toxin ◽

Three Dimensional ◽

Kidney Injury ◽

Renal Tissue ◽

Three Dimensional Model ◽

Drug Induced ◽

Tissue Model

Shiga toxins (Stx) are a family of cytotoxic proteins that can cause hemolytic-uremic syndrome (HUS), a thrombotic microangiopathy, following infections by Shiga toxin-producingEscherichia coli(STEC). Renal failure is a key feature of HUS and a major cause of childhood renal failure worldwide. There are currently no specific therapies for STEC-associated HUS, and the mechanism of Stx-induced renal injury is not well understood primarily due to a lack of fully representative animal models and an inability to monitor disease progression on a molecular or cellular level in humans at early stages. Three-dimensional (3D) tissue models have been shown to be morein vivo-like in their phenotype and physiology than 2D cultures for numerous disease models, including cancer and polycystic kidney disease. It is unknown whether exposure of a 3D renal tissue model to Stx will yield a morein vivo-like response than 2D cell culture. In this study, we characterized Stx2-mediated cytotoxicity in a bioengineered 3D human renal tissue model previously shown to be a predictor of drug-induced nephrotoxicity and compared its response to Stx2 exposure in 2D cell culture. Our results demonstrate that although many mechanistic aspects of cytotoxicity were similar between 3D and 2D, treatment of the 3D tissues with Stx resulted in an elevated secretion of the kidney injury marker 1 (Kim-1) and the cytokine interleukin-8 compared to the 2D cell cultures. This study represents the first application of 3D tissues for the study of Stx-mediated kidney injury.

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