scholarly journals Is there a rational basis for cannabinoids research and development in ocular pain therapy? A systematic review of preclinical evidence

2022 ◽  
Vol 146 ◽  
pp. 112505
Author(s):  
D. Scuteri ◽  
L. Rombolà ◽  
K. Hamamura ◽  
T. Sakurada ◽  
C. Watanabe ◽  
...  
Keyword(s):  
Systematic Review ◽  
Research And Development ◽  
Pain Therapy ◽  
Rational Basis ◽  
Ocular Pain

scholarly journals Botanical biopesticides: research and development trends, a focus on the Annonaceae family

2019 ◽  
Vol 13 (3) ◽  
pp. 371-383
Author(s):  
Ana Isabel Giraldo-Rivera ◽  
Gloria-Edith Guerrero-Alvarez
Keyword(s):  
Public Health ◽  
Systematic Review ◽  
Research And Development ◽  
Plant Extracts ◽  
Subsequent Development ◽  
Review Of The Literature ◽  
Development Trends ◽  
Market Trends ◽  
Pesticide Regulation ◽  
Botanical Extracts

This document analyzed research and development trends related to chemical, biological and economical biopesticides based on plant extracts, with emphasis on the Annonaceae family. A systematic review of the literature between 1947 and 2018 was done with an advance search equation in a specialized data base. This paper contains the development of plant bio pesticides, their modes of action, the more prominent families according to their bioactivity and the secondary metabolites that exert control over pests that are significant in agriculture and public health. The dynamics of publications, at the national and international levels, were identified, along with the countries that lead research, patents assigned in the last 20 years, market trends and bio pesticide regulation. The reviewed research is relevant to bioprospecting plant extracts with potential insecticidal activity and to the subsequent development of biocides using botanical extracts; the Annonaceae family is promising.

scholarly journals A systematic review of analgesia practices in dogs undergoing ovariohysterectomy

2018 ◽  
pp. 1725-1735 ◽  
Author(s):  
Willy E. Mwangi ◽  
Eddy M. Mogoa ◽  
James N. Mwangi ◽  
Paul G. Mbuthia ◽  
Susan W. Mbugua
Keyword(s):  
Systematic Review ◽  
Drug Therapy ◽  
Pain Management ◽  
Drug Administration ◽  
Pain Therapy ◽  
Rescue Analgesia ◽  
Analgesic Drugs ◽  
Manual Search ◽  
Post Operative Pain ◽  
Before And After

Aim: This was a systematic review conducted to evaluate the analgesic drugs and techniques used in the management of pain in dogs undergoing ovariohysterectomy. Materials and Methods: Systematic searches in PubMed, Google Scholar, and ScienceDirect were conducted for peer-reviewed articles written in English and published from 1995 to 2015. The key search words were dogs, ovariohysterectomy, pain, and analgesics. This was followed by a manual search of the references within the primary data sources. Inclusion and exclusion of studies and data extraction were performed independently by two reviewers. All randomized studies evaluating the effects of analgesics during ovariohysterectomy in dogs were included. Results: A total of 31 trials met the criteria and were, therefore, included in the study. Data on the type of analgesic drugs used, the technique of administration, and the need for rescue analgesia were extracted from the papers. Individual analgesic protocols were used in 83.9% of the studies compared to multimodal drug therapy, which was used in 16.1% of the studies. Opioids were used in 39.0% of studies, nonsteroidal anti-inflammatory drugs (NSAIDs) in 19.4%, a combination of NSAIDs and opioids in 19.4%, local analgesics in 6.5%, and acupuncture in 3.2% of the studies. Drug administration was done using three approaches that included pre-operative (64.5%), post-operative (22.6%) as well as combined pre- and post-operative approach (12.9%). In 77.4% of the studies, administration of analgesics was done once, while in 12.9%, it was done as a 72-h post-operative course. 24-h and 48-h courses of post-operative pain therapy were done in 6.5% and 3.2% of the studies, respectively. About 57% of the dogs in the control groups required rescue analgesia as compared to 21.6% in the single and 11.3% in multimodal drug therapy groups. The requirement for rescue analgesics was highest in dogs treated using acupuncture (43.8%) and lowest in dogs treated using NSAID-opioid combination (8.6%). Fewer dogs among those that received pain medication preoperatively and postoperatively required rescue analgesia compared to those in groups given drugs before and after surgery only. More dogs (26.4%) among those given analgesics only once postoperatively required rescue analgesia as compared to those that received analgesics daily for 72 h (4.4%). Conclusions: This study provides evidence that opioids are the mainstream analgesic drugs used in managing acute post-operative pain in dogs' post-ovariohysterectomy. In addition, multimodal drug therapy, particularly, NSAID-opioids combination is more effective for pain management than single drug administration. Administering analgesics both before and after surgery is associated with better outcomes and so is a protracted course of post-operative pain therapy. Although these practices should be encouraged, controlled studies should be conducted to conclusively determine the best practices for pain management in dogs undergoing ovariohysterectomy.

Improvement on upper limb body-powered prostheses (1921–2016): A systematic review

2017 ◽  
Vol 232 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Nur Afiqah Hashim ◽  
Nasrul Anuar Abd Razak ◽  
Noor Azuan Abu Osman ◽  
Hossein Gholizadeh
Keyword(s):  
Systematic Review ◽  
Research And Development ◽  
Upper Limb ◽  
Web Of Science ◽  
Proprioceptive Feedback ◽  
Electronic Database ◽  
Design And Development ◽  
Work Related ◽  
Rehabilitation Research ◽  
The Web

Body-powered prostheses are known for their advantages of cost, reliability, training period, maintenance, and proprioceptive feedback. This study primarily aims to analyze the work related to the improvement of upper limb body-powered prostheses prior to 2016. A systematic review conducted via the search of the Web of Science electronic database, Google Scholar, and Google Patents identified 155 papers from 1921 to 2016. Sackett’s initial rules of evidence were used to determine the levels of evidence, and only papers categorized in the design and development category and patents were analyzed. A total of 40 papers in the sixth level of “Design and Development” of an upper limb body-powered prosthesis were found. Approximately 81% were categorized under mechanical alteration. Most papers were patent-type documents (48%), with the Journal of Rehabilitation Research and Development publishing most of the articles related to the design and development of body-powered prostheses. Papers in the scope of the study were published once every 3 years in almost a century, proving that only a few studies were conducted to improve body-powered arms compared with myoelectric technology. Further research should be carried out mainly in areas that have received less attention.

Which electronic health record system should we use? - a systematic review (Preprint)

2020 ◽  
Author(s):  
Vanash Patel ◽  
George Garas ◽  
James Hollingshead ◽  
Drostan Cheetham ◽  
Thanos Athanasiou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Electronic Health Records ◽  
Research And Development ◽  
User Satisfaction ◽  
Electronic Records ◽  
Published Data ◽  
Health Records ◽  
Electronic Health ◽  
And Performance ◽  
The Uk

BACKGROUND Electronic health records are digital records of a patient’s health and care. At present in the UK, patients may have several paper and electronic records stored in various settings. The UK government, via NHS England, intends to introduce a comprehensive system of electronic health records in England by 2020. These electronic records will run across primary, secondary and social care linking all data in a single digital platform. OBJECTIVE This is the first systematic review to look at all published data on EHRs to determine which systems are advantageous. METHODS Design: A systematic review was performed by searching EMBASE and Ovid MEDLINE between 1974 and November 2019. Participants: All original studies that appraised EHR systems were included. Main outcome measures: EHR system comparison, implementation, user satisfaction, efficiency and performance, documentation, and research and development. RESULTS The search strategy identified 701 studies, which were filtered down to 46 relevant studies. Level of evidence ranged from 1 to 4 according to the Oxford Centre for Evidence-based Medicine. The majority of the studies were performed in the USA (n = 44). N=6 studies compared more than one EHR, and Epic followed by Cerner were the most favourable through direct comparison. N=17 studies evaluated implementation which highlighted that it was challenging, and productivity dipped in the early phase. N=5 studies reflected on user satisfaction, with women demonstrating higher satisfaction than men. Efficiency and performance issues were the driving force behind user dissatisfaction. N=26 studies addressed efficiency and performance, which improved with long-term use and familiarity. N=18 studies considered documentation and showed that EHRs had a positive impact with basic and speciality tasks. N=29 studies assessed research and development which revealed vast capabilities and positive implications. CONCLUSIONS Epic is the most studied EHR system and the most commonly used vendor on the market. There is limited comparative data between EHR vendors, so it is difficult to assess which is the most advantageous system.

scholarly journals Dimensions of teachers’ transdisciplinary competence based on a systematic review of three transdisciplinary areas

2020 ◽  
Vol 4 (3-4) ◽  
pp. 117-138
Author(s):  
Bjørn Smestad ◽  
Astrid Gillespie
Keyword(s):  
Systematic Review ◽  
Research And Development ◽  
Professional Competence ◽  
Blind Spot ◽  
Research Literature ◽  
Deficit Thinking ◽  
Digital Competence ◽  
Knowledge And Skills ◽  
Diversity Competence ◽  
Being And Becoming

This study contributes to the conceptualisation of teachers’ competence through a systematic review (a concept synthesis) of three key transdisciplinary competencies—teachers’ diversity competence, teachers’ research and development competence, and teachers’ digital competence. Based on our analysis, we propose a set of dimensions to consider—within which there were important tensions in the research literature reviewed—when discussing teachers’ professional competence. These dimensions are: the 1) beneficiary, 2) teachers’ role, 3) attitudes, knowledge and skills, 4) sources of competence, 5) relationship to disciplinary content and 6) assessment. We discuss the three areas in light of these dimensions. We suggest that the complexity of being and becoming a teacher is a blind spot in research on teachers’ transdisciplinary competence and that many articles show deficit thinking about teachers.

scholarly journals Indian contribution toward biomedical research and development in COVID-19: A systematic review

2021 ◽  
Vol 53 (1) ◽  
pp. 63
Author(s):  
Bikash Medhi ◽  
Hardeep Kaur ◽  
Manpreet Kaur ◽  
Anusuya Bhattacharyya ◽  
Manisha Prajapat ◽  
...  
Keyword(s):  
Systematic Review ◽  
Research And Development ◽  
Biomedical Research ◽  
Indian Contribution

scholarly journals Which electronic health record system should we use? – a systematic review

2020 ◽  
Author(s):  
Mohammed Al Ani ◽  
George Garas ◽  
James Hollingshead ◽  
Drostan Cheetham ◽  
Thanos Athanasiou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Research And Development ◽  
User Satisfaction ◽  
Positive Impact ◽  
Published Data ◽  
Level Of Evidence ◽  
Record System ◽  
Ovid Medline ◽  
The Usa ◽  
And Performance

ABSTRACTObjectivesThis is the first systematic review to look at all published data on EHRs to determine which systems are advantageous.DesignA systematic review was performed by searching EMBASE and Ovid MEDLINE between 1974 and November 2019.ParticipantsAll original studies that appraised EHR systems were included.Main outcome measuresEHR system comparison, implementation, user satisfaction, efficiency and performance, documentation, and research and development.ResultsThe search strategy identified 701 studies, which were filtered down to 46 relevant studies. Level of evidence ranged from 1 to 4 according to the Oxford Centre for Evidence-based Medicine. The majority of the studies were performed in the USA (n = 44). N=6 studies compared more than one EHR, and Epic followed by Cerner were the most favourable through direct comparison. N=17 studies evaluated implementation which highlighted that it was challenging, and productivity dipped in the early phase. N=5 studies reflected on user satisfaction, with women demonstrating higher satisfaction than men. Efficiency and performance issues were the driving force behind user dissatisfaction. N=26 studies addressed efficiency and performance, which improved with long-term use and familiarity. N=18 studies considered documentation and showed that EHRs had a positive impact with basic and speciality tasks. N=29 studies assessed research and development which revealed vast capabilities and positive implications.ConclusionEpic is the most studied EHR system and the most commonly used vendor on the market. There is limited comparative data between EHR vendors, so it is difficult to assess which is the most advantageous system.

scholarly journals Microwave Planar Resonant Solutions for Glucose Concentration Sensing: A Systematic Review

2021 ◽  
Vol 11 (15) ◽  
pp. 7018
Author(s):  
Carlos G. Juan ◽  
Benjamin Potelon ◽  
Cédric Quendo ◽  
Enrique Bronchalo
Keyword(s):  
Systematic Review ◽  
Dielectric Properties ◽  
Research And Development ◽  
Glucose Concentration ◽  
Relative Sensitivity ◽  
Scientific Activity ◽  
Glucose Content ◽  
Resonant Sensors ◽  
Key Points ◽  
Potential Applications

The measurement of glucose concentration finds interesting potential applications in both industry and biomedical contexts. Among the proposed solutions, the use of microwave planar resonant sensors has led to remarkable scientific activity during the last years. These sensors rely on the changes in the dielectric properties of the medium due to variations in the glucose concentration. These devices show electrical responses dependent on the surrounding dielectric properties, and therefore the changes in their response can be related to variations in the glucose content. This work shows an up-to-date review of this sensing approach after more than one decade of research and development. The attempts involved are sorted by the sensing parameter, and the computation of a common relative sensitivity to glucose is proposed as general comparison tool. The manuscript also discusses the key points of each sensor category and the possible future lines and challenges of the sensing approach.

A systematic review of the outcomes reported in multimodal pain therapy for chronic pain

2015 ◽  
Vol 20 (1) ◽  
pp. 51-63 ◽  
Author(s):  
S. Deckert ◽  
U. Kaiser ◽  
C. Kopkow ◽  
F. Trautmann ◽  
R. Sabatowski ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Pain ◽  
Pain Therapy ◽  
Multimodal Pain Therapy
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