scholarly journals Physiological changes due to hepatotoxicity and the protective role of some medicinal plants

2016 ◽  
Vol 5 (2) ◽  
pp. 134-146 ◽  
Author(s):  
Howida S. Abou Seif
Author(s):  
Eshita Sharma ◽  
Tapan Behl ◽  
Monika Sachdeva ◽  
Rashita Makkar ◽  
Sandeep Arora

Medicinal plants play a beneficial role in health care and are commonly used in preventing and testing diseases and specific ailments. The advantage associated with herbals plants are numerous and cannot be ignored as they have less adherence issues and are accepted widely by the population due to greater belief in Ayurveda since ancient times. Neuropathic pain has immersed as a serious threat to patient that occurs by damaging the blood vessels leading to morbidity and mortality. The present review paper aims in providing an account of various herbal plants that could be employed in treatment of neuropathic pain.


2021 ◽  
Vol 36 (2) ◽  
pp. 167-174
Author(s):  
Nura I. Al-Zail

Vinyl cyanide (VCN) is an aliphatic nitrile product which is extensively used in various synthetic chemical industries. VCN is known to exert toxic actions to human beings as well as experimental animals. The present study was designed to examine the ability of β-cryptoxanthin, a naturally occurring antioxidant, to attenuate VCN-induced testicular toxicity in adult albino rats. Daily oral administration of VCN at a dose level of 30 mg/kg b.w. (7.2mg/ animal) to male rats for a period of 5 days significantly reduced the levels of serum testosterone (T), androsterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) which indicates injury to the testis function. Compared to VCN-treated animals, pretreatment with β-cryptoxanthin and its co-administration with VCN once daily at a dose of 40 mg/kg b.w. (9.6mg/ animal) for 30 days induced a remarkable degree of improvement in the levels of endocrine parameters including T, androsterone, FSH and LH. In conclusion, the present results clearly demonstrate the protective role of β-cryptoxanthin against VCN-induced physiological changes in the testis of rats.


2020 ◽  
Vol 134 (1) ◽  
pp. 71-72
Author(s):  
Naseer Ahmed ◽  
Masooma Naseem ◽  
Javeria Farooq

Abstract Recently, we have read with great interest the article published by Ibarrola et al. (Clin. Sci. (Lond.) (2018) 132, 1471–1485), which used proteomics and immunodetection methods to show that Galectin-3 (Gal-3) down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. Authors concluded that ‘antioxidant activity of Prx-4 had been identified as a protein down-regulated by Gal-3. Moreover, Gal-3 induced a decrease in total antioxidant capacity which resulted in a consequent increase in peroxide levels and oxidative stress markers in cardiac fibroblasts.’ We would like to point out some results stated in the article that need further investigation and more detailed discussion to clarify certain factors involved in the protective role of Prx-4 in heart failure.


2015 ◽  
Vol 36 (3) ◽  
pp. 170-176 ◽  
Author(s):  
Erin N. Stevens ◽  
Joseph R. Bardeen ◽  
Kyle W. Murdock

Parenting behaviors – specifically behaviors characterized by high control, intrusiveness, rejection, and overprotection – and effortful control have each been implicated in the development of anxiety pathology. However, little research has examined the protective role of effortful control in the relation between parenting and anxiety symptoms, specifically among adults. Thus, we sought to explore the unique and interactive effects of parenting and effortful control on anxiety among adults (N = 162). Results suggest that effortful control uniquely contributes to anxiety symptoms above and beyond that of any parenting behavior. Furthermore, effortful control acted as a moderator of the relationship between parental overprotection and anxiety, such that overprotection is associated with anxiety only in individuals with lower levels of effortful control. Implications for potential prevention and intervention efforts which specifically target effortful control are discussed. These findings underscore the importance of considering individual differences in self-regulatory abilities when examining associations between putative early-life risk factors, such as parenting, and anxiety symptoms.


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