scholarly journals A short survey of dengue protease inhibitor development in the past 6 years (2015–2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases

2021 ◽  
Vol 49 ◽  
pp. 116415
Author(s):  
Sheikh Murtuja ◽  
Deepak Shilkar ◽  
Biswatrish Sarkar ◽  
Barij Nayan Sinha ◽  
Venkatesan Jayaprakash
Adeptus ◽  
2013 ◽  
pp. 83-96
Author(s):  
Justyna Michniuk

Lusatia from the inside – a society through the eyes of Sorbian teachers, artists and politicians. A short survey based on research conducted in Bautzen and the surrounding area in November 2011Lusatia is a region in the heart of Europe. The Sorbs – a West Slavic nation, people who have lived in Lusatia for more than 1000 years, is not one homogeneous nation, but is divided into Upper and Lower Sorbs, with two dissimilar languages, two religions and two mentalities. I decided to rediscover Lusatia and talk with the people who are Sorbs. A one month stay in Bautzen was possible thanks to financial and scientific support from the Sorbian Institute (Serbski institut / Sorbisches Institut). Examining the past and current situation of the people in Lower and Upper Lusatia, I focused on their language, history and culture. In my studies I did not want to show the external image of the Sorbs, I did not try to create it either. All I wanted was to find out from the Sorbs themselves from which ‘elements’ does their individual identity originate. I was also interested to discover if Sorbs, as the smallest Slavic nation without their own country, feel more connected to a Sorbian origin, or perhaps to German citizenship.


2013 ◽  
Vol 1 (1) ◽  
pp. 17-22
Author(s):  
Anica Phillott

Abstract This study examined the perception of the quality of life in a small group of boys (aged 8-15) who have severe haemophilia and have also developed inhibitors and their parents. The study design was a qualitative research methodology using a phenomenology theory approach in order to gain perspectives from participants in a series of semi-structured interviews. The study showed that inhibitor development had an impact on the perceived quality of life of these boys and their families and in so doing threatened the coping mechanisms that had worked effectively for them in the past. Although there is adequate awareness among haemophilia treaters of the psychosocial impact of inhibitor development on family life, this may not always be seen as a priority when managing these boys. The study also identified gaps in the published evidence as well as scope for future study. Commentary, J Haem Pract 2014;1(1):23.


2017 ◽  
Vol 32 (31) ◽  
pp. 1730024 ◽  
Author(s):  
Peter Koch ◽  
Berndt Müller ◽  
Johann Rafelski

This is a short survey of signatures and characteristics of the quark–gluon plasma in the light of experimental results that have been obtained over the past three decades. In particular, we present an in-depth discussion of the strangeness observable, including a chronology of the experimental effort to detect QGP at CERN-SPS, BNL-RHIC, and CERN-LHC.


1987 ◽  
Vol 43 (1/2) ◽  
pp. 99-120
Author(s):  
D. J.C. Van Wyk

The missionary work of the Nederduitsch Hervormde Kerk van Afrika in theory and practice: in the past, present and futureIn this article a short survey is given of the missionary work, both in theory and practice, of the Nederduitsch Hervormde Kerk during the last fifty years. There is also an indication that the Church has reached a crucial point which is going to require thorough rethinking and reconsideration of our missionary work.


1933 ◽  
Vol 79 (327) ◽  
pp. 746-752
Author(s):  
Joan West

The use of occupational therapy in mental or physical illness, as an adjunct to medical treatment, has developed rapidly during the past twelve years. As definitions often prove a snare to the uninitiated, and as no comprehensive phrase has been coined for this scientifically applied activity, it seems advisable to give a short survey—based largely on experience gained in the United States—of the manner and degree in which this therapy is contributing to the recovery of the sick to-day.


2014 ◽  
Vol 39 (01) ◽  
pp. 226-233
Author(s):  
Christopher Tomlins

Intended as a short survey text, Kitty Calavita's Invitation to Law & Society expertly summarizes many of the central themes of law and society scholarship as they have developed over the past fifty years. It also clearly identifies the field's object of attention: “real” law. I use this commentary on the book as an opportunity to assess the field as it enters its sixth decade. How has the field changed? What are its defining characteristics? What is “real” law? Does law and society research have a future?


1872 ◽  
Vol 18 (83) ◽  
pp. 397-414
Author(s):  
Henry Maudsley

In beginning the work of this Section, over which I have the honour to preside, I shall confine myself to a few introductory remarks of a general character, leaving to those who will come after me the more exact scientific work of which we have fair promise in the papers that are to be read. The occasion seems fitting to take a short survey of the position of medical psychology in relation to certain important questions of the day, and to consider the bearing which its progress must eventually have upon them. Permit me, then, to ask you, first, to look back a little way at what medical psychology was, in order the better to realise what it is, and, if possible, to forecast something of the character of its future work. A glance at the past will show how great a step forward has been made, and may yield some reason for congratulation; a glance at the present, showing, as it cannot fail to do, how small a proportion the gains bear to what remains to be acquired, will prove that as yet we have rather discovered the right path than made much way on it—that we are, in truth, only on the threshold of the history of medical psychology as a science.


2018 ◽  
Vol 44 (06) ◽  
pp. 509-516 ◽  
Author(s):  
Mariano Intrieri ◽  
Maurizio Margaglione

AbstractOver the past few decades, important knowledge on why inhibitors develop and better information about significant risk factors have become available. A series of both genetic and nongenetic factors are recognized and clinical score systems were proposed to quantify the risk for each patient. In addition, modulation of the immunological response was acknowledged to play a pivotal role in the occurrence of inhibitors. However, with the exception of mutation testing in severe hemophilia B patients, no single risk factor or clinical score is currently utilized in clinical practice. “Omics” technologies are large-scale hypothesis-generating approaches, which provide the tools to study issues contributing to a complex and multifactorial phenomenon, such as inhibitor development. Newer cutting edge technologies may enable a more accurate estimation of the personal risk profile and provide a reliable tool to accurately measure the risk periodically, thereby enabling strategies to foresee and prevent inhibitor formation.


1935 ◽  
Vol 35 (2) ◽  
pp. 219-237 ◽  
Author(s):  
Lawrence P. Garrod

It is now almost universally recognised that a test for disinfectants which is to yield results of direct practical significance must include appropriate “organic matter” in the test mixture. Some types of disinfectant, notably those which act by liberating chlorine or oxygen, are greatly reduced in activity by the addition of only small quantities of any extraneous material with which these elements can combine. Other disinfectants are more resistant to this influence; they are capable of efficient action in the presence of excreta and dirt of other kinds if used in adequate concentration. What this concentration should be under such unfavourable conditions it is necessary to determine, since the degree of interference is not the same for all disinfectants even in the same class, and no constant relationship exists between efficiency under these conditions and that displayed in a medium of distilled water as determined by the Rideal-Walker test. Numerous efforts have been made in the past to introduce tests employing adequate amounts of complex organic matter; few of these have achieved permanence and none popularity. The following short survey of past work is concerned only with what may be termed “excremental” disinfectants; the testing of surgical disinfectants, which may reasonably be held to demand different methods, is outside the scope of this paper.


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