The investigation of the relationship among the polymorphisms of ER and VDR gene and BMD in women with postmenopause osteoporosis in harbin

The transmission and evolution of leprosy depends on several aspects, including immunological and genetic factors of the host, as well as genetic factors of Mycobacterium leprae. This study evaluated the association of single nucleotide polymorphisms (SNPs) on the FokI (rs2228570), TaqI (rs731236), ApaI (rs7975232) regions of the vitamin D receptor (VDR) gene with leprosy. A total of 405 individuals were evaluated, composed by groups of 100 multibacillary and 57 paucibacillary patients, and 248 healthy contacts. Blood samples were collected from patients and contacts. The genotyping was performed by sequencing of the interest regions. The alleles of the studied SNPs, and of SNP FokI genotypes, were not associated with leprosy. For the SNP on TaqI region, the relationship between the tt genotype, and for the SNP ApaI, the AA genotype, revealed an association with susceptibility to MB form, while Aa genotype with protection. The extended genotypes AaTT and AaTt of ApaI and TaqI were associated with protection to against MB form. Futher studies analyzing the expression of the VDR gene and the correlation with its SNPs might help to clarify the role of polymorphisms on the immune response in leprosy.

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Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship

Annals of Nutrition and Metabolism ◽

10.1159/000490669 ◽

2018 ◽

Vol 73 (2) ◽

pp. 89-99 ◽

Cited By ~ 13

Author(s):

Francisco Javier Ruiz-Ojeda ◽

Augusto Anguita-Ruiz ◽

Rosaura Leis ◽

Concepcion M. Aguilera

Keyword(s):

Vitamin D ◽

Adipose Tissue ◽

Molecular Mechanism ◽

Molecular Mechanisms ◽

Genetic Factors ◽

Vdr Gene ◽

Association Analyses ◽

Hydroxyvitamin D ◽

Wide Range ◽

The Relationship

Vitamin D (vitD) deficiency is associated with a wide range of chronic diseases and conditions, including obesity, and with an increasing severity of metabolic dysregulation, such as insulin resistance, hyperlipidemia, liver disease, and hypertension, both in children and adults. However, the nature of the association between low vitD status and obesity remains unclear. This fact has motivated the scientific community to conduct genetic association analyses between 25-hydroxyvitamin D (25[OH]D)-related genes and obesity traits. In this line, the variation in the vitD receptor (VDR) gene represents the bulk of the findings. Specifically, polymorphisms in the VDR gene have been associated with obesity traits in some but not all, studies. Thus, results regarding this matter remain inconclusive. Other genes aside from VDR have also been investigated in relation to obesity-related traits. However, again, findings have been inconsistent. In general, results point to the fact that the DBP/GC gene could be an important protein-linking obesity and vitD status. On the other hand, several studies have attempted to determine the molecular mechanism of the relationship between 25(OH)-D levels and obesity. Some of these studies suggest that vitD, due to its fat-soluble characteristic, is retained by the adipose tissue and has the capacity to metabolize 25(OH)-D locally, and this can be altered during obesity. Additionally, vitD is capable of regulating the gene expression related to adipogenesis process, inflammation, oxidative stress, and metabolism in mature adipocytes. Therefore, the aim of the present review was to evaluate the association between obesity and vitD deficiency describing the main molecular mechanism of the relationship and the link with genetic factors. Key Messages: Low serum 25(OH)-D is positively associated with obesity or BMI in adults and children. Circulating vitD concentrations are, at least, partially determined by genetic factors. VitD plays an important role in the adipogenesis process and inflammation status in adipocytes and adipose tissue.

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Urinary tract infections and vitamin D: prospects for use in prevention and treatment

Medical Council ◽

10.21518/2079-701x-2021-11-148-155 ◽

2021 ◽

pp. 148-155

Author(s):

I. N. Zakharova ◽

A. N. Tsutsaeva ◽

S. V. Dolbnya ◽

V. A. Kuryaninova ◽

L Ya. Klimov ◽

...

Keyword(s):

Vitamin D ◽

Urinary Tract ◽

Urinary Tract Infections ◽

Defense Mechanisms ◽

Bacterial Infections ◽

Vdr Gene ◽

Vdr Gene Polymorphisms ◽

Modern Medical Practice ◽

Tract Infections ◽

The Relationship

Urinary tract infections are a common global problem among physicians of various specialties, including therapists, pediatricians, nephrologists and urologists. Today UTI is one of the leading bacterial infections in both adult and child populations. The main type of therapy and prevention of recurrent UTI is the use of drugs with an antibacterial effect (antibiotics, uroseptics). An urgent problem in modern medical practice is the increasing antibiotic resistance, which requires the development of new approaches to therapy and prevention, including UTI. In recent years, special attention has been paid to the study of vitamin D receptor (VDR) gene polymorphisms as a possible risk factor determining the predisposition to a number of infectious and noninfectious diseases. More than 200 polymorphisms of the VDR gene have been identified, four of which – FokI, BsmI, ApaI, and TaqI – are particularly common. Different VDR alleles can cause small changes in receptor function, which can affect resistance or susceptibility to a particular infection. The review presents data from modern studies demonstrating the relationship between vitamin D supply and development, the frequency of recurrence and the nature of the course of UTI. In one study, vitamin D has been shown to enhance the cathelicidin-mediated antibacterial action of bladder epithelial cells. It also demonstrated the currently known defense mechanisms of vitamin D against urinary tract infections, including its effect on components of the innate immune system.

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TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients

Egyptian Journal of Medical Human Genetics ◽

10.1186/s43042-021-00206-4 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Estela Morales Peralta ◽

Yaíma Zúñiga Rosales ◽

Teresa Collazo Mesa ◽

Elvia Nelmi Santos González ◽

Yadira Hernández Pérez ◽

...

Keyword(s):

Vdr Gene ◽

Clinical Behavior ◽

Taqi Polymorphism ◽

Clinical Forms ◽

The Relationship

Abstract Purpose To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. Methods TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. Results There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243–17.842], even severe [OR = 1.200, 95% CI: 0.217–6.638], related to the tt genotype. Conclusion There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.

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G.P.4.07 A preliminary study on the relationship between VDR gene polymorphisms and risk for childhood SMA disease

Neuromuscular Disorders ◽

10.1016/j.nmd.2008.06.134 ◽

2008 ◽

Vol 18 (9-10) ◽

pp. 762

Author(s):

M. Stavarachi ◽

P. Apostol ◽

D. Cimponeriu ◽

M. Toma ◽

N. Butoianu ◽

...

Keyword(s):

Gene Polymorphisms ◽

Vdr Gene ◽

Vdr Gene Polymorphisms ◽

Preliminary Study ◽

The Relationship

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Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis

Nutrients ◽

10.3390/nu14020360 ◽

2022 ◽

Vol 14 (2) ◽

pp. 360

Author(s):

Ricardo Usategui-Martín ◽

Daniel-Antonio De Luis-Román ◽

José María Fernández-Gómez ◽

Marta Ruiz-Mambrilla ◽

José-Luis Pérez-Castrillón

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Vitamin D Receptor ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Vdr Gene ◽

Genotypic Distribution ◽

Vdr Gene Polymorphisms ◽

Genetic And Environmental Factors ◽

The Relationship

The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. The best studied polymorphisms in the VDR gene are Apal (rs7975232), BsmI (rs1544410), Taql (rs731236) and Fokl (rs10735810). We conducted a systematic review and meta-analysis to evaluate the response to vitamin D supplementation according to the BsmI, TaqI, ApaI and FokI polymorphisms. We included studies that analysed the relationship between the response to vitamin D supplementation and the genotypic distribution of these polymorphisms. We included eight studies that enrolled 1038 subjects. The results showed no significant association with the BsmI and ApaI polymorphisms (p = 0.081 and p = 0.63) and that the variant allele (Tt+tt) of the TaqI polymorphism and the FF genotype of the FokI variant were associated with a better response to vitamin D supplementation (p = 0.02 and p < 0.001). In conclusion, the TaqI and FokI polymorphisms could play a role in the modulation of the response to vitamin D supplementation, as they are associated with a better response to supplementation.

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The relationship between selected VDR gene polymorphisms and susceptibility to inflammatory bowel disease in Slovak population

Biologia ◽

10.2478/s11756-019-00212-3 ◽

2019 ◽

Vol 74 (5) ◽

pp. 573-581 ◽

Cited By ~ 2

Author(s):

Martina Stuchlíková ◽

Tibor Hlavatý ◽

František Ďuriš ◽

Juraj Javor ◽

Anna Krajčovičová ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Gene Polymorphisms ◽

Vdr Gene ◽

Slovak Population ◽

Vdr Gene Polymorphisms ◽

Inflammatory Bowel ◽

The Relationship

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Interstellar gas in the central region of the Galaxy

Symposium - International Astronomical Union ◽

10.1017/s0074180900101032 ◽

1967 ◽

Vol 31 ◽

pp. 239-251 ◽

Cited By ~ 3

Author(s):

F. J. Kerr

Keyword(s):

Central Region ◽

Galactic Plane ◽

Neutral Hydrogen ◽

Continuum Emission ◽

Galactic Centre ◽

Interstellar Gas ◽

Hydrogen Recombination ◽

The Galaxy ◽

Centre Region ◽

The Relationship

A review is given of information on the galactic-centre region obtained from recent observations of the 21-cm line from neutral hydrogen, the 18-cm group of OH lines, a hydrogen recombination line at 6 cm wavelength, and the continuum emission from ionized hydrogen.Both inward and outward motions are important in this region, in addition to rotation. Several types of observation indicate the presence of material in features inclined to the galactic plane. The relationship between the H and OH concentrations is not yet clear, but a rough picture of the central region can be proposed.

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The relationship of the scleractinian corals to the rugose corals

Paleobiology ◽

10.1017/s0094837300025707 ◽

1980 ◽

Vol 6 (02) ◽

pp. 146-160 ◽

Cited By ~ 29

Author(s):

William A. Oliver

Keyword(s):

Critical Points ◽

Scleractinian Corals ◽

Convincing Evidence ◽

Early Triassic ◽

Rugose Corals ◽

History Of ◽

The Subject ◽

Relationship Of ◽

The Relationship ◽

Biologic Factors

The Mesozoic-Cenozoic coral Order Scleractinia has been suggested to have originated or evolved (1) by direct descent from the Paleozoic Order Rugosa or (2) by the development of a skeleton in members of one of the anemone groups that probably have existed throughout Phanerozoic time. In spite of much work on the subject, advocates of the direct descent hypothesis have failed to find convincing evidence of this relationship. Critical points are:(1) Rugosan septal insertion is serial; Scleractinian insertion is cyclic; no intermediate stages have been demonstrated. Apparent intermediates are Scleractinia having bilateral cyclic insertion or teratological Rugosa.(2) There is convincing evidence that the skeletons of many Rugosa were calcitic and none are known to be or to have been aragonitic. In contrast, the skeletons of all living Scleractinia are aragonitic and there is evidence that fossil Scleractinia were aragonitic also. The mineralogic difference is almost certainly due to intrinsic biologic factors.(3) No early Triassic corals of either group are known. This fact is not compelling (by itself) but is important in connection with points 1 and 2, because, given direct descent, both changes took place during this only stage in the history of the two groups in which there are no known corals.

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Choosing a Markov blanket

Behavioral and Brain Sciences ◽

10.1017/s0140525x19002632 ◽

2020 ◽

Vol 43 ◽

Author(s):

Thomas Parr

Keyword(s):

Markov Blanket ◽

Target Article ◽

The Relationship

Abstract This commentary focuses upon the relationship between two themes in the target article: the ways in which a Markov blanket may be defined and the role of precision and salience in mediating the interactions between what is internal and external to a system. These each rest upon the different perspectives we might take while “choosing” a Markov blanket.

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