scholarly journals TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Estela Morales Peralta ◽  
Yaíma Zúñiga Rosales ◽  
Teresa Collazo Mesa ◽  
Elvia Nelmi Santos González ◽  
Yadira Hernández Pérez ◽  
...  
Keyword(s):  
Vdr Gene ◽  
Clinical Behavior ◽  
Taqi Polymorphism ◽  
Clinical Forms ◽  
The Relationship

Abstract Purpose To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. Methods TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. Results There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243–17.842], even severe [OR = 1.200, 95% CI: 0.217–6.638], related to the tt genotype. Conclusion There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.

scholarly journals Association of VDR gene TaqI polymorphism with the susceptibility to prostate cancer in Asian population evaluated by an updated systematic meta-analysis

2018 ◽  
Vol Volume 11 ◽  
pp. 3267-3280 ◽  
Author(s):  
Liangliang Chen ◽  
Junjun Wei ◽  
Shuwei Zhang ◽  
Zhongguan Lou ◽  
Xue Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Meta Analysis ◽  
Asian Population ◽  
Vdr Gene ◽  
Taqi Polymorphism

scholarly journals Association of the polymorphism of the vitamin D receptor gene (VDR) with the risk of leprosy in the Brazilian Amazon

2021 ◽  
Author(s):  
Jasna Letícia Pinto Paz ◽  
Maria do Perpétuo Socorro Corrêa Amador Silvestre ◽  
Letícia Siqueira Moura ◽  
Ismari Perini Furlaneto ◽  
Yan Corrêa Rodrigues ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Genetic Factors ◽  
Receptor Gene ◽  
Mycobacterium Leprae ◽  
Nucleotide Polymorphisms ◽  
Vdr Gene ◽  
Single Nucleotide ◽  
The Relationship

The transmission and evolution of leprosy depends on several aspects, including immunological and genetic factors of the host, as well as genetic factors of Mycobacterium leprae. This study evaluated the association of single nucleotide polymorphisms (SNPs) on the FokI (rs2228570), TaqI (rs731236), ApaI (rs7975232) regions of the vitamin D receptor (VDR) gene with leprosy. A total of 405 individuals were evaluated, composed by groups of 100 multibacillary and 57 paucibacillary patients, and 248 healthy contacts. Blood samples were collected from patients and contacts. The genotyping was performed by sequencing of the interest regions. The alleles of the studied SNPs, and of SNP FokI genotypes, were not associated with leprosy. For the SNP on TaqI region, the relationship between the tt genotype, and for the SNP ApaI, the AA genotype, revealed an association with susceptibility to MB form, while Aa genotype with protection. The extended genotypes AaTT and AaTt of ApaI and TaqI were associated with protection to against MB form. Futher studies analyzing the expression of the VDR gene and the correlation with its SNPs might help to clarify the role of polymorphisms on the immune response in leprosy.

scholarly journals Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship

2018 ◽  
Vol 73 (2) ◽  
pp. 89-99 ◽  
Author(s):  
Francisco Javier Ruiz-Ojeda ◽  
Augusto Anguita-Ruiz ◽  
Rosaura Leis ◽  
Concepcion M. Aguilera
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Molecular Mechanism ◽  
Molecular Mechanisms ◽  
Genetic Factors ◽  
Vdr Gene ◽  
Association Analyses ◽  
Hydroxyvitamin D ◽  
Wide Range ◽  
The Relationship

Vitamin D (vitD) deficiency is associated with a wide range of chronic diseases and conditions, including obesity, and with an increasing severity of metabolic dysregulation, such as insulin resistance, hyperlipidemia, liver disease, and hypertension, both in children and adults. However, the nature of the association between low vitD status and obesity remains unclear. This fact has motivated the scientific community to conduct genetic association analyses between 25-hydroxyvitamin D (25[OH]D)-related genes and obesity traits. In this line, the variation in the vitD receptor (VDR) gene represents the bulk of the findings. Specifically, polymorphisms in the VDR gene have been associated with obesity traits in some but not all, studies. Thus, results regarding this matter remain inconclusive. Other genes aside from VDR have also been investigated in relation to obesity-related traits. However, again, findings have been inconsistent. In general, results point to the fact that the DBP/GC gene could be an important protein-linking obesity and vitD status. On the other hand, several studies have attempted to determine the molecular mechanism of the relationship between 25(OH)-D levels and obesity. Some of these studies suggest that vitD, due to its fat-soluble characteristic, is retained by the adipose tissue and has the capacity to metabolize 25(OH)-D locally, and this can be altered during obesity. Additionally, vitD is capable of regulating the gene expression related to adipogenesis process, inflammation, oxidative stress, and metabolism in mature adipocytes. Therefore, the aim of the present review was to evaluate the association between obesity and vitD deficiency describing the main molecular mechanism of the relationship and the link with genetic factors. Key Messages: Low serum 25(OH)-D is positively associated with obesity or BMI in adults and children. Circulating vitD concentrations are, at least, partially determined by genetic factors. VitD plays an important role in the adipogenesis process and inflammation status in adipocytes and adipose tissue.

scholarly journals The Relationship between Educators’ Clinical Behavior and Nursing Students’ Learning in Shiraz University of Medical Sciences in 2015

2017 ◽  
Vol 30 (109) ◽  
pp. 10-22
Author(s):  
C Torabizadeh ◽  
FA Hoseini ◽  
A Parvane ◽  
Z Yazdanbakhsh ◽  
◽  
...  
Keyword(s):  
Nursing Students ◽  
Medical Sciences ◽  
Clinical Behavior ◽  
The Relationship

The investigation of the relationship among the polymorphisms of ER and VDR gene and BMD in women with postmenopause osteoporosis in harbin

Bone ◽  
2008 ◽  
Vol 43 ◽  
pp. S126
Author(s):  
Yang Zhi Qiang ◽  
Tao Tian Zun ◽  
Pan Hai Le ◽  
Tao Shu Qing ◽  
et al.
Keyword(s):  
Vdr Gene ◽  
The Relationship

scholarly journals Benign rolandic epilepsy: clinical and electroencephalographic correlates

2000 ◽  
Vol 58 (3B) ◽  
pp. 852-861 ◽  
Author(s):  
RUDIMAR DOS SANTOS RIESGO ◽  
PRASANNA JAYAKAR ◽  
NEWRA TELLECHEA ROTTA
Keyword(s):  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Clinical Classification ◽  
Rolandic Epilepsy ◽  
Clinical Behavior ◽  
Structural Alterations ◽  
The Creation ◽  
The Relationship ◽  
Organic Lesions

Benign rolandic epilepsy (BRE) is known for its dissociation from structural alterations. Nevertheless, the number of cases with reported organic lesions has been increasing. This led to the creation of two subgroups, "benign" and "non benign" BRE, and resulted in the need for additional parameters to define electrographic benignity. We assessed the possible associations between interictal electroencephalographic findings and clinical behavior in 60 BRE cases, testing four parameters of electrographic benignity (paroxysm morphology, horizontal dipole, base rhythms, laterality of rolandic spikes). We also assessed the relationship between neuroimaging findings and electrographic and clinical classifications, and found a statistically significant association (sensitivity=73.5%; specificity=81.8%; positive predictive value=94.8%; negative predictive value=40.9%). Three of the electrographic parameters proposed were associated with clinical classification: paroxysm morphology, horizontal dipole, and base rhythms. Cases electrographically classified as benign have 21 times more chances to be equally classified as clinically benign according with the tested criteria.

scholarly journals Association of Vitamin D with the TaqI Polymorphism of the VDR Gene in Older Women Attending the Basic Health Unit of the Federal District, DF (Brazil)

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Renata de Souza Freitas ◽  
Caroline Ferreira Fratelli ◽  
Calliandra Maria de Souza Silva ◽  
Luciano Ramos de Lima ◽  
Marina Morato Stival ◽  
...  
Keyword(s):  
Vitamin D ◽  
Elderly Population ◽  
Serum Vitamin ◽  
Federal District ◽  
Hypovitaminosis D ◽  
Control Group ◽  
Case Group ◽  
Vdr Gene ◽  
Serum Vitamin D ◽  
Taqi Polymorphism

Aging is accompanied by various functional modifications determined by their environment, lifestyle, nutrition, and genetics. Based on these factors, it is essential to verify the vitamin deficiency in the elderly population. Hypovitaminosis D is commonly present in human aging, increasing the chances of developing noncommunicable chronic diseases. The VDR gene TaqI polymorphism may modify the vitamin D metabolic pathway by altering the interaction between the vitamin D receptor and the active circulating vitamin D. Therefore, this study aimed to investigate the association between serum vitamin D and biochemical and genetic factors, considering the TaqI polymorphism of the VDR gene, in an elderly population of the Federal District. The study was a descriptive, case-control, quantitative, and cross-sectional type and was conducted in two basic health units in the administrative region of Ceilândia, Federal District, DF, Brazil, with women aged 60 years or older. Anthropometric, biochemical, and genetic parameters (VDR TaqI polymorphism) were evaluated. The adopted significance level was 5%, and statistical analyses were performed using the SPSS version 20.0 program. The study consisted of 128 participants. The most prevalent age was from 60 to 65 years (N = 53; 41.4%). 66 elderly (51.6%) were part of the case group (hypovitaminosis D), while 62 were in the control group. In the case group, 30.2% had grade I obesity, 77.3% were hypertensive, and 51.5% were diabetic. The TT genotype was present in 47% of the case group and 54.8% in the control group (p=0.667). There was no association between serum vitamin D levels and the VDR gene variant TaqI polymorphism in an elderly Brazilian population.

The cell count of milk in relation to milk yield

1978 ◽  
Vol 45 (1) ◽  
pp. 5-14 ◽  
Author(s):  
A. Meijering ◽  
F. H. J. Jaartsveld ◽  
M. W. A. Verstegen ◽  
M. J. M. Tielen
Keyword(s):  
Cell Count ◽  
Milk Yield ◽  
Yield Losses ◽  
Clinical Forms ◽  
Cell Counts ◽  
The Relationship

SummaryQuarter-milk cell counts and milk yields from 1000 cows in the province of Noord-Brabant were obtained over a 12-month period. The data from 933 animals, mainly heifers, were used to examine statistically the relationship between cell counts, as a criterion for sub-clinical forms of mastitis, and milk yield. Losses in milk were assessed by quarter, by pairs of quarters and by cow. The conclusions were that the losses in milk due to sub-clinical forms of mastitis, as indicated by cell count, can be substantial. The existence of a compensating increase in milk yield from a healthy gland, in response to the loss of milk from a neighbouring quarter with raised cell count, could not be demonstrated.

scholarly journals CLINICAL FORMS OF ULCERATIVE COLITIS AND THEIR FEATURES IN CHILDREN

2020 ◽  
Author(s):  
Денисова М. Ф. ◽  
Букулова Н. Ю.
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Process ◽  
Clinical Laboratory ◽  
Fecal Calprotectin ◽  
Clinical Activity ◽  
Clinical Forms ◽  
Γ Globulins ◽  
Endoscopic Characteristics ◽  
And Gender ◽  
The Relationship

This article presents frequency of occurrence of clinical forms of the disease depending on the localization and activity of the inflammatory process, their age and gender differences, risk factors and disease triggers, based on a retrospective analysis of 116 cases of children with ulcerative colitis at the age of 4-18 years. Comparative clinical, laboratory and endoscopic characteristics of total, segmental and distal colitis have been also analyzed. It was found that clinical activity of total colitis is characterized by more severe course of the disease, accompanied with systemic and local extraintestinal manifestations (OR = 4,504±0,506, p<0.05), more pronounced changes in hemo- and proteinogram parameters (p<0.05). Endoscopic criteria for differences in the clinical forms of ulcerative colitis are the presence of ulcers (OR = 9,667±0,645, p <0,05), erosions (OR = 3,569±0,429, p<0,05), contact bleeding (OR = 4,364± ,444, p< 0.05), changes in the vascular pattern (OR = 3,748±0,477, p<0.05). Correlation analysis of the relationship between clinical (PUCAI), endoscopic (Rachmilewitz index) and laboratory markers of the inflammatory process (leukocytes, platelets, erythrocyte sedimentation rate, γ-globulins, fecal calprotectin, hemoglobin) has been also performed, the criteria of which might be used to monitor the course of the disease and the effectiveness of therapy.

scholarly journals Urinary tract infections and vitamin D: prospects for use in prevention and treatment

2021 ◽  
pp. 148-155
Author(s):  
I. N. Zakharova ◽  
A. N. Tsutsaeva ◽  
S. V. Dolbnya ◽  
V. A. Kuryaninova ◽  
L Ya. Klimov ◽  
...  
Keyword(s):  
Vitamin D ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Defense Mechanisms ◽  
Bacterial Infections ◽  
Vdr Gene ◽  
Vdr Gene Polymorphisms ◽  
Modern Medical Practice ◽  
Tract Infections ◽  
The Relationship

Urinary tract infections are a common global problem among physicians of various specialties, including therapists, pediatricians, nephrologists and urologists. Today UTI is one of  the  leading bacterial infections in  both adult and child populations. The main type of therapy and prevention of recurrent UTI is the use of drugs with an antibacterial effect (antibiotics, uroseptics). An urgent problem in modern medical practice is the increasing antibiotic resistance, which requires the development of new approaches to therapy and prevention, including UTI. In recent years, special attention has been paid to the study of vitamin D receptor (VDR) gene polymorphisms as a possible risk factor determining the predisposition to a number of infectious and noninfectious diseases. More than 200 polymorphisms of the VDR gene have been identified, four of which – FokI, BsmI, ApaI, and TaqI – are particularly common. Different VDR alleles can cause small changes in receptor function, which can affect resistance or susceptibility to a particular infection. The review presents data from modern studies demonstrating the relationship between vitamin D supply and development, the frequency of recurrence and the nature of the course of UTI. In one study, vitamin D has been shown to enhance the cathelicidin-mediated antibacterial action of bladder epithelial cells. It also demonstrated the currently known defense mechanisms of vitamin D against urinary tract infections, including its effect on components of the innate immune system.

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