scholarly journals Highly Pegylated Sterically Stabilized Micelles in Aqueous Media: Structure, Dynamics, and Storage of Therapeutic Agents

2012 ◽  
Vol 102 (3) ◽  
pp. 498a
Author(s):  
Lela Vukovic ◽  
Fatima A. Khatib ◽  
Stephanie P. Drake ◽  
Antonett Madriaga ◽  
Kenneth S. Brandenburg ◽  
...  
Keyword(s):  
Aqueous Media ◽  
Therapeutic Agents ◽  
Structure Dynamics ◽  
Sterically Stabilized Micelles ◽  
And Storage

scholarly journals Host-Guest Interaction between Herbicide Oxadiargyl and Hydroxypropyl-β-Cyclodextrin

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Sofia Benfeito ◽  
Tiago Rodrigues ◽  
Jorge Garrido ◽  
Fernanda Borges ◽  
E. Manuela Garrido
Keyword(s):  
Aqueous Media ◽  
Industrial Effluents ◽  
Ultrapure Water ◽  
Buffer Solutions ◽  
Water Treatment Plants ◽  
Pesticide Formulations ◽  
The Face ◽  
Ph Buffer ◽  
Environmentally Sound ◽  
And Storage

In the face of a growing human population and increased urbanization, the demand for pesticides will simply rise. Farmers must escalate yields on increasingly fewer farm acres. However, the risks of pesticides, whether real or perceived, may force changes in the way these chemicals are used. Scientists are working toward pest control plans that are environmentally sound, effective, and profitable. In this context the development of new pesticide formulations which may improve application effectiveness, safety, handling, and storage can be pointed out as a solution. As a contribution to the area, the microencapsulation of the herbicide oxadiargyl (OXA) in (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD) was performed. The study was conducted in different aqueous media (ultrapure water and in different pH buffer solutions). In all cases an increment of the oxadiargyl solubility as a function of the HP-β-CD concentration that has been related to the formation of an inclusion complex was verified. UV-Vis and NMR experiments allowed concluding that the stoichiometry of the OXA/HP-β-CD complex formed is 1 : 1. The gathered results can be regarded as an important step for its removal from industrial effluents and/or to increase the stabilizing action, encapsulation, and adsorption in water treatment plants.

scholarly journals Structure and Dynamics of Highly PEG-ylated Sterically Stabilized Micelles in Aqueous Media

2011 ◽  
Vol 133 (34) ◽  
pp. 13481-13488 ◽  
Author(s):  
Lela Vuković ◽  
Fatima A. Khatib ◽  
Stephanie P. Drake ◽  
Antonett Madriaga ◽  
Kenneth S. Brandenburg ◽  
...  
Keyword(s):  
Aqueous Media ◽  
Structure And Dynamics ◽  
Sterically Stabilized Micelles

scholarly journals Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 55 ◽  
Author(s):  
Xuemei Ge ◽  
Minyan Wei ◽  
Suna He ◽  
Wei-En Yuan
Keyword(s):  
Scale Up ◽  
Therapeutic Agents ◽  
Production Costs ◽  
Ionic Surfactant ◽  
Protein Drugs ◽  
Surfactant Vesicles ◽  
Pharmacokinetic Properties ◽  
New Strategy ◽  
Low Toxicity ◽  
And Storage

Non-Ionic surfactant based vesicles, also known as niosomes, have attracted much attention in pharmaceutical fields due to their excellent behavior in encapsulating both hydrophilic and hydrophobic agents. In recent years, it has been discovered that these vesicles can improve the bioavailability of drugs, and may function as a new strategy for delivering several typical of therapeutic agents, such as chemical drugs, protein drugs and gene materials with low toxicity and desired targeting efficiency. Compared with liposomes, niosomes are much more stable during the formulation process and storage. The required pharmacokinetic properties can be achieved by optimizing components or by surface modification. This novel delivery system is also easy to prepare and scale up with low production costs. In this paper, we summarize the structure, components, formulation methods, quality control of niosome and its applications in chemical drugs, protein drugs and gene delivery.

Physicochemical Properties of Alkaline Aqueous Sodium Metaborate Solutions

2006 ◽  
Vol 4 (1) ◽  
pp. 88-98 ◽  
Author(s):  
Caroline R. Cloutier ◽  
Akram Alfantazi ◽  
Elod Gyenge
Keyword(s):  
Ionic Conductivity ◽  
Physicochemical Properties ◽  
Aqueous Solutions ◽  
Aqueous Media ◽  
Ion Concentration ◽  
X Ray Diffraction ◽  
Sodium Metaborate ◽  
Commercial Viability ◽  
The Impact ◽  
And Storage

Background: The transition to a hydrogen fuel economy is hindered by the lack of a practical storage method and concerns associated with its safe handling. Chemical hydrides have the potential to address these concerns. Sodium borohydride (sodium tetrahydroborate, NaBH4), is the most attractive chemical hydride for H2 generation and storage in automotive fuel cell applications, but recycling from sodium metaborate (NaBO2), is difficult and costly. An electrochemical regeneration process could represent an economically feasible and environmentally friendly solution. Method of Approach: We report a study of the properties of concentrated NaBO2 alkaline aqueous solutions that are necessary to the development of electrochemical recycling methods. The solubility, pH, density, conductivity, and viscosity of aqueous NaBO2 solutions containing varying weight percentages (1, 2, 3, 5, 7.5, and 10wt.%) of alkali hydroxides (NaOH, KOH, and LiOH) were evaluated at 25°C. The precipitates formed in supersaturated solutions were characterized by x-ray diffraction and scanning electron microscopy. Results: All NaBO2 physicochemical properties investigated, except solubility, increased with increased hydroxide ion concentration. The solubility of NaBO2 was enhanced by the addition of KOH to the saturated solution, but decreased when LiOH and NaOH were used. The highest ionic conductivity (198.27S∕m) was obtained from the filtrate of saturated aqueous solutions containing more than 30wt.%NaBO2 and 10wt.% NaOH prior to filtration. At 10wt.% hydroxide, the viscosity of the NaBO2 solution was the highest in the case of LiOH (11.38 cP) and lowest for those containing NaOH (6.37 cP). The precipitate was hydrated, NaBO2 for all hydroxides, but its hydration level was unclear. Conclusions: The use of KOH as the electrolyte was found to be more advantageous for the H2 storage and generation system based on NaBO2 solubility and solution half-life. However, the addition of NaOH led to the highest ionic conductivity, and its use seems more suitable for the electroreduction of NaBO2. Further investigations on the impact of KOH and NaOH on the electroreduction of NaBO2 in aqueous media have the potential to enhance the commercial viability of NaBH4.

An Overview of Digital Image Processing and Recognition (Invited Paper)

1982 ◽  
Vol 40 ◽  
pp. 700-702
Author(s):  
R. C. Gonzalez
Keyword(s):  
Image Processing ◽  
New York ◽  
Digital Image Processing ◽  
Digital Image ◽  
Practical Implementation ◽  
Submarine Cable ◽  
Vigorous Growth ◽  
Digitized Pictures ◽  
Processing Techniques ◽  
And Storage

Interest in digital image processing techniques dates back to the early 1920's, when digitized pictures of world news events were first transmitted by submarine cable between New York and London. Applications of digital image processing concepts, however, did not become widespread until the middle 1960's, when third-generation digital computers began to offer the speed and storage capabilities required for practical implementation of image processing algorithms. Since then, this area has experienced vigorous growth, having been a subject of interdisciplinary research in fields ranging from engineering and computer science to biology, chemistry, and medicine.

Control of Secretory Production in the Isopod Hepatopancreas

1972 ◽  
Vol 30 ◽  
pp. 166-167
Author(s):  
John W. Roberts ◽  
E. R. Witkus
Keyword(s):  
B Cells ◽  
Morphological Data ◽  
Secretory Product ◽  
Secretory Function ◽  
Secretory Material ◽  
Blind Ending ◽  
Secretory Production ◽  
Regenerative Cells ◽  
Immature Cells ◽  
And Storage

The isopod hepatopancreas, as exemplified by Oniscus ascellus. is comprised of four blind-ending diverticula. The regenerative cells at the tip of each diverticula differentiate into either club-shaped B-cells, which serve a secretory function, or into conoid S-cells, which serve in the absorption and storage of nutrients.The glandular B-cells begin producing secretory material with the development of rough endoplasmic reticulum during their process of maturation from the undifferentiated regenerative cells. Cytochemical and morphological data indicate that the hepatopancreas sequentially produces two types of secretory material within the large club-shaped cells. The production of the carbohydrate-like secretory product in immature cells seems to be phased out as the production of the osmiophilic secretion was phased in as the cell matured.

Quantitative Analysis Of X-Ray Images From Geological Materials

1990 ◽  
Vol 48 (2) ◽  
pp. 244-245
Author(s):  
J. M. Paque ◽  
R. Browning ◽  
P. L. King ◽  
P. Pianetta
Keyword(s):  
Quantitative Analysis ◽  
Bulk Composition ◽  
Principal Component ◽  
Analytical Description ◽  
Bulk Sample ◽  
Geological Samples ◽  
X Ray ◽  
Software And Hardware ◽  
And Storage ◽  
Insight Into

Geological samples typically contain many minerals (phases) with multiple element compositions. A complete analytical description should give the number of phases present, the volume occupied by each phase in the bulk sample, the average and range of composition of each phase, and the bulk composition of the sample. A practical approach to providing such a complete description is from quantitative analysis of multi-elemental x-ray images.With the advances in recent years in the speed and storage capabilities of laboratory computers, large quantities of data can be efficiently manipulated. Commercial software and hardware presently available allow simultaneous collection of multiple x-ray images from a sample (up to 16 for the Kevex Delta system). Thus, high resolution x-ray images of the majority of the detectable elements in a sample can be collected. The use of statistical techniques, including principal component analysis (PCA), can provide insight into mineral phase composition and the distribution of minerals within a sample.

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