Molecular targets and anti-cancer potential of escin

2018 ◽  
Vol 422 ◽  
pp. 1-8 ◽  
Author(s):  
Dorothy H.J. Cheong ◽  
Frank Arfuso ◽  
Gautam Sethi ◽  
Lingzhi Wang ◽  
Kam Man Hui ◽  
...  
Keyword(s):  
Molecular Targets ◽  
Anti Cancer

Understanding Molecular Process and Chemotherapeutics for the Management of Breast Cancer.

2020 ◽  
Vol 14 ◽  
Author(s):  
Abhishek Kumar ◽  
Neeraj Masand ◽  
Vaishali M. Patil
Keyword(s):  
Breast Cancer ◽  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Molecular Classification ◽  
Neoplastic Disease ◽  
Molecular Process ◽  
The Past ◽  
Anti Cancer ◽  
Molecular Etiology ◽  
Near Future

Abstract: Breast cancer is the most common and highly heterogeneous neoplastic disease comprised of several subtypes with distinct molecular etiology and clinical behaviours. The mortality observed over the past few decades and the failure in eradicating the disease is due to the lack of specific etiology, molecular mechanisms involved in initiation and progression of breast cancer. Understanding of the molecular classes of breast cancer may also lead to new biological insights and eventually to better therapies. The promising therapeutic targets and novel anti-cancer approaches emerging from these molecular targets that could be applied clinically in the near future are being highlighted. In addition, this review discusses some of the details of current molecular classification and available chemotherapeutics

Chemopreventive Properties of Tolfenamic Acid: A Mechanistic Review

2018 ◽  
Vol 25 (14) ◽  
pp. 1598-1608 ◽  
Author(s):  
David Feldman ◽  
Elizabeth Leahy ◽  
Seong-Ho Lee
Keyword(s):  
Therapeutic Strategy ◽  
Molecular Mechanisms ◽  
Growth Arrest ◽  
Molecular Targets ◽  
Tolfenamic Acid ◽  
Research Groups ◽  
Cancer Hallmarks ◽  
Cancer Models ◽  
Anti Cancer ◽  
Inflammatory Drugs

Tolfenamic acid is one of the conventional non-steroidal anti-inflammatory drugs (NSAIDs) commonly used for the treatment of inflammation, migraines and pain. There has been a growing body of experimental evidence that tolfenamic acid possesses anti-cancer activity. However, in order to develop a therapeutic strategy using tolfenamic acid for the treatment of cancer, further research is required to highlight reliable cellular and molecular mechanisms of anti-cancer properties. Tolfenamic acid has been shown to alter the expression of several genes that represent cancer hallmarks including apoptosis, growth arrest, angiogenesis and metastasis. Recently, a couple of research groups including ours reported that tolfenamic acid targets multiple oncogenic or tumor suppressive signaling pathways in various types of cancer models. Here, we highlight multiple molecular targets responsible for the anti-cancer mechanism of tolfenamic acid and the benefits of combinational use of this drug with other anti-cancer drugs.

Emerging Molecular Targets for Anti-Cancer Drug Design

2018 ◽  
Vol 12 (1) ◽  
pp. 88-99
Author(s):  
Rohit Dutt ◽  
Vandana Garg ◽  
Anil K. Madan
Keyword(s):  
Drug Design ◽  
Molecular Targets ◽  
Cancer Drug ◽  
Anti Cancer

Anticancer potential of Naringenin, Biosynthesis, Molecular target, and structural perspectives

2021 ◽  
Vol 21 ◽  
Author(s):  
Om Prakash ◽  
Ruchi Singh ◽  
Namrata Singh ◽  
Shazia Usmani ◽  
Mohd Arif ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Molecular Targets ◽  
Cathepsin K ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Scientific Papers ◽  
Inhibitory Potential ◽  
Flavanone Glycoside ◽  
Plant Sources ◽  
Comprehensive Study

: Numerous novel medicinal agents isolated from plant sources were used as indigenous remedies for the management and treatment of various types of cancer diseases. Naringenin is a naturally occurring flavanone glycoside and aglycone (genin) moiety of naringin, predominantly found in citrus and grapefruits, has emerged as a potential therapeutic agent for the management of a variety of diseases. A huge number of scientific papers have been published on naringenin describing its detailed studies and its therapeutic application in different diseases. The current study highlights, a comprehensive study on naringenin concerning its biosynthesis, molecular targets/pathways involved in carcinogenesis, mechanism of actions (MOAs), and structure-activity relationships (SARs), and patents granted have been highlighted. Naringenin and its derivatives has remarkable anti-cancer activity due to their inhibitory potential against diverse targets namely ABCG2/P-gp/BCRP, 5a-reductase, 17-bhydroxysteroid dehydrogenase, aromatase, proteasome, HDAC/Situin-1, VEGF, VEGFR-2 kinase, MMP-2/9, JAK/STAT signaling pathways, CDC25B, tubulin, topoisomerase-II, cathepsin-K, Wnt, NF-kB, B-Raf and mTOR, etc. With the huge knowledge of molecular targets, structural intuition, and SARs, the current study may be beneficial to design more potent, safe, effective, and economic anti-cancer naringenin. This is concluded that naringenin is a promising natural product for the management and therapy of cancer. Further evolution for pharmacological importance, clinical research, and trials are required to manifest its therapeutic action on metabolic syndrome in the human community.

scholarly journals Pharmacological Utilization of Bergamottin, Derived from Grapefruits, in Cancer Prevention and Therapy

2018 ◽  
Vol 19 (12) ◽  
pp. 4048 ◽  
Author(s):  
Jeong-Hyeon Ko ◽  
Frank Arfuso ◽  
Gautam Sethi ◽  
Kwang Ahn
Keyword(s):  
Causes Of Death ◽  
Treatment Options ◽  
Unmet Need ◽  
Molecular Targets ◽  
Pharmacological Agents ◽  
Natural Agents ◽  
Anti Cancer ◽  
Prevention And Therapy

Cancer still remains one of the leading causes of death worldwide. In spite of significant advances in treatment options and the advent of novel targeted therapies, there still remains an unmet need for the identification of novel pharmacological agents for cancer therapy. This has led to several studies evaluating the possible application of natural agents found in vegetables, fruits, or plant-derived products that may be useful for cancer treatment. Bergamottin is a furanocoumarin derived from grapefruits and is also a well-known cytochrome P450 inhibitor. Recent studies have demonstrated potent anti-oxidative, anti-inflammatory, and anti-cancer properties of grapefruit furanocoumarin both in vitro and in vivo. The present review focuses on the potential anti-neoplastic effects of bergamottin in different tumor models and briefly describes the molecular targets affected by this agent.

scholarly journals Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 679 ◽  
Author(s):  
Nurul Azwa Abd. Wahab ◽  
Nordin H. Lajis ◽  
Faridah Abas ◽  
Iekhsan Othman ◽  
Rakesh Naidu
Keyword(s):  
Prostate Cancer ◽  
Molecular Targets ◽  
B Cell Lymphoma ◽  
Signalling Pathways ◽  
Cancer Disease ◽  
Diverse Range ◽  
Wide Range ◽  
Anti Cancer ◽  
Cancerous Cells ◽  
Androgen Independent

Prostate cancer (PCa) is a heterogeneous disease and ranked as the second leading cause of cancer-related deaths in males worldwide. The global burden of PCa keeps rising regardless of the emerging cutting-edge technologies for treatment and drug designation. There are a number of treatment options which are effectively treating localised and androgen-dependent PCa (ADPC) through hormonal and surgery treatments. However, over time, these cancerous cells progress to androgen-independent PCa (AIPC) which continuously grow despite hormone depletion. At this particular stage, androgen depletion therapy (ADT) is no longer effective as these cancerous cells are rendered hormone-insensitive and capable of growing in the absence of androgen. AIPC is a lethal type of disease which leads to poor prognosis and is a major contributor to PCa death rates. A natural product-derived compound, curcumin has been identified as a pleiotropic compound which capable of influencing and modulating a diverse range of molecular targets and signalling pathways in order to exhibit its medicinal properties. Due to such multi-targeted behaviour, its benefits are paramount in combating a wide range of diseases including inflammation and cancer disease. Curcumin exhibits anti-cancer properties by suppressing cancer cells growth and survival, inflammation, invasion, cell proliferation as well as possesses the ability to induce apoptosis in malignant cells. In this review, we investigate the mechanism of curcumin by modulating multiple signalling pathways such as androgen receptor (AR) signalling, activating protein-1 (AP-1), phosphatidylinositol 3-kinases/the serine/threonine kinase (PI3K/Akt/mTOR), wingless (Wnt)/ß-catenin signalling, and molecular targets including nuclear factor kappa-B (NF-κB), B-cell lymphoma 2 (Bcl-2) and cyclin D1 which are implicated in the development and progression of both types of PCa, ADPC and AIPC. In addition, the role of microRNAs and clinical trials on the anti-cancer effects of curcumin in PCa patients were also reviewed.

scholarly journals Emerging anti-cancer molecular mechanisms of aminobisphosphonates

2006 ◽  
Vol 13 (1) ◽  
pp. 7-26 ◽  
Author(s):  
Michele Caraglia ◽  
Daniele Santini ◽  
Monica Marra ◽  
Bruno Vincenzi ◽  
Giuseppe Tonini ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Clinical Studies ◽  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Anti Cancer ◽  
Ras Family ◽  
Skeletal Related Events ◽  
Breast And Prostate Cancer ◽  
Related Proteins

Bone metastases are common in patients with many types of cancer, especially breast and prostate cancer — in which the incidence is approximately 70% among patients with advanced metastatic disease. Aminobisphosphonates (NBPs) have entered clinical practice in the treatment of bone metastases from several neoplasms, including breast and prostate adenocarcinoma, as a result of their anti-resorption properties. However, evidence has accumulated on the direct anti-tumour effects of NBPs. This review describes the metabolic pathways that are putative molecular targets of NBPs and that are involved in the prenylation processes of several intracellular small GTP-binding proteins (ras family related proteins). The latter regulate the intracellular survival and proliferative pathways of tumour cells and could be the intracellular molecular targets of the NBPs responsible for the direct anti-cancer effects, even if definitive conclusions cannot be drawn at present. Different mechanisms have been reported to account for the anti-neoplastic action of NBPs, including: the induction of apoptosis; cell cycle perturbations; and anti-invasive, anti-migration and anti-angiogenic effects. Moreover, this review describes the most important clinical studies that demonstrate the activity of NBPs in preventing skeletal-related events induced by bone metastases. The main pharmacokinetic pitfalls of NBPs are described, and methods of overcoming these pitfalls through the use of liposome vehicles are proposed. Finally, the principal pre-clinical studies on the interaction between NBPs and other biological agents are also described; these studies may enable reductions in the in vivo NBP concentrations required to achieve anti-tumour activity. To date, however, the real molecular targets of NBPs are not completely known and new technological platforms are required in order to detect them and to develop new anti-cancer strategies based on the use of NBPs.

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